Student SYB

Chet Cunha MS IVJanuary 29, 2009

History

•35 y/o M complaining of dyspnea on exertion.

•Has had DOE x 5 years, but has recently worsened.

•Smokes 2ppd x 19yrs

CT Chest

CT Chest

CT Chest

CT Chest

Alpha 1-antitrypsin deficiency

CXR Radiographic findings

•Loss of lung markings

Alpha 1-antitrypsin deficiency

CT Radiographic findings

•Panacinar emphysema predominantly involving the lower lung fields

•Simplification of lung architecture (normal lung structures are replaced by abnormal airspaces)

•Diffuse cystic bronchiectasis

•Ground glass opacities

Alpha 1-antitrypsin

deficiency Treatment Options

•Supplemental O2

•Inhaled Beta agonists and corticosteroids

•Alpha 1-antitrypsin replacement therapy

•Lung volume reduction surgery

•Lung transplantation

Further Reading

• Gourtsoyiannis, N.C., Ros, P.R. Radiologic-Pathologic Correlations from Head to Toe. Springer Publishing, Berlin 2005.

• Grossman, Z.D., Katz, D. S., et al. Cost-Effective Diagnostic Imaging. Mosby Elsevier, Philadelphia, 2006.

• CXR image courtesy of eMedicine

Thank you!