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STOMACH AND DUODENUM
Begashaw m (MD)
Introduction
PUD is a common problem Helicobacter pylori (H. pylori) - important
associated risk factor Gastric cancer
-One of the top five cancers
-Worst prognosis - difficulty to diagnose
-High index of suspicion
Stomach Anatomy
Asymmetric dilation of the proximal gastro intestinal tract
Capacity-1.5 to 2.0 LCardia, Fundus, Body, Antrum & PylorusPyloric sphincter- regulates gastric emptying
& prevents refluxWall - Four layers Mucosa, Submucosa,
Muscularis & Serosa
Anatomy
Types of cells & secretion
Functions
A-Food breakdown to form chyme
- mechanical digestion and
- acid and pepsin action
B-Reservoir through receptive relaxation Phases of gastric secretion
_Cephalic - Acetylcholin by the vagus nerve
_Gastric - Gastrin (by G cells)
_Intestinal - mainly inhibitory - Secretin
Histology
Surface epithelial cells alkaline mucus
Mucus cells_mucus, HCO3¯
Parietal cellsHCl, Intrinsic factor
Chief cells pepsinogens, lipases
Pathogenesis
imbalance in aggressive activity of acid & pepsin & defensive mechanisms
Factors
1. Helicobacter pylori
2. NSAIDs - aspirin
3. Acid hypersecretion
4. Rapid gastric emptying
5. Impaired duodenal acid disposal
6. Impaired gastric mucosal defense
7. Duodenogastric reflux
Classification
Erosive gastritisAcute gastritis - after major trauma, shock,
sepsis, head Injury & ingestion of aspirin & alcohol -“Stress erosion”
Chronic gastritis->Established inflammatory reaction
Duodenal ulcer -occurs in the proximal duodenum with in 1 to 2 cm of the pylorus & there is acid hyper secretion
Gastric ulcer_ acid secretion is either normal or decreased
Classification
Summary of clinical features
Investigations
A- Gastroduodenoscopy and biopsy
B- Barium meal
C- Blood studies ↓ hemoglobin (Hgb) shows chronic blood loss
D-H.pylori test
Treatment
Medical treatment Acid reduction
- H2 – receptor antagonists– cimetidine 800 mg/night for 6 wks
- Proton pump inhibitor – omeprazole 20 mg/day
- Irritants_avoid Anti H. pylori treatment
-Bismuth tablets
-Amoxicillin for 2 – 4 weeks
-Metronidazole
Surgical treatment
A - Complications
– obstruction
_ perforation
_ bleeding
B - Intractability
Complications of PUD
Perforated peptic ulcer
- Sex ratio 2:1 , age 45-55 years
- Anterior surface of duodenum (location)
- Past history of PUD is common
- Gastric contents spill over the peritoneum and bring about peritonism which will be followed by bacterial peritonitis after 6 hours
Clinical features
Sudden onset of abdominal painPale, anxiousRaised pulse rateAbdomen still, not moving with respiration tender,
board like rigidityAfter 6 hrs peritonitis - silent abdominal distentionErect plain abdominal x-ray/CXR - air under
diaphragm
Air under diaphragm
Treatment
ResuscitateAntibiotic therapyContinuous gastric aspiration Urgent laparotomy - peritoneal toilet and
closure of perforation with omental patchAnti H-pylori treatment - recurrence
Omental patch
Graham patch technique
Bleeding Peptic Ulcer
- Slight bleeding -trauma from solid food
- Severe hemorrhage - erosion of an artery at the base of the ulcer located posteriorly (gastoduodenal, splenic)
- Patient presents with hematemesis and/or melena
Management
Conservative
- IV fluid resuscitation
- Blood transfusion if indicated
- Naso gastric tube insertion and saline lavage
- H2 receptor antagonist
- Endoscopic evaluation
- Serial hematocrit
Gastric Outlet Obstruction-GOO
results from cicatrisation and fibrosis due to long standing duodenal or juxtapyloric ulcer
Clinical feature
- pain, fullness, vomiting of large foul smelling vomit
- peristaltic wave from left to right
- succussion splash
- electrolyte disturbance and metabolic alkalosis
- Barium meal-large stomach full of food residue with delay in evacuation
Treatment
Surgery – truncal vagotomy and bypass operation after preliminary gastric lavage with saline for 4-5 days
Correction of fluid and electrolytes using crystalloid fluids
Gastric Cancer
Epidemiology
- Age 40-60 years
- Sex M:F 3:1 More common in Far East – Japan Etiology Premalignant conditions Risk factors:
Gastric polyp,pernicious anemia, post gastrectomy stomach, gastritis, cigarette smoking
& genetic makeup
Pathology
- Prepyloric region is the most common site
- Microscopic - AdenocarcinomaSpread
-Direct
-lymphatic
-transperitoneal
-blood stream
Clinical features
New onset dyspepsia -above 40 yrs Anorexia ,loss of weight Anemia, tiredness, weakness, pallor Persistent pain with no response to medical treatment Gastric distention Dysphagia or fullness, belching , vomiting Other signs
- Virchow’s nodes , Krukenberg tumor
- Abdominal mass
- Ascites
Gastric ca
Investigations
- Gastroscopy and biopsy
- Hgb
- Barium meal shows filling defect
- Laparotomy (diagnostic)
Treatment
- Gastrectomy when possible
- Palliative bypass surgeryPrognosis
- Over all 5 years survival is about 10 -20%