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StilnoxStilnox
StilnoxStilnox
• Industrial name: Stilnox• Generic name: Zolpidem Tartrate• Indication: Short term treatment of insomnia• Date of birth:1988• Manufactured in France by Sanofi-Synthelabo• Entered to Israel: 1993• Distribution by Mediline• Approved by the FDA
• The incidence of insomnia increases with age.30% of adults complain of sleep disorders.90% of patients in nursing homes take sleep medication regularly.
• The target market - adults over 60, who complain about sleep disorders.
• There are two main groups of sleep drugs- benzodiazepines and non-benzodiazepines.
• The benzodiazepines market includes Vaben, Bondormin, Valium, and Lorivan. The non-benzodiazepines market includes: Imovan, Nocturno, Stilnox.
StilnoxStilnox
StilnoxStilnox• Stilnox appears in one presentation of 10mg.
20 tablets in two blisters.• Dosage: 1 tablet before sleep.
(For adults over 65 half tablet before sleep).• Stilnox is selective for Ω1 in GABA receptor, which
is the specific site for sleep in the brain.• Stilnox generally induces sleep within 20-30 minutes
of administration, and is recommended to take immediately before sleep.
• Stilnox significantly increases the mean total sleep time.
• Stilnox significantly reduces the number of early awakenings.
• Stilnox can be taken intermittently - “as needed”.
Advantages of StilnoxAdvantages of Stilnox
• Non – BZD image (1st member of a new chemical class) – Ω1 selective.
• Optimal half-life T1/2 = 21/2 hr. (long enough for good night’s sleep, short enough for a full active day.
• Preserves natural sleep architecture. • Minimal potential for dependence.• Can be taken intermittently- “as needed”.• Does not cause metal taste.• Stilnox is a non addictive drug.
Who may benefit from StilnoxWho may benefit from Stilnox
• Adults complaining of sleep disorders.
• A large group of “untreated patients”.
• Large group of patients are still treated with benzodiazepines and other medications.
How to switch to StilnoxHow to switch to Stilnox
• Withdrawal - stopping treatment with Benzodiazepine should be gradual and not sudden
• Waiting - Washout period 2-3 days depending on half-life of the Benzodiazepine
• Prescription of Stilnox
Withdrawal Waiting Prescription
Thank you …Thank you …