STEVEN C. KOENIGcv2i.org/wp-content/uploads/2012/04/Koenig-cv-Oct-7-2009.pdf · 07/10/2009 · Steven C. Koenig, Ph.D. Curriculum Vitae 2 PROFESSIONAL AFFILIATIONS and TRAINING (continued):

STEVEN CHRISTOPHER KOENIG

Associate Professor – Department of Bioengineering Adjunct Associate Professor – Department of Surgery

Cardiovascular Innovation Institute 302 East Muhammad Ali Blvd, room 408

University of Louisville Louisville, KY 40202 TEL: (502)-852-7320 FAX: (502)-852-1795

Home: (812)-923-1378 [email protected]

http://louisville.edu/speed/bioengineering/faculty/koenig/

PERSONAL

EDUCATION:

1996 Ph.D. in Biomedical Engineering. University of Texas, Austin, TX

1990 Master of Science in Electrical Engineering. University of New Hampshire, Durham, NH

1989 Bachelor of Science in Electrical Engineering. University of New Hampshire, Durham, NH

ACADEMIC AND PROFESSIONAL EXPERIENCE:

1996 – present University of Louisville, Louisville, Kentucky, Department of Bioengineering (BE), Associate Professor, 2004 – Present; Department of Surgery, Adjunct Associate Professor, 2004 – Present, Associate Professor, 2002 – 2004, Assistant Professor, 1997 – 2002, Instructor, 1996 - 1997; Department of Electrical and Computer Engineering, Associate Faculty, 1998 – Present.

1991 – 1996 Brooks Air Force Base, Brooks City-Base, TX, Physiology Research Branch, Chief Engineering Section and USAF Captain, 1994-96; Laboratory for Aerospace Cardiovascular Research, Biomedical Research Engineer and USAF Lieutenant, 1991-94.

1989 – 1991 University of New Hampshire, Durham, NH. Department of Electrical Engineering, Biomedical Research Engineer, 1991; Graduate Student Research Assistant,1989-90; Marine Sciences Laboratory, Research Engineer,1989.

PROFESSIONAL AFFILIATIONS and TRAINING:

American Society for Artificial Internal Organs (ASAIO) – Board of Trustees & Member

Tau Beta Pi Engineering Honor Society – Member

Sigma Xi Research Society – Member

IEEE Engineering in Medicine and Biology Society (EMBS) – Member

Institute of Electrical and Electronics Engineers (IEEE) – Member

Cardiovascular Pathophysiology for Engineers, MIT, Boston, MA

MotionBASIC Programming/Advanced Applications, Rochester, NY

Design and Analysis of Multifactor Experiments, Brooks AFB, TX

mailto:[email protected]

http://louisville.edu/speed/bioengineering/faculty/koenig/

Steven C. Koenig, Ph.D. Curriculum Vitae

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PROFESSIONAL AFFILIATIONS and TRAINING (continued):

Design of Experiments and Planning of Clinical Trials, Brooks AFB, TX

LabVIEW Basics Course, National Instruments, Austin, TX

Good Laboratory Practice Training Course, Louisville, KY

Matlab and Simulink, MathWorks, Inc., Natick, MA

AWARDS and RECOGNITION:

University Scholar (University of Louisville), 2009-11

College of Fellows of American Institute for Medical and Biological Engineering (AIMBE), 2009

ASAIO Willem J Kolff Young Investigator Fellowship Award, 2007

Co-Chair for the INTERMACS Registry Focused Research and Mission Activities Subcommittee, 2007-present

Elected to the ASAIO Board of Trustees, 2006-present

Editorial Board – ASAIO Journal, 2005-present

Co-Chair for the INTERMACS Registry Blood and Tissue Subcommittee, 2005-2006

1st Place Innovation in Biotechnology, Research!Louisville, 2005

Most Outstanding Management and Technology Paper by Association for the Advancement of Medical Instrumentation (AAMI), 2005

2nd Place-National Instruments LabVIEW Application of the Year (Austin, TX), 1999

Most Productive Researcher, Research!Louisville, 1998

Air Force Commendation Medal, 1994

2-yr Research Assistantship, 1989 -1990

4-yr AFROTC Scholarship, 1985-1989

American Legion Scholastic Excellence Award, 1985-87

Outstanding College Students of America, 1989

Eagle Scout, 1985

SCHOLARSHIP OF DISCOVERY, INTEGRATION AND APPLICATION

Research Specialties

Development (SCR – CPD, AVD) and Testing (Abiomed - AbioCor, Impella, IABP; Thoratec – HM XVE and HM II; and HeartWare – HVAD, MVAD) of Mechanical Circulatory Support (MCS) devices to promote myocardial recovery in heart failure patients; development of physiologic data acquisition and analysis systems; biomedical instrumentation and transducers; FDA, IACUC and IRB approved protocols; and establishment of Good Laboratory Practice (GLP) program.


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PUBLICATIONS:

Summary of 5-yr Impact Factor or Peer Reviewed Journal Articles

Journal Factor Journal Factor

American Journal of Physiology 3.736 ASAIO Journal 1.504

Journal of Thoracic & Cardiovascular Surgery 3.508 Computers in Medicine & Biology 1.427

Annals of Biomedical Engineering 2.999 Journal Cardiac Surgery 1.313

Journal of Heart & Lung Transplant 2.805 Journal of Investigative Surgery 1.298

Annals of Thoracic Surgery 2.592 Comparative Medicine 1.267

Medical Engineering & Physics 2.314 Aviation Space & Environ Med 0.958

European Journal of Cardiovascular Surgery 2.140 Heart Surgery Forum 0.623

Artificial Organs 1.828 Acta Astraunatica 0.424

Physiology 1.739 Biomedical Instrument & Tech ---

Medical & Biological Engineering & Computing 1.600 Journal Gravitational Physiology ---

Peer-Reviewed Journals

1. Pantalos GM, T Horrell, C Ionan, S Sahetya, KJ Gillars, and SC Koenig. Expanded Pediatric Cardiovascular Simulator for Research and Training. ASAIO Journal (in Press).

2. Slaughter MS, CR Bartoli, MA Sobieski, GM Pantalos, GA Giridharan, RD Dowling, SD Prabhu,

DJ Farrar, and SC Koenig. Intraoperative evaluation of HeartMate II flow estimator. J Heart Lung Transplant, 28:39-43, 2009.

3. Koenig SC, GA Giridharan, DL Ewert, MJ Schroeder, C Ionan, MS Slaughter, MA Sobieski, GM Pantalos, RD Dowling, and SD Prabhu. Human, bovine and porcine systemic vascular input impedance are not equivalent: Implications for device testing in heart failure. J Heart Lung Transplant, 27:1340-47, 2008.

4. Koenig SC, KN Litwak, GA Giridharan, GM Pantalos, RD Dowling, SD Prabhu, MS Slaughter, MA Sobieski, and PA Spence. Chronic Counterpulsation for Heart Failure: Hemodynamic Performance and Hemocompatability of a 30- ml Subcutaneous Counterpulsation Device. ASAIO Journal, 54:578-84, 2008.

5. Pantalos GM, GA Giridharan, J Colyer, M Mitchell, J Speakmen, C Lucci, G Johnson, M Gartner,

and SC Koenig. Effect of continuous and pulsatile flow left ventricular assist on pulsatility in a pediatric animal model of left ventricular dysfunction: pilot observations. ASAIO Journal, 53:385-91, 2007.

6. Kaebnick BW, GA Giridharan, and SC Koenig. Quantification of pulsatility as a function of vascular input impedance: an in vitro study. ASAIO Journal, 53:115-121, 2007.


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Publications (continued)

7. Travis AR, GA Giridharan, GM Pantalos, RD Dowling, SD Prabhu, MS Slaughter, MA Sobieski, A

Undar, and SC Koenig. Vascular pulsatility in patients with a pulsatile or continuous flow ventricular assist device. Journal of Thoracic and Cardiovascular Surgery, 133:517-24, 2007.

8. Giridharan GA, SC Koenig, M Mitchell, M Gartner, and GM Pantalos. A computer model of the pediatric circulatory system for testing pediatric assist devices. ASAIO Journal, 53:74-81, 2007.

9. Makkar A, J Banchs, MA Hauck, TS Siddiqui, SA Jortani, R Valdes, SC Koenig, ME Mitchell, A Tomita-Mitchell, and SD Prabhu. Identification of Genetic Variants of the Tumor Necrosis Factor Receptor 2 Gene (TNFRSF1B) in Patients with Heart Failure. American College of Cardiology, Atlanta, GA, March 11-14, 2006.

10. Koenig SC, KN Litwak, GM Pantalos, PA Spence, and RD Dowling. Development and early testing of a simple subcutaneous circulatory support device. ASAIO Journal, 52:362-67, 2006.

11. Slaughter MS, MA Sobieski, SC Koenig, PS Pappas, AJ Tatooles, and MA Silver. Left ventricular assist device weaning: hemodynamic response and relationship to stroke volume and rate reduction protocols. ASAIO Journal, 52:228-33, 2006.

12. Giridharan GA, SC Koenig, GM Pantalos, KN Litwak, and PA Spence. Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical approach. ASAIO Journal, 52:39-46, 2006.

13. Litwak KN, SC Koenig, GA Giridharan, C Cheng, KJ Gillars, and GM Pantalos. Effect of VAD outflow graft location on hemodynamics and pressure-volume relationship in an adult mock circulation. Artificial Organs, 29:629-635, 2005.

14. Litwak, KN, A McMahan, KA Lott, LE Lott, and SC Koenig. Monensin toxicosis in the bovine calf: a large animal model of cardiac dysfunction. Comparative Medicine, 44(3):45-49, 2005.

15. Giridharan GA, DL Ewert, GM Pantalos, KJ Gillars, KN Litwak, LA Gray, and SC Koenig. Left ventricular and myocardial perfusion responses to volume unloading and afterload reduction in a computer simulation. ASAIO Journal, 50(5):512-518, 2004.

16. Litwak KN, SC Koenig, H Tsukui, S Kihara, Z Wu, and GM Pantalos. Effects of left ventricular assist device support and outflow graft location on aortic blood flow. ASAIO Journal, 50(5):432-437, 2004.

17. Giridharan GA, GM Pantalos, KJ Gillars, SC Koenig, and M Skliar. Physiologic control of rotary blood pumps: an in vitro study. ASAIO Journal, 50(5):403-409, 2004.

18. Ewert DL, B Wheeler, C Doetkott, C Ionan, GM Pantalos, and SC Koenig. The effect of heart rate, preload, and afterload on the visco-elastic properties of the swine myocardium. Ann. Biomed. Eng., 32(9):1211-1222, 2004.

19. Schroeder MJ, B Perrrault, DL Ewert, and SC Koenig. HEART: An automated beat-to-beat

cardiovascular analysis package using Matlab . Computers in Biology and Medicine, 34:371-388, 2004.

20. Koenig SC, C Woolard, GD Drew, L Unger, KJ Gillars, DL Ewert, LA Gray, and GM Pantalos. Integrated data acquisition system for medical device testing and physiology research in compliance with Good Laboratory Practices Biomed. Instr. & Tech. 38(3):229-40, 2004.


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21. Koenig SC, GP Pantalos, KJ Gillars, DL Ewert, KN Litwak, and SW Etoch. Hemodynamic responses to continuous and pulsatile assist in an adult mock circulation. ASAIO Journal, 50:15-24, 2004.

22. Pantalos GM, SC Koenig, KJ Gillars, GA Giridharan, and DL Ewert. Characterization of an adult mock circulation for testing cardiac support devices. ASAIO Journal, 50:37-46, 2004.

23. Koenig SC, DL Ewert, DA Ludwig, JW Fanton, and VA Convertino. Effects of fluid shifts during bed rest confinement on left ventricular and systemic arterial elastances. Aviation Space & Environmental Medicine, 75:7-15, 2004.

24. Zonnevijlle E, GP Abadia, NN Somia, M Kon, JH Barker, SC Koenig, DL Ewert, and RW Stremel. A technique for sequential segmental neuromuscular stimulation with closed loop feedback control. Journal of Investigative Surgery, 15:91-99, 2002.

25. Koenig SC, DA Ludwig, CA Reister, JW Fanton, DL Ewert, and VA Convertino. Left ventricular, systemic arterial, and baroreflex responses to Ketamine and TEE in chronically-instrumented rhesus monkeys (Mucaca mulatta). Comparative Medicine, 51:406-412, 2001.

26. Schroeder MJ, V Phaniraj, SC Koenig, RD Latham, and DL Ewert. The role of arterial elastance in ventricular-arterial coupling in normal gravity and altered acceleration environments. Aviation Space & Environmental Medicine, 72:1-7, 2001.

27. Dowling RD, SW Etoch, K Steven, A Butterfield, SC Koenig, A Johnson, B Chiang, and LA Gray.

Initial experience with the AbioCor implantable replacement heart at the University of Louisville. ASAIO Journal, 46:579-581, 2000.

28. Graen, MD, DL Ewert, JS Glower, LA Gray, and SC Koenig. Can a linear electrical analog model of a mechanical valve predict flow using a pressure gradient? ASAIO Journal, 46:563-68, 2000.

29. JW Fanton, SR Zarr, DL Ewert, RW Woods, and SC Koenig. Cardiovascular responses to propofol and etomidate in long-term instrumented rhesus monkeys (Macaca mulatta). Comparative Medicine, 50(3):303-308, 2000.

30. VanHimbergen DJ, SF Jaber, SC Koenig, MA Kashem, B BhaskerRao, and PA Spence. A new technique to create an artificial stenosis in the native LAD using a hemoclip. Journal of Investigative Surgery, 13:7-13, 2000.

31. Dowling RD, SC Koenig, MA Laureano, and LA Gray. Intermediate Term Results of Partial Left Ventriculectomy. Journal of Cardiac Surgery, 13:214-217, 2000.

32. Koenig SC, M Shafie, A Pearson, MA Laureano, P Cerrito, DL Ewert, MJ Schroeder, and RD Dowling. Intraoperative assessment of acute hemodynamic changes after partial left ventriculectomy. Journal of Cardiac Surgery, 14:152-56, 2000.

33. Convertino VA, SC Koenig, JW Fanton, CA Reister, FA Gaffney, DA Ludwig, DL Ewert, and CH Wade. Alterations in the volume stimulus-renal response relationship during exposure to simulated microgravity. Journal of Gravitational Physiology, 6:1-10, 1999.

34. VanHimbergen DJ, SC Koenig, SF Jaber, PB Cerrito, and PA Spence. A review of transit-time flow measurement for assessing graft patentcy. Heart Surgery Forum, 2:226-229, 1999.


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35. Koenig SC, DJ VanHimbergen, SF Jaber, DL Ewert, P Cerrito, and PA Spence. Spectral analysis of graft flow for anastomotic error detection in off-pump CABG. European Journal of Cardiothoracic Surgery, 16:S83-S87, 1999.

36. Schaub J, SC Koenig, MJ Schroeder, DL Ewert, GA Drew, and RD Swope. Development of a flow-feedback pulse duplicator system with rhesus monkey arterial input impedance characteristics. ASAIO Journal, 45:334-338, 1999.

37. Graen MA, DL Ewert, JS Glower, LA Gray, and SC Koenig. Electrical analog model of the aortic valve for beat-to-beat aortic flow using pressure gradient. ASAIO Journal, 45:204-210, 1999.

38. Essler S, MJ Schroeder, V Phaniraj, SC Koenig, RD Latham, and DL Ewert. Fast estimation of arterial vascular parameters for transient and steady beats with application to hemodynamic state under variant gravitational conditions. Annals of Biomedical Engineering, 27:486-97, July 1999.

39. Cerrito P, SC Koenig, DJ Van Himbergen, S Jaber, DL Ewert, B BhaskerRao, and PA Spence. Neural Network Pattern Recognition Analysis of Graft Flow Characteristics Improves Intra-operative Anastomotic Error Detection in Minimally Invasive CABG. European Journal of Cardiothoracic Surgery, 16:88-93, 1999.

40. Dowling RD, SC Koenig, DL Ewert, MA Laureano, and LA Gray. Case Study: Acute hemodynamic benefits of partial left ventriculectomy without mitral valve repair. Annals of Thoracic Surgery, 67:1470-72, 1999.

41. Etoch SW, SC Koenig, MA Laureano, P Cerrito, LA Gray, and RD Dowling. Results after partial left ventriculectomy versus heart transplantation for idiopathic cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery, 117:952-59, 1999.

42. BhaskerRao B, DJ VanHimbergen, HL Edmunds, S Jaber, A Ali, S Pagni, SC Koenig, and PA Spence. Evidence for Improved Cerebral Function after Minimally Invasive Bypass Surgery. Journal of Cardiac Surgery, 13:27-31, 1999.

43. Dowling RD, SC Koenig, MA Laureano, P Cerrito, and LA Gray. Results of partial left ventriculectomy in patients with end stage idiopathic dilated cardiomyopathy. Journal of Heart & Lung Transplant, 17:1208-12, 1998.

44. Jaber S, SC Koenig, B Jaber S, SC Koenig, B Bhasker-Rao, D VanHimbergen, and PA Spence. Brief Communication: Can visual assessment of flow waveform morphology detect anastomotic error in off-pump coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg. 14:476-79, 1998.

45. Reister C, SC Koenig, J Schaub, DL Ewert, RD Swope, and JW Fanton. Evaluation of dual-tip pressure catheters during chronic 21-day implantation in goats. Medical Engineering & Physics, 20:410-417, 1998.

46. Bhasker-Rao, D VanHimbergen, PB Cerrito, DL Ewert, LA Gray, and PA Spence. Role of Graft Flow Measurement Technique in Anastomotic Quality Assessment in Minimally Invasive CABG. Annals of Thoracic Surgery, 66:1087-92, 1998.

47. Bidiwala SB, MS Mansour, CK Stengel, SA Klein, SM Carroll, SC Koenig, AH Desoky, GR Tobin, C Maldanado, and JH Barker. Quantification of the morphological features of a full microvascular network. Medical & Biological Engineering & Computing, 36:621-26, 1998.


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48. Koenig SC, VA Convertino, CA Reister, JW Fanton, D Ludwig, FA Gaffney, and RD Latham. Evidence for increased cardiac compliance during exposure to simulated microgravity. American Journal of Physiology, 275:1343-1352, 1998.

49. Convertino VA, SC Koenig, VP Krotov, JW Fanton, DL Ewert, VI Korolkov, EV Trambovetsky, A Truzhennikov, and RD Latham. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey: A feasibility study for spaceflight experiments. Acta Astranautica, 42:255-263, 1998.

50. Koenig SC, JD Schaub, DL Ewert, and RD Swope. In-line pressure-flow module for cardiovascular dynamics in vitro modeling and biosensor evaluation. Medical & Biological Engineering & Computing, 35(5):549-52, 1997.

51. Koenig SC, CA Reister, J Schaub, RD Swope, DL Ewert, and JW Fanton. Evaluation of transit-time and electromagnetic flow measurements in a chronically-instrumented non-human primate model. Journal of Investigative Surgery, 9(6):455-461, 1996.

52. Latham RD, JW Fanton, CD White, MN Vernalis, RP Crisman and SC Koenig. Circulatory filling pressures during transient microgravity induced by parabolic flight. The Physiologist 36(1):S18-19, 1993.

Peer-Reviewed Journals – Submitted

1. MS Slaughter, SC Koenig, Bartoli CR, GC Wilson, GA Giridharan, MA Sobieski, PA Spence, and SD Prabhu. Acute Testing of a Subcutaneous Counterpulsation Device over a Range of Physiological Conditions. Journal of Cardiology Research, (in review).

2. Giridharan GA, C Lederer, A Berthe, L Goubergrits, J Hutzenlaub, MS Slaughter, PA Spence, and

SC Koenig. Flow visualization and in-vivo testing of a novel counterpulsation device demonstrates low risk of hemolysis and thromboembolic events. Annals of Biomedical Engineering (in review).

3. Pantalos GM, SC Koenig, KJ Gillars, RD Dowling, and LA Gray. Intraaortic balloon pump timing discrepancies in adult patients. Journal Thoracic and Cardiovascuar Surgery (in review).

Articles Published in Peer-Reviewed Conference Proceedings

1. Dong H, SC Koenig, DJ Dosdall, RE Ideker, JF Naber, and RS Keynton. Development of High-Density Surface Microelectrode Arrays for High Spatial Resolution Cardiac Mapping, Proc. of the 5th MMB, Quebec, Canada, April 1-3, 2009.

2. Giridharan G, G Pantalos, SC Koenig, K Gillars, and M Skliar. Achieving physiologic perfusion with ventricular assist devices: comparison of control strategies. American Control Conference (AACC), Portland, OR June 8-10, 2005.

3. Koenig SC, GM Pantalos, KN Litwak, KJ Gillars, M Maguire, and PA Spence. Hemodynamic and left ventricular pressure-volume responses to counterpulsation in adult mock circulation and large animal models. Proceedings of the 26

th Annual IEEE-EMBS Conference, San Francisco, CA,

September 1-4, 2004.


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4. Glower JS, R Cheng, GA Giridharan, KJ Gillars, GM Pantalos, DL Ewert, and SC Koenig. In vitro evaluation of control strategies for an artificial vascular device. Proceedings of the 26

th Annual

IEEE-EMBS Conference, San Francisco, CA, September 1-4, 2004.

5. Koenig SC, MJ Schroeder, B Wheeler, J Jorgenson, and DL Ewert. Uncertainty analysis of measurement error in calculating vascular input impedance: How many harmonics can be resolved? 2

nd Joint EMBS-BMES Conference, Houston, TX, October 23-26, 2002.

6. Pantalos GM, SC Koenig, KJ Gillars, and DL Ewert. Mock circulatory system for testing cardiovascular devices. 2

nd Joint EMBS-BMES Conference, Houston, TX, October 23-26, 2002.

7. Ripplinger CM, DL Ewert, and SC Koenig. Toward a new method of analyzing cardiac performance. Biomed Sci Instr., 37:313-8, 2001.

8. Latham, RD, JW Fanton, CD White, RD Crisman, and SC Koenig. Circulatory filling pressures during transient microgravity induced by parabolic flight. American Physiology Society, pp. 23-26, Colorado, Springs, CO, September 1992.

9. White CD, SC Koenig, JW Fanton, RD Latham, DA Self, RW Owens, and RE Mendenhall. Chronic instrumentation for right heart cardiovascular studies in a human surrogate model. Proceedings of the 14

th Annual IEEE Engineering in Medicine and Biology Society International Conference, 92(2):

722-23, Paris France, October 1992.

10. Koenig SC and JR LaCourse. The Actimeter: analyzing human functional mobility, Proceedings of the 17

th Annual Northeast Bioengineering Conference, pp. 149-50, Hartford CT, April 1991.

11. Koenig SC and JR LaCourse. The Actimeter: analyzing bilateral human functional mobility. Proceedings of the 13

th Annual IEEE Engineering in Medicine and Biology Society International

Conference, 13(4):1861-62, Orlando FL, October 1991.

12. Koenig SC and JR LaCourse. Analysis of human functional mobility. Proceedings of the 12th

Annual IEEE Engineering in Medicine and Biology Society International Conference, Philadelphia PA, November 1990.

13. Hinkle R, SC Koenig, N Vroman, JR LaCourse, R Croce, and A Seidel. Vocational rehabilitation team stressing university student interaction: a model. Proceedings of the 16

th Annual Northeast

Bioengineering Conference, pp.13-14, University Park, PA, March 1990.

14. Koenig SC, CD White, RE Mendenhall, G Muniz, and T Ferguson. Instrumentation and recording scheme for cardiovascular studies in chronically instrumented human surrogates and non-invasively instrumented humans during parabolic flight. Proceedings of the 14

th Annual IEEE Engineering in

Medicine and Biology Society International Conference, 92(2):728-29, Paris France, October 1992.

15. Koenig SC, C Reister, J Schaub, G Muniz, T Ferguson, and JW Fanton. Evaluation of flow biosensor technology in a chronically instrumented non-human primate model. Proceedings of the 17

th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,

pp. 1573-74, Montreal, Canada, September 1995.

16. Offerdahl CD, JD Schaub, SC Koenig, RD Swope, and DL Ewert. Development of an In-Vitro Circulatory System with Known Resistance and Compliance. Biomed. Sci. Instr., 32:183-188, March 1996.


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17. Zonnevijlle E, Abadia GP, N Somia, R Stremel, C Maldanado, SC Koenig, M Palacio, P Werker, M Kon, and J Barker. Feedback (Closed Loop) Control of a Urinary Graciloplasty Neo-Sphincter. Proceedings of the American College of Surgeons, pp. 621-22, Orlando, FL, October 1998.

18. Abadia GP, E Zonnevijlle, N Somia, R Stremel, SC Koenig, M Palacio, P Werker, M Kon, C Maldanado, G Tobin, and J Barker. Dynamic Graciloplasty: Sequential Stimulation Neuromuscular Stimulation (SSNS) Improves Neo-Sphincter Performance. Proceedings of the American College of Surgeons, pp. 669-70, Orlando, FL, October 1998.

Abstracts Published in Peer Reviewed Conference Proceedings (1presentor,

2conference award winner,

3 < 25% acceptance rate)

1. H Dong, MM Crain, SC Koenig, DJ Dosdall, RE Ideker, JF Naber, and RS Keynton. Flexible High-Density Surface Microelectrode Arrays for High Spatial Resolution Cardiac Mapping, Accepted BMES 2009 Annual Fall Meeting, Pittsburgh, PA, Oct. 7-10, 2009.

2. Slaughter MS, MS Ising, D Tamez, G O'Driscoll, N Voskoboynikov, CR Bartoli, SC Koenig, and

GA Giridharan. Reappearance of a Normal Circadian Rhythm after Ventricular Assist Device Implantation. Presented at the 13th Annual Scientific Meeting Heart Failure Society of America, Boston, MA, September 13-16, 2009.

3. Giridharan GA, C Bartoli, R Lewis, MS Slaughter, SD Prabhu, and SC Koenig. Hemodynamic responses to pulsatile and continuous flow LVAD in an ischemic cardiac dysfunction calf model. Presented at the 55th ASAIO conference, May 28-30, 2009.

4. Lederer C, A Berthe, L Goubergrits, GA Giridharan, MS Slaughter, PA Spence, and SC Koenig. Flow visualization and in-vivo testing of a counterpulsation device demonstrates low risk of hemolysis and thromboembolic events. Presented at the 55th ASAIO conference, May 28-30, 2009.

5. Giridharan GA, P Freislederer, SC Koenig, and MS Slaughter. Effects of continuous flow and pulsatile flow ventricular assist device failure: In-silico, in-vitro and in-vivo study. Presented at the 55th ASAIO conference, May 28-30, 2009.

6. Holman WL, RL Kormos, MA Miller, FD Pagani, E Blume, T Cleeton, SC Koenig, DC Naftel, JK Kirklin, and L Edwards. Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study. 27(2):S244, presented at the 28

th International Society for

Heart and Lung Transplantation Meeting in Boston, MA, April 10, 2008.

7. Bartoli CR, SC Koenig, GA Giridharan, MS Slaughter, MA Sobieski, RD Dowling, SD Prabhu, and PA Spence. Testing of a subcutaneous counterpulsation device for the treatment of heart failure over a physiologic range of hemodynamic conditions. Presented at 54

th ASAIO Conference in San

Francisco, CA June 19-21, 2008.

8. GA Giridharan, MS Slaughter, MA Sobieski, RD Dowling, S Aggarawal, SD Prabhu, GM Pantalos, D

Farrar, and SC Koenig. LVAD support increase transvalvular pressure gradient. Presented at 54th

ASAIO Conference in San Francisco, CA June 19-21, 2008.

9. MS Slaughter, MA Sobieski, GA Giridharan, GM Pantalos, RD Dowling, SD Prabhu, DJ Farrar, and

SC Koenig. Intraoperative evaluation of the Heartmate II flow estimator. Presented at 54th

ASAIO Conference in San Francisco, CA June 19-21, 2008.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHG-4WWJ02K-62&_user=134779&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1031489132&_rerunOrigin=google&_acct=C000011238&_version=1&_urlVersion=0&_userid=134779&md5=ddc7eb9f58874c73125c2237921f922b#aff1


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10. Koenig SC, GA Giridharan, C Ionan, GM Pantalos, RD Dowling, S Prabhu, MA Sobieski, and MS Slaughter. Systemic vascular input impedance in humans, calves, and pigs: clinical implications with medical devices and xenotransplantation. 26(2):S91-92, presented at 27

th International Society

for Heart and Lung Transplantation Meeting in San Francisco, CA, April 25-28, 2007.

11. Slaughter MS, MA Sobieski, GM Pantalos, GA Giridharan, RD Dowling, S Prabhu, DJ Farrar, and

SC Koenig. Left ventricular pressure unloading with continuous and pulsatile left ventricular assist devices in advanced heart failure patients. 26(2):S88, presented at 27

th International Society for

Heart and Lung Transplantation Meeting in San Francisco, CA, April 25-28, 2007.

12. 2Koenig SC, GA Giridharan, RD Dowling, S Prabhu, and MS Slaughter. Comparative studies

between human, bovine, and porcine systemic vascular input impedances. Presented at 53rd

ASAIO Conference in Chicago, IL, June 7-9, 2007.

13. Cheng RC, GA Giridharan, DL Ewert, and SC Koenig. Strategies for impedance control using an artificial vasculature device. Presented at 53

rd ASAIO Conference in Chicago, IL, June 7-9, 2007.

14. Giridharan GA and SC Koenig. Quantification of pulsatility as a function of vascular input impedance: an in vitro study. Presented at 53

rd ASAIO Conference in Chicago, IL, June 7-9, 2007.

15. Koenig SC, RD Dowling, KN Litwak, GM Pantalos, and PA Spence. Development and in vivo testing of a simple subcutaneous circulatory support device. Presented at the American College of Cardiology, Atlanta, GA, March 11-14, 2006.

16. 1Koenig SC, RD Dowling, KN Litwak, GM Pantalos, and PA Spence. Development and in vivo

testing of a simple subcutaneous circulatory support device. Presented at 55th

American College of Cardiology, Atlanta, GA, March 11-14, 2006.

17. 1Koenig SC, RD Dowling, MS Slaughter, MA Sobieski, GA Giridharan, and GM Pantalos. Vascular

pulsatility in patients with a continuous or pulsatile VAD. Presented at 52nd

ASAIO Conference in Chicago, IL, June 8-10, 2006.

18. Koenig SC, 2GA Giridharan, GM Pantalos, and KN Litwak. Acute hemodynamic and pressure-

volume responses to continuous and pulsatile assist in diminished cardiac function calf model. Presented at 52

nd ASAIO Conference in Chicago, IL, June 8-10, 2006.

19. Dowling RD, SC Koenig, KN Litwak, GM Pantalos, and PA Spence. Development and in vivo testing of a subcutaneous counterpulsation device. Presented at 52

nd ASAIO Conference in

Chicago, IL, June 8-10, 2006.

20. 2Giridharan GA, SC Koenig, GM Pantalos, KN Litwak, and PA Spence. Predicted hemodynamic

benefits of counterpulsation therapy using a superficial counterpulsation approach. Presented at 52

nd ASAIO Conference in Chicago, IL, June 8-10, 2006.

21. Giridharan GA, SC Koenig, M Mitchell, M Gartner, and GM Pantalos,. A computer model of the pediatric circulatory system for testing pediatric assist devices. Presented at 52

nd ASAIO

Conference in Chicago, IL, June 8-10, 2006.

22. 1Koenig SC, KN Litwak, GM Pantalos, and PA Spence. Counterpulsation therapy to promote

myocardial recovery. Presented at 51st ASAIO in Washington, D.C., June 9-11, 2005.

23. 2McMahan AM, KN Litwak KN, and SC Koenig. Left ventricular hemodynamics with continuous

flow VAD support. Presented at 51st ASAIO in Washington, D.C., June 9-11, 2005.


11


24. Pantalos GM, CE Ionan, SC Koenig, JW Speakman, CS Lucci, and MJ Gartner. Initial in vitro performance results for the 4” and 3” PCAS pediatric assist device. Presented at 51

st ASAIO in

Washington, D.C., June 9-11, 2005.

25. Giridharan GA, SC Koenig, GM Pantalos, KN Litwak, and PA Spence. Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical approach. Presented at the Gordon Conference on Assisted Circulation in Big Sky, MT, August 21-26, 2005.

26. Koenig SC, KN Litwak, GM Pantalos, and PA Spence. Chronic counterpulsation therapy to promote myocardial recovery. Presented at the Gordon Conference on Assisted Circulation in Big Sky, MT, August 21-26, 2005.

27. Giridharan GA, JS Glower, DL Ewert, GM Pantalos, KJ Gillars, KN Litwak, and SC Koenig. Control algorithms for an artificial vasculature device. Presented at 50

th ASAIO in Washington, D.C., June

17-19, 2004.

28. Glower JS, H Nybloom, DL Ewert, GA Giridharan, and SC Koenig. A simulation study for the effects of varying the load seen by the left ventricle. Presented at 50

th ASAIO in Washington, D.C.,

June 17-19, 2004.

29. Glower JS, H Nybloom, DL Ewert, GA Giridharan, and SC Koenig. A simulation study on the effect of the left ventricle ejection profile. Presented at 50

th ASAIO in Washington, D.C., June 17-19,

2004.

30. Cheng RC, GA Giridharan, KJ Gillars, GM Pantalos, 1SC Koenig, and KN Litwak. Aortic blood flow

with pulsatile or continuous VADs is a function of outflow graft location not pump type: an in vitro study. Presented at 50

th ASAIO in Washington, D.C., June 17-19, 2004.

31. Pantalos GM, CE Ionan, KJ Gillars, SC Koenig, AM McMahan, EH Austin, and LA Gray. Extracorporeal membrane oxygenation (ECMO) vs intraaortic balloon pump (IABP) for pediatric left ventricular assistance. Presented at 50


32. Litwak KN, SC Koenig, KA Lott, LE Lott, and GM Pantalos. Diminished cardiac function in calves: developlment of a more relevant model for physiologic testing with VAD support. Presented at 50

th

ASAIO in Washington, D.C., June 17-19, 2004.

33. Giridharan GA, DL Ewert, KJ Gillars, GM Pantalos, KN Litwak, LA Gray, and SC Koenig. Control strategy for an artificial vascular unloading device. Presented at 49

th ASAIO in Washington, D.C.,

June 19-21, 2003.

34. Giridharan GA, M Skliar, KJ Gillars, SC Koenig, and GM Pantalos. Physiologic control of rotary blood pumps: an in-vitro study. Presented at 49


35. Pantalos GM, KJ Gillars, SC Koenig, RD Dowling, S Etoch, A McMahan, and LA Gray. Intraaortic balloon pump (IABP) timing errors in adult patients. Presented at 49

th ASAIO in


36. Pantalos GM, CE Ionan, KJ Gillars, SC Koenig, EH Austin, and LA Gray. Extracorporeal membrane oxygenation (ECMO) vs. pulsatile blood flow for pediatric left ventricular assist. Presented at 49



12


37. Litwak KN, S Kihara , Z Wu, A Sinha, D Lohman, and SC Koenig. Pulsatile and continuous flow VAD aortic hemodynamics: outflow graft location is the key. Presented at 49

th ASAIO in


38. 1Koenig SC, GM Pantalos, KJ Gillars, J Alesnik, LA Gray, and SW Etoch. Hemodynamic

responses to continuous and pulsatile ventricular assist in an adult mock circulation. Presented at 48

th ASAIO in New York, NY, June 13-15, 2002.

39. Gillars KJ, MJ Schroeder, DL Ewert, GM Pantalos, and SC Koenig. Non-linear parameter estimation technique for calculation of flow through prosthetic heart valves. Presented at ASAIO in New York, NY, June 7-9, 2001.

40. Pantalos GM, KJ Gillars, SC Koenig, C Ionan, and LA Gray. Expanded pediatric cardiovascular simulator for research and training. Presented at 47

th ASAIO in New York, NY, June 7-9, 2001.

41. Pantalos GM, SC Koenig, KJ Gillars, RD Dowling, and LA Gray. Characterization of intraaortic balloon pump (IABP) timing errors using an adult cardiovascular simulator. Presented at 47

th

ASAIO in New York, NY, June 7-9, 2001.

42. Pantalos GM, SC Koenig, RD Dowling, KJ Gillars, and LA Gray. Intraoperative determination of intraaortic balloon pump (IABP) timing errors in adult patients. Presented at 47

th ASAIO in New

York, NY, June 7-9, 2001.

43. Schaub JD, R Cheng, DL Ewert, MD Graen, LA Gray, and SC Koenig. Development of a flow-feedback pulse duplicator system with rhesus monkey arterial input impedance characteristics. Presented at ASAIO in San Diego, CA, June 2-5, 1999.

44. Graen MD, DL Ewert, JS Glower, LA Gray, and SC Koenig. Evaluation of flow calculation technique in prosthetic heart valves. Presented at ASAIO in San Diego, CA, June 2-5, 1999.

45. Dowling RD, SC Koenig, DL Ewert, MA Laureano, PA Cerrito, and LA Gray. Does partial left ventriculectomy improve left ventricular systolic and diastolic function? Presented at the 72nd session of the American Heart Association in Atlanta, GA, November 7-10, 1999.

46. 2Jaber S, B Bhasker-Rao, D VanHimbergen, SC Koenig, and PA Spence. Graft Flow is Not a

Reliable Indicator of Anastomotic Quality. Presented at the Third Annual Minimally Invasive Surgery Conference, Utrecht, Netherlands, September 1997 (

#Top Ten Award). Surgery, New Orleans LA,

January 1998.

47. Jaber S, A Ali, DJ VanHimbergen, B BhaskerRao, P Cerrito, SC Koenig, and Paul Spence. Role of Transit-Time Flow Probes in Assessing Anastomotic Quality in Off-Pump CABG. Presented at the Facts and Myths World Symposium on Minimally Invasive Cardiac

48. Dowling RD, SC Koenig, MA Laureano, P Cerrito, and LA Gray. Results of partial left ventriculectomy in patients with end stage idiopathic dilated cardiomyopathy. Presented at the International Society Heart & Lung Transplantation, Chicago, IL, April 15-18, 1998.

49. 1Koenig SC, DL Ewert, JS Glower,

#Graen MA, and LA Gray. Electrical analog model of the

aortic valve for beat-to-beat aortic flow using pressure gradient. Presented at the 44th Annual Conference of the American Society for Artificial Internal Organs (ASAIO), 44(2):85A, New York, NY, April 23-25, 1998 (

#Whitaker Bioengineering Fellowship Award).


13


50. Etoch SW, RD Dowling, SC Koenig, MA Laureano, P Cerrito, and LA Gray. Results after partial left ventriculectomy versus heart transplantation for idiopathic cardiomyopathy. Presented at the Western Surgical Forum, Vancouver, British Columbia, June 24-27, 1998.

51. 1Koenig SC, M Shafie, A Pearson, MA Laureano, P Cerrito, DL Ewert, MJ Schroeder, and RD

Dowling. Intraoperative assessment of acute hemodynamic changes after partial left ventriculectomy. Presented at the Left Ventricular Volume Reduction: The Batista Operation Conference, Pescara, Italy, June 25-26, 1998.

52. Dowling RD, 1SC Koenig, MA Laureano, and LA Gray. Partial left ventriculectomy versus heart

transplantation as treatments for idiopathic cardiomyopathy. Presented at the Left Ventricular Volume Reduction: The Batista Operation Conference, Pescara, Italy, June 25-26, 1998.

53. 2Jaber S, P Cerrito, B BhaskerRao, D VanHimbergen, SC Koenig, and PA Spence. Neural

network pattern recognition analysis of graft flow characteristics improves intra-operative anastomotic error detection in minimally invasive CABG. Fourth Annual Minimally Invasive Surgery Conference, Utrecht, Netherlands, September 1998 (Top Five Award).

54. Cerrito P, S Jaber, B BhaskerRao, DJ Van Himbergen, SC Koenig, and PA Spence. Neural Network Pattern Recognition Analysis of Graft Flow Characteristics Improves Intra-operative Anastomotic Error Detection in Minimally Invasive CABG. European Conference on Minimally Invasive Cardiac Surgery, Belgium, September 1998.

55. Jaber S, B BhaskerRao, D VanHimbergen, D Ewert, P Cerrito, SC Koenig, and PA Spence. Spectral analysis of flow waveform morphology significantly improves anastomotic stenosis detection in off-pump CABG. Second International Symposium on Controversies in Cardiothoracic Surgery, Hong Kong, China, November 1998.

56. 1Koenig, SC, VA Convertino, VP Krotov, JW Fanton, VI Korolkov, EV Trambovetsky, A

Truzhennikov, and RD Latham. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey. Presented at the 12th Man in Space Symposium, Washington DC, June 8-13, 1997, p.3.

57. 1Koenig SC, CD White, JW Fanton, RD Latham, RE Mendenhall. Chronic instrumentation for

right/left heart cardiovascular studies in human surrogate models. Presented at the Proceedings of the Eleventh Annual Conference on Biomedical Engineering Research, Houston TX, February 1993.

58. White CD, 1SC Koenig, JW Fanton, RD Latham, and RE Mendenhall. Specialized pulse doppler

flow probe for chronic application in the ascending aortic root. Presented at the Proceedings of the Eleventh Annual Conference on Biomedical Engineering Research, Houston TX, February 1993.

59. White CD, SC Koenig, JW Fanton, and RD Latham. Instrumentation for chronic human surrogate model in altered-G environments. Presented at the Proceedings of Tenth Annual Conference on Biomedical Engineering Research, Houston TX, March 1992.

60. 1Koenig SC, CD White, JW Fanton, and RD Latham. Instrumentation for chronic human surrogate

cardiovascular model in altered-G environments. Presented at the Aerospace Medical Association (ASMA) 63

rd Annual Scientific Meeting, Miami FL, May 1992.


14


61. Latham, RD, CD White, SC Koenig, DA Self, MN Vernalis, and RD Crisman. Central circulatory hemodyanmics under altered gravitational loads for aerospace environments. Presented at the Aerospace Medical Association (ASMA) 63

rd Annual Scientific Meeting, Miami FL, May 1992.

62. JR LaCourse, P Cocaran, A Seidel, and SC Koenig. Physical Activity Profiles: Using the Actimeter for vocational assessment. RESNA 14

th Annual Conference, Kansas City MO, 1991.

63. Vroman N, R Croce, A Seidel, JR LaCourse, R Hinkle, and SC Koenig. A university-based rehabilitation technology project, 13

th Annual RESNA Conference, Washington, D.C., 1990.

Book Chapters

1. Drew GA and SC Koenig, “Biomedical Patient Monitoring, Data Acquisition, and Playback with LabVIEW®,” in Virtual Bio-Instrumentation: Biomedical, Clinical, and Healthcare Applications in LabVIEW®, Olansen, J. B. and Rosow, E., 180-186, Prentice Hall, 2002.

2. Schroeder MJ, T Yeh Jr., EH Austin, and SC Koenig, “A Virtual Instrument for Critical Care Monitoring of Newborn Patients with Hypoplastic Left Heart Syndrome Following Norwood Operation Using LabVIEW®”, in Virtual Bio-Instrumentation: Biomedical, Clinical, and Healthcare Applications in LabVIEW®, Olansen, J. B. and Rosow, E., 176-180, Prentice Hall, 2002.

3. Cerrito P, SC Koenig, and PA Spence. Automated classification procedures and neural network models to predict the level of anastomotic stenosis in off-pump CABG surgery. Chapter 8: In Intraoperative graft patency verification in cardiac and vascular surgery. Futura Publishing Company, Armonk, NY, May 2001.

4. Drew GA and SC Koenig. Biomedical patient monitoring, data acquisition and playback with LabVIEW. Ch. 2 (pp 92-98): In LabVIEW for Automative, Telecommunications, Semiconductor, Biomedical, and other Applications. Prentice Hall PTR, Upper Saddle River, NJ, 2000.

Patents

1. Giridharan GA, SC Koenig, and MS Slaughter. System and Method for controlling blood pumps (UofL invention disclosure filed May 14, 2009)

2. Giridharan GA, SC Koenig, and MS Slaughter. System and method for timing phasic pump parameters with blood pumps (UofL invention disclosure filed May 14, 2009)

3. Koenig SC, GA Giridharan, KN Litwak, J Glower, and DL Ewert. Artificial vasculature device for ventricular support and recovery: concept, control, implementation, and applications. (US Patent no. 7,572,217 awarded August 11, 2009).

4. Koenig SC, LS Unger, GM Pantalos, KN Litwak, KJ Gillars, C Woolard, J Mulcahy, and S Skaggs. Physiologic data acquisition and analysis software compliant with Good Laboratory Practices (GLP). (patent pending; UofL file No. 04019).

5. Drew G, R Woods, B Humes, and SC Koenig. Non-Human Primate Research Support Table (patent 5,943,983; AF Invention No. 00184; IDEA No. BAFB 98-0025).

6. Owens R, G Muniz, C Reister, R Persky, and SC Koenig. Pressure Catheter Calibration Chamber (patent 08/939,345; AF Invention No. 00182; IDEA No. BAFB 98-0027).


15

Publications (continued) Technical Reports

1. Cheng R, DL Ewert, and SC Koenig. Development of a Virtual Instrument for Control and Data

Acquisition of a Cardiovascular Pulse Duplicator System Using LabVIEW . LabVIEW Users Solution, 2000.

2. Schroeder MJ, T Yeh, E Austin, and SC Koenig. A Virtual Instrument for Critical Care Monitoring of Newborn Patients with Hypoplastic Left Heart Syndrome Following Norwood Operation. LabVIEW Users Solution, 2000.

3. Drew GA and SC Koenig. Biomedical patient monitoring, data acquisition, and playback with LabVIEW. LabVIEW Users Solution. *2nd place-National Instruments LabVIEW Application of the Year for 1999.

4. Dowling RD, LA Gray, and SC Koenig. New Operative Therapy for Congestive Heart Failure: Left Ventricular Remodeling. Louisville Medicine, 45(7):343-45, December 1997.

5. RD Latham, VA Convertino, JW Fanton, RP Crisman, SC Koenig, DL Ewert, V Korolkov, V Krotov, E Trambovetsky, A Truzhennikov, R Ballard, J Connolly, and D Helwig. Effects of 12 days

of 10 head-down tilt on central circulatory hemodynamics in the rhesus monkey: A feasibility study for spaceflight experiments. Armstrong Laboratory Technical Report AL/AO-TR-1996-0025, pp. 1-49, 1996.

Thesis and Dissertation

1. Koenig SC. Analyzing human functional mobility via the Actimeter. Master Thesis, University of New Hampshire, Durham, NH, December 1990 (Advisor: John LaCourse)

2. Koenig SC. Modeling of Mechanisms of Alterations in Central Venous Pressure During Exposure

to 10 Head Down Tilt in a Chronically-Instrumented Non-Human Primate, Ph.D. Dissertation, Univ. Texas at Austin, October 1996 (Advisors: Jon Valvano and Victor Convertino)


16

GRANTS and CONTRACTS

Active 2R44HL083586-02A1 (PI: Spence, subcontract PI: Koenig) 8/1/2008 –7/31/2010 NIH-SBIR Phase II Grant $1,440,170 Development of a Counterpulsation Therapy Device

The major goals are to (1) complete engineering development and surgical procedures, (2) demonstrate reliability and hemocompatablity, and (3) demonstrate safety and biocompatibility of a novel counterpulsation device (CPD) to treat early stage heart failure. Role: Principle Investigator subcontract (25% effort) 2R44HL088760-02 (PI: Spence, subcontract PI: Koenig) 4/1/2009 –3/31/2011 NIH-SBIR - Phase II Grant $1,580,486 Portable pneumatic driver for counterpulsation therapy

The major goals of this project are to (1) complete engineering development, (2) demonstrate reliability and hemocompatablity, and (3) demonstrate safety and biocompatibility of a portable pneumatic driver for a novel counterpulsation device (CPD) to treat early stage heart failure. Role: Principle Investigator subcontract (25% effort) KSTC-184-512-08-054 (PI: Spence, subcontract PI: Koenig)10/1/2008 –4/30/2010 Kentucky Science and Technology Corporation (KSTC) Grant $500,000 Implantable Sensing and Triggering System

The major goal of this project is to develop and test sensors and electronics for reliable measurement of ECG to be used a triggering system to time inflation and deflation of the membrane for a novel counterpulsation device (CPD) to treat heart failure. Testing will be conducted in a mock flow loop, and acute and chronic large animal model during hypertensive, hypotensive, and heart failure test conditions. Role: Principle Investigator subcontract (25% effort) Industry Contract (Koenig) 8/1/2008 –12/31/2009 Abiomed (Danvers, MA) $549,235 MCS Device Testing Study

The major goal of this project is investigate the acute physiologic responses of Abiomed mechanical circulatory support (MCS) devices to (1) peripheral support, (2) atrial and transvalvular cannulation, and (3) pulsatile synchronous and asynchronous support in an acute large animal ischemic heart failure model. Role: Principle Investigator (20% effort) Industry Contract (Slaughter) 9/1/2008 –12/31/2009 HeartWare (Miramar, FL) $148,827 MCS Device Acute Testing Study

The major goal of this project is test HeartWare mechanical circulatory support devices in a chronic animal model to evaluate device safety, reliability, and efficacy. Role: co-investigator (5% effort)


17

Grants and Contracts (continued)

Industry Contract (Slaughter) 9/1/2008 –12/31/2009 HeartWare (Miramar, FL) $358,123 MCS Device Chronic Testing Study

The major goal of this project is test HeartWare mechanical circulatory support devices in an acute animal model to evaluate device safety, reliability, and efficacy. Role: co-investigator (5% effort) 0730319N (Giridharan) AHA National Scientist Development Award 1/1/07 – 12/31/10 Physiologic Control and Fault Detection for Blood Pumps $260,000 The major goal of this project is to develop control and fault detection strategies for mechanical circulatory support devices using computer simulation, mock circulation, and large animal models. Role: co-investigator (3% effort) VA Merit Grant, 0001 (Prabhu) 4/1/2008 –3/31/2012 Veterans Administration (VA) $516,000 TNF Receptors and Inflammation in Chronic Heart Failure The major goal of this project is support acute and chronic animal experiments in mouse model to elucidate mechanisms of heart failure. Role: co-investigator (3% effort) UofL CEGIB Grant (Prabhu) 1/5/2009 –12/31/2009 Center for Environmental Genomics and Integrative Biology (CEGIB) $60,000 MicroRNAs as Biomarkers of Human Heart Failure The major goal of this project is elucidate potential biomarkers as predictors of myocardial recovery in heart failure patients that receive left ventricular assist devices (LVAD). Role: co-investigator (3% effort) Industry Contract (Slaughter) 8/1/2009 –6/30/2010 HeartWare (Miramar, FL) $240,000 MCS Device Acute Testing Study

The major goal of this project is test HeartWare HVAD in a large animal model to evaluate device safety, reliability, and efficacy. Role: co-investigator (5% effort)

Pending xxxxxxxxxxxx (Slaughter) 9/1/2009 –8/31/2011 NIH RC2 grant $2,000,000 INTERMACS Biorepository: Impact of Mechanical Support on Myocardial Expression

The major goal of this to use the molecular analysis to develop a prediction model for clinical outcomes post LVAD placement using a risk assessment score. Role: co-investigator (10% effort)


18


xxxxxxxxxxxxx (Prabhu) 9/1/2009 –8/31/2011 NIH RC1 Grant (*8% priority score*) $1,000,000 MicroRNA signatures of biomechanical support in advanced heart failure

The major goal of this project to identify microRNA biomarkers in the blood and failing heart tissue that can distinguish patient responses to LVAD support. Role: co-investigator (10% effort) xxxxxxxxxxxx (Slaughter) 3/1/2010 –2/28/2011 NIH STTR phase I Grant $307,570 Feasibility Testing of Longhorn MVAD

The major goal of this project is to test re-designed Longhorn MVAD (HeartWare, Miami Lakes, FL) in an acute animal model to demonstrate feasibility. Role: co-investigator (2.5% effort) xxxxxxxxxxxx (Koenig) 3/1/2010 –2/28/2011 NIH SBIR phase I Grant $261,965 Subcutaneous ECG sensing

The major goal of this project is to develop an implantable version of the current CPD system with specific focus on converting from a pneumatic to an electro-mechanical drive system. Role: co-investigator (2.5% effort)

Completed Industry Contract (Koenig) 2/1/2006 –3/31/2009 SCR, Inc (Louisville, KY) $265,674 Pilot 30-day CPD study

The major goal of this project is complete acute (n=2) and chronic (n=3) testing of a novel counterpulsation device (CPD) in a large animal model to investigate cannula and hemocompatability issues (i.e. thrombus and hemolysis). Role: Principle Investigator subcontract (10% effort) KSTC-02-DCIS-021 (PI: Spence, subcontract PI: Koenig) 10/1/2008 –2/28/2009 Kentucky Science and Technology Corporation (KSTC) Grant $100,000 Counterpulsation device to promote myocardial recovery

The major goal of this project is to compare hemodynamic efficacy of SCR, Inc portable pneumatic driver to standard clinical IABP driver. This will be accomplished in acute large animal model during hypertensive, hypotensive, and heart failure test conditions. Role: Principle Investigator subcontract (5% effort)


19


Industry Contract (Koenig) 3/1/2008 –12/31/2008 Mitralign (Lowell, MA) $100,936 Clinical VAD study

The major goal of this project is support acute and chronic animal experiments in porcine model to evaluate efficacy of Mitralign mitral valve repair surgical technique. Role: Principle Investigator (10% effort) Industry Contract (Koenig) 4/1/2007 –3/31/2008 Advocate Christ Medical Center (Oak Lawn, IL) $50,000 Clinical VAD study

The major goal of this project is support bioengineering students to conduct clinical research (VAD heart failure patients) at Jewish Hospital and ACMC Hosptial (Oak Lawn, IL). Role: Principle Investigator (10% effort) 1R43HL088760-01 (PI: Spence, subcontract PI: Koenig) 8/1/2007 –7/31/2008 NIH-SBIR - Phase I Grant $268,790 Portable pneumatic driver for counterpulsation therapy

The major goal of this project is to develop a pneumatic driver for a 30-ml chronic counterpulsation device and compare acute physiologic responses to a clinical IABP in a large animal model. Role: Principle Investigator subcontract (25% effort) Industry Contract (Koenig) 3/1/2007 –2/28/2008 Advocate Christ Medical Center (Oak Lawn, IL) $24,310 Development of a Data Acquisition System

The major goal of this project is fabricate a data acquisition (DAQ) system to support future collaborative research projects at ACMC large animal facility for mechanical circulatory support device testing. Role: Principle Investigator (5% effort) KSTC-184-512-07-011 (PI: Spence, subcontract PI: Koenig) 3/1/2007 –12/31/2007 Kentucky Science and Technology Corporation (KSTC) Grant $100,000 Counterpulsation device to promote myocardial recovery

The major goal of this project is to test a novel counterpulsation device (CPD) in three chronic 30-day CPD implant studies. The state of Kentucky provides grant support to match NIH SBIR phase I award to acquire additional preliminary data beyond the scope of the phase I award to support NIH SBIR phase II applications. Role: Principle Investigator subcontract (10% effort)


20


Office Technology Transfer (Koenig) 3/1/2007 –12/31/2007 University of Louisville – Proof of Concept Grant $25,000 Development of an artificial vasculature device

The major goal of this project is to complete preliminary testing of prototype artificial vasculature device (AVD) in mock circulation and acute large animal models. These data will be used to support NIH STTR and R21 grant proposals. Role: Principle Investigator (5% effort) 1R43HL083586-01 (PI: Spence, subcontract PI: Koenig) 6/1/2006 – 1/31/2007 NIH-SBIR Phase I Grant $172,749 A counterpulsation device to promote myocardial recovery

The major goal of this project is to develop a novel 30ml, pneumatic counterpulsation device that will be cannulated to the subclavian artery to promote myocardial recovery by reducing ventricular workload and augmenting myocardial perfusion. Role: Principle Investigator subcontract (10% effort) NSF-PFI 0438604 (Keynton) 10/1/2004 – 9/30/2006 National Science Foundation – Partnership for Innovation Grant $600,000 A new paradigm for entrepreneurial discovery and business development

The major goal of this project is to develop a program for the Cardiovascular Innovation Institute at UofL that trains and promotes graduate students and faculty to start-up biotechnology industry in KY. Role: co-investigator (10% effort) NSF-MRI 0421057 (Sharp) 8/1/2004 – 7/31/2006 National Science Foundation – Major Research Instrumentation Grant $289,991 Particle Image Velocimetry

The funding for this equipment grant is used to purchase a commercial particle image velocimeter (PIV) system to support flow visualization research, including cardiovascular devices. Role: co-investigator (5% effort) KSEF-327-RDE-003 (Koenig) 7/1/2003 – 9/30/2005 Kentucky Science and Technology Corporation Grant $179,221 GLP compliant cardiovascular data acquisition and analysis

The major goal of this project is to develop a strategic plan for computer software for automated digital data recordings and beat-to-beat analyses that is in compliance with FDA guidelines for testing medical devices. Role: Principle Investigator (20% effort)


21


RG-01-0310 (Koenig) 7/1/2002 – 9/30/2005 Whitaker Foundation $239,863 Development of an artificial vasculature device as a bridge to myocardial recovery

The major goal of this project is to develop an artificial vasculature device to control the systemic input impedance seen during ejection by the failing heart during the myocardial recovery process Role: Principle Investigator (40% effort) Industry Contract (Koenig) 2/1/2004 – 7/31/2004 Accelerated Technologies (New York, NY) $60,000 Evaluation of counterpulsation device

The major goal of this project is to test and evaluate a novel counterpulsation cardiac assist device. Provide engineering support (instrumentation, study design, data acquisition and analysis) during adult mock circulation and large animal studies. Role: Principle Investigator (5% effort) Industry Contract (Koenig) 8/1/2004 – 12/31/2004 Accelerated Technologies (New York, NY) $25,000 Evaluation of atrial shunt device

The major goal of this project is to test and evaluate a novel atrial shunt device. Provide engineering support (instrumentation, study design, data acquisition and analysis) during adult mock circulation studies. Role: Principle Investigator (5% effort)

01-0785 (Koenig) 7/1/2001 – 6/30/2002 NASA- KY Space Grant Consortium $10,000 Effect of head-down tilt and lower body negative pressure on left ventricular-arterial coupling

The major goal of this project is to investigate the effects of HDT and LBNP on the coupling relationship between the left ventricle and systemic arterial vasculature and identify potential mechanism(s) associated with orthostatic intolerance following spaceflight. Role: Principle Investigator (10% effort) 0060250B (Koenig) 7/1/2000 – 6/30/2002 AHA/Ohio Valley Affiliate $70,000 Can porcine and bovine aortic and pulmonary vasculatures be used to test human cardiac replacement therapies?

The major goal of this project is to determine if porcine and/or bovine systemic and pulmonary vascular impedances as a function of heart rate differ from human patients with congestive heart failure. Role: Principle Investigator (20% effort)


22


0051419Z (Ewert) 7/1/2000 – 6/30/2002 AHA/Northlands Affiliate $100,000 Porcine cardiac source impedance as a xenotransplantation assessment tool

The major goal of this project is to determine the cardiac source impedance of porcine at varying heart rates and varying load impedances, which will be used to develop a model of cardiac source impedance. Role: co-investigator (10% effort) 01-0806 (Sharp) 7/1/2001 – 6/30/2002 NASA- KY Space Grant Consortium $50,000 Computer Modeling of Cardiovascular Function in Astronauts

The major goal of this project is to develop a comprehensive model of the cardiovascular system that will mimic hemodynamic responses of astronauts. The model will be used to investigate potential mechanism(s) associated with orthostatic intolerance. Role: co-investigator (5% effort) 01-0809 (Pantalos) 7/1/2001 – 6/30/2002 NASA- KY Space Grant Consortium $50,000 Chest compression efficacy for CPR in microgravity

The major goal of this project is to test four different techniques for administering CPR during weightless (spaceflight) and evaluate their effectiveness. Partial chest compressions will be performed on human test subjects during parabolic flight. Role: co-investigator (5% effort)

0060250B (Koenig) 5/30/2000 – 8/30/2000 AHA/Ohio Valley Affiliate $2,500

Responses of the systemic vasculature to variations in heart rate in calves with AbioCor total replacement heart.

Funding was provided to support an undergraduate student (Mariah Weyland) for one summer. Mariah received training in cardiovascular modeling and Matlab, which she used to analyzed hemodynamic

data recorded in calves implanted with the AbioCor artificial heart for 30-days. Role: Principle Investigator (5% effort) Industry Contract (Koenig) 8/1/1999 – 12/31/1999 Applied Medical (Laguna Hills, CA) $55,954

Evaluation of Applied Medical vascular clips for minimally invasive CABG surgery. The major goal of this project was to test a proprietary surgical sealant for clinical use during cardiac surgery in a chronic large animal model using an aortic graft procedure. Role: Principle Investigator (10% effort)


23


Industry Contract (Koenig) 2/1/1998 – 4/30/1998 Focal (Lexington, MA) $11,475

FocalSeal Sealant for aortic graft surgery: feasibility study

The major goal of this project was to test a proprietary surgical sealant for clinical use during cardiac surgery in a chronic large animal model (pig) using an aortic graft procedure. Role: Principle Investigator (10% effort) Industry Contract (Koenig) 1/1/1998 – 12/31/1998 Medtronic (Minneapolis, MN) $100,000 Evaluation of EchoCath flowmeter for assessment of quality of anastamosis in minimally invasive coronary artery bypass graft (CABG) surgery.

The major goal of this project was to test and evaluate a novel technique (doppler) to measure graft flow in an acute large animal (dog) model to demonstrate the ability to assess the quality of anastomosis intraoperatively during CABG surgery. Role: Principle Investigator (10% effort) Industry Contract (Koenig) 2/1/1998 – 2/28/1998 Arrow International (Reading, PA) $7,800 Evaluation of Arrow International intra-aortic balloon (IAB) pump.

The major goal of this project was to compare pressure sensing techniques (fluid filled, high-fidelity transducer, fiber optic catheter) for algorithm development and control of an IABP system. Three acute pilot experiments were completed using an acute large animal model (pig). Role: Principle Investigator (5% effort) 098946 (Koenig) 5/1/1997 – 4/30/1998 Jewish Hospital $25,000 Cardiovascular dynamics modeling system

The major goal of this project was to develop a mock circulation of the cardiovascular system using a hydrodynamic pulse duplicator. The mock circulation can be used to test valves and devices. Role: Principle Investigator (10% effort) Industry Contract (Koenig) 7/1/1997 – 12/31/1997 Focal (Lexington, MA) $37,025

FocalSeal Sealant for MIDCAB procedures: feasibility study

The major goal of this project was to test a proprietary surgical sealant for clinical use during cardiac surgery in an acute large animal model (dog) of multiple coronary artery bypass grafts (CABG). Role: Principle Investigator (10% effort)


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NASA W-18599 (Convertino) 7/1/1994 – 6/30/1997 National Aeronautics and Space Administration Grant – Life Sciences $336,000 Mechanisms of alterations in central venous pressure during exposure to simulated microgravity

The major goal of this project was to elucidate mechanisms of cardiovascular adaptation (cardiac compliance, CVP set-point, and/or arterial elastance) associated with head-down tilt in rhesus monkeys. Role: biomedical research engineer (5% effort)

ACADEMIC INSTRUCTION

Engineering Courses

Course Course Title Instruction Semester Rating

BE 621 Bioinstrumentation Course Instructor Fall 2009 ---

BE 691 Biomedical Rotation Course Instructor Summer 2009 3.89

BE 611 Cardiovascular Dynamics Guest Lecture (6 ea) Summer 2009 ---

BE 480 Medical Device Design Course Instructor Spring 2009 3.61

BE 423 Biomeasurements Laboratory Guest Lecture (1 ea), Lab (2 ea) Spring 2009 ---

BE 101 Intro Bioengineering Guest Lectures (2 ea) Spring 2009 ---

BE 480 Medical Device Design Developed Curriculum Spring 2008 3.97

BE 423 Biomeasurements Laboratory Developed Curriculum Spring 2008 3.39

BE 101 Introduction to Bioengineering Guest Lectures (4 ea) Spring 2008 ---

BE 101 Introduction to Bioengineering Guest Lectures (4 ea) Fall 2007 ---



ECE 640 Introduction to Bioengineering Cardiovascular (10 lectures) Fall 2004 ---

ECE 640 Introduction to Bioengineering Cardiovascular (10 lectures) Fall 2003 ---

ECE 640 Introduction to Bioengineering Developed Cardiovascular Section (10 lectures)

Fall 2002 ---


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Graduate and Undergraduate Students Advised (*manuscript(s) published)

1. Mickey Ising (bioengineering undergraduate student) Development of a physiologic control strategy for continuous flow ventricular assist devices, Fall 2009

2. Sean Warren (bioengineering undergraduate student) Development of a physiologic control strategy for continuous flow ventricular assist devices, Fall 2009

3. Joel Graham (bioengineering masters student) „Development of novel polycarbonate cannula for ventricular assist devices‟, 2009-10.

4. Kevin Lufmant (medical student) „Clinical VAD study – incidence of heart disease following heart transplantation‟, summer 2009.

5. Rick Bowles (medical student) „Clinical VAD study – 5-yr retrospective review of VAD patient outcomes‟, summer 2009.

6. Andre Faul (electrical engineering doctoral student) „Development of Artificial Vasculature Device Control Strategy‟ (independent study), 2008-present

7. *Carlo Bartoli (MD-PhD student) „LVAD for myocardial recovery study‟, 2007-present

8. *Reagan Carter (medical student) „Clinical VAD study – aortic valve dynamics‟, summer 2007

9. *Greg Wilson (medical student) „Counterpulsation study – portable driver‟, summer 2007

10. *Joel Graham (bioengineering student) „CPD study - DAQ‟, January 1, 2007 - present

11. *Tim Horrell (bioengineering student) „Clinical VAD study - DAQ‟, 2007

12. Robert Buchberger (bioengineering student) „VAD control study‟, 2007

13. *Brian Kaebnick, BS (medical student) „Relationship between vascular input impedance and energy equivalent pressure‟, summer, 2006.

14. *Adam Travis, BS (medical student) „Physiologic Benefits of Ventricular Assist‟, summer 2005.

15. *Chip Cheng, MS „Development of an Artificial Vasculature Device, 2003 – 2007.

16. *Guruprasad Giridharan, Ph.D. (post-doc). „Development of an Artificial Vasculature Device, January 1, 2003 – 2005.

17. *Kent Weyland, BS. “Vascular Input Impedances”, summer research 2002-05.

18. David King, MS. “Non-linear Estimation of Arterial Parameters”, 2002.

19. *Mariah Weyland, BS. “Responses of the systemic vasculature to variations in heart rate in

calves with AbioCor total replacement heart”, summer 2000.

20. *Crystal Ripplinger, BS. “Time-varying elastance-resistance model of the left ventricle”, summer 2000.

21. *Chip Cheng*, BS. “Software Development for a Cardiovascular Pulse Duplicator System”, summer 1999 and summer 2000.

22. *Scott Zarr, MS. “Isovolumic Pressure Estimation Technique”, May 2000.

23. Johnny Sears, MS. “Development of an In Vivo Heart Valve Monitor using Telemetry with a Microcontroller Interface”, May 1999.

24. *Matt Graen, MS. “Computational Analysis of a “Smart” Heart Valve”, May 1999.

25. Brian Mathews, MS. “Application of a 2.45GHz Telemetry System for Implantable Medical Devices”, May 1998.


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Student Awards

Carlo Bartoli

National Institutes of Health Heart, Lung, and Blood F30 Individual pre-Doctoral Fellowship Award (5-yr, $200,000, 2009-14) to study physiologic responses to mechanical circulatory support devices in a large animal heart failure model.

1st Place Medical Student Award, Research!Louisville 2008, Student Poster Presentation (CPD –

innovative technology) Guruprasad Giridharan

American Heart Association Post-Doctoral Fellowship Award (2-yr, $75,000, 2004-06) to develop novel control and fault detection algorithms for mechanical circulatory support devices (rotary blood pumps).

Mariah Weyland

American Heart Undergraduate Fellowship Award (summer, $2500, 2000) to study „responses

of the systemic vasculature to variations in heart rate in calves with AbioCor total replacement heart‟.

Saad Jaber

Top Ten Award for abstract entitled „Graft Flow is Not a Reliable Indicator of Anastomotic Quality‟ that was presented at the Third Annual Minimally Invasive Surgery Conference, Utrecht, Netherlands, September 1997 (

#Top Ten Award).

PROFESSIONAL AND SERVICE ACTIVITIES

University Service

Established Rolando „Chip‟ Cheng, Jr Bioengineering Scholarship Endowment ($50,000), 2009 Chair, Bioengineering Faculty Search Committee, 2009 – present ABET, Outcomes Committee, 2008 - present Member, Speed School Promotion and Tenure Committee, 2007-present Member, Speed School Committee on Procedures and Committees, 2007-present Bioengineering Faculty Search Committee, 2005 – 2007 Member Jewish Hospital Heart & Lung Education Committee, 1998-2000 Professional Service

INTERMACS Mechanical Circulatory Support Registry for Focused Research and Mission Activities, co-chair, 2007-present

Bioengineering Track Chair for 56th

ASAIO conference (Baltimore, MD), May 27-29, 2010 Program Committee for 53

nd ASAIO conference (Chicago, IL), June 7-9, 2007

Board of Trustees, ASAIO, 2006-present Program Committee for 52

nd ASAIO conference (Chicago, IL), June 9-12, 2006

Section Chair for 52nd

ASAIO conference (Chicago, IL), June 9-12, 2006 Section Chair for 51

st ASAIO conference (Washington, DC), June 9-11, 2005


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Community Service

Co-Chair of Floyds Knobs Elementary School Science Fair, 2002-2008 Member New Albany-Floyds Knobs School Foundation Board, 2003-04 Reviewer of Manuscripts

Reviewer for Medical & Biological Engineering & Computing, 1997-present Reviewer for Journal of Applied Physiology, 2000-present Reviewer for Aviation, Space, & Environmental Medicine, 2002-present Reviewer for ASAIO Journal, 2004-present Reviewer for American Journal of Physiology, 2005-present Reviewer for Medical Engineering & Physics, 2005-present Reviewer for Annals Thoracic Surgery, 2007-present Reviewer for Journal Thoracic and Cardiovascular Surgery, 2007-present Editorial Board for ASAIO Journal, 2005-present

Documents

STEVEN C. KOENIGcv2i.org/wp-content/uploads/2012/04/Koenig-cv-Oct-7-2009.pdf · 07/10/2009 · Steven C. Koenig, Ph.D. Curriculum Vitae 2 PROFESSIONAL AFFILIATIONS and TRAINING (continued):