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8/8/2019 Stephen Holt MD-Toxic Waistlines Impair Longevity
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TOXIC WAISTLINES IMPAIR
LONGEVITY
Stephen Holt, MD, PhD, DSc, DNM, LLD.
Distinguished Professor of Medicine
(Emeritus)
Scientific Advisor, Natural Clinician LLCContact: [email protected]
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WEIGHT CONTROL
(COMPREHENSIVE PROGRAM) Calorie Control
Energy Expenditure
Socio-behavioral Interventions
Detoxification
Sleep Restoration
Stress Management
Insulin Resistance/Syndrome X
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THE POT BELLY
The hallmark of obesity in mature subjects andwaistline expansion is common in Syndrome X.
A sign ofvisceral adiposity associated with ugly
disease companions of obesity.
Visceral fat elaborates hormones and inflammatorymessenger molecules
Visceral fat concentrates organic chemicals that can
interfere with intermediary metabolism in fat stores
e.g. organophosphates, parabens etc.The pot belly is a toxic waste dump in the body
and it is a useless acquired endocrine organ.
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DETOXIFICATION
Organochemicals appear to important
miscreants in obesity
Lessons from the 9/11 World Trade Center
collapse where rescue workers developedMetabolic Syndrome X as a result of several
factors, including toxicants.
Sta
nda
rd detoxifica
tion protocols do noteffectively eliminate organic toxins that are
stored in in visceral fat.
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DETOXIFICATION
Extensive detoxific
ation progr
ams in
volving s
auna(about 33 continuous days), vitamin supplement
regimens, exercise and lifestyle change are quite
effective (9/11 Detox Program, Manhattan).
Ancillary detoxific
ation techniques m
ayadd
valuebut are unlikely to succeed when used alone e.g.
colon cleansing, colon hydrotherapy, dietary
changes, chelation therapies etc.
There is
acle
ar evidence-b
ase to
appro
ach obesity
management from a perspective of environmental
medicine and detoxification programs are emerging
as evidence-based in weight loss protocols.
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THERMOGENESIS
Heat production by the body
Obligatory (digestion, absorption
and metabolism)
Adaptive (increase in metabolic
rate stimulated by eating)
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THERMOGENIC
NUTRACEUTICALS
Caffeine*
Green Tea Polyphenols
Coffee Bean Polyphenols
Fucoxanthin
Hydroxycitrate*
Berry Antioxidants*
Natural Amines (p-synephrine)
*PROBLEMS
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NATURAL AMINES
(PLANT ALKALOIDS) Stimulate adrenergic receptors:
alpha-1, alpha-2, Beta-1, Beta-2,
Beta-3, ephedra is non-selective Beta-3 receptor semi-selectivity
(p-synephrine)
Patented extracts ofCitrusaurantium (ADVANTRA Z)
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CITRUS AURANTIUM EXTRACTS:
ADVANTRA Z (P-SYNEPHRINE)
P-Synephrine has less propensity to
stimulate cardiovascular orCNS function
(BP, Heart Rate/Arrythmogenesis), but
may increase muscle mass (increased
muscle uptake ofamino acids).
Evidence-base for: lipolysis,
thermogenesis, ergogenesis, increased
muscle mass.
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ADVANTRA Z PATENTS U.S. 6,224,873: Regulation ofappetite, body weightand athletic function with materials derived fromcitrus varieties.
U.S. 6,316,499: Methods for increasing muscle mass
ofa human with materials derived from citrusvarieties.
U.S. 6,340,481: Regulation ofathletic function withmaterials derived from citrus varieties.
U.S. 6,340,482: Methods for inducing weight loss ina human with materials derived from Citrus varieties.
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SAFETY DATA (ADVANTRA Z)
Ephedra withdrawal 2004, New
YorkTimes Article, 2004.
Case reports, but combinations andincomplete reporting cloud the
issues (Nykamp et al, 2004)
No serious adverse event reporting
or product liability claims (>10y.)
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SAFETY DATA (ADVANTRA Z)
Haller et al, 2000, blood pressure rosepost exercise but normalized at 90 min(peak diastolic BP)
Talbott et al, 2007, Advantra Z (80mg ofp-synephrine) showed no increase in BP,resting heart rate over six weeks of
supplementa
tion. Haaz et al, 2006, generally stable heart
rate and BP in humans, animals variable.
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ADVANTRA Z EFFICACY
Gougeon et al, 2008. Advantra Z increasesmetabolic rate and enhances thermal
responses to food, notably in females.
Preuss et al, 2002. Citrus aurantium may be
the best thermogenic susbstitute for ephedra.
Metabolic rate increase with Advantra Z and
p-synephrine in several clinical observations
(Germano C. Advantra Z, KensingtonPublishers, 1998, Holt S, Peel Off the
Weight, HIOM, 2009).
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ADVANTRA Z EFFICACY
(SUMMARY)
Three studies show weight loss: Colker
et al, 1999, Jones, 2001, Germano, 1998 Four studies show enhancement of
metabolic rate: Colker et al, 1999,
Pathakand Gougeon, 1999,
Hedrei
andGougeon, 1997, Germano, 1998)
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CAUTIONS WITH AMINES
Children, Pregnancy
MAO Inhibitors/Cough ColdRemedies
Established cardiovascular or
stroke risk
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METABOLIC SYNDROME X
A key management initiative to
promote longevity. It highlights
the most significant componentsof the pathophysiology of obesity.
Clinical Metabolic Syndrome X
Nutritional Factors
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MARINE FISH OIL
EPA and DHA in at least a dosage of
600 mg and 400 mg, respectively.
Enhanced bio
availability of
active fatty
acids and improved patient compliance
by enteric coating.
Cardiovascularand anti-inflammatory
benefits with PPAR-receptoractions.
Very important in Syndrome X.
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COMBAT SLEEPLESSNESS
Sleep deprivation alters hormonal
controls ofappetite, ghrelin increase,
leptin decrease.
Restoration of sleep rhythms may cause
weight loss without other interventions.
Sleeplessness induces stress response. Insulin resistance decreased with sleep.
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CALORIE RESTRICTION
MIMETICS
CR increases average and maximum
lifespan
CRM c
an mimic the benefici
albiophysiological changes that occur
during CR
Clinical Calorie Restriction Mimetics
(cinnamon, avocado, resveratrol,
gymnema, alpha lipoic acid)
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ANTI-AGING SIGNIFICANCE
Excess bodyweight is associated with
premature morbidity and mortality.
70 million Americans h
ave Syndrome X.
Calorie restriction mimetics often
regulate blood glucose and decrease
insulin resistance.
Telomere shortening is associated with
insulin resistance and CVS disease.
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FACT
OBESE KIDS BECOME UNHAPPY,UNHEALTHY OBESE ADULTS
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CONCLUSION
Patented extracts ofCitrus aurantium(Advantra Z) are the most credibleevidence-based weight lossnutraceuticals to date.
Thermogenesis combined with lipolysis,ergogenesis and retain lean body massoccur with ADVANTRA Z.
Calorie Restriction is a cornerstone for
weight control and longevity promotion(Calorie Restriction Mimetics)
Contact: [email protected]