Stemcell Eu Research Projects

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Stem Cells

European research projects involving stem cells in the 6th Framework Programme

EUROPEAN COMMISSION

Stem CellsEuropean research projects involving stem cells in the 6th Framework Programme

Edited by: Gwennal Joliff-Botrel Pascale Perrin

European Commission - Directorate General for Research Life Sciences, Genomics and Biotechnologies for Health

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Table of content

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INTRODUCTION - Stem cells and European Union funded research Introduction and glossary UNDERSTANDING - Fundamental knowledge relevant to human healthCELLS INTO ORGANS DNA REPAIR EMBRYOMICS EPISTEM Functional genomics for development and disease of mesodermal organ systems DNA damage response and repair mechanisms Embryomics: reconstructing in space and time the cell lineage tree Role of p63 and related pathways in epithelial stem cell proliferation and differentiation and in rare EEC-related syndromes ESTOOLS Platforms for biomedical discovery with human ES cells EUCOMM The European Mouse Genome Mutagenesis Program EUGENE2 European network on functional genomics of type 2 diabetes EuReGene European renal genome project EURO-Laminopathies Nuclear envelope-linked rare human diseases: From molecular pathophysiology towards clinical applications EuroBoNet European network to promote research into uncommon cancers in adults and children: Pathology, biology and genetics of bone tumors EuroHear Advances in hearing science: from functional genomics to therapies EUROPEAN MCL NETWORK European Mantle Cell Lymphoma Network: Translational determination of molecular prognostic factors and pharmacogenomics in a European interdisciplinary collaboration EURYTHRON Molecular Control of Erythropoiesis EuTRACC European Transcriptome, Regulome and Cellular Commitment Consortium EVI-GENORET Functional genomics of the retina in health and disease FunGenES Functional genomics in engineered ES cells HeartRepair Heart failure and repair INTERDEVO Gene networks in cortical interneuron development: modeling interneuron function in health and disease LYMPHANGIOGENOMICS Genome-wide discovery and functional analysis of novel genes in lymphangiogenesis MCSCs Migrating cancer stem cells in breast and colon cancer MSCNET Myeloma stem cell Network. A translational programme identifying and targeting the early myeloma cell hierarchy MUGEN Integrated functional genomics in mutant mouse models as tools to investigate the complexity of human immunological disease MYORES Multi-organismic approach to study normal and aberrant muscle development, function and repair ONCASYM Cancer stem cells and asymmetric division Plurigenes Pluripotency associated genes to de-differentiate neural cells into pluripotent cells REGULATORY GENOMICS Advanced genomics instruments, technology and methods for determination of transcription factor binding specificities; applications for identification of genes predisposing to colorectal cancer SIROCCO Silencing RNAs: organisers and coordinators of complexity in eukaryotic organisms THE EPIGENOME Epigenetic plasticity of the genome TRANSCODE Novel tool for high-throughput characterization of genomic elements regulating gene expression in chordates

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DEVELOPING - Tools for new therapies and medicinesAnti-tumor targeting CONSERT CRYSTAL E.E.T.-Pipeline EPI-VECTOR EURO-THYMAIDE EuroCSC EUROSTEMCELL EUROXY EVGN GIANT INTHER KIDSTEM Modulation of the recruitment of vessels and immune cells by malignant tumors: Targeting of tumor vessels and triggering of anti-tumor defense mechanisms Concerted safety & efficiency evaluation of retroviral transgenesis in gene therapy of inherited diseases CRYo-banking of Stem cells for human Therapeutic AppLication European Embryonal Tumor Pipeline Episomal vectors as gene delivery systems for therapeutic applications Novel approaches to pathogenesis, diagnosis and treatment of autoimmune diseases based on new insights into thymus-dependent self-tolerance Targeting cancer stem cells for therapy European consortium for stem cell research Targeting newly discovered oxygen-sensing cascades for novel cancer treatments: Biology, equipment, drug candidates European Vascular Genomics Network Gene therapy: an integrated approach for neoplastic treatment Development and application of transposons and site-specific integration technologies as non-viral gene delivery methods for ex vivo gene-based therapies Developing a Stem Cell Based Therapy to Replace Nephrons Lost through Reflux Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1

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magselectofection MODEST MOL CANCER MED MYOAMP NEURONE NEUROscreen NSR OsteoCord SKINTHERAPY STEM-HD STEMS SyntheGeneDelivery TherCord TUMOR-HOST GENOMICS X-ALD

Combined isolation and stable nonviral transfection of hematopoietic cells ? a novel platform technology for ex vivo hematopoietic stem cell gene therapy Modular devices for ultrahigh-throughput and small volume nucleofection Developing molecular medicines for cancer in the post genome era based on telomerase and related telomere-maintenance mechanisms as targets Amplification of human myogenic stem cells in clinical conditions Molecular mechanisms of neuronal degeneration: from cell biology to the clinic The Discovery of Future Neuro-therapeutic Molecules Nervous System Repair Bone from blood: Optimised isolation, characterisation and osteogenic induction of mesenchymal stem cells from umbilical cord blood Gene therapy for Epidermolysis Bullosa: a model system for treatment of inherited skin diseases Embryonic stem cells for therapy and exploration of mechanisms in Huntington Disease Pre-clinical evaluation of stem cell therapy in stroke Ex vivo gene delivery for stem cells of clinical interests using synthetic processes of cellular and nuclear import and targeted chromosomal integration Development and preclinical testing of cord blood-derived cell therapy products Genome-wide analysis of signaling pathways in regulation of the interactions between tumor and host cells: Applications for cancer therapy X-linked adrenoleukodystrophy (X-ALD): pathogenesis, animal models and therapy

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BUILDING - Tissue engineering3G-SCAFF AUTOBONE BARP+ BIOSYS CellPROM CORNEA ENGINEERING Custom-IMD EXPERTISSUES GENOSTEM HIPPOCRATES LIVEBIOMAT NANOBIOCOM NanoEar NEWBONE SILKBONE SmartCaP STEPS VASCUPLUG Third generation scaffolds for tissue engineering & regenerative medicine Production unit for the decentralised engineering of autologous cell-based osteoinductive bone substitutes Development of a bioartificial pancreas for type I diabetes therapy - nanotechnology biomaterial engineering transplantation Intelligent biomaterial systems for cardiovascular tissue repair Cell programming by nanoscaled devices Three-dimensional reconstruction of human corneas by tissue engineering SME supply chain integration for enhanced fully customisable medical implants, using new biomaterials and rapid manufacturing technologies, to enhance the quality of life for eu citizens Novel therapeutic strategies for tissue engineering of bone and cartilage using second generation biomimetic scaffolds Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side A hybrid approach for bone and cartilage tissue engineering using natural origin scaffolds, progenitor cell and growth factors Development of new polymeric biomaterials for in vitro and in vivo liver reconstruction Intelligent nanocomposite for bone tissue repair and regeneration 3g-Nanotechnology based targeted drug delivery using the inner ear as a model target organ Development of load-bearing fibre reinforced composite based non-metallic biomimetic bone implants Development and evaluation of mineralized silk based composites for orthopaedic applications Injectable macroporous biomaterial based on calcium phosphate cement for bone regeneration A systems approach to tissue engineering processes and products - biomaterial engineering biomedical engineering nanotechnology Bioreactive composite scaffold design for improved vascular connexion of tissue-engineered products

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MODELLING - Mathematical & biology models, alternatives to animals testingARTEMIS CARCINOGENOMICS CONTROL CANCER STEM INVITROHEART M3CS-TU TH NEURO PREDICTOMICS ReProTect VITROCELLOMICS In Vitro Neural Tissue System For Replacement Of Transgenic Animals With Memory / Learning Deficiencies Development of a high throughput genomics-based test for assessing genotoxic and carcinogenic properties of chemical compounds in vitro Developing a virtual and molecular control board for diverting cancer stem cell to nonmalignance Reducing Animal Experimentation in Drug Testing by Human Cardiomyocyte In Vitro Models Derived from Embryonic Stem Cells Modeling, Mathematical Methods and Computer Simulation of Tumour Growth and Therapy Towards the neuronal machine Short-term in vitro assays for long-term toxicity Development of a novel approach in hazard and risk assessment or reproductive toxicity by a combination and application of in vitro, tissue and sensor technologies Reducing Animal Experimentation in Preclinical Predictive Drug Testing by Human Hepatic In Vitro Models Derived from Embryonic Stem Cells

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REPAIRING - Towards clinical applications for diseases and impairementsBETACELLTHERAPY EuroSTEC MYOCARDIAL REPAIR RESCUE SC&CR STEMSTROKE STROKEMAP THERAPEUSKIN Ulcer Therapy Beta cell programming for treatment of diabetes Soft tissue engineering for congenital birth defects in children: new treatment modalities for spina bifida, urogenital and abdominal wall defects Clinical experience with bone marrow cells and myoblasts transplantation for myocardial repair From stem cell technology to functional restoration after spinal cord injury Application and process optimization of human stem cells for myocardium repair Towards a stem cell therapy for stroke Multipotent Adult Progenitor Cells to treat Stroke Ex vivo gene therapy for recessive dystrophic epidermolysis bullosa: pre-clinical and clinical studies Gene transfer in skin equivalents and stem cells: novel strategies for chronic ulcer repair and tissue regeneration

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TREATING - Improvement of standard hematopoeitic stem cell transplantationALLOSTEM The development of Immunotherapeutic strategies to treat haematological and neoplastic diseases on the basis of optimised allogeneic stem cell transplantation CLINT Facilitating International Prospective Clinical Trials in Stem Cell Transplantation EUROPEAN LEUKEMIA NET Strengthen and develop scientific and technological excellence in research and therapy of leukemia (CML, AML, MDS, CLL, adult ALL) by cooperation and integration of the leading national leukemia networks and groups in Europe FIRST Further improvement of radiotherapy of cancer through side effect reduction by application of adult stem cell therapy RISET Reprogramming the immune System for the Establishment of Tolerance STEMDIAGNOSTICS The development of new diagnostic tests, new tools and non-invasive methods for the prevention, early diagnosis and monitoring for haematopoietic stem cell transplantation TRANS-NET Identification of genomic and biological markers as predictive/diagnostic/therapeutic tools for use in allogeneic stem cell transplantation: Translational research towards individualised patient medicine TRIE Transplantation Research Integration across Europe

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INTEGRATING - Ethics, legal, societal aspects, trainingEMRS EU hESC registry EUROCITS imgbchimerashybrids INDUSTRYVECTORTRAIN INVIVOVECTORTRAIN REPROGENETICS SENECA StemCellPatents Worldwide study A European multimedia repository of science - video 1: stem cells to repair the heart European human embryonic stem cell registry Europe, its citizens and stem cell research: a one-day conference Chimeras and hybrids in comparative European and international research scientific, ethical, philosophical and legal aspects European labcourse: Advanced methods for industrial production, purification and characterisation of gene vectors European labcourse: Towards clinical gene therapy: preclinical gene transfer assessment Reprogenetics: the ethics of men making men From Cellular Senescence and Cell Death to Cancer and Ageing Stem cell patents: European patent law and ethics A worldwide study of umbilical cord cell banking

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Introduction and glossary ANNEX - Classification of projects by tissues, organs and diseases

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INTRODUCTION

STEM CELLS

What are stem cells ?Tissues and organs in the body are made of specialised cells that assure their specific functions. Maintenance and repair of these tissues and organs depend upon resident unspecialised adult stem cells. They are still at an early stage of development and retain the potential to turn into the different types of cells of that tissue or organ. In bones, some typical adult stem cells, the bone marrow stem cells, give rise to all kinds of blood cells. Apart from those of the blood cell lineage, other stem cells are found in the bone, which are able to mature into cells specific to bone, cartilage, fat, tendons, muscle and heart. During pregnancy, cells from bone marrow of the developing foetus find their way into the umbilical cord and placenta. Research suggests that umbilical cord blood stem cells, less mature than those from adult bone marrow, might be induced to turn into non-blood cells. The only cells that can evolve into any cells in the body are found in few day-old fertilised eggs, and are called embryonic stem cells.

Stem cells are crucial for a healthy organismStem cells play a central role in the normal growth and development of animals and humans. They have three properties that distinguish them from other cell types and make them interesting to scientists: - they are unspecialised - they are able to divide and produce copies of themselves - they have the potential to produce other cell types.

Stem cells are central to many research areasStem cells provide an ideal model to understand the development of organisms under healthy and disease condition. It should help decrease animal use. Stem cells are expected to offer means to develop new families of drugs and new therapies: harnessing cell specialisation will lead to regenerative medicine. Stem cells are daily used to treat cancer: bone marrow grafts have been used against le...