Upload
josh-lamberte
View
183
Download
2
Tags:
Embed Size (px)
Citation preview
Aballe, Karen Marie L.
Lamberte, Joshua L.
Sebastian, Marie Elaine S.
Ateneo de Zamboanga University
• Stem cell divides by mitosis to yield either 2 daughter cells like itself or one that is a partially progenitor cell
• Stem cell is the main cell that reproduces 2 different types of daughter cell
• There are 260 or so cell types in the body develop from stem and progenitor cells such as blood cell, connective tissue cell, bone cell, neuron, skin cell and sebaceous gland cells
Cell Lineages
PATHWAY TO
CELL
SPECIALIZATIO
N
STEM CELL VS PROGENITOR
CELLS
Totipotent – gives rise to any cell types
Pluripotent – gives rise to any cell under a certain cell type
Multipotent – gives rise to other types of cell but is limited in its ability to be differentiated
Unipotent – gives rise to a certain cell
Stem Cell Potentialities
STEM CELL POTENTIALITIES DURING EMBRYONIC DEVELOPMENT
Fertilization
Totipotent cells
Blastocystformation
Pluripotentcells
Gastrulation
Multipotentcells
Organogenesis and so on
Unipotent
STEM CELL TECHNOLOGY
USING EMBRYOS
- Stem cells is one type of, “regenerative medicine”
- In 1998, a breakthrough occurred when led by James Thomson
- SOURCES
* all organs (rare)
* earliest embryo through the elderly
* even from corpses and medical waste
(e.g fatty material discarded after liposuction and surgically removed organs.)
USING EMBRYOS
2 sources of ES Cells
1. Use of embryos from fertility clinics
where couples undergoing in vitro (test
tube).
2. Somatic-cell nuclear transfer
EMBRYONIC STEM (ES)
CELLS
SOMATIC-CELL NUCLEAR TRANSFER (SCNT)
STEM CELL TECHNOLOGY
USING CELLS FROM ADULTS
Stem cells can heal hearts
Somatic Stem Cell Therapy: Using
a Bone Marrow Transplant to Cure
Leukemia
• A sample of donor bone marrow containinghealthy stem cells is introduced into thepatient's bloodstream.
• Stem cells will migrate into the patient's bonemarrow and begin producing new, healthyleukocytes to replace the abnormal cells.
Peripheral Blood Stem cells
• Stem cells from bloodstreams
• PBSCs are easier to collect than bone marrow stem cells, which must be extracted from within bones.
Umbilical Cord Blood Stem Cells
Umbilical cord blood stem cell transplants are less prone to rejection than either bone marrow or peripheral blood stem cells.
References:
http://www.explorestemcells.co.uk/
http://stem-and-progenitor.blogspot.com/