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Stem Cell Overview Presented by Mohammed El Majdoubi, Ph.D. Slides courtesy of NICHD Grant for Specialized Cooperative Centers Program in Reproductive Research (SCCPRR) University of Kansas Medical Center, Center for Reproductive Sciences. Stem Cells. Unspecialized cells - PowerPoint PPT Presentation
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Stem Cell OverviewPresented by Mohammed El Majdoubi, Ph.D.
Slides courtesy of NICHD Grant for Specialized Cooperative Centers Program in Reproductive Research (SCCPRR)
University of Kansas Medical Center, Center for Reproductive Sciences
Stem Cells• Unspecialized cells
• Give rise to more than 250 specialized cells in the body
• Serve as the body’s repair system– Renew itself– Replenish other cells
• Adult & Embryonic Stem Cells…
Sources of Adult Stem Cells
Mature Stem Cells typically develop into the cell types of the tissue or organ from which they originate
• Isolated immediately following birth
• More flexibility
• Research is limited but growing
Umbilical Cord & Placenta
Treatment Example
Advantages of Adult Stem Cells
• Mature Stem Cells• Partly specialized• Less coaxing in culture required to
stimulate growth of specific cell types• Some are easy to find
(e.g., blood stem cells)• Organ/tissue rejection unlikely if
patient receives own stem cells
Disadvantages of Adult Stem Cells
• Limited longevity in cell culture • Difficult to isolate and extract• Limited flexibility or types of cells that
can be made• Uncommon cells; more scarce with
age• Questionable quality due to age,
toxins, and disease
Embryonic Stem Cells
5 days ofdevelopment
Sources of Embryonic Stem Cells
Stem Cells from Skin Cells
Somatic Cell Nuclear Transfer
How Would SCNT Treat Disease?
Characteristics of Embryonic Stem Cells
• Easy to grow in cell culture • Can be maintained for long periods
of time in cell culture• Very flexible – can make all body
cell types• Potential unlimited source of all
types of clinically relevant cells
In Vitro Differentiation of Embryonic Stem Cells
Mouse Embryonic Stem Cells in Culture
Neurons from Embryonic Stem Cells in Culture
Neuroendocrine Cells from Embryonic Stem Cells
Cardiac Cells From Embryonic Stem Cells
• Joyce Valencia
• Angela Giertych
• Eric Hinderleider
• Chris Heiser
• Peter Hoang