Status & Highlights of the NMR & MRI Program

• New Avance III Console for 900 MHz - upgraded console for WB600 #2 with old 900 MHz console

• New WB500 to be shared with Anant Paravastu in Chem and BioMed Engineering

• NMR/MRI Probes:1) Novel probes for in vivo imaging in vertical bore magnets maintain normal animal physiology2) New triple resonance 3.2 mm MAS probe provides better than commercial probe capabilities - excellent B1 homogeneity and field strengths

• Hired Jason Kitchen into the RF program to work on MRI probe developments

• Two recent NIH grants provide support for RF probe developments

• NSF Proposal for Series Connected Hybrid NMR/MRI console & probes appears to have been reviewed well for the third time ($1.8 M for co-development project with Agilent)

High-Field NMR Study of Solid Oxide Fuel CellC. Grey SUNY Stony Brook/Cambridge UK; Z. Gan, NHMFL

• High-field 45Sc multiple-quantum magic-angle spinning (MQMAS) reveals the 5-coordinate Sc site associated with an oxygen vacancy responsible to anionic conductance.

• Perovskite-type material shows the best results as conductor in solid oxide fuel cells at intermediate operating temperatures

• The electric-field-gradient and chemical shift para-meters are obtained from the MQMAS lineshape.

830 MHz NMR Data

Status and Highlights of the NMR & MRI Program

• 900 MHz Data

• 22 kDa structure of M2

M2 Proton Conductance Domain Structure and MechanismSharma et al., Science 2010: An NIH funded collaboration between David Busath, BYU;

Huan-Xiang Zhou, FSU Physics & Tim Cross, NHMFL

•Mechanism for Proton Conductance

Solid state NMR is a unique tool for structural characterization in native like lipid bilayers. Here, a novel atomic resolution functional mechanism has been determined by solid state NMR and Molecular modeling for a drug target membrane protein from Influenza A virus.

Vision for the NMR & MRI Program

• Strong user programs in solid state NMR, solution NMR and MRI facilitating NHMFL funding efforts for next generation magnets, such as the MR science drivers for the SCH. • These user programs will focus on the development of new technology and novel applications at

high fields spanning a broad range of scientific disciplines.• The user programs will be primarily based on two 600WB, a new high field solution NMR

instrument, 830NB, 900UWB, SCH and a new HTS/LTS magnet.

• A strong RF technology program will facilitate reaping the full benefits of high field magnet developments for the scientific community. A new platform for high field solution NMR probe development is needed.

• A strong program in DNP will be jointly developed by AMRIS, EMR and the NMR & MRI programs.

• Using the Series Connected Hybrid we envision the demonstration of:• High performance high field probes for solid state NMR, solution NMR and MRI for science on the

SCH and for high field HTS/LTS magnets.• 1H detection for solid state NMR taking advantage of greater 1H dispersion and leading to dramatic

sensitivity enhancements• Characterization of relaxation parameters for solution NMR potentially with the development of

C-TROSY effect. Characterization of high field alignment effects for both solution and solid state NMR spectroscopy. Characterization of high field contrast enhancement for MRI.