Statistical and Computational Methods, Volume 1 Volume 2 ......Next-Generation Sequencing Technologies and Fragment Assem-bly Algorithms.- Gene Prediction.- Alignment ... Biochemistry,

Biomedicine springer.com/NEWSonline

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M. Anisimova, ETH Zürich, Switzerland (Ed.)

Evolutionary GenomicsStatistical and Computational Methods, Volume 1

Together with early theoretical work in population genetics, the debate on sources of genetic makeup initiated by proponents of the neutral theory made a solid contribution to the spectacular growth in statistical methodologies for molecular evolution.

Features 7 Serves as an ideal reference for young and ex-perienced researchers alike 7 Features practical, step-by-step guidance to methodologies being used in the field 7 Includes key implementation advice from the experts

Contents Introduction to Genome Biology: Features, Processes, and Structures.- Diversity of Genome Organization.- Probability, Statistics, and Com-putational Science.- The Essentials of Computa-tional Molecular Evolution.- Next-Generation Sequencing Technologies and Fragment Assem-bly Algorithms.- Gene Prediction.- Alignment Methods: Strategies, Challenges, Benchmarking, and Comparative Overview.- Whole-Genome Alignment.- Inferring Orthology and Paralogy.- Detecting Laterally Transferred Genes.- Genome Evolution in Outcrossing Vs. Selfing Vs. Asexual Species.- Transposable Elements And Their Identification.- Evolution of Genome Content: Population Dynamics of Transposable Elements in Flies and Humans.- Detection and Phylogenetic Assessment of Conserved Synteny Derived from Whole Genome Duplications.- Analysis of Gene Order Evolution Beyond Single-Copy Genes.- Dis-covering Patterns in Gene Order.

Fields of interestsHuman Genetics; Evolutionary Biology

Target groupsProfessional/practitioner

Product categoryContributed volume

Due February 2012

2012. XX, 354 p. 86 illus., 16 in color. (Methods in Molecular Biology, Volume 855) Hardcover7 * € (D) 117,65 | € (A) 120,95 | sFr 146,507 € 109,95 | £99.00ISBN 978-1-61779-581-7

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M. Anisimova, ETH Zürich, Switzerland (Ed.)

Evolutionary GenomicsStatistical and Computational Methods, Volume 2

Contents Tangled Trees: The Challenge of Inferring Species Trees from Coalescent and Non-Coalescent Genes.- Modeling Gene Family Evolution and Reconciling Phylogenetic Discord.- Genome-Wide Comparative Analysis of Phylogenetic Trees: The Prokaryotic Forest of Life.- Philosophy and Evolution: Minding the Gap Between Evolutio-nary Patterns and Tree-Like Patterns.- Selection on the Protein Coding Genome.- Methods to Detect Selection on Non-Coding DNA.- The Origin and Evolution of New Genes.- Evolution of Protein Domain Architectures.- Estimating Recombination Rates from Genetic Variation in Humans.- Evolution of Viral Genomes: Interplay Between Selection, Recombination, and Other Forces.- Association Mapping and Disease: Evolutionary Perspectives.- Ancestral Populati-on Genomics.- Non-Redundant Representation of Ancestral Recombinations Graphs.- Using Genomic Tools to Study Regulatory Evolution.- Characterization and Evolutionary Analysis of Protein-Protein Interaction Networks.- Statistical Methods in Metabolomics.- Introduction to the Analysis of Environmental Sequences: Metageno-mics with MEGAN.- Analyzing Epigenome Data in Context of Genome Evolution and Human Diseases.- Genetical Genomics for Evolutionary Studies.- Genomics Data Resources: Frameworks and Standards.- Sharing Programming Resources Between Bio* Projects through Remote Procedure Call and Native Call Stack Strategies.- Scalable Computing for Evolutionary Genomics.

Fields of interestsHuman Genetics; Evolutionary Biology



Due February 2012

2012. XVI, 685 p. 113 illus., 64 in color. (Methods in Molecular Biology, Volume 856) Hardcover7 * € (D) 133,70 | € (A) 137,45 | sFr 166,507 € 124,95 | £112.50ISBN 978-1-61779-584-8

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T. Balla, National Institutes of Health, Bethesda, MD, USA; M. Wymann, University of Basel, Switzerland; J. D. York, Duke University Medical Center, Durham, NC, USA (Eds)

Phosphoinositides I: Enzymes of Synthesis and DegradationPhosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammati-on, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion.

Features 7 In depth discussion of the state of the art of phosphoinositide research 7 Experts in the field discussing the 'hot' topics in phosphoinositide research 7 A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides

Contents 1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback.- 2. PIP kinases from the cell membrane to the nucleus.- 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoi-nositide 3-Kinases – A Historical Perspective.- 5. PI 3-kinases – drug targets in inflammation and cancer.- 6. Phosphoinositide 3-kinases in health and disease.- 7. Phosphoinositide phosphatases: just as important as the kinases.- 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.

Fields of interestsBiomedicine general; Neurosciences; Human Genetics

Target groupsResearch


Due March 2012

2012. X, 280 p. 29 illus., 16 in color. (Subcellular Biochemistry, Volume 58) Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-94-007-3011-3

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www.springer.com/978-1-61779-581-7www.springer.com/978-1-61779-584-8www.springer.com/978-94-007-3011-3

News 12/2011 Biomedicine

13

T. Balla, National Institutes of Health, Bethesda, MD, USA; M. Wymann, University of Basel, Switzerland; J. D. York, Duke University Medical Center, Durham, NC, USA (Eds)

Phosphoinositides II: The Diverse Biological FunctionsPhosphoinositides play a major role in cellular signaling and membrane organization.

Features 7 In depth discussion of the state of the art of phosphoinositide research 7 Experts in the field discussing the 'hot' topics in phosphoinositide research 7 A volume dedicated to processes regulated by phosphoinositides

Contents 1. Ca2+ signalling by IP3 receptors. - 2. Phosphoi-nositide signaling during membrane transport in Saccharomyces cerevisiae. - 3. Phosphoinositides in the mammalian endo-lysosomal network. - 4. Role of PtdIns(4,5)P2 in vesicle exocytosis and membrane fusion. - 5. Role of phosphoinositides at the neuronal synapse. - 6. Phosphatidylinositol 4,5-bisphosphate and the actin cytoskeleton. - 7. Phosphoinositides in chemotaxis. - 8. Phosphoi-nositides in Golgi complex function. - 9. Sec14 like PITPs couple lipid metabolism with phosphoi-nositide synthesis to regulate Golgi functionality. - 10. Phosphoinositide sensitivity of ion channels, a functional perspective. - 11. Nuclear phosphoi-nositides: location, regulation and function. - 12. Phosphoinositides and cellular pathogens. - 13. Defining signal transduction by inositol phospha-tes. - 14. Cell signalling by inositol pyrophospha-tes.

Fields of interestsBiomedicine general; Neurosciences; Human Genetics



Due March 2012

2012. X, 390 p. 10 illus. in color. (Subcellular Biochemistry, Volume 59) Hardcover7 * € (D) 181,85 | € (A) 186,94 | sFr 226,507 € 169,95 | £153.00ISBN 978-94-007-3014-4

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Y. Bigot, UMR INRA-CNRS, Physiologie de la Reproduction et des Comportements, France (Ed.)

Mobile Genetic ElementsProtocols and Genomic Applications

Contents Transposable Elements as Tools for Reshaping the Genome: it‘s a Huge World After All !.-Using and Understanding RepeatMasker.-Roadmap for Annotating Transposable Elements in Eukaryote Genomes.-To Detect and to Analyze Sequence Repeats Whatever their Origin.-Exploring Bacte-rial Insertion Sequences with ISfinder: Objectives, Uses and Future Developments.-Methods and Software in NGS for TE Analysis.-The Application of LTR Retrotransposons As Molecular Markers in Plants.-Individual Analysis of Transposon Polymorphisms by AFLP.-Construction of a Library of Random Mutants in the Spirochete Leptospira Biflexa using a Mariner Transposon.-Ac-Ds Solutions for Rice Insertion Mutagenesis.-Engineering the Caenorhabditis elegans Genome by Mos1 Induced Transgene-Instructed Gene Conversion (MosTIC).-Genome-wide Manipula-tions of Drosophila Melanogaster with Transpo-sons, Flp Recombinase and FC31 Integrase.-The Sleeping Beauty Transposon Toolbox.-PiggyBac tool box.-Insertion Site Pattern: Global Approach by Linear Amplification-mediated PCR (LAM-PCR) and Mass Sequencing.-Comprehensive DNA Methylation Profiling of Human Repetitive DNA Elements using a MeDIP-on-RepArray Assay.-Novel Approach for the Development of New Antibodies Directed Against Transposase-derived Proteins Encoded by Human Neogenes.

Fields of interestHuman Genetics



Due March 2012

2nd ed. 2012. XII, 359 p. 66 illus., 24 in color. (Methods in Molecular Biology, Volume 859) Hardcover7 * € (D) 101,60 | € (A) 104,45 | sFr 126,507 € 94,95 | £85.50ISBN 978-1-61779-602-9

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R. G. Dumitrescu, Saba University Medical School, Netherland Antilles; M. Verma, National Cancer Institute, Bethesda, MD, USA (Eds)

Cancer EpigeneticsMethods and Protocols

Contents Epigenetic Markers of Early Tumor Development.-Epigenetics of Solid Cancer Stem Cells.-DNA Methylation and Histone Modifications in Breast Cancer.-DNA Methylation Changes in Prostate Cancer.-DNA Methylation in Promoter Region as Biomarkers in Prostate Cancer.-Epigenetics of Bladder Cancer.-Epigenetics in Myeloid Malignancies.-The Epigenetics of Brain Tumors.-DNA Methylation Changes in Cervical Cancers.-Epigenetics of Colon Cancer.-Promoter Methylati-on in Head and Neck Tumorigenesis.-Epigenome and DNA Methylation in Oral Squamous Cell Carcinoma.-Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung Cancer.-The Role of microRNAs in the Management of Liver Cancer.- Epigenetics in Ovarian Cancer.-DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite Modification.-Detection and Analysis of DNA Methylation by Pyrosequencing.-Screening for miRNA Expres-sion Changes using Quantitative PCR (Q-PCR).-Genome-wide Methylation Analysis.-Microarray for Epigenetic Changes: Gene Expression Arrays.-Detecting DNA Methylation using the Methyla-ted CpG Island Amplification and Microarray Technique.- Nutrigenomics – Implications for Breast and Colon Cancer Prevention.-Dietary and Lifestyle Factors of DNA Methylation.-Diet, Epigenetics and Cancer.-Role of Epigenetics in Cancer Health Disparities.-Multifactorial Etiology of Gastric Cancer.-Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation. [...]

Fields of interestCancer Research



Due March 2012

2012. X, 646 p. 42 illus., 32 in color. (Methods in Molecular Biology, Volume 863) Hardcover7 * € (D) 133,70 | € (A) 137,45 | sFr 166,507 € 124,95 | £112.50ISBN 978-1-61779-611-1

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14

I. D. Duncan, University of Wisconsin-Madison, WI, USA; R. J. Franklin, University of Cambridge, UK (Eds)

Myelin Repair and Neuroprotection in Multiple SclerosisMultiple sclerosis (MS) is the most prevalent de-myelinating disease of the central nervous system (CNS). It affects over 400,000 people in the USA alone and is a common disease world wide. This book will cover a new and emerging field in the development of strategies to treat MS. Until now, the only therapies available for MS treatment have been those directed against inflammation and the immune attack on the CNS. Other treatments are used for symptomatic relief.

Features 7 First book on this topic 7 Authorship from many of the major players in the field of MS and myelin repair 7 Of equal interest to academic clinical neurologists and neuroscientists

Contents Myelin and Oligodendrocyte Biology.-Demyeli-nation in MS.-Remyelination in MS.-The Role of Astrocytes in Inhibiting Remyelination.-Microglia Promote or Inhibit Remyelination.-Imaging of Demyelination/Remyelination.-Remyelination-Endogenous.-Remyelination-Exogenous.-Testing the Physiologic Response of Remyelination Therapies.-Immunomodulation and Repair Following Neural Stem Transplantation.-Phar-macologic Protection of Nerve Fibers in MS.-Clinical Trials-Measuring Repair Clinically and by Surrogates.-Biomarkers in Remyelination/Repair.-P. Methods of Evaluating Neuroprotection in MS Patients.

Fields of interestsNeurosciences; Neurology; Neuroradiology



Due April 2012

2012. 350 p. Hardcover7 approx. * € (D) 165,80 | € (A) 170,44 | sFr 206,507 approx. € 154,95 | £139.50ISBN 978-1-4614-2217-4

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T. W.-M. Fan, A. N. Lane, R. M. Higashi, University of Louisville, KY, USA (Eds)

The Handbook of MetabolomicsVital to academic researchers, the medical field, and especially to biotech and pharmaceutical sci-entists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms.

Features 7 Examines the rapidly expanding field of metabolomics with a focus on toxicology and pharmaceutical applications 7 Integrates metabolomics with transcriptomics and prote-omics 7 Features extensive bibliographies and resources

Contents Introduction to Metabolomics.- Considerations of Sample Preparation for Metabolomics Investigati-on.- Clinical Aspects of Metabolomics.- Structural Mass Spectrometry for Metabolomics.- Metabolo-mic Applications of Inductively Coupled Plasma- Mass Spectrometry (ICP-MS).- Principles of NMR for Applications in Metabolomics.- Novel NMR and MS Approaches to Metabolomics.- Metabolic Flux Analysis.- Introduction to Metabolic Control Analysis (MCA).- Application of Tracer-Based Metabolomics and Flux Analysis in Targeted Cancer Drug Design.- Non-Invasive Fluxomics in Mammals by Nuclear Magnetic Resonance Spec-troscopy.- Compositional Analysis of Phospho-lipids by Mass Spectrometry and Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy.- The HumanCyc Pathway-Genome Database and Pathway Tools Software as Tools for Imaging and Analyzing Metabolomics Data.- Metabolomics-Edited Transcriptomics Analysis (META).

Fields of interestPharmacology/Toxicology



Due March 2012

2011 2011. XIV, 569 p. 137 illus., 80 in color. (Methods in Pharmacology and Toxicology, Volume 17) Hardcover7 * € (D) 117,65 | € (A) 120,95 | sFr 146,507 € 109,95 | £99.00ISBN 978-1-61779-617-3

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R. A. Figlin, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA; W. K. Rathmell, University of North Carolina, Chapel Hill, NC, USA; B. Rini, Cleveland Clinic Taussig Cancer Institute, OH, USA (Eds)

Renal Cell CarcinomaTranslational Biology, Personalized Medicine, And Novel Therapeutic Targets

Contents Preface.- The Genetic Basis of Kidney Cancer and Implications for Targeted Therapies.- Molecular Biology of Clear Cell Renal Carcinoma.- HIF Biology in RCC: Implications for Signaling, Disease Progression, and Treatment.- Tissue Biomarkers in Renal Cell Carcinoma: Intermedi-ate Endpoints in the Selection of Targeted Agents for RCC.- Molecular Characterization of Renal Cell Carcinoma.- Targeting The Vegf Pathway In Renal Cell Carcinoma.- Angiopoetins and Other Non-VEGF Antiangiogenic Targets In Advanced Renal Cell Carcinoma.- Towards Personalized Cancer Medicine.- Epigenetic Targeting and Histone Deacetylase Inhibition in RCC.- C-MET as a Novel Target for the Treatment of Renal Cell Carcinoma.- Characterizing and Modulating the Tumor Micro-Environment in Renal Cell Carcino-ma: Potential Therapeutic Strategies.- Carbonic Anhydrase IX: Its role as a biomarker, diagnostic, and therapeutic target in Renal Cell Carcinoma.- Presurgical Therapy for Renal Cell Carcinoma and Implications for Window of Opportunity Trials.- Mechanisms of Resistance to VEGF Directed Therapy and Implications for Future Trial Design.- Vaccine Based Immunotherapy and Targeting the Tumor Microenvironment in Renal Cell Carcino-ma.- Index.

Fields of interestsCancer Research; Pharmacology/Toxicology



Due March 2012

2012. XV, 270 p. 34 illus., 31 in color. Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-1-4614-2399-7

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15

Forensic Pathology of Infancy and ChildhoodEditors-in-chief: R. W. Byard, University of Adelaide, SA, Australia; K. A. Collins, Fulton County Medical Examiner‘s Office, Atlanta, GA, USA

Contents The History of Pediatric Forensic Pathology and the Pediatric Autopsy.- Death Scene Investigati-on.- The Autopsy.- Fetal, Perinatal and Neonatal Death.- Birth Trauma.- Placental and Maternal Conditions.- Neonaticide.- Fatal Craniocereb-ral and Spinal Trauma.- Biomechanics of Head Injury.- Ocular Findings in Inflicted Injury.- Blunt Abdominal and Chest Injuries.- Cutaneous Fin-dings in the Young.- The Pathological Evaluation of Fractures at Autopsy.- Dating of Other Injuries.- Homicide in the Older Child.- Sexual Abuse.- Starvation, Dehydration, Malnutrition, and Fatal Neglect.- Poisoning and Toxicological Issues.- Fac-titious Illness by Proxy.- Conditions Simulating Inflicted Injury. [...]

Fields of interestsForensic Science; Forensic Medicine; Pharmacolo-gy/Toxicology


Product categoryReference work

Due January 2013

Print

2013. 1000 p. (In 2 volumes, not available separately) 7 approx. * € (D) 544,63 | € (A) 559,90 | sFr 780,507 approx. € 499,00 | £453.00ISBN 978-1-61779-402-5

9 eReference

2013. 7 approx. ** € (D) 593,81 | € (A) 598,80 | sFr 698,007 approx. € 499,00 | £449.50ISBN 978-1-61779-403-2

9 Print + eReference

2013. 1000 p. (In 2 volumes, not available separately) 7 approx. * € (D) 667,68 | € (A) 686,40 | sFr 831,007 approx. € 624,00 | £562.00ISBN 978-1-61779-404-9

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J. Green, T. Ried, National Cancer Institute, Bethesda, MD, USA (Eds)

Genetically Engineered Mice for Cancer Researchdesign, analysis, pathways, validation and pre-clinical testing

Contents Foreword.- Preface.- Overview of Designing Genetically-Engineered Mouse Models.- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer.- Using Re-combineering Technology To Create Genetically Engineered Mouse Models.- Insertional Mutage-nesis for Generating Mouse Models of Cancer.- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer.- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat.- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology.- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer.- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytoche-mistry.- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing.- Imaging mouse models of human cancer.- Identifying Mammary Epithelial Stem and Progenitor Cells.- Differentia-tion Programs in Development and Cancer.- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse.- Mouse Models for Colorectal Cancer.- Src family tyrosine kinases: Implications for mammary tumor progression.- Maspin and Suppression of Tumor Metastasis.- Epigenetic Mouse Models.- Modeling Transforming Growth Factor-ß Signaling in Cancer. [...]

Fields of interestsCancer Research; Human Genetics; Laboratory Medicine


Product categoryProfessional book

Due November 2011

2012. XX, 632 p. 75 illus., 47 in color. Hardcover7 * € (D) 181,85 | € (A) 186,94 | sFr 244,007 € 169,95 | £153.00ISBN 978-0-387-69803-8

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P. J. Gutiérrez, University of Valladolid, Spain; I. H. Russo, J. Russo, Fox Chase Cancer Center, Philadelphia, PA, USA

The Evolution of the Use of Mathematics in Cancer ResearchThe book will provide an exhaustive and clear explanation of how Statistics, Mathematics and In-formatics have been used in cancer research, and seeks to help cancer researchers in achieving their objectives. To do so, state-of-the-art Biostatistics, Biomathematics and Bioinformatics methods will be described and discussed in detail through illustrative and capital examples taken from cancer research work already published.

Features 7 Provides a clear perspective on how mathema-tics have been used in cancer research 7 Pro-vides examples of mathematics to correlate biomathematics, biostatistics, and bioinformatics to cancer research 7 Thoroughly examines the procedures of cancer-related biomathematics, biostatistics, and bioinformatics

Contents Preface.- Historical Introduction.- Descriptive biostatistics.- Inferential biostatistics I: Estimating values of biomedical magnitudes.- Inferential biostatistics II: Estimating biomedical behavi-ors.- Equations: Formulating biomedical laws and biomedical magnitudes.- Systems of equations: The explanation of biomedical phenomena(I). Basic questions.- Systems of equations: The expla-nation of biomedical phenomena(II). Dynamic interdependencies.- Optimal control theory: From knowledge to control (I). Basic concepts.- Optimal control theory: From knowledge to control (II). Biomedical applications.- Game theory.- Index.

Fields of interestsCancer Research; Pharmacology/Toxicology


Product categoryMonograph

Due March 2012

2012. IV, 286 p. 67 illus., 33 in color. Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-1-4614-2396-6

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www.springer.com/978-1-61779-402-5www.springer.com/978-1-61779-403-2www.springer.com/978-1-61779-404-9www.springer.com/978-0-387-69803-8www.springer.com/978-1-4614-2396-6


16

M. Hayat, Kean University, Union, NJ, USA (Ed.)

Stem Cells and Cancer Stem Cells, Volume 5Therapeutic Applications in Disease and Injury

Contents Cancer Stem Cells.- 1 Signaling Pathways In Cancer Stem Cells Therapeutic Implications.- 2 Inhibition Of Telomerase With Imetelstat Causes Depletion Of Cancer Stem Cells.- 3 Targeting Self-Renewal Pathways In Cancer Stem Cells.- 4 Detection Of Cancer Stem Cells Using Ac133 Antibody.- Tissue Injury.- 5 Peripheral Nerve Regeneration After Traumatic Injury And Stem Cell Therapy.- 6 Neural Stem Cell Proliferation Surrounding The Area Of Traumatic Brain Injury Role Of Exercise Therapy.- 7 Mesenchymal Stem Cell Treatment For Ischemic Brain Injury.- 8 Role Of Neuropeptide Y On The Maintenance Of Self- Renewal And Proliferation Of Human Embryonic Stem Cells.- Cardiovascular Applications.- 9 Differentiation Of Human Adipose-Derived Stem Cells Into Cardiomyocytes.- 10 Cellu-lar Cardiomyoplasty Arterial Cells-Stem Cells Transplantation.- 11 Cardiac Stem Cells Derived From Epithelial-Mesenchymal Transition Of The Epicardial Cells Role In Heart Regeneration (Method).- 12 Allogenic Mesenchymal Stem Cells In Experimental Ischaemic Stroke Translation To The Clinic?- Bone Diseases.- 13 Bone Reconst-ruction Utilizing Mesenchymal Stem Cell Sheets For Cell Delivery.- 14 Dental Implants Application Using Tissue Engineering Technology.- 15 Dental Stem Cells Regeneration Of Dentin Upon Tooth Injury.- 16 Scaffolds For Human Dental Stem Cells To Regenerate Cementum.- Eye Disorders.- 17 Eye Disorders Caused By Limbal Stem Cell Deficien-cy.- Viral Applications. [...]

Fields of interestsCancer Research; Gene Expression; Laboratory Medicine



Due February 2012

2012. XIV, 297 p. 45 illus., 38 in color. (Stem Cells and Cancer Stem Cells, Volume 5) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2899-8

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Stem Cells and Cancer Stem Cells, Volume 6Therapeutic Applications in Disease and Injury

Contents I Embryonic stem cells.-1 Propagation of human embryonic stem cell: role of tgf β.-2 Self-renewal of embryonic stem cells: cell cycle regulation.-3 Gene expression and epigenetic signatures of germ cell-derived pluripotent stem cells and embryonic stem cells.-4 Human embryonic stem cell bank : implication of human leukocyte antigens and abo blood group antigens for cell transplantation.-5 Differentiation of embryonic stem cells into glu-tamatergic neurons (methods).-6 Differentiation of embryonic stem cells into endoderm-derived hepatocytes.-7 Differentiation of embryonic stem cells into cardiomyocytes: role of ouabain.-8 Func-tion of myc for generation of induced pluripotent stem cells masato nakagawa and shinya yamana-ka.-9 Differentiation of human pluripotent stem cells into retinal cells.-10 Derivation and invasive function of trophoblast from human pluripotent stem cells. II Mesenchymal stem cells.-11 Differen-ces between germ-line stem cells and multipotent adult germ-line stem cells role of micrornas.-12 Molecular and signaling pathways that modula-te mesenchymal stem cell self-renewal.-13 The biology and regenerative potential of stem cells and their mesenchymal progeny.-14 Mesenchymal stem cells: clinical applications (an overview).-15 Mesenchymal stem cells for the treatment of cancer.-16 Treatment of neurodegenerative patho-logies using undifferentiated mesenchymal stem cells.-17 Utility of mesenchymal stem cell therapry in type 1 diabetes.-18 Differentiation of mesen-chymal stem cells into adipocyte lineage: role of cytoskeleton-associated proteins. [...]

Fields of interestsCancer Research; Stem Cells; Pathology



Due March 2012

2012. XX, 476 p. 62 illus., 56 in color. (Stem Cells and Cancer Stem Cells, Volume 6) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2992-6

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Teratoid/Rhabdoid, Brain Tumors, and GliomaContents Part I Teratoid/Rhabdoid.- 1. Pediatric Atypical Teratoid/Rhabdoid Tumors (An Overview).- 2. Pediatric Atypical Teratoid/Rhabdoid Tumor .- 3. Pediatric Rhabdomyosarcoma: Role Of Cell Cycle Regulators Alteration.- 4. Pediatric Atypical Teratoid/Rhabdoid Tumors: Imaging With Ct And Mri.- 5. Pediatric Atypical Teratoid/Rhabdoid Tumor: Diagnosis Using Imaging Techniques And Histopathology.- 6. Pediatric Atypical Teratoid/Rhabdoid Tumors: Differential Diagnosis.- Part II Brain Tumors (General).- 7. Pediatric Brain Tumors (An Overview).- 8. Pediatric Cns Primitive Neuroectodermal Tumor: Role Of The Wnt Pathway.- 9. Neuroblastic Tumors: Status And Role Of Her Family Recep-tors.- 10. Children With Neurofibromatosis Type 1: Positron Emission Tomography.- 11. Metabolite Profile Differences In Childhood Brain Tumors: 1h Magic Angle Spinning Nmr Spectroscopy.- 12. Central Nervous System Imaging In Childhood Leukemia.- 13. Immunohistochemistry In The Differential Diagnosis Of Adult And Pediatric Brain Tumors.- 14. Children With Brain Tumors: Role Of The Neurosurgeon.- 15. Pediatric Intra-ventricular Brain Tumors: Endoscopic Neurosur-gical Techniques.- 16. Neurosurgical Management Of Pediatric Brain Tumors.- 17. Pediatric Brain Tumor Biopsy Or Resection: Use Of Postoperative Nonnarcotic Analgesic Medication.- 18. Clinical Trials In Pediatric Brain Tumors; Radiotherapy.- 19. Epileptic Seizures And Supratentorial Brain Tumors In Children.- 20. Postoperative Pain In Children: Advantage Of Using Nonnarcotic Analgesic Regimen. [...]

Fields of interestsCancer Research; Pediatric Surgery; Imaging / Radiology



Due March 2012

2012. XIX, 369 p. 57 illus., 27 in color. (Pediatric Cancer, Volume 2) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2956-8

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17


Tumors of the Central Nervous System, Volume 7Meningiomas and Schwannomas

Contents MENINGIOMAS.- Molecular Genetics.- 1. Me-ningiomas: Role Of Semaphorin3a Protein In Antiangiogenesis.- 2. Meningiomas: Role Of Carbonic Ahydrase Ii.- 3. Meningiomas: Role Of Genetic Instabilities Of The E- Cadherin Gene.- 4. Intracranial Meningiomas: Role Of Exogenous Hormones.- 5. Meningiomas: Clinical Needs And Molecular Insights.- 6. Meningioma: Urokinase Plasminogen Activator.- 7. Mir-200a Regulation Of The Wnt Signaling In Meningioma Tumori-genesis.- Diagnosis.- 8. Meningiomas: Determi-nation Of Subtypes Using Perfusion Magnetic Resonance Imaging.- 9. Intracranial Meningioma In Mice: Noninvasive Bioluminescence Imaging.- 10. Incidentally Discovered Meningiomas: Growth Rates And Patterns.- 11. Cycstic Papillary Menin-gioma: Diagnosis.- 12. Meningioma Tumors: De-tection Of Subgroups.- 13. Prognostic Parameters In Atypical And Malignant Meningiomas.- 14. Sporadic Meningioangiomatosis: Diagnosis With Computed Tomography And Magnetic Resonance Imaging Therapy.- 15. Atypical Meningioma: Distinguishing Features And Role Of Adjuvant Radiation.- 16. Gamma Knife Radiosurgery For Benign Meningioma: Significance And Therapeu-tic Potential.- 17. Oncocytic Meningioma: Neuro-surgery.- 18. Intracranial Meningiomas: Treatm-nent And Quality Of Life.- 19. Cavernous Sinus Meningiomas: Optimal Treatment.- Recurrence.- 20. Genetic And Clinical Features Associated With Recurrence In Atypical Meningioma.- 21. Recurrence And Progression In Meningiomas. [...]

Fields of interestsCancer Research; Laboratory Medicine; Drug Resistance



Due February 2012

2012. XLII, 359 p. 67 illus., 35 in color. (Tumors of the Central Nervous System, Volume 7) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2893-6

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M. S. Islam, Karolinska Institutet, Stockholm, Sweden (Ed.)

Calcium SignalingContents Preface.-1 The regulation of a cell‘s Ca2+ signaling toolkit: the Ca2+ homeostasome.-2 Methods to detect Ca2+ in living cells.-3 Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs.-4 Two-photon calcium imaging in the intact brain.-5 Sig-naling through the Extracellular Calcium-Sensing Receptor (CaSR).-6 Ca2+ signaling: an outlook on the characterization of Ca2+ channels and their importance in cellular functions.-7 Ryanodine receptor calcium release channels: an evolutionary perspective.-8 Techniques and methodologies to study the ryanodine receptor at the molecu-lar, subcellular and cellular level.-9 Ryanodine Receptor Physiology and its role in Disease.-10 Phospholipase C.-11 Inositol 1,4,5-trisphosphate and its receptors.-12 Discovery and structural in-vestigation of the IP3 receptor and the associated IRBIT, a personal account.-13 Pyridine nucleotide metabolites and calcium release from intracellular stores.-14 NAADP on target.-15 Store-operated Ca2+ entry.-16 Structure, regulation and biophy-sics of ICRAC, STIM/Orai1.-17 Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units.-18 Calcium around the Golgi apparatus: implications for intracellular memb-rane trafficking.-19 Calcium binding proteins.-20 Cytoplasmic calcium buffering.-21 Elementary calcium release events from the sarcoplasmic reticulum in the heart.-22 Calcium oscillations and pacemaking.-23 Calcium Oscillations and Waves in Cells.-24 Calcium signaling: From single channels to pathways.-25 Simulation strategies for calcium microdomains and calcium-regulated calcium channels. [...]

Fields of interestsBiomedicine general; Neurosciences; Receptors

Target groupsGraduate


Due February 2012

2012. XX, 1012 p. 199 illus., 143 in color. (Advances in Experimental Medicine and Biology, Volume 740) Hardcover7 * € (D) 213,95 | € (A) 219,94 | sFr 266,507 € 199,95 | £180.00ISBN 978-94-007-2887-5

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JIMD Reports Society for the Study of Inborn Errors o (Ed.)

Volume 3

Society for the Study of Inborn Errors o, SSIEM, London, UK (Ed.)

JIMD Reports - Case and Research Reports, 2011/3JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to me-tabolic disorders 7 All contributions rigorously peer-reviewed

Contents Different Case Reports.

Fields of interestsHuman Genetics; Metabolic Diseases; Pediatrics



Due December 2011

2012. VII, 139 p. 37 illus., 13 in color. Softcover7 * € (D) 106,95 | € (A) 109,95 | sFr 133,507 € 99,95 | £90.00ISBN 978-3-642-24935-8

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S. Kaul, R. Wadhwa, National Institute of Advanced Industrial Science & Technology, Ibaraki, Japan (Eds)

Mortalin Biology: Life, Stress and DeathContents Contributors.- Foreword.- Preface.- Section 1: Structure and Function of Mortalin.- 1. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer.- 2. Mortalin’s Machinery.- 3. The Role of Mortalin in Iron Homeostasis .- 4. Functional Characteristics of Mortalin.- Section 2: Mortalin in Evolution2 Deocaris.- 5. Mortalin and Drosophila DmH-sp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis .- 6. Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes .- 7. Mortalin and Stem Cells: A Study from Planarians.- Section 3: Morta-lin in Health and Disease.- 8. Mortalin in Cell Protection from Immune Attack .- 9. Mortalin in Neurological Diseases.- 10. Loss of Mortalin Function in Parkinson’s Disease – Supporting the Mitochondrial Pathway of Neurodegeneration.- 11. Hsp75/mortalin and Protection from Ischemic Brain Injury.- 12. Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders.- 13. Chapero-nopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis.- Section 4: Mortalin and Cancer.- 14. The Many Faces of Mortalin and Tid1.- 15. Mortalin: A Positive Regulator of Centrosome Duplication and Amplification.- 16. Mortalin Ex-pression in Normal and Neoplastic Tissues .- 17. Mortalin - p53 Interaction as A Target for Liver Cancer Therapy.- 18. Mortalin Targeting Gadgets for Cancer Therapy. [...]

Fields of interestsMolecular Medicine; Gene Function; Cancer Research



Due March 2012

2012. 300 p. 77 illus., 27 in color. Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-94-007-3026-7

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W. J. Kress, D. L. Erickson, Smithsonian Institution, Washington, DC, USA (Eds)

DNA BarcodesMethods and Protocols

Features 7 A compendium of the latest information on generating, applying, and analyzing DNA 7 Pro-vides step-by-step detail essential for reproducible results 7 Contatins key notes and implementati-on advice from the experts

Contents Foreword.-Introduction.-Introduction to Animal DNA Barcoding Protocols.-DNA Barcodes for the Tree of Life – A. Animals - Insects.-Barcoding Me-thods for Invertebrates.-DNA Barcoding of Am-phibians and Reptiles.-DNA Barcoding Fishes.-DNA Barcoding Birds: from Field Collection to Data Analysis.-DNA Barcoding in Mammals.-Methods for DNA Barcoding of Fungi.-Methods for DNA Barcoding Photosynthetic Protists Emphasizing the Macroalgae and Diatoms.-DNA Barcoding Methods for Land Plants.-Field Infor-mation Management Systems (FIMS) for DNA Barcoding.-Laboratory Information Manage-ment Systems (LIMS) for DNA Barcoding.-DNA Extraction, Preservation and Amplification.-DNA Mini-barcodes.-Next Generation Sequencing: Multiplexing Multiple Barcode Amplicons into Single 454 Run.-The Practical Evaluation of Bar-code Efficacy.-Plant DNA Barcodes, Taxonomic Management and Species Discovery in Tropical Forests.-Construction and Analysis of Phyloge-netic Trees using DNA Barcode Data.- Phyloge-netic Analyses of Ecological Communities Using Barcode Data.-DNA Barcodes: FISH-BOL, a Case Study.-Generating Plant DNA Barcodes for Trees in Long-term Forest Dynamics Plots.- Future Directions.

Fields of interestsHuman Genetics; Animal Genetics and Genomics; Plant Genetics & Genomics



Due April 2012

2012. 435 p. 71 illus., 10 in color. (Methods in Molecular Biology, Volume 858) Hardcover7 approx. * € (D) 112,30 | € (A) 115,45 | sFr 137,507 approx. € 104,95 | £93.00ISBN 978-1-61779-590-9

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S. D. Mittleman, University of Southern California, Los Angeles, CA, USA; N. A. Berger, Case Western Reserve University, Cleveland, OH, USA (Eds)

Energy Balance and Hematologic MalignanciesThe obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obe-se. Hematologic malignancies have recently been identified among the obesity associated malignan-cies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lympho-ma and others.

Features 7 Focuses on the relation of obesity to hemato-logic malignancies, the epidemiology, potential mechanisms, and therapeutic considerations on energy balance 7 Adds to the burgeoning field of information on metabolism and cancer 7 In-cludes effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance

Contents Preface.- The Epidemiology of Obesity and Hematologic Malignancies.- Adipocytes, Lipid Metabolism and Hematopoiesis.- Mechanisms Linking Obesity and Leukemia Prognosis.- Obesi-ty and Multiple Myeloma.- The Impact of Obesity on Pharmacokinetics and Dosing of Leukemia Chemotherapy.- The Impact of Obesity on Stem Cell Transplant.- Obesity Following Childhood Leukemia: Mechanisms and Consequences.- Phy-sical Activity and Recovery from Hematological Malignancy.- Index.

Fields of interestsPharmacology/Toxicology; Cancer Research



Due March 2012

2012. VI, 144 p. 20 illus., 19 in color. (Energy Balance and Cancer, Volume 5) Hardcover7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 201,007 approx. € 139,95 | £126.50ISBN 978-1-4614-2402-4

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New SeriesSpringer Series in Translational Stroke ResearchSeries editor: J. Zhang

The Springer Series in Translational Stroke Re-search will cover basic, translational and clinical research, emphasizing novel approaches to help translate scientific discoveries from basic stroke research into the development of new strategies for the prevention, assessment, treatment, and en-hancement of central nervous system repair after stroke and other forms of neurotrauma.

P. A. Lapchak, Cedars-Sinai Medical Center, Los Angeles, CA, USA; J. H. Zhang, Loma Linda University, CA, USA (Eds)

Translational Stroke ResearchFrom Target Selection to Clinical Trials

Contents Vascular Targets For Ischemic Stroke Treatment.- Identifying Vascular Targets to Treat Hemorrhagic Stroke.- Experimental Platforms For Assessing White Matter Pathophysiology In Stroke.- Neu-roprotection in Stroke.- Protein Aggregation And Multiple Organelle Damage After Brain Ischemia.- Antioxidants And Stroke. Success And Pitfalls.- Caspase-Independent Stroke Targets.- Hypoxia-Inducible Factor: A New Hope To Counteract Stroke.- Thrombin in Ischemic Stroke Targe-ting.- Toll-Like Receptor Agonists As Antecedent Therapy For Ischemic Brain Injury: Advancing Preclinical Studies To The Nonhuman Prima-te.- Angiogenesis and Arteriogenesis As Stroke Targets.- Hematopoietic Growth Factor Family For Stroke Drug Development.- Soluble Epoxide Hydrolase As A Stroke Target.- Membrane Poten-tial As Stroke Target.- Hypothermia To Identify Therapeutic Targets For Stroke Treatment.- Stroke Preconditioning To Identify Endogenous Protec-tive Or Regenerative Mechanisms.- MicroRNAs in Ischemic Brain: The Fine-tuning Specialists and Novel Therapeutic Targets.- Neuroglobin: A Novel Target For Endogenous Neuroprotection.- Characterization Of Novel Neuroprotective Lipid Analogues For The Treatment Of Stroke.- Na+/H+ Exchangers As Therapeutic Targets For Cerebral Ischemia.- Iron as a therapeutic target in intracerebral hemorrhage: Preclinical testing of deferoxamine.- Overcoming Barriers To Transla-tion From Experimental Stroke Models. Animal Models Of Stroke For Preclinical Drug Develop-ment: A Comparative Study Of Flavonols For Cytoprotection. [...]

Fields of interestsNeurosciences; Neurobiology

Target groupsUpper undergraduate


Due February 2012

2012. XXX, 974 p. 162 illus., 107 in color. (Springer Series in Translational Stroke Research) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-1-4419-9529-2

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S. Markowitz, N. A. Berger, Case Western Reserve University, Cleveland, OH, USA (Eds)

Energy Balance and Gastrointestinal CancerThe gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, eso-phagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemio-logic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies.

Features 7 Explores relation between obesity and gastrointestinal cancer 7 Features up-to-date re-search 7 Examines the effects of physical activity on colon cancer prognosis

Contents Preface.- Obesity and Gastrointestinal Cancers: Epidemiology.- Genetics of Colon Cancer Suscep-tibility.- Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation and Inflammation.- The ApcMin/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy.- Obesity and the Pathogenesis of Barrett’s Esophagus.- Obesity and Pancreatic Cancer.- Obesity, Insulin Resistance Pathway Factors and Colon Cancer.- Ras/Raf and their Influence in Glycolysis in Colon Cancer.- Energy Balance and Other Modifiable Host Fac-tors on Colorectal Cancer Prognosis.- Cyclooxy-genase-2 and Chronic Inflammation: Drivers of Colorectal Tumorigenesis.- Index.

Fields of interestsCancer Research; Human Physiology



Due March 2012

2012. V, 158 p. 15 illus., 9 in color. (Energy Balance and Cancer, Volume 4) Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-1-4614-2366-9

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www.springer.com/978-1-4419-9529-2www.springer.com/978-1-4614-2366-9


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S. Modrow, University of Regensburg, Germany; D. Falke, Mainz, Germany; U. Truyen, University Leipzig, Germany; H. Schätzl, Technical University Munich, Germany

Molecular VirologyContents A General part.- Historical overview.- Viru-ses: definition, structure, classification.- Virus proliferation and replication.- Pathogenesis.- Cell damage.- Transformation and carcinogene-sis.- Immunology.- Cytokines, chemokines and interferons.- Chemotherapy.- Vaccines.- Epide-miology.- Virus evolution.- Laboratory methods for detection virus infections.- B Special part.- Vi-ruses with single-stranded, positive-sense RNA genomes.- Viruses with single-stranded, non-seg-mented, negative-sense RNA genomes.- Viruses with single-stranded, segmented, negative-sense RNA genomes.- Viruses with double-stranded, segmented RNA genomes.- Viruses with single-stranded RNA genomes and double stranded DNA as intermediate products. [...]

Fields of interestsMolecular Medicine; Virology; Medical Micro-biology

Target groupsGraduate

Product categoryReference work

Due September 2012

Print

2013 2013. XX, 800 p. 161 illus. 7 * € (D) 533,93 | € (A) 548,90 | sFr 715,507 € 499,00 | £449.50ISBN 978-3-642-20717-4

9 eReference

2013 2013. XX, 800 p. 161 illus. 7 ** € (D) 593,81 | € (A) 598,80 | sFr 752,007 € 499,00 | £449.50ISBN 978-3-642-20718-1

9 Print + eReference

2013 2013. XX, 800 p. 161 illus. 7 * € (D) 667,68 | € (A) 686,40 | sFr 895,007 € 624,00 | £562.00ISBN 978-3-642-20719-8

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P. Salvi, IRCCS Istituto Auxologico Italiano, Milano, Italia

Onde di polsoCome l‘emodinamica vascolare determina la pressione arteriosa

Come origina la pressione arteriosa? Come interpretare i valori pressori? È più importante la pressione sistolica o la diastolica? Questi sono solo alcuni degli interrogativi che si pone il medico quando affronta nella pratica clinica quotidiana il problema dell’ipertensione arteriosa. Questo libro intende presentare, in maniera imme-diata ed efficace, le complesse nozioni di base dell’emodinamica vascolare e della sua fisiopato-logia, sottolineando l’importanza delle proprietà meccaniche delle grandi arterie nella genesi della pressione arteriosa.

Features 7 I concetti fisici più complessi sono presentati in maniera immediata ed efficace 7 Le numerose figure e il linguaggio accessibile rendono il testo più comprensibile e la lettura più agevole 7 Box e riquadri individuano gli argomenti più speciali-stici e distinguono le parti essenziali del testo dagli ulteriori approfondimenti

Contents Introduzione.- La pressione arteriosa media.- La pressione pulsatoria; Le proprietà meccaniche delle grandi arterie.- Valutazione delle proprietà meccaniche delle grandi arterie.- La pressione arteriosa centrale.- Analisi della curva di pressione centrale.- Pressione centrale e rischio cardiovasco-lare.- Acquisizione non-invasiva della pressione arteriosa centrale.- Strumenti per l’analisi dell’onda pressoria e la misura della velocità dell’onda di polso.- Velocità dell’onda di polso e pressione cen-trale in animali da laboratorio.- Bibliografia.

Fields of interestsHuman Physiology; Cardiology


Product categoryMonografia

Pubblicazione prevista per il mese di January 2012

2012. Approx. 150 pagg. 120 figg. Brossura7 approx. * € (D) 36,99 | € (A) 38,02 | sFr 46,507 approx. € 34,57 | £31.99ISBN 978-88-470-2423-6

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R. Scatena, P. Bottoni, B. Giardina, Catholic University, Rome, Italy (Eds)

Advances in Mitochondrial MedicineContents Section I – Physiology and structure of Mito-chondria.- 1. The oxidative phospho-rylation system in mammalian mitochondria.- 2. Physiology and pathophysiology of mitochondrial DNA.- 3. Mitochondrial calcium as a key regulator of mitochondrial activities.- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology.- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology?.- 6. Uncoupling proteins: molecular, functional, re-gulatory, physiological and pathological aspects.- 7. The mitochondrial pathways of apoptosis.- Sec-tion II – Mitochondria and disease.- 8. Inherited mitochondrial disorders.- 9. Mitochondria and metabolism diseases.- 10. Mitochondria and diabetes. An intriguing pathogenetic role.- 11. Mi-tochondria and heart diseases.- 12. Mitochondria in neurodegeneration.- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation.- Section III – Mitochondria and Aging.- 14.Mitochondria and aging.- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors.- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological dis-orders: genetics and pathogenetic mechanisms.- 18. Anthracyclines and mitochondria.- Section IV- Applications of Mitochondrial science.- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer.- 20. Mitochondria in Anthropology and forensic medicine.

Fields of interestsBiomedicine general; Cancer Research; Molecular Medicine



Due February 2012

2012. VII, 492 p. 59 illus., 28 in color. (Advances in Experimental Medicine and Biology, Volume 942) Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2868-4

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www.springer.com/978-3-642-20717-4www.springer.com/978-3-642-20718-1www.springer.com/978-3-642-20719-8www.springer.com/978-88-470-2423-6www.springer.com/978-94-007-2868-4


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S. Shankar, R. Srivastava, University of Kansas Medical Center, Kansas City, KS, USA (Eds)

Nutrition, Diet and CancerContents 1.Aberrant signaling pathways in cancer: Mo-dulation by the dietary flavonoid, quercetin.- 2. “Micronutrient and Cancer: Add Spice to Your Life”.- 3. Chemoprevention of prostate cancer with cruciferous vegetables: role of epigenetics.- 4. Molecular insight and preclinical perspective of thymoquinone as chemopreventive agent and the-rapeutic adjunct in cancer.- 5. Dietary biofactors in the management of cancer: Reality or Myth?.- 6. Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition. -7. STAT Sig-naling in Cancer Prevention.- 8. gdT cells, tea and cancer.- 9. Phytochemical Intakes with a Mediter-ranean Diet: Levels Achievable with an Exchange List Diet and Potential Biomarkers in Blood.- 10. Plant polyphenols and their role in cancer prevention and chemotherapy.- 11. Role of Food Micro-molecules in the Prevention of Cancer.- 12. The protective role of zinc in cancer: A potential chemopreventive agent.- 13. Diet-induced Epige-netic Changes and Cancer Prevention: A Mantra for Healthy Living.- 14. Western Diet-Induced Pancreatic Cancer.- 15. Intracellular signaling net-work as a prime chemotherapy target of green tea catechin, (–)-epigallocatechin-3-gallate.- 16. Role of Dietary Antioxidants in Cancer.- 17. Curcumin: Structure, Biology and Clinical Applications.- 18. Obesity, cancer and psychopathology: can vegetarian diet be of help?.- 19. Dietary Phytoche-micals as Epigenetic Modulators in Cancer.- 20. “Modulation of the Nrf2 signaling pathway by chemopreventive dietary phytoconstituents”.- 21. Role of fish oil from gene expression to pharmaco-logical effects in cancer prevention.- 22. “Antioxi-dant supplements: An evidence-based approach to health benefits and risks“. [...]

Fields of interestsBiomedicine general; Cancer Research; Nutrition



Due March 2012

2012. X, 548 p. 44 illus., 23 in color. Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-2922-3

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W. S. Spielman, N. Parameswaran, Michigan State University, East Lansing, MI, USA (Eds)

RAMPsAmong the many GPCRs discovered, the calci-tonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family.

Features 7 Source of basic studies that range from bioche-mistry to molecular biology to receptor pharma-cology and physiology 7 Written by authors well known in the RAMPs field 7 Provides informa-tion for scientists at different stages of their career including graduate students, post-doctoral fellows and senior scientists who are new to the RAMPs field

Contents Introduction to RAMPs.- RAMPs and CGRP Receptors.- Regulation of GPCR Trafficking by RAMPs.- Regulation of Calcium Sensing Receptor Trafficking by RAMPs.- Understanding RAMPs through Genetically Engineered Mouse Models.- RAMPs as Drug Targets.- Ramp Like Proteins: RTP and REEP Family of Proteins.- Regulation of RAMP Expression in Diseases.- Perspectives on some Recent Studies on RAMPs.

Fields of interestsBiomedicine general; Cell Biology; Molecular Medicine



Due February 2012

2012. XVIII, 116 p. 14 illus. (Advances in Experimental Medicine and Biology, Volume 744) Hardcover7 approx. * € (D) 112,30 | € (A) 115,45 | sFr 137,507 approx. € 104,95 | £93.00ISBN 978-1-4614-2363-8

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Y.-K. Tu, D. C. Greenwood, University of Leeds, UK (Eds)

Modern Methods for EpidemiologyFeatures 7 Discussion of modern statistical methods for epidemiology and biomedical research that cannot be found in most textbooks, e.g. latent growth curve models, latent class analysis, growth mixture models, regression trees, generalised additive mo-dels, and G-estimation etc. 7 Written by experts in accessible language for upper-level undergra-duate and postgraduate students in epidemiology and biostatistics 7 Real life data sets are used extensively in the book to illustrate how these method may be applied in real research 7 Each chapter contains a section for further reading list for readers who wish to pursue these methods in greater details

Contents Preface.-1 Confounding and Causal path diagrams.-2 Statistical modelling of partially ob-served data using multiple imputation: principles and practice.-3 Measurement errors in epidemio-logy.-4 Selection bias in epidemiologic studies.-5 Multilevel modelling.-6 Modelling data that exhibit an excess number of zeros: zero-inflated models and generic mixture models.-7 Multilevel latent class modelling.-8 Bayesian bivariate disease mapping.-9 A multivariate random frailty effects model for multiple spatially dependent survival data.-10 Meta-analysis of observational studies.-11 Directed acyclic graphs and structural equation modelling.-12 Latent growth curve models.-13 Growth mixture modelling for life course epi-demiology.-14 G-estimations.-15 Generalised additive models.-16 Regression and classification trees.-17 Statistical interactions and gene-environ-ment joint effects. Index.

Fields of interestsBiomedicine general; Epidemiology; Biostatistics



Due March 2012

2012. XV, 365 p. 60 illus., 10 in color. Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-94-007-3023-6

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