Risk Ratio for Coronary Heart Disease Mortality in 59 Randomized Risk Ratio for Coronary Heart Disease Mortality in 59 Randomized Controlled Trials of Cholesterol-Lowering InterventionsControlled Trials of Cholesterol-Lowering Interventions

StatinsStatins 0.69 (0.59-0.80)0.69 (0.59-0.80)n=13 (16,228/11,279)n=13 (16,228/11,279)n-3 fatty acidsn-3 fatty acids 0.44 (0.18-1.07)0.44 (0.18-1.07)n=3 (1,348/1,349)n=3 (1,348/1,349)FibratesFibrates 0.98 (0.78-1.24)0.98 (0.78-1.24)n=12 (9,873/11,496)n=12 (9,873/11,496)ResinsResins 0.71 (0.51-0.99)0.71 (0.51-0.99)n=8 (3,280/3,257n=8 (3,280/3,257HormonesHormones 1.04 (0.93-1.17)1.04 (0.93-1.17)n=8 (4,516/9,039)n=8 (4,516/9,039)Niacin acidsNiacin acids 0.85 (0.83-1.10)0.85 (0.83-1.10)n=2 (1,196/2,932)n=2 (1,196/2,932)DietDiet 0.91 (0.82-1.01)0.91 (0.82-1.01)n=16 (48,481/59,042)n=16 (48,481/59,042)

1.01.0.9.9.8.8.7.7.6.6.5.5.4.4.3.3.2.2.1.1 22

Risk Ratio % 95% CIRisk Ratio % 95% CIBenefitBenefit HarmHarm

Arterioscler Thromb Vasc Biol. 1999;19:187-195Arterioscler Thromb Vasc Biol. 1999;19:187-195

Risk Ratio for Overall Mortality in 59 Randomized Controlled Risk Ratio for Overall Mortality in 59 Randomized Controlled Trials of Cholesterol-Lowering InterventionsTrials of Cholesterol-Lowering Interventions

StatinsStatins 0.79 (0.71-0.89)0.79 (0.71-0.89)n=13 (16,228/11,279)n=13 (16,228/11,279)n-3 fatty acidsn-3 fatty acids 0.66 (0.53-0.88)0.66 (0.53-0.88)n=3 (1,348/1,349)n=3 (1,348/1,349)FibratesFibrates 1.06 (0.78-1.48)1.06 (0.78-1.48)n=12 (9,873/11,496)n=12 (9,873/11,496)ResinsResins 0.85 (0.66-1.08)0.85 (0.66-1.08)n=8 (3,280/3,257n=8 (3,280/3,257HormonesHormones 1.09 (1.00-1.20)1.09 (1.00-1.20)n=8 (4,516/9,039)n=8 (4,516/9,039)Niacin acidsNiacin acids 0.96 (0.86-1.08)0.96 (0.86-1.08)n=2 (1,196/2,932)n=2 (1,196/2,932)DietDiet 0.97 (0.81-1.15)0.97 (0.81-1.15)n=16 (48,441/59,042)n=16 (48,441/59,042)

1.01.0.9.9.8.8.7.7.6.6.5.5.4.4 22

Risk Ratio % 95% CIRisk Ratio % 95% CIBenefitBenefit HarmHarm

Arterioscler Thromb Vasc Biol. 1999;19:187-195Arterioscler Thromb Vasc Biol. 1999;19:187-195

Risk Ratio for Mortality Other Than From CHD in 59 Randomized Risk Ratio for Mortality Other Than From CHD in 59 Randomized Controlled Trials of Cholesterol-Lowering InterventionsControlled Trials of Cholesterol-Lowering Interventions

StatinsStatins 0.97 (0.81-1.16)0.97 (0.81-1.16)n=13 (16,228/11,279)n=13 (16,228/11,279)n-3 fatty acidsn-3 fatty acids 1.16 (0.63-2.12)1.16 (0.63-2.12)n=3 (1,348/1,349)n=3 (1,348/1,349)FibratesFibrates 1.16 (0.63-2.12)1.16 (0.63-2.12)n=12 (9,873/11,496)n=12 (9,873/11,496)ResinsResins 1.07 (0.74-1.55)1.07 (0.74-1.55)n=8 (3,280/3,257n=8 (3,280/3,257HormonesHormones 1.29 (1.08-1.57)1.29 (1.08-1.57)n=8 (4,516/9,039)n=8 (4,516/9,039)Niacin acidsNiacin acids 0.99 (0.76-1.29)0.99 (0.76-1.29)n=2 (1,196/2,932)n=2 (1,196/2,932)DietDiet 1.00 (0.95-1.05)1.00 (0.95-1.05)n=16 (48,481/59,042)n=16 (48,481/59,042)

1.01.0.9.9.8.8.7.7.6.6 22

Risk Ratio % 95% CIRisk Ratio % 95% CIBenefitBenefit HarmHarm

Arterioscler Thromb Vasc Biol. 1999;19:187-195Arterioscler Thromb Vasc Biol. 1999;19:187-19533