Stanford Bio 118 2014 Final

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The final for Bio 118: Advanced Genetics, through Stanford University.

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    Question 10: (25 points) A researcher is interested in understanding the genetics of hair density on the scalp. The researcher decides to use the jackalope as an experimental system. Note that the genetics of the jackalope are similar to those of the mouse with the following exception. Jackalopes are hermaphrodites that can either be outcrossed or self-mated. She begins by examining a large number of highly inbred jackalope strains and identifies two strains that differ markedly in their hair density. Strain A has sparse hair, while Strain B has extremely dense hair. The two strains are crossed to each other to generate an F1 that is intermediate in hair density. The F1 are bred to each other to generate an F2. Each of the F2 is genotyped for 9 SNP markers (1 marker each for the 9 jackalope chromosomes) and assayed for hair density. The plots below show the results. For each marker, the average hair density of the F2 bearing each of the three possible genotypes is indicated (the horizontal line shows the average, while the vertical line indicates the interval into which 95% of the progeny fell).