Sta-chol® feed additive by- pass for ruminants

MLC technology target by-pass

RUMEN PROTECTED CHOLINE RUMEN PROTECTED CHOLINE

Metabolic destiny of choline into rumenOver 90% of degradation (Sharma & Erdman, 1988)

Why make sense to use rumen protected choline in ruminant

nutrition?

Moreover degradation of choline by rumen flora leads to production of harmful substances: trimethylamines

Because ruminants need nutritional strategy and

ingredients matching their digestive physiology

Sta-chol® feed additive by- pass for ruminants

MLC technology target by-pass

Protection of choline with proven rumen by-pass is a crucial tool to meet the correct requirements for

ruminants.

Technical aspects of a rumen protected choline

in order to be by-pass

Sta-chol® feed additive by- pass for ruminants

MLC technology target by-pass

tecnolgia MLC by-pass selettivo

2. Proven stability to feed compounder procedures

1. Proven rumen stability in vivo (nylon bag in situ)

3 Valuable physiological remarks

4. Proven animal performance

Ideal choline for ruminants

Sta-chol® feed additive by-pass for ruminants

MLC technology target by-pass

Rumen performance “in situ” of Sta-chol®(PSU - Dairy and Animal Science, Prof. G.Varga, 2004)

05

10

1520253035

404550

0 2 4 8 16 23 48

incubation/h

% d

egra

dabi

lity

Sta-chol

Progressive degradability

>75% by-pass

Sta-chol® feed additive by-pass for ruminants

MLC technology target by-pass MLC technology target by-pass MLC technology target by-pass MLC technology target by-pass

MLC technology target by-pass

MLC technology target by-pass

by-pass in situ confirmed by quick check in vitro

Comparison between by-pass in vivo and in in vitro Sta-Chol in 8 hours incubation

In situ by nylon bagIn vitro (Daisy Ankom) by enzymatic methodbioscreen technologies lab., Dr Farnedi

8 h incubation05

10152025303540455055606570758085 85

75

In vitroIn situ

By-p

ass

%

MLC technology target by-pass

proven intestinal uptake

Physiological remarks

Higher levels of blood choline gives evidence for rumen by-pass and bio-availability

University of di Milano - Pinotti e Baldi, 2003

Blood levels of Choline (phosphotodilcholine) in peripartum cows fed with Sta-chol®

Day -7 Day+ 200

102030405060708090

100110120130140150160170180 172 171

150

127

Sta-chol Choline

mg/

dl p

lasm

a

tecnolgia MLC by-pass selettivo

Proven choline metabolization

NEFA palsma level in peripartum cows fed with Sta-chol®

NEFA decreasing level is a good indicator of relief of hepatic cell overload.

University of Milano-Pinotti e Baldi, 2003

Day -7 Calving0

0,050,1

0,150,2

0,25

0,30,35

0,40,45

0,5

0,550,6

0,65

0,29

0,54

0,3

0,6

Sta-chol Choline

nmol

/ l p

alsm

a

proven transfer of choline from food to the udder

MLC technology target by-pass

Choline level in milk of peripartum cows fed with Sta-chol®

Increased level of choline in milk is a clear indication of intestinal uptake and transfer from food to the udder

University of Milano - Pinotti e Baldi, 2003

1° month lactation0

102030405060708090

100110120130140 138,5

99,66

Sta-cholColinam

g/kg

milk

Productivity via a better state of health

MLC technology target by-pass

Milk yeld of cows fed with Sta-chol® during peripartum

University of Milano- Pinotti e Baldi, 2003

Several field tests showed positive effects of Sta-chol at beggining lactation as result of improved metabolic activity ( antichetonic effect)

1° month lactation

0

2,5

5

7,5

10

12,5

15

17,5

20

22,5

25

27,5

30

32,530,85

26,45

Sta-cholColina

kg m

il 3,

5% F

CM

Sta-chol feed additive by- pass for ruminants

MLC technology target by-pass

i

PREMIXTURE FOR RUMINANT NUTRITION ingredients per kg

Choline chloride: 500.000 mgCarrier up to: 1.000 gRecommended use and dosage

peripartum cows: 25 g/head/day (Recommended 20-50 g) (preferably 2 weeks before calving and 4 weeks after

beef cattle: 10-30 g/head/day (referably in finishing)

Lactating goats and sheeps: 5- 10 g/head/day Finishing lambs and kids: 3-5 g/head/day

Packaging: 25 kg box, 10 kg bag

®

Sta-chol®

MLC specific feed ingredients for ruminant nutrition

MLC technology target by-pass

Focus on milk production

0-2 2

Rumaster plusRumaster plus

→ → →

chol RUMASTERSta-

Rumaster plusRumaster pluscholSta-

calving

a-

b-

Weeks after calving 12-15