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Jau-Shin Lou, MD, PhD, MBA
(May 23, 2015)
Office Address: 700 1st Ave S, Fargo, ND 58104
Email Address: [email protected]
Phone (701) 234-4499
MEDICAL LICENSES
North Dakota ND 13013
(Active)
ACTIVE BOARD CERTIFICATIONS
1. American Board of Psychiatry and Neurology
2. American Board of Neuromuscular and Electrodiagnostic Medicine
3. Added qualification in Neuromuscular Diseases
EDUCATION
Postgraduate: 7/91 - 6/93 Clinical Associate in Movement Disorders and Neurophysiology, with Dr. Mark
Hallett at Human Motor Control Section, National Institute of Neurological Diseases and Stroke, National Institute of Health.
7/88 - 6/91 Resident, Department of Neurology, Baylor College of Medicine.
7/87 - 6/88 Resident, Department of Internal Medicine, Baylor College of Medicine.
7/86 - 6/87 Postdoctoral Fellow, Barrow Neurological Institute, Phoenix, Arizona.
7/84 - 6/86 Research Assistant, University of Minnesota.
8/81 - 6/84 Teaching Assistant, University of Minnesota.
7/79 - 5/81 Military Physician, Taiwan.
6/78 - 6/79 Rotating Internship at National Taiwan University Hospital.
Graduate:
01/09-12/11 MBA in Healthcare Management, Oregon Health & Science University and Portland State University Joint Program
8/81 - 6/86 Ph.D.: Graduate School, University of Minnesota Majored in Neurophysiology, Ph.D.
Medical School:
9/72 - 6/79 M.D.: Medical School, National Taiwan University, Taipei, Taiwan
ACADEMIC POSITIONS
11/2013-Present Professor and Chair, Roger Gilbertson Endowed Chair of Neurology at University of
North Dakota School of Medicine & Health Science/ Sanford Health Fargo, ND
Accomplishments:
1. Established Sanford Parkinson’s disease Research Lab (May 2015)
2. Epilepsy Monitor Unit started to operate in March, 2015.
3. Solicited an anonymous endowment in Parkinson’s Disease, $1,000,000 (12/2014)
4. Founding MS3 neurology clerkship director (07/2014)
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5. Founding MS4 neurology elective director (07/2014)
6. Stroke Center awarded Gold Plus Center by American Stroke Association (05/2014).
7. Recruited first stroke specialist in Sanford (02/2014)
6/99-11/2013 Oregon Health and Sciences UniversityPortland, OR
-Director EMG Fellowship Program 6/99-11/2013 -Executive Committee Member, Neurology 6/99-11/2013
-Director, EMG laboratory 6/99 – 11/2013
-Director, Clinical Neurophysiology Fellowship Program 6/99 - 9/06
-Assistant Professor, Department of Neurology 6/99 -7/02
-Director, Neuromuscular program 7/00 - 4/05
-Medical Director, ALS Center of Oregon 10/00 – 11/2013
-Director, MDA-ALS Clinic 11/00 – 11/2013
-Associate Professor, Department of Neurology 07/02 -6/12
-Co-Director, MDA clinic 04/05 – 08/00
-Co-Director, Neuromuscular Program 04/05 – 08/00
-Director, MDA clinic 08/00 – 11/2013
-Director, Neuromuscular Program 08/00-11/2013
-Committee Member, OHSU Limited Submission Review Committee 12/09-11/2013
-Committee Member, OHSU Institutional Review Board 3/09-6/12
-Committee Member, OHSU Medical Research Foundation 6/06-02/08
- Professor, Department of Neurology 6/2012-11/2013
- Committee Member, Promotion and Tenure Committee, Neurology 01/2013-11/2013
9/97-5/99 Barrow Neurological Institute, Phoenix, AZ
-Director, Clinical Neurophysiology Fellowship Program 9/97 - 5/99
8/93-8/97 University of Rochester
Rochester, NY
-Director, EMG Laboratory 8/95 - 8/97
-Director, Clinical Neurophysiology Fellowship Program 7/93 - 8/97
-Director, Dystonia Clinic, University of Rochester 7/93 - 8/97
-Assistant Professor 7/93 - 8/97
-Director, Ataxia Clinic 7/93 - 8/97
-Associate Director, EMG Laboratory 7/93 - 8/95
HOSPITAL APPOINTMENTS
Sanford Health, Fargo 11/2013 –present
Oregon Health and Sciences University Hospital Portland, OR -Attending Physician, Neurology 6/99-11/2013
-Director of EMG Laboratory 6/99-11/2013
St. Joseph Hospital Phoenix, AZ
-Attending Physician, Neurology 9/97-5/99
University of Rochester Hospital, Rochester, NY
-Attending Physician, Neurology 8/93-8/97
-Director, EMG Laboratory 8/95-8/97
-Associate Director, EMG Laboratory 7/93-8/95
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PROFESSIONAL ORGANIZATIONS
North Dakota Medical Association (NDMA): Vice president, First district May, 2015
American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM)
-Chair, Symposim in “Diabetic Neuropathy” 2014-2016
-Chair, Special Interest Group Committee 2014-2016
-Member, research Committee 2012, 2013,2014
-Chair, Symposium in “muscle diseases” 2011, 2012
-Chair, Special Interest Group in “diabetic neuropathy” 2010, 2011,2012
-Chair, Round Table workshop in “small fiber neuropathy” 2010- present
-Chair, Symposium on “Update in ALS” 2010 -Chair, Special Interest Group in Diabetic Neuropathy 2010
-Program Committee 2008-2011
-Chair, Special Interest Group in Transcranial Magnetic Stimulation and Evoked Potential 2007-2009
-Chair, Symposium on “Neuroprothesis” 2009
-Chair, Symposium on “Quantitative EMG” 2008
-Research Committee Member 2001-2006 -Task Force on Dynamic EMG 2002 - 2005
-National Training Program Committee 1990-2002
National Ataxia Foundation -Executive Committee, Cooperative Ataxia 1999-2000
-Board of Research, National Ataxia Foundation 1998-2003
American Academy of Neurology -Member, Neuromuscuar Section 2001-present -Member, Clinical Neurophysiological Section 2001-present
-Member, Movement Disorders Section 2001-present -Active Member 2001-present
-Co-Chair, Scientific Platform Session (Parkinson’s Disease) 2003
-Meeting Abstract Reviewer, Annual Meeting (Parkinson’s Disease) 2003
American Neurological Association - Committee member – Public Policy and Relations Committee 2013-1016
- Annual meeting abstract reviewer 2013;2014;2015 -Active Member (Inducted by Invitation Only) 2006-present
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EDITORIAL POSITIONS
Internatioal Journal of Neuroscience (Journal) -Editorial Board
Muscle and Nerve (Journal)
2009-present
-Editorial Board Member 2009-present
JOURNAL AND GRANT REVIEWER
Muscle and Nerve (Journal) Ad Hoc Reviewer
Neurology (Journal) Ad Hoc Reviewer
Movement Disorders (Journal) Ad Hoc Reviewer
Journal of Clinical Neuromuscular Disease Ad Hoc Reviewer
Journal of Neurophysiology Ad Hoc Reviewer
J. Neurol. Neurosurg. Psychiatry Ad Hoc Reviewer
Annals of Behavioral Medicine (Journal) Ad Hoc Reviewer
Clinical Neurophysiology (Journal) Ad Hoc Reviewer
Journal of Neurology Ad Hoc Reviewer
Clinical Neuropharmocology (Journal) Ad Hoc Reviewer
Department of Defense, Peer reviewed medical research, grants review panel for ALS 2004-2005
COURSE DIRECTOR
Course Director, Symposium: Botulinum toxin for dystonia. 1994
Course Director, Update in Neuromuscular Diseases 2001, 2006
TEACHING
Overview of my Role as an Educator: 1. As the director of the EMG laboratory and the director of the clinical neurophysiology fellowship at
University of Rochester (UR) from 1993 to 1997 and at OHSU since 1999, I have trained 15 fellows in
clinical neurophysiology or EMG/neuromuscular diseases over the last 15 years.
2. As the primary electromyographer at UR and OHSU, I teach neurology residents principles and techniques
in EMG. A neurology resident rotates in my EMG lab each month.
3. I mentor junior faculty members – Dr. Lisa Silbert (NIH K23) and Dr. Tom Gregory (NIH R01).
4. I am a small group facilitator for the course “Biostatistics in Medicine” of the Principles of Clinical
Medicine (PCM) during the winter quarter, 2009 (12/2008-2/2009).
Fellows and Students:
University of Rochester
Fellows
Patricia Shipley, M.D. Fellow in Neurophysiology, July 1993-June 1994
Jamie Asnis, M.D. Fellow in Neurophysiology, July 1993-June 1994
Robert Snyder, M.D. Fellow in Neurophysiology, July 1994 -June 1995
Richard Ferguson, M.D. Fellow in Neurophysiology, July 1994-June 1995
Allen Pettee, M.D. Fellow in Neurophysiology, July 1995-June 1996
Fawzy Salama, M.D. Fellow in EMG, July 1995-June 1996
Gubert Tan, M.D. Fellow in EMG, July 1995-June 1997
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Anthony Pakiam, M.D. Fellow in EMG, July 1996-June 1997
Students
Benjy Kozower Summer medical student, June 1994-August 1994
Presented "Impaired motor adaptation of speech
output in stutterers" Student Poster Day
Michael Eiffert Summer Medical Student, 1995.
Lysa Gregoire Summer undergraduate student. (1995 Advantage Scholars internship).
Leo Carusone Neuroscience student, Special research project, October 1995-present.
Megan Grace Summer undergraduate student (1996 Advantage Scholars
internship).
Oregon Health & Science University
Fellows
James Sheffield, MD Fellow in Neurophysiology, OHSU, 8/1999 – 7/ 2000
Lisa Silbert, MD Fellow in Neurophysiology, 8/ 2000 – 7/2002
Daniel Friedman, MD Fellow in Neurophysiology, 8/2001 – 7/2003
Todd Dunaway, MD Fellow in EMG/Neuromuscular disease 7/2002-6/2003
Joshua Johnson, MD Fellow in EMG/Neuromuscular disease 7/2003-6/2004 Lawrence Neville, MD Fellow in EMG/Neuromuscular disease 7/2004-6/2005
Amy Harper, MD Fellow in EMG neuromuscular disease 10/2005-12/2006
Sherwin Cho, MD Fellow in EMG/neuromuscular Disease 7/2007-6/2008
Michael Leone, MD Fellow in EMG/neuromuscular Disease 7/2008-6/2009
Prin Burusnukel, MD Fellow in neuromuscular Disease /EMG 7/2008-6/2010
Eric Edgar, MD Fellow in neuromuscular Disease /EMG 7/2009-6/2010 Ben Brennan, MD Fellow in neuromuscular Disease /EMG 11/2010-10/2011
Brent Burroughs, MD Fellow in neuromuscular Disease /EMG 7/2011-6/2012 Haz Jafari, MD Fellow in neuromuscular Disease /EMG 7/2011-6/2012 M. Satayaprasert, MD Fellow in neuromuscular Disease /EMG 7/2011-6/2013 Alex Dimitrova, MD, NIH T32 research fellow, 7/2011-6/2014
Students
Jesse Jacobs PhD candidate, serve as an advisor for his PhD thesis, 2002-2006
Samuel Hellman Summer Undergraduate student, 2007
Junior Faculty mentoring
Dr. Lisa Silbert, One of our junior faculty member, finished her fellowship in dementia/clinical neurophysiology
with me. I am one of Dr. Silbert’s mentors for her NIH K23 clinical investigator award. Dr. Silbert has been
carrying out part of her research in my transcranial magnetic stimulation (TMS) laboratory, investigating the
pathophysiology of white matter changes in the elderly.
I also mentor Dr. Tom Gregory, an assistant professor in the Department of Obstetrics and Gynecology. Dr.
Gregory expressed his interests to me in studying the neurophysiology of pelvic floor disorders in women in 2001. I
trained him in performing neurophysiology studies of the pelvic floor and supervised him to conduct research in this
area. Dr. Gregory has subsequently published his pilot studies with me. He becomes one of the nation’s leading
experts in the neurophysiology of the pelvic floor. Dr. Gregory has run the teaching courses in this area at the
American Association of Neuromuscular diseases & Electrodiagnostic Medicine (AANEM) annual meeting for the
past two years. Dr. Gregory’s RO1 grant using neurophysiology and MRI to investigate fecal incontinence in
women is funded by NIH for 5 years, and I serve as a co-investigator with 7.5 % effort.
Lectur es:
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1. “Fatigue in Parkinson’s disease” - 9/1999, Neuroscience Grand Round
2. “ Vasculitic Neuropathy” – 9/1999, Neurology noon conference
2. “Case presentions in Movement Disorders” – 3/2000, Neurology noon Conference
3. “How to approach patients with numbness, tingling and weakness” – 3/2000, Medical resident noon conference.
4. “ Why do I choose neurology as my specialty?” 10/2000, Medical Students Special interest group in neurology 5. “ Diagnosis of Peripheral Neuropathy” – 10/2000, Neurology Teaching Conference
6. “Amyotrophic Lateral Sclerosis” – 3/2001, Neurology Teaching Conference
7. “Neuromuscular diseases” – 4/2001, a 2-hour lecture for students in the physician assistant program.
8. “Distal Myopathy”- 9/2002, Neurology Teaching Conference
9. "Elctrodiagnosis for neurosurgeons" - 9/2002, neurosurgery teaching conferences
10. "Electrodiagnosis for vasculitic neuropathy" - 4/2003, Internal medicine, grand round
11. "Neuromuscular diseases for Neurosurgeons" - 9/2003, Teaching conferences for neurosurgeons
12. "All you need to know about ALS" - 10/2003, Neurology teaching conference
13. "Perioperative neuropathy" - 10/2003, anesthesiology, grand round 14. “Electrodiagnosis and neuromuscular diseases for neurosurgeons”, neurosurgery teaching conference, 2/2004
15. Neuroscience Grand round “ CPC: Neuromuscular crisis”, January, 2005
16. “Basic principles of electrodiagnosis for neurosurgeons”. Neurosurgery teaching conference, January, 2005
17. “neuromuscular diseases for neurosurgeons’, neurosurgery teaching conferences, February, 2005
18. "“Basic principles of electrodiagnosis for neurosurgeons”. Neurosurgery teaching conference, January, 2006
19. “Neuromuscular diseases” – A 1-hour lecture to students in the physician assistant program, 2006
20. “Neuromuscular diseases for rheumatologists” – a teaching lecture for rheumatology fellows, October, 2008
Lectur e series:
I develop and organize Clinical Neurophysiology Lecture Series, as a part of neurophysiology fellowship and EMG
fellowship.
Jour na l Club:
I organize a journal club (meet monthly) in motor control and transcranial magnetic stimulation
SCHOLARSHIP
Area(s) of Research/Scholarly Interest:
Fatigue in Parkinson’s Disease
Transcranial Magnetic Stimulation
Clinical trials in ALS
Grants and Contracts:
Federal (Include Title, Sour ce, PI, Amount Period, and % Effort)
Past funding:
1. NIH R01HD049541 Pelvic floor injury at childbirth, , Total funding, direct $1,267,881
Co-investigator: Lou (PI: Gregory, Dr. Lou’s Mentee); 06/07 – 05/12; 7.5% effort
2. NIH R43 “AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke.
Co-I, 8.5% effort, funding Period: 08-01-10 to 07-31-11
3. Udall PD center Pilot Grant: Rivastigmine and Atomoxetine for mental fatigue in PD.
PI: Lou, $ 30,000, 10/2010 to 09/2011
4. NIH R21AT002656 Centella asiatica triterpene extract for diabetic neuropathy - a pilot study, Total
funding direct $325,000, PI: Lou; 9/30/2006 - 8/31/2010; 19% effort
5. NIH 5U19AT002656 , Project 1 – Expectations & Response to L-dopa & Acupuncture, , total funding direct
$300,000, PI: Lou; 10/1/2004 - 9/30/2007; 15% effort
6. NIH R21 MH066214 Neuromodulatory effects of repetitive transcranial magnetic stimulation in
patients with Parkinson's Disease, Total funding direct $250,000, PI: Lou; 03/02 - 02/04; 15 % effort
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7. NIH, Creatine in Amyotrophic Lateral Sclerosis, Site
PI: Lou; 09/02-12/05; 5 % effort
8. NIH, Phase III Trial of Minocycline in ALS, Site
PI: Lou; 5/1/2003 - 6/1/2007; 5% effort
Other Support (Include Title, Source, PI, Amount Period, and % Effort) Past funding:
2. Placebo-Controlled Trial of Buspirone in Friedreich's Ataxia, Muscular Dystrophy Association PI: Lou, total funding direct $108,568; 7/1/94 - 12/30/97; 10% effort
3. Developmental Stuttering: A Movement Disorder, Research Development Award - Strong Children's
Research Center
PI: Lou, total funding direct $15,000; 7/1/95 - 6/30/96; 5% effort
4. Senile Gait Disorder: A Motor Control Disorder, Junior Faculty Award, Rochester Area Pepper Center PI: Lou, total funding direct $20,000; 7/1/95 - 6/30/96; 10% effort
5. A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of Intramuscular Botox
(Botulinum Toxin Type A) Purified Neurotoxin Complex for the Treatment of Cervical Dystonia,
Allergan
Site PI: Lou, total funding direct $30,000; 7/1/95 - 6/30/96; 5% effort
6. Quantitative Assessment of the Fampridine for Motor Deficit in Multiple Sclerosis, Elan
Pharmaceutical Research Company
Co-I: Lou, total funding direct $90,000; 7/1/95 - 6/30/96; 5% effort
7. Preclinical Detection of Parkinson’s Disease - A Neurophysiological Approach, Lucille P. Markey
Charitable Trust Award
PI: Lou total funding direct $10,000; 4/1/96 - 3/31/97; 10 % effort 8. A randomized, double-blind, parallel-group study to compare the safety and efficacy of zydis
selegiline 1.25 to 2.5 mg QD with placebo as an adjunct in the management of Parkinsonian patients
being treated with levodopa who exhibit deterioration in the quality of their response to this therapy
Site PI: Lou; 9/1/97 - 5/30/99; 5 % effort
9. A prospective, randomized, parallel-group, double-blind, placebo-controlled, multi-center study to
evaluate the short-term efficacy and safety of entacapone administered together with levodopa in
subjects with Parkinson's disease without motor fluctuation
Site PI: Lou; 9/1/97 - 5/30/99; 5% effort
10. A multicenter, randomized, double-blind, placebo controlled, parallel Group, Dose-Ranging study to
assess the efficacy, safety, and tolerability of escalating transdermal doses of SPM 962 in subjects with
early stage Parkinson’s disease
Site PI: Lou; 11/99 - 11/00; 5% effort 11. Fatigue in Parkinson’s disease: Characterization, Quantification, and Response to Levodopa, Medical
Research Foundation of Oregon
PI: Lou, $25,000; 03/00 - 02/01; 15% effort
12. Central motor fatigue in Parkinson’s disease and the effect of levodopa: a transcranial magnetic
stimulation study, Parkinson’s Disease Foundation
PI: Lou, $32,161; 07/00 - 06/01; 15 % effort
13. Using alpha-Lipoic acid to treat physical fatigue and mental fatigue in patients with Parkinson's disease
a double-blind, placebo-controlled study, Oregon Center for Complementary and Alternative Medicine
in Neurological Disorders (ORCCAMIND)
PI: Lou, $20,000; 05/01 - 04/02; 5% effort
14. Characterizing the effects of repetitive transcranial magnetic stimulation frequency and intensity on cortical excitability and physical fatigue in patients with Parkinson's disease, Parkinson’s Disease
Foundation
PI: Lou, $33,093; 07/01 - 06/02; 5% effort
15. Quantitative multi-MUP and interference pattern analysis of external anal sphincter muscles in
nulliparous and postpartum females, Medical Research Foundation of Oregon
Co-I: Lou, (PI: Gregory); 06/02-05/03; 5 % effort
16. Three-dimensional ultrasound of the anal sphincter in nulliparous and postpartum females.
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Co-I: Lou, (PI: Gregory); 06/03-05/04; 5 % effort
17. Modafinil for fatigue in PD, National Parkinson Foundation PI: Lou, $40,000; 07/04 - 06/05; 5% effort
18. Combination Drug Selection Trial in Amyotrophic Lateral Sclerosis, ALS Association
PI: Paul Gordon, MD; 1/1/2006 - 12/1/2007; 5%
19. Michael J Fox Foundation, The Physiological Mechanisms & Treatment of Fatigue in PD - A
longitudinal study, . Total funding direct: $285,925
PI: Lou; 5/1/2006 - 4/30/2009; 15%
20. Collins Medical Trust. Alpha-lipoic acid for Chronic Inflammatory demyelinating polyneuropathy-a
double-blind, placebo-controlled study. $ 29,438, PI: Lou; 05/2009-04/2010; 5%
PUBLICATIONS
Peer-reviewed
1. Lou JS. and Bloedel JR. The response of simultaneously recorded Purkinje cells to the perturbation of the step
cycle in the walking ferret: A study using a new analytical method - The Real Time Postsynaptic Response (RTPR). Brain Research 1986;356:340-344
2. Lou JS. and Bloedel JR. A study of cerebellar cortical involvement in motor learning using a new avoidance
paradigm involving limb movement. Brain Research 1988;445:171-174. 3. Lou JS. and Bloedel JR. A new conditional paradigm: conditioned limb movement in locomoting decerebate
ferrets. Neur oscience Letter 1988;84:184-190.
4. Lou JS. and Jankovic J. Essential tremor: Clinical correlates in 350 patients. Neur ology 1991; 41:234-238. 5. Lou JS. and Bloedel JR. Responses of sagittally aligned Purkinje cells during perturbed locomotion:
synchronous activation of climbing fiber inputs. J. Neur ophysiol. 1992;68:570-580.
6. Lou JS. and Bloedel JR. Responses of sagittally aligned Purkinje cells during perturbed locomotion: Relation
of climbing fiber activation to simple spike modulation. J. Neur oph ysiol. 1992;68:1820-1833.
7. Pascual-Leone A., Grafman J., Clark K., Stewart M., Massaquoi S., Lou JS. and Hallett M. Procedural learning
in Parkinson's disease and cerebellar degeneration. Ann Neurol 1993; 34:594-602.
8. Lou JS., Valls-Sole J., Toro C., Hallett M. Facial action myoclonus in patients with olivopontocerebellar
atrophy. Movement Disord 1994; 9:223-226.
9. Valls-Sole J., Lou JS., Hallett M. Brainstem reflexes in patients with olivopontocerebellar atrophy.
Muscle & Nerve 1994; 17:1439-1448.
10. Karp BI., Cole RA., Cohen LG., Grill S., Lou JS., Hallett M. Long-term botulinum toxin treatment of focal hand dystonia. Neur ology 1994;44:70-76.
11. Wessel K, Zeffiro T, Lou JS, Toro C, Hallett M. Regional cerebral blood flow during a self-paced sequential
finger opposition task in patients with cerebellar degeneration. Brain 1995; 118:379-393 12. Lou JS, Goldfarb L, McShane L, Gatev P, Hallett M. Buspirone for cerebellar ataxia: An open-label study.
Arch Neurol 1995; 52:982-988
13. Lou JS, Pleninger P, Kurlan R. Botulinum toxin is effective in treating trismus caused by radiation-induced
myokymia. Movement Disorders1995; 10:680-681.
14. Gatev P, Thomas S., Lou JS., Hallett M. Effects of diminished and conflicting sensory information on balance
in patients with cerebellar deficits. Mov. Disorders, 1996; 11:654-664.
15. Vadasz AG, Chance PF, Epstein LE, Lou JS. Familia autosomal-dominant carpal tunnel syndrome presnting in
a 5 year old-case report and review of the literature. Muscle and Nerve 1997; 376-378
16. Dimitrov M. Grafman J. Kosseff P. Wachs J. Alway D. Higgins J. Litvan I, Lou JS. Hallett M. Preserved cognitive processes in cerebellar degeneration. Behaviour al Brain Research,1996:79,131-5.
17. Lou JS, Snyder R, Griggs RC. Long-term treatment preserves sensory nerve action potential and muscle
functions. Journal Neurology Neurosurg. Psychiatry 1997:62:671-672.
18. Lou JS, Kearns G, Oken B, Sexton G, and Nutt J. Exacerbated physical fatigue and mental fatigue in
Parkinson’s disease. Movement Disorders, 2001,16:190-196.
19. LouJS, Reeves A, Benice T, Sexton G. Fatigue and depression are associated with poor quality of life in ALS
Neurology, 2003;60:122-123.
20. Lou JS, Benice T, Sexton G, Nutt J. Levodopa normalizes exercise related cortico-motoneuron excitability
abnormalities in Parkinson’s disease. Clinical Neurophysiology 2003;114:930-937.
21. Lou JS, Kearns G, Benice T, Oken B, Sexton G, Nutt J. Levodopa improves physical fatigue in Parkinson’s
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disease - a double-blind, placebo-controlled crossover study. Movement Disorders 2003;18:1108-1114.
22. Gregory WT, Lou JS, Stuyvesant A, Clark A. Quantitative electromyography of the anal sphincter after
uncomplicated vaginal delivery. Obst Gyncol 2004;104:327-335.
23. Carter GT, Weiss MD, Lou JS, Jensen MP, Abresch RT, Martin TK, Hecht TW, Han JJ, Weydt P, Kraft GH.
Modafinil in amyotrophic lateral sclerosis: an open label pilot study. Am J Hosp Palliat Med 2005 22(1):55-59.
24. Gregory WT. Clark AL. Johnson J. Willis K. Stuyvesant A. Lou JS. Anal sphincter electromyography: editing
of sampled motor unit action potentials. Muscle & Nerve. 31:256-9, 2005.
25. Leis BC. Rand MK. Van Gemmert AW. Longstaff MG. Lou JS. Stelmach GE. Movement precues in planning
and execution of aiming movements in Parkinson's disease. [Journal Article] Experimental Neurology. 2005,
194:393-409,
26. Silbert LC. Nelson C. Holman S. Eaton R. Oken BS. Lou JS. Kaye JA. Cortical excitability and age-related
volumetric MRI changes. Clinical Neurophysiology. 2006;117:1029-1036.
27. Fried-Oken, M., Fox, L., Rau, M.T., Tullman, J., Baker, G., Hindal, M., Wile, N., & Lou, J.S. Purposes of
AAC Device Use for Persons with ALS as Reported by Caregivers. Augmentative and Alternative
Communication. 2006,22:209-221.
28. Friedman JH. Brown RG. Comella C. Garber CE. Krupp LB. Lou JS. Marsh L. Nail L. Shulman L. Taylor CB.
Working Group on Fatigue in Parkinson's Disease. Fatigue in Parkinson's disease: a review. Movement
Disorders. 2007; 22:297-308.
29. Benice TS, Lou JS, Eaton R, Nutt J. Hand coordination as a quantitative measure of motor abnormality and therapeutic response in Parkinson's disease. Clinical Neurophysiology, 2007;118:1776-1784.
30. Gregory WT. Lou JS. Simmons K. Clark AL. Quantitative anal sphincter electromyography in primiparous
women with anal incontinence. American Journal of Obstetrics & Gynecology. 2008; 198(5):550.e1-6, May.
31. Gordon PH. Cheung YK. Levin B. Andrews H. Doorish C. Macarthur RB. Montes J. Bednarz K. Florence J.
Rowin J. Boylan K. Mozaffar T. Tandan R. Mitsumoto H. Kelvin EA. Chapin J. Bedlack R. Rivner M.
McCluskey LF. Pestronk A. Graves M. Sorenson EJ. Barohn RJ. Belsh JM. Lou JS. Levine T. Saperstein D.
Miller RG. Scelsa SN. Combination Drug Selection Trial Study Group. A novel, efficient, randomized selection
trial comparing combinations of drug therapy for ALS.[see comment]. Amyotrophic Lateral Sclerosis.
2008;9:212-22.
32. Rosenfeld J. King RM. Jackson CE. Bedlack RS. Barohn RJ. Dick A. Phillips LH. Gelinas DF. Lou JS.
Creatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRS. Amyotrophic Lateral Sclerosis. 2008;9:266-72.
33. Lou JS. Physical and mental fatigue in Parkinson’s Disease: Epidemiology, pathophysiology, and treatments.
Drug and Aging. 2009;26(3):195-208.
34. Lou JS, Dimitrova DM, Park BS, Johnson SC, Eaton R, BS, Arnold G, BS, Nutt JG. Using Modafinil to
treat fatigue in PD - A double-blind, placebo-controlled pilot study. Clinical Neuropharmacology, 2009
;32:305-310.
35. Lou JS, Moore D, Gordon PH, and Miller R for the Minocycline Study Group. Correlates of quality of life in
ALS: Lessons learned from the minocycline study. Amyotrophic lateral Sclerosis, 2010;11:116-121
36. Lou JS, Weiss MD, Carter GT. Assessment and management of fatigue in neuromuscular disease. American Journal of
Hospice and Palliative Care, 2010;27:145-157.
37. Bedlack RS, Genge A, Amato AA, Shaibani A, Jackson CE, Kissel JT, Wall C, King WM, Cupler E, Lou JS, Ensrud E,
Tan E, Goldstein JM, Katz J, Dimachkie MM, Barohn RJ, Mozaffar T. Correspondence Regarding: TDP-43 Proteinopathy
and Motor Neuron Disease in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol 2010:69;918-19
38. Davis M. Lou JS. Management of amyotrophic lateral sclerosis (ALS) by the family nurse practitioner: a timeline for
anticipated referrals. Journal of the American Academy of Nurse Practitioners. 2011; 23:464-72,
39. Lou, JS, Dimitrova, DM, Hammerschlag, Nutt J, Hunt EA, MPH1, Eaton RW, Johnson SC, Davis MD, Arnold,
GC, Andrea SB, Oken, BS. The effect of expectancy and personality on cortical excitability in Parkinson’s
disease. Movement Disorders, 2013,28 (9): 1257-1262.
40. Cordo p, Wolf S, Lou JS, Bogey R, Stvenson M, Hayes J, Roth E. Treatment of severe hand impairment
following stroke by combining assisted movement, muscle vibration, and biofeedback. J Neurol Phys Ther
2013,37(4):194-203.
41. Wills A-M, Hubbard J, Macklin EA, Glass J, Tandan R, Simpson EP, Brooks B, Gelinas D, Mitsumoto H,
Mozaffar T, Hanes GP, Ladha SS, Heiman-Patterson T, Katz J, Lou JS, Mahoney K, Grasso D, Lawson R, Yu
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H, Cudkowicz M for the MDA clinical Research Network. Hyperalimentation in Amyotrophic Lateral Sclerosis: a
randomized double-blind placebo-controlled trial. Lancet Neurology, 2014,June14;383 (9934):2065-2072.
42. Lou, JS. Fatigue in Parkinson’s disease and potential interventions. Neurorehabilitation, 2015;37 (1): 25-34
Chapters 1. Lou JS. and Jankovic J. Tremors. In: Appel, SH (ed), Current Neurology 1991;11:199-232.
2. Lou JS. and Jankovic J. Tremor in cerebellar disease. In: Lechtenberg, R. (ed), The Handbook of Cerebellar
Disease, 1992, p. 45-63.
3. Lou JS. Evidence-based alternative and complementary medicine in amyotrophic lateral sclerosis. In: Oken B
(editor) CAM in Neurology: An evidence-based approach to clinical practice, 2004.
4. Lou JS. Evidence-based alternative and complementary medicine in Parkinson’s disease. In: Oken B (editor)
CAM in Neurology: An evidence-based approach to clinical practice, 2004
5. Lou JS. Approaching fatigue in neuromuscular diseases. Physical Medicine & Rehabilitation Clinics of
North America. 16(4):1063-79, 2005
6. Lou JS. Fatigue in Amyotrophic lateral Sclerosis. Physical Medicine and Rebabilitation Clinics.
2008;19(3):533-544. 7. Lou JS. Techniques in assessing fatigue in neuromuscular diseases. Physical Medicine & rehabilitation Clinics of
North America. 2012;23:11-22.
Electronic Publications 1. Lou JS. Amyotrophic Lateral Sclerosis, In: Gilman S, editor. Medlink Neurology. San Diego: MedLink
Cooperation, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008 2. Satayaprasert M, Lou JS. Periodic paralysis and related disorders. In: Rowland L., editor. Medlink Neurology. San Diego: MedLink Cooperation, 2012, 2013 Reviews and others
1. Lou JS. Fatigue in early Parkinson’s disease. Journal Watch ( Neurology),2008;10(12):9
Abstracts
1. Lou JS. and Hallett M. Systematic errors in multijoint coordination in normal and patients with cerebellar
deficits.Muscle Nerve 1992; 15:1171. 2. Lou JS., Grill S., Hallett M. Perception of durations of kinesthetic
stimuli in cerebellar patients. Abst. Soc. Neur osci. 1992;
3. Palmer C., Lou JS., Pascual-Leone A., Dang N., Hallett M. Patterns of piano playing in patients with writer's cramp. Neur ology 1993; 43(suppl):A267.
4. Gatev P., Thomas S., Lou JS., Hallett M. Sensory organization of balance of patients with cerebellar deficits.
Neur ology 1993; 43(suppl):A378.
5. Sherzai A., Lou JS., Hallett M. Physiologic tremor regulates preferred frequencies of finger tapping.
Neur ology 1993;(suppl):A379.
6. Lou JS., Hallett M. Essential tremor and preferred frequency of finger tapping.
Neur oph ysiol 1993;87(suppl):S121. Electroenceph Clin
7. Grill S., Marcus C., Hallett M., Lou JS., McShane L. Disturbances of kinesthesia in persons with cerebellar
disorders. Abst. Soc. Neurosci. 1993;19:981.
8. Lou JS, Toro C, Nee L, Goldfarb L, Hallett M. Electrophysiologic and clinical study of a large family with
coexistence of essential tremor and dystonia. Neur ology 1994; (suppl 1).
9. Lou JS, Massaquoi S, Marinelli B, Hallett M. Systematic error in multijoint coordination in cerebellar patients. Abs Soc Neurosci 1994; 20:1747.
10. Lou, JS, Snyder R, Griggs R. Refsum's disease: Long-term treatment preserves sensory nerve action
potentials and muscle functions. Muscle Nerve 1995; 18:1055.
11. Vadasz AG, Epstein LG, Lou JS. Familial multiple nerve entrapments in the upper extremities of a 5 year old.
Muscle Nerve 1995; 18:1048.
12. Lou JS, Kozower B, Marinelli B. Impaired motor adaptation of speech in stutterers. Electromyography and
Motor Control 1995; 97:S238.
13. Carusone L, Kananen W, Amadon A, Lou JS. Errors in multijoint coordination in cerebellar patients may be
attributed to greater force control deficits in proximal than in distal joints. Neurol Control of Movement, Sixth
Annual Meeting, April 1996.
14. Lou JS, Gregoire L, Amadon A. Abnormal blink reflex recovery in stutterers. Neurology 1996;
Page 11 of 20
46(suppl1):A185. 15. Lou JS, Gregoire L, Amadon A. Abnormal brainstem functions in developmental stutterers. Movement
Disorders 1996; 11 (suppl 1):71
16. Tan G, Schwid S, Amadon A, Goodman A, Lou JS. CMCT and CMAP duration are related to quantitative
motor measurements in multiple sclerosis presented at the 19th annual AAEM meeting in Minneapolis, MN.
17. Lou JS, Carusone L, Kananen W. Force control deficits in the proximal joints of cerebellar patients are
correlated with abnormal agonist EMG activity. Society for Neuroscience Abst. 1996;22:1700.
18. Vadasz AG, Lou JS, Tawil R, Torres CF. Atypical spinal muscular atrophy with diaphramatic paralysis and
hypereflexia. Presented at 20th
annual AAEM meeting in San Diego, CA, September, 1997
19. Pakiam A, Lou JS, Amadon A. Altered sensory facilitation of transcranial magnetic stimulation evoked
responses in dystonia. presented at the AAN meeting in Minneapolis, Minnesota, April, 1998.
20. Leis BC, Van Gemmert WA, Lou JS, Stelmach GE. Movement planning and execution operation in
Parkinson’s disease. Presented at the Neuroscience Meeting in Miami, October, 1999.
21. Lou JS, McDermott M, G Paige. Use of Buspirone for Treatment of Friedreich’s Ataxia and Sporadic
Spinocerebellar ataxias – A randomized, double-blind, placebo-controlled pilot study. Presented at “The
inherited ataxia”, a focus group meeting sponsored by Movement Disorders Society in association with the
1999 annual ANA meeting in Seattle
22. Lou JS, Kearns G, Oken B, Sexton G, and Nutt J. Exacerbated physical fatigue and mental fatigue in
Parkinson’s disease. Movement Disorders, Movement Disorders,2000;15(Supp. 1):174. 23. Lou JS, Kearns G, Rufener S, Benice T and Nutt J. A small dose of levodopa improves dwell time but not
movement time and brief practice improves movement time but not dwell time of finger tapping in patients
with Parkinson's disease (PD)-- A study using a keyboard with Musical Instrument Digital Interface (MIDI).
Clinical Neurophysiology,2001,112(supp.1):S15
24. Lou JS, Kearns G, Benice T, Oken B, M.D., Sexton G, Nutt J. A small dose of levodopa improves mental
fatigue but worsens reaction time in patients with Parkinson’s disease - A randomized, double-blind, placebo-
controlled crossover study. presented at 2001 AAN meeting
25. Lou JS, Benice T, Kearns G and Nutt J A small dose of levodopa partially correct the abnormalities in post-
exercise facilitation and post-exercise depression in patients with Parkinson's disease (PD) – A transcranial
magnetic stimulation study, presented at The PSG's 15th Annual Symposia "Etiology, Pathogenesis and
Treatment of Parkinson's Disease and Other Movement Disorders" ,Chicago, September 30, 2001.
26. Lou JS, Reeves A, Benice T, Sexton G. Fatigue and depression mediate quality of life in patients with amyotrophic lateral sclerosis. Presented at 2002 American Academy of Neurology Annual meeting in Denver,
CO.
27. Lou JS, Benice T, Reeves A, Sexton G, Nutt J. Low-rate repetitive transcranial magnetic stimulation causes a
‘levodopa-like’ decrease in cortical excitability in Parkinson’s disease. Presented at 2002 Society of
Neuroscience Meeting in Orlando, FL
28. Gregory WT, Lou J-S ,Stuyvesant A, Clark AL. Multiple Motor Unit Potential (Multi-MUP) Analysis of
External Anal Sphincter Muscles Shows Nerve Damage Following Vaginal Delivery. Women’s Reproductive
Health Research Scholars Symposium, March 31-April 1, 2003, NIH, Bethesda, MD.
29. Gregory WT, Lou J-S ,Stuyvesant A, Clark AL. Multiple Motor Unit Potential (Multi-MUP) Analysis of External Anal Sphincter Muscles Shows Nerve Damage Following Vaginal Delivery. American
Urogynecologic Society 24th
Annual Scientific Meeting. Hollywood, FL. September 11-13 2003.
30. Gregory WT, Lou J-S, Stuyvesant A, Clark AL. Comparison of Three Methods of Motor Unit Action Potential
Selection from the External Anal Sphincter in Multi-MUAP Electromyographic Analysis. American Association
of Electrodiagnostic Medicine 50th
Annual Scientific Meeting, San Francisco, CA. September 17-
20, 2003.
31. Gregory WT, Lou J-S ,Stuyvesant A, Clark AL. Quantitative Multi-MUP and IP analysis of external anal
sphincter muscles in nulliparous and postpartum females. International Continence Society 33rd Annual
Scientific Meeting. Florence, Italy. October 5-9, 2003.
32. Lou JS, Eaton R, Benice T., Coakley B, Sexton G, Nutt J. Neuromodulatory of repetitive transcranial
magnetic stimulation in patient with Parkinson’s disease. Presented at Transcranial Magnetic Stimulation in
Movement Disorders, (Sponsored by Movement disorder Society) Genova, Italy, March, 2003
33. Fried-Oken M, Fox L, Rau MT, Tullman J, Lou JS. Using augmentative communication technology to interact: Why caregivers and persons with ALS converse. Presented at the 14th International symposium on
Page 12 of 20
ALS/MND, November, 2003, Milan. ALS and other motor neuron disorders 2003;4 (Supp1): 219.
34. Silbert, L, Holman, S. Eaton, R., Sexton, G., Oken, B., Lou, JS, Kaye, J. Age-Related Subcortical White
Matter Change is Associated with Increased Cortical Excitability - A TMS Study. Neurology 62 (suppl. 5),
2004.
35. Lisa Silbert MD, Sean Holman BA, Barry Oken MD, Jau-Shin Lou MD, Jeffrey Kaye MD. Decreased Resting
Motor Threshold in Elderly with varying degrees of Subcortical White Matter Hyperintensity Volume change is
associated with performance on tests of Cognitive Function. Neurobiology of Aging, Vol. 25, No. S2, pp. S460,
July, 2004.
36. Silbert LC MD, Holman S BA, Oken B MD, Lou JS MD, PhD, Kaye J MD. Resting motor threshold in
elderly is associated with motor function test scores. Muscle & Nerve, November, 2004;30:544.
37. Anderson VC, Lou JS, Eaton RW, Anderson RL, Seetharaman S, Berruhill PC, Burchill K. The effect of Vim surgery on digital motor performance in essential tremor. Presented at Movement disorders Congress in
Rome, Germany, 2004.
38. Gregory WT, Lou JS, Clark AL. Multi Motor Unit Action Potential (Multi-MUAP) Analysis of External Anal
Sphincter Muscles in Women with Fecal Incontinence Immediately After Childbirth. American Association of
Electrodiagnostic Medicine. Savannah, GA. Nov 3-6, 2004. Muscle and Nerve; 30(4):539-540.
39. Gregory WT, Lou JS, Clark AL. Pelvic Floor Nerve Injury After Childbirth. NICHD Women’s Reproductive
Health Research Scholars Symposium, May 15-17, 2005, University of Cincinnati, Cincinnati, OH.
40. Gregory WT, Lou JS, Simmons K, Clark AL, Normative Data for Interference Pattern Analysis of the
External Anal Sphincter, International Continence Society 35th
Annual Meeting, Montreal Canada, August 31-
September 2, 2005.
41. Clark, AL, Gregory, WT, Pearson, JM, Lou, JS, Nixon, R and Slayden OD, Spontaneous Grade III Pelvic
Organ Prolapse (POP) in the Rhesus Macaque, American Urogynecologic Society 26th Annual Scientific
Meeting, Abstract #1160, Atlanta, Georgia, September 15-17, 2005. 42. Silbert LC MD, Nelson C BA, Homan S BA, Oken B MD, Lou JS MD, PhD, Kaye JA MD. Effects of
Hemispheric Resting Motor Threshold Differences on motor performance in the Elderly. Neurology 64 (suppl.
1), pp A362, April, 2005.
43. Lou JS, Coakley B, Reeves A, Benice T, Eaton R, Oken B, Kramer D, Morris C, Nutt J. .Lipoic Acid for
Fatigue in PD: A Double-Blind, Placebo- Controlled Pilot Study. Movement Disorders 2005,20:1246
(Presented at ANA 2005 Annual Meeting)
44. Lou JS, Eaton R, Blaine K, Coakley B, Sexton G, and Nutt J. Motor-Evoked Potential as a Physiological Marker for the Placebo Effect in PD. Ann Neurol, 2005; 58 (S9): S53. (Presented at ANA 2005 meeting)
45. Neville L, Cupler E, Lou JS. Rituximab may prevent axonal damage in anti-MAG distal demyelinating
neuropathy. Neuromuscular Disorders 2006; 16:S177 (presented at 2006 International Congress on
Neuromuacular Diseases )
46. Harper A, Lou JS, Cupler E. Phenotypic variability in a Charcot Marie Tooth Neuropathy Type 2A (CMT2A)
Oregon Kindred with a Mitofusin 2 (MFN2) G740C missence mutation. Neuromuscular Disorders 2006;
16:S132 (presented at 2006 International Congress on Neuromuacular Diseases )
47. Silbert LC MD, Nelson C BA, Homan S BA, Oken B MD, Lou JS MD, PhD, Kaye JA MD. Altered
intracortical facilitation is associated with age-related MRI MRI volume change and impaired motor
performance in the elderly. American Academy of Neurology Annual Meeting, April, 2006.
48. Silbert LC MD, Nelson C BA, Oken B MD, Lou JS MD, PhD, Kaye JA MD. Slower Transcallosal Conduction Time is associated with Degenerative Volumetric change on MRI and poorer performance on
some tests of Cognitive Processing in nondemented elderly. 10th International Conference on Alzheimer’s
Disease and Related Disorders. Madrid, Spain. July 2006.
49. Lou JS, Dimitrova D, Eaton R, Davis M, Blaine K, Park B, Nutt J. Effects of varying repetitive transcranial
magnetic stimulation in PD. (Presented at 2006 ANA annual meeting)
50. Lou JS, Dimitrova D, Eaton R, Davis M. Changes in motor performance and cortical excitability induced by
rTMS in normal subjects. (Presented at 2006 Neuroscience annual meeting)
51. Lou JS, Dimitrova D, Johnson S, Arnold G. Nutt. Premotor rTMS of the non-dominant hemisphere improves
figner tapping and reduced motor fatigue in PD (Presented at 2007 Neuroscience annual meeting).
52. Lou JS, Dimitrova D, Johnson S, Eaton R, Nutt J. Modafinil reduces physical fatigue in PD -- A double-blind,
placebo-controlled pilot study (Presented at the 2007 ANA annual meeting) 53. Lou JS, Dimitrova D, Arnold G, S, Helman, Nutt J. Execrated mental fatigue in PD. (Presented at 2008
Page 13 of 20
Movement Disorders Congress)
54. Lou JS, Dimitrova D, Johnson S, Davis M, Arnold G, Gregory W., Nutt J. Expectancy, personality, and
placebo effect in Parkinson’s disease (presented at 2008 ANA meeting).
55. Lou JS, Diana Dimitrova D, Arnold G, Byun Park and John Nutt. Cortical excitability and physical fatigability
in Parkinson’s disease: a 12-month longitudinal study. (Presented at The second international TMS and tDCS
meeting in Germany 2008).
56 Lou JS, Dimitrova D, Arnold G, Belding H, Nutt J. The differential effect of 5 Hz and 1 Hz rTMS on cortical
excitability in PD (Presented at the 2009 annual AAN meeting ).
57. MaDaneld L, Landfield A, Lou JS, Bourdette D. Myelopathy associated with remicade – a case report (to be
presented at 2009 annual AAN meeting)
58. Lou JS, Dimitrova D, Park B, Arnold G, Belding H, Nutt J. Cortical Excitability in PD: A 18-month
longitudinal study. Ann Neuol 2009;66:S13: S51
59. Lou JS, Dimitrova D, Olszewski E. Fatigue and Stress in the Elderly. (presented at 2010 ANA annual
meeting). 60. Lou JS, Soumyanath A, Dimitrova D, Arnold G, Belding H, Seifer N, Le N. Centella asiatica for diabetic
neuropathy, a randomized, double-blind, placebo-controlled study (Presented at 2012 AAN annual meeting).
61. Lou JS, Dimitrova KA, Chung KA, Andrea SB, Nutt J. The effects of Rivastigmine and atomoxetine in non-
demented Parkinson’s disease. Movement Disorders, 2013;S1:S191
62. Lou JS, Dimitrova SB, Murchison C, Arnold G, Oken B, Nutt J, The Effect of levodopa dose on
attention and vigilance in non-demented patients with Parkinson’s disease. Movement Disorders,
2014,29, S1:S353
63. Dimitrova A, Andrea S, Luo Y, Lou JS, Oken B. Local Effects of Acupuncture on the Median and Ulnar Nerves
in Patients with Carpal Tunnel Syndrome (CTS): study design and preliminary results. Presented at 2014 the
International Research Congress on Integrative Medicine and Health (IRCIMH) meeting in mid-May in Miami:
http://www.ircimh.org/
INVITED LECTURES, CONFERENCE PRESENTATIONS, & PROFESSORSHIPS
International and National
Oral presentations:
5/2001 “A small dose of levodopa improves dwell time but not movement time and brief practice improves
movement time but not dwell time of finger tapping in patients with Parkinson's disease (PD) - a
study using a keyboard with Musical Instrument Digital Interface (MIDI)” - presented at XV
International Congress of Clinical Neurophysiology, Buenos Aires, Argentina
10/2004 “Fatigue in ALS”,Invited Keynote Speaker, ALS awareness and wellness conference, MDA, Tacoma,
WA
10/2007 “A 20 y/o woman presented with distal hand atrophy” - Challenging Neuromuscular Cases Symposium at
the 2007 annual AANEM meeting
11/2007 “Factors affecting quality of life in ALS – lessons learned from 412 subjects who enrolled in the
Minocycline trial”,Western ALS Study group (WALS), 18th International Symposium on ALS/MND.
3/2008 “Fatigue in PD: why does it matter?”, Grand Rounds, University of Texas Medical Branch, Galveston
10/2008 “ALS: an update”,Grand Rounds, Wake Forest Medical Center
2/2009 “Fatigue in PD”, Invited lecture at University of Kansas, Kansas, Missouri
8/2009 Chair, workshop on “Quantitative EMG” at the National Neurological Society meeting in Santa Mata,
Columbia
8/2009 “Autonomic Function Test” , the National Neurological Society meeting in Santa Mata, Columbia
9/2010 “Evidence-Based Medicine in ALS”, 2010 AANEM annual meeting, Quebec City, Quebec, Canada
9/2010 “Small fiber neuropathy”, Roundtable at the 2010 AANEM annual meeting Quebec City, Quebec,
Canada
Page 14 of 20
9/2010 “Centella for Diabetic Neuropathy: Study design”, 2010 AANEM annual meeting Quebec City, Quebec,
Canada
6/2011 Chair, Workshop on “sleep and fatigue on “Sleep and fatigue in Parkinson’s disease” at the 15th
International Congress of Parkinson’s Disease and Movement Disorders in Toronto
9/2011 “The effect of centella in diabetic neuropathy”, 2011 AANEM annual meeting San Francisco, CA
2011-2014 “Small fiber neuropathy”, Roundtable at the 2011 AANEM annual meeting
Regional and Local
University of Rochester
8/1993 "Electrophysiology of facial action myoclonus in olivopontocerebellar atrophy", Neurology Grand Rounds, University of Rochester, Rochester, NY.
10/1993 "Botulinum toxin in dystonia", Physical Medicine Grand Rounds
6/1994 Symposium: Botulinum toxin in the treatment of facial dystonia and other facial conditions -
Course Director, University of Rochester, Rochester, NY.
6/1994 "Botulinum Toxin: General aspects of therapy including mechanism of action and distant effects",
Symposium: Botulinum toxin in the treatment of facial dystonia and other medical conditions where?
6/1994 "Limb dystonia and tremor", Symposium: Botulinum toxin in the treatment of focal dystonia and
other medical conditions, University of Rochester, Rochester, NY.
8/1994 "Magnetic stimulation: Its mechanism and clinical applications”, Neurology Grand Rounds
7/1996 "Floppy infant" at Clinical Conference, University of Rochester, Rochester, NY.
5/1997 "Dopa-reponsive dystonia" at Clinical Conference, University of Rochester, Rochester, NY.
Barrow Neurological Institute
11/1998 “Therapeutic trial in cerebellar ataxias”, clinical conference
Oregon Health & Science University 7/1999 “Vasculitic Neuropathy”, Clinical Conference, Department of Neurology 9/1999 “Fatigue in Parkinson’s disease: How to measure it”, Grand Round, Department of Neurology
6/2000 “Movement disorders: Cases presentation (a case of hyperekplexia; a family with dopa- responsive
dystonia)", Clinical Conference, Department of Neurology
4/2001 “Amotrophic Lateral Sclerosis”, Clinical Conference, Department of Neurology
5/2002 “ALS”, Neuroscience Graduate Program Topics Cours, OHSU
6/2002 “Distal Myopathy”, Clinical conference, Department of Neurology
9/2009 “Fatigue in PD: Why we care”, Neurosciences Grand Rounds, OHSU 11/2010 “ALS: an update”, Clinical Conference, Department of Neurology
Oregon (Outside OHSU)
9/2002 “Cost effective evaluation of polyneuropathy” in “Neurology for Primary Care Physicians”, Ashland, OR 11/2004 MDA-OHSU ALS patients caregiver symposium, Portland, OR, Symposium director
11/2005 “ An update in ALS research” at MDA-OHSU ALS patients caregiver symposium, Portland, OR1/2006
"An update in ALS” presented at "Updates in neuromuscular diseases"symposium at Governor’s Hotel,
Portland, OR,
11/2006 “Comprehensive ALS clinic at OHSU” in MDA-OHSU ALS patients caregiver symposium, Portland, OR
5/2007 “Quality of life in ALS” in MDA-OHSU ALS patients caregiver symposium, Portland, OR
5/2009 “ Clinical trials in ALS” in MDA ALS patients caregiver symposium, Portland, OR
5/2011 “ When should a patient with ALS consider PEG or noninvasive ventilation?” MDA-OHSU ALS patients
caregiver symposium, Portland, OR
9/2011 “Medical management of peripheral neuropathies: differential diagnosis, workup, treatments, and
referral” at ‘Clinical Neuroscience for primary care at the Oregon coast’ Symposium at Salishan Spa &
Golf Resort, Lincoln City, OR
Page 15 of 20
Educator’s Portfolio
Jau-Shin Lou, MD, PhD, MBA Direct Teaching:
STUDENTS
Teaching
Activity/Role
Year Quantity #
Learners
Quality
Evidence of Engagement
with the Community of
Educators
Student Lectures/Small Group Seminars/Practicum
Medical Student
Neurology SIG
2000 1 hr 30
Physician assistants
clinical lectures
2004-
2006
3 hrs/yr 30-40
1st yr med students
Biostatistics (PCM)
12/2008-
2/2009
45 hrs 15
Student Clinical Teaching
Inpatient Attending 1999-
2009
6 weeks/yr 12/yr
Page 16 of 20
RESIDENTS & FELLOWS
Teaching
Activity/Role
Year Quantity #
Learners
Quality
Evidence of Engagement
with the Community of
Educators
Resident & Fellow Lectures/Small Group Seminars
Neurology
Resident Thursday
Conferences
1999-
present
1 in 1999
3 in 2000
2 in 2001
1 in 2002
1 in 2003
1 in 2010
30 per lecture
Neurosurgery
Residents
conferences
2002,
2003,
2004,
2005,
2006
1 hr each
year
15
Rheumatology
Fellow conferences
2008
2009
2011
1 hr each
year
5
Resident & Fellow Clinical Teaching
Fellows in
EMG/NM (See the
appendix for the
list of fellows and
their current
positions)
1999-
present
4-6 half
days per
week ( 20
hrs/wk)
As the director of
the fellowship, I
have trained 14
fellows over last
12 years at OHSU
Resident EMG
rotation
1999 –
present
3 half-days
a week (10-
12
hours/wk)
As the primary
EMGer at OHSU,
I teach neurology
residents
principles and
techniques of
EMG. One
resident rotates
through EMG lab
every month.
Inpatient Attending 1999-
2009
4 weeks/yr 4 residents per yr
Page 17 of 20
OTHER LEARNERS
Teaching
Activity/Role
Year Quantity #
Learners
Quality
Evidence of Engagement
with the Community of
Educators
Multiple Level Learners
Neurology
Department Grand
Rounds
1999,
2005,
2009
1/year Students,
residents,
fellows,
faculty
Anesthesia Grand
round
2003 1/year Students,
residents,
fellows,
faculty
CME
“Updates in
neuromuscular
diseases”
conferences
2001,
2006
Conference
Director
Residents,
fellows,
Practitioners
More than 70
attendees both times
Funding obtained from
sponsoring agents to
support this as an
educational events
“Peripheral
neuropathy” in
Clinical
Neurosciences for
PCP at Oregon
Coast
2011 1 Practitioners 30 attendees Organized by the Oregon
Brain Institute
Page 18 of 20
Advising and Mentoring:
Name of
Advisee or
Protégé
Level of
Advisee
or
Protégé
Purpose of
Relationship
Duration and
Process
Current Status
of Protégé
Outcome(s) of
Relationship
Jessie
Jacobs
PhD
student
Advisor for PhD
research projects
2002-2006
Provide advice in
research
Assistant
Professor of
Rehabilitation
and movement
Science at U of
Vermont
PhD received 2006
Published PhD
thesis
Lisa
Silbert,
MD
Junior
Faculty
Providing advice
in developing
research
proposal and
grant application
2002-2004
1-on-1 + e-mail
Assistant
Professor in
Neurology
NIH Career
development award
Tom
Gregory,
MD
Junior
faculty
Mentoring him
to perform pelvic
floor physiology
testing
2001-2002 Associate
Professor in
OB/Gyn
NIH R01 grant
Page 19 of 20
Educational Administration and Leadership:
Year Time
Commitment
Administrative or
Leadership Role
Description of
Activities
Quality Outcomes
1999-
present
Ongoing, as
needed.
Director, EMG
fellowship
Develop curriculum,
design educational
methods and evaluation;
Highly competitive
fellowship program
2010 –
present
Ongoing, as
needed
Neuromuscular
fellowship Director
Develop curriculum,
design educational
methods and evaluation
for 1-2 fellows per
academic year
Highly competitive
fellowship program
Page 20 of 20
Appendix: Fellows trained and their current positions
University of Rochester:
Name Year Current position Patricia Shipley, M.D. 7/1993-6/1994 practice
Jamie Asnis, M.D 7/1993-6/1994 practice
Robert Snyder, M.D. 7/1994-6/1995 practice
Richard Ferguson, M.D. 7/1994-6/1995 practice
Allen Pettee, M.D. 7/1995-6/1996 practice
Fawzy Salama, M.D. 7/1995-6/1996 practice
Gubert Tan, M.D. 7/1995-6/1997 practice
Anthony Pakiam, M.D. 7/1996-6/1997 practice
OHSU:
Name Year Current position James Sheffield, MD 8/1999 – 7/ 2000 Practice
Lisa Silbert, MD 8/ 2000 – 7/2002 Neurology faculty, OHSU
Daniel Friedman, MD 8/2001 – 7/2003 practice
Todd Dunaway, MD 7/2002-6/2003 Adjunct neurology faculty at U of
Oklahoma, practice
Joshua Johnson, MD 7/2003-6/2004 practice
Lawrence Neville, MD 7/2004-6/2005 practice
Amy Harper, MD 10/2005-12/2006 Pediatric neuromuscular faculty at U
of North Carolina
Sherwin Cho, MD 7/2007-6/2008 US Navy Medical officer
Michael Leone, MD 7/2008-6/2009 Practice
Prin Burusnukel, MD 7/2008-6/2010 Practice in Thailand
Eric Edgar, MD 7/2009-6/2010 Practice
Ben Brennan, MD 11/2010-10/2011 Practice
Brent Burroughs, MD 7/2011-6/2012 Practice Mananya Satayaprasert, MD 7/2011-6/2013 Haz Jafari, MD 7/2011-6/2013 Alex Dimitrova, MD,
NIH T32 research fellow
7/2011-6/2014
