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TABLE OF CONTENTS Participant Enrollment...................................................... 2 General Demographics at Baseline............................................3 SF-8 Health Survey at Baseline..............................................9 PROMISE Questionnaire at Baseline..........................................11 Health Problems at Baseline................................................17 Lifestyle Habits at Baseline...............................................19 Total Number of People Taking Specific Drugs - at Baseline or Follow-up....24 Health Problems at Follow-Up...............................................28

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Page 1: ssri.duke.edu · Web viewProgram Name: /ct/murdock/murdock_1_5/tables/promise_ *For participants that withdrew, time to last follow-up, does not include time from last visit to withdrew

TABLE OF CONTENTS

Participant Enrollment...............................................................................................................................................2

General Demographics at Baseline........................................................................................................................3

SF-8 Health Survey at Baseline..............................................................................................................................9

PROMISE Questionnaire at Baseline...................................................................................................................11

Health Problems at Baseline.................................................................................................................................17

Lifestyle Habits at Baseline....................................................................................................................................19

Total Number of People Taking Specific Drugs - at Baseline or Follow-up.....................................................24

Health Problems at Follow-Up...............................................................................................................................28

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Murdock 1.5 Page 2

Participant Enrollment

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/graphs/enrollment.sas

11469

0

2000

4000

6000

8000

10000

12000

Parti

cipa

nts

Enro

lled

Jan Jul Jan Jul Jan Jul Jan Jul Jan Jul Jan Jul Jan Jul2009 2010 2011 2012 2013 2014 2015

Month

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Murdock 1.5 Page 3

General Demographics at Baseline

All ParticipantsN=11469

Sex Male 3903/11468 (34.0%) Female 7565/11468 (66.0%)

Ethnicity Not Hispanic or Latino 9882/11405 (86.6%) Hispanic or Latino 1419/11405 (12.4%) Dont know 104/11405 (0.9%)

Race White/Caucasian 8619/11441 (75.3%) Black or African American 1568/11441 (13.7%) American Indian or Alaska Native 205/11441 (1.8%) Asian 106/11441 (0.9%) Native Hawaiian or Other Pacific Islander 16/11441 (0.1%) Other Race 1065/11441 (9.3%) Don't know/Not sure/Prefer not to answer 116/11441 (1.0%)

Age N 11469 Mean (Std Dev) 51.7 (16.3) Median (25th, 75th) 52.0 (40.0, 64.0) (Min, Max) (14, 105)

Height (in) N 11408 Mean (Std Dev) 66.2 (4.0) Median (25th, 75th) 66.0 (63.0, 69.0) (Min, Max) (48, 89)

Weight (lbs) N 11387 Mean (Std Dev) 181.5 (46.0) Median (25th, 75th) 175.0 (148.0, 206.0) (Min, Max) (70, 540)

BMI N 11353 Mean (Std Dev) 29.1 (6.7) Median (25th, 75th) 27.9 (24.4, 32.4) (Min, Max) (11, 82)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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Murdock 1.5 Page 4

General Demographics at Baseline

All ParticipantsN=11469

Systolic Blood Pressure N 11435 Mean (Std Dev) 125.0 (19.0) Median (25th, 75th) 123.0 (112.0, 137.0) (Min, Max) (14, 231)

Diastolic Blood Pressure N 11435 Mean (Std Dev) 75.8 (11.8) Median (25th, 75th) 75.0 (68.0, 83.0) (Min, Max) (19, 134)

Heart rate N 11429 Mean (Std Dev) 71.8 (11.6) Median (25th, 75th) 71.0 (64.0, 79.0) (Min, Max) (34, 158)

Waist circumference N 11378 Mean (Std Dev) 95.7 (18.6) Median (25th, 75th) 94.3 (83.4, 106.1) (Min, Max) (10, 896)

Pregnant No 7584/7687 (98.7%) Yes 103/7687 (1.3%)

Menstrual cycle Regular periods during the last year 2037/7512 (27.1%) Irregular periods during the last year 937/7512 (12.5%) No periods during the last year 4538/7512 (60.4%)

Hormone replacement therapy as treatment for menopause Yes 539/7518 (7.2%) No 6935/7518 (92.2%) Dont Know 44/7518 (0.6%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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General Demographics at Baseline

All ParticipantsN=11469

Hours of sleep per night N 11410 Mean (Std Dev) 7.0 (1.2) Median (25th, 75th) 7.0 (6.0, 8.0) (Min, Max) (2, 16)

Primary Care or Main Doctor Have a primary care doctor or provider 8931/11206 (79.7%) Dont have a primary care doctor or provider 1798/11206 (16.0%) Dont know 477/11206 (4.3%)

Primary Care Practice Have a primary care practice 9411/11341 (83.0%) Dont have a Primary Care Practice 0/11341 (0.0%) Dont know 564/11341 (5.0%)

Marital status Married 7170/11446 (62.6%) Divorced 1251/11446 (10.9%) Widowed 772/11446 (6.7%) Separated 425/11446 (3.7%) Never Married 1446/11446 (12.6%) Domestic Partner 382/11446 (3.3%)

Highest level of education Less than high school graduate 1118/11455 (9.8%) High school graduate (includes equivalent such as GED) 2444/11455 (21.3%) Some college or associate's degree 4086/11455 (35.7%) Bachelor's degree 2326/11455 (20.3%) Master's or higher professional degree 1481/11455 (12.9%)

Highest level of education mother achieved Less than high school graduate 3412/11457 (29.8%) High school graduate (includes equivalent such as GED) 3864/11457 (33.7%) Some college or associate's degree 2059/11457 (18.0%) Bachelor's degree 1047/11457 (9.1%) Master's or higher professional degree 450/11457 (3.9%) Dont Know 625/11457 (5.5%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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General Demographics at Baseline

All ParticipantsN=11469

Highest level of education father achieved Less than high school graduate 3773/11458 (32.9%) High school graduate (includes equivalent such as GED) 3153/11458 (27.5%) Some college or associate's degree 1618/11458 (14.1%) Bachelor's degree 1087/11458 (9.5%) Master's or higher professional degree 784/11458 (6.8%) Dont Know 1043/11458 (9.1%)

Employment during the past 12 months Yes 6856/11460 (59.8%) No 4604/11460 (40.2%)

Current employment status Working now full-time 4102/11325 (36.2%) Working now part-time 1340/11325 (11.8%) Unemployed/looking for work 940/11325 (8.3%) Stay at home full-time for parenting, care giving, or other responsibilities 826/11325 (7.3%) Retired 2691/11325 (23.8%) Temporarily laid off or sick/maternity leave 97/11325 (0.9%) Permanently disabled 759/11325 (6.7%) Student 260/11325 (2.3%) Other 310/11325 (2.7%)

Times laid off from work 1 Time 607/6668 (9.1%) 2 Times 112/6668 (1.7%) 3 Times 22/6668 (0.3%) 4 Times 12/6668 (0.2%) >=5 Times 18/6668 (0.3%)

Where does subject live A single family home that is detached from other homes 9412/11445 (82.2%) A single family home that is attached to other homes (like a townhouse or duplex) 521/11445 (4.6%) An apartment 892/11445 (7.8%) Other 620/11445 (5.4%)

Pay for housing I make a mortgage payment 5445/11431 (47.6%) I pay rent 2351/11431 (20.6%) I don't have to pay for housing because I own my house outright 2191/11431 (19.2%) I don't have to pay for housing because I live with family or friends 882/11431 (7.7%) Other 562/11431 (4.9%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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General Demographics at Baseline

All ParticipantsN=11469

Total household income last year Under $10,000 738/11279 (6.5%) $10,000-29,999 1930/11279 (17.1%) $30,000-49,999 1916/11279 (17.0%) $50,000-69,999 1602/11279 (14.2%) $70,000-89,999 1219/11279 (10.8%) $90,000 or more 2381/11279 (21.1%) Dont Know 1493/11279 (13.2%)

How many people currently live in household (including self)? Children under age 18 0 7318/11420 (64.1%) 1 1624/11420 (14.2%) 2 1520/11420 (13.3%) 3 643/11420 (5.6%) 4 205/11420 (1.8%) 5 78/11420 (0.7%) 6 18/11420 (0.2%) 7 7/11420 (0.1%) 8 4/11420 (0.0%) 10 2/11420 (0.0%) 11 1/11420 (0.0%)

Adults aged 18-65 0 2116/11438 (18.5%) 1 2229/11438 (19.5%) 2 4891/11438 (42.8%) 3 1429/11438 (12.5%) 4 598/11438 (5.2%) 5 114/11438 (1.0%) 6 39/11438 (0.3%) 7 7/11438 (0.1%) 8 7/11438 (0.1%) 9 1/11438 (0.0%) 10 7/11438 (0.1%)

Adults over age 65 0 8078/11402 (70.8%) 1 1734/11402 (15.2%) 2 1558/11402 (13.7%) 3 28/11402 (0.2%) 4 4/11402 (0.0%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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General Demographics at Baseline

All ParticipantsN=11469

How well off was family growing up Poor 1653/11437 (14.5%) Below average 2048/11437 (17.9%) About average 6190/11437 (54.1%) Above average 1363/11437 (11.9%) Quite well off 183/11437 (1.6%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/demog_baseline.sas

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Murdock 1.5 Page 9

SF-8 Health Survey at Baseline

All ParticipantsN=11469

Overall health Excellent 555/3503 (15.8%) Very good 1189/3503 (33.9%) Good 1139/3503 (32.5%) Fair 472/3503 (13.5%) Poor 132/3503 (3.8%) Very poor 16/3503 (0.5%)

During past 4 weeks, physical health limits usual physical activities Not at all 1757/3505 (50.1%) Very little 840/3505 (24.0%) Somewhat 569/3505 (16.2%) Quite a lot 299/3505 (8.5%) Could not do physical activities 40/3505 (1.1%)

During past 4 weeks, physical health made daily work difficult None at all 2145/3505 (61.2%) A little bit 678/3505 (19.3%) Some 420/3505 (12.0%) Quite a lot 215/3505 (6.1%) Could not do daily work 47/3505 (1.3%)

Bodily pain during past 4 weeks None 777/3503 (22.2%) Very mild 1152/3503 (32.9%) Mild 763/3503 (21.8%) Moderate 619/3503 (17.7%) Severe 168/3503 (4.8%) Very Severe 24/3503 (0.7%)

Energy during past 4 weeks Very much 397/3504 (11.3%) Quite a lot 1494/3504 (42.6%) Some 1252/3504 (35.7%) A little 313/3504 (8.9%) None 48/3504 (1.4%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/sf8_baseline.sas

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SF-8 Health Survey at Baseline

All ParticipantsN=11469

During past 4 weeks, physical health or emotional problems limit social activities Not at all 1952/3505 (55.7%) Very little 854/3505 (24.4%) Somewhat 495/3505 (14.1%) Quite a lot 176/3505 (5.0%) Could not do social activities 28/3505 (0.8%)

During past 4 weeks, bothered by emotional problems Not at all 1557/3501 (44.5%) Slightly 1206/3501 (34.4%) Moderately 480/3501 (13.7%) Quite a lot 213/3501 (6.1%) Extremely 45/3501 (1.3%)

During past 4 weeks, personal or emotional problems limit usual work, school, or other daily activities Not at all 2375/3505 (67.8%) Very little 712/3505 (20.3%) Somewhat 302/3505 (8.6%) Quite a lot 99/3505 (2.8%) Could not do daily activities 17/3505 (0.5%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/sf8_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

In general, would you say your health is: Excellent 687/7956 (8.6%) Very good 2263/7956 (28.4%) Good 3169/7956 (39.8%) Fair 1527/7956 (19.2%) Poor 310/7956 (3.9%)

Limited in climbing one flight of stairs Not at all 4877/7954 (61.3%) Very little 1102/7954 (13.9%) Somewhat 1265/7954 (15.9%) Quite a lot 555/7954 (7.0%) Cannot do 155/7954 (1.9%)

Limited in walking more than a mile Not at all 4680/7954 (58.8%) Very little 960/7954 (12.1%) Somewhat 1090/7954 (13.7%) Quite a lot 631/7954 (7.9%) Cannot do 593/7954 (7.5%)

Limited lifting or carrying groceries Not at all 5317/7952 (66.9%) Very little 1011/7952 (12.7%) Somewhat 962/7952 (12.1%) Quite a lot 499/7952 (6.3%) Cannot do 163/7952 (2.0%)

Limited bending, kneeling, or stooping Not at all 4016/7953 (50.5%) Very little 1340/7953 (16.8%) Somewhat 1461/7953 (18.4%) Quite a lot 899/7953 (11.3%) Cannot do 237/7953 (3.0%)

Limited in doing vigorous activities Not at all 2392/7952 (30.1%) Very little 1233/7952 (15.5%) Somewhat 1784/7952 (22.4%) Quite a lot 1196/7952 (15.0%) Cannot do 1347/7952 (16.9%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

Able to do chores such as vacuuming or yard work Without any difficulty 4990/7954 (62.7%) With a little difficulty 1343/7954 (16.9%) With some difficulty 935/7954 (11.8%) With much difficulty 422/7954 (5.3%) Unable to do 264/7954 (3.3%)

Able to dress yourself Without any difficulty 6819/7956 (85.7%) With a little difficulty 658/7956 (8.3%) With some difficulty 314/7956 (3.9%) With much difficulty 124/7956 (1.6%) Unable to do 41/7956 (0.5%)

Able to wash and dry body Without any difficulty 7181/7957 (90.2%) With a little difficulty 463/7957 (5.8%) With some difficulty 221/7957 (2.8%) With much difficulty 72/7957 (0.9%) Unable to do 20/7957 (0.3%)

Able to get on and off the toilet Without any difficulty 7221/7958 (90.7%) With a little difficulty 489/7958 (6.1%) With some difficulty 174/7958 (2.2%) With much difficulty 58/7958 (0.7%) Unable to do 16/7958 (0.2%)

Able to run five miles Without any difficulty 718/7948 (9.0%) With a little difficulty 834/7948 (10.5%) With some difficulty 1287/7948 (16.2%) With much difficulty 996/7948 (12.5%) Unable to do 4113/7948 (51.7%)

Felt fearful Never 4621/7952 (58.1%) Rarely 1905/7952 (24.0%) Sometimes 1193/7952 (15.0%) Often 186/7952 (2.3%) Always 47/7952 (0.6%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

Found it hard to focus on anything other than anxiety Never 4665/7949 (58.7%) Rarely 1809/7949 (22.8%) Sometimes 1157/7949 (14.6%) Often 253/7949 (3.2%) Always 65/7949 (0.8%)

Worries overwhelmed Never 3795/7946 (47.8%) Rarely 2072/7946 (26.1%) Sometimes 1598/7946 (20.1%) Often 351/7946 (4.4%) Always 130/7946 (1.6%)

Felt uneasy Never 3244/7949 (40.8%) Rarely 2496/7949 (31.4%) Sometimes 1794/7949 (22.6%) Often 328/7949 (4.1%) Always 87/7949 (1.1%)

Felt worthless Never 5746/7952 (72.3%) Rarely 1166/7952 (14.7%) Sometimes 770/7952 (9.7%) Often 218/7952 (2.7%) Always 52/7952 (0.7%)

Felt unhappy Never 3494/7949 (44.0%) Rarely 2358/7949 (29.7%) Sometimes 1641/7949 (20.6%) Often 386/7949 (4.9%) Always 70/7949 (0.9%)

Felt depressed Never 4002/7947 (50.4%) Rarely 1895/7947 (23.8%) Sometimes 1533/7947 (19.3%) Often 409/7947 (5.1%) Always 108/7947 (1.4%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

Felt hopeless Never 5499/7950 (69.2%) Rarely 1312/7950 (16.5%) Sometimes 854/7950 (10.7%) Often 215/7950 (2.7%) Always 70/7950 (0.9%)

Fatigued on average Not at all 1712/7951 (21.5%) A little bit 3279/7951 (41.2%) Somewhat 1761/7951 (22.1%) Quite a bit 955/7951 (12.0%) Very much 244/7951 (3.1%)

Felt run-down on average Not at all 2273/7956 (28.6%) A little bit 3070/7956 (38.6%) Somewhat 1543/7956 (19.4%) Quite a bit 860/7956 (10.8%) Very much 210/7956 (2.6%)

Felt tired on average Not at all 1255/7951 (15.8%) A little bit 3650/7951 (45.9%) Somewhat 1809/7951 (22.8%) Quite a bit 967/7951 (12.2%) Very much 270/7951 (3.4%)

Pain rate on average 0 2462/7950 (31.0%) 1 1185/7950 (14.9%) 2 989/7950 (12.4%) 3 853/7950 (10.7%) 4 571/7950 (7.2%) 5 603/7950 (7.6%) 6 420/7950 (5.3%) 7 390/7950 (4.9%) 8 280/7950 (3.5%) 9 112/7950 (1.4%) 10 85/7950 (1.1%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

Pain interfered with day to day activities Not at all 4300/7955 (54.1%) A little bit 1947/7955 (24.5%) Somewhat 906/7955 (11.4%) Quite a bit 606/7955 (7.6%) Very much 196/7955 (2.5%)

Pain interfered with social activities Not at all 5430/7954 (68.3%) A little bit 1153/7954 (14.5%) Somewhat 742/7954 (9.3%) Quite a bit 453/7954 (5.7%) Very much 176/7954 (2.2%)

Pain interfered with enjoyment of life Not at all 4832/7952 (60.8%) A little bit 1664/7952 (20.9%) Somewhat 798/7952 (10.0%) Quite a bit 450/7952 (5.7%) Very much 208/7952 (2.6%)

Satisfied with sleep Not at all 831/7955 (10.4%) A little bit 1339/7955 (16.8%) Somewhat 2190/7955 (27.5%) Quite a bit 1889/7955 (23.7%) Very much 1706/7955 (21.4%)

Felt angry Never 2450/7949 (30.8%) Rarely 3258/7949 (41.0%) Sometimes 1874/7949 (23.6%) Often 323/7949 (4.1%) Always 44/7949 (0.6%)

Satisfied with ability to perform daily routines Not at all 516/7954 (6.5%) A little bit 663/7954 (8.3%) Somewhat 1416/7954 (17.8%) Quite a bit 2042/7954 (25.7%) Very much 3317/7954 (41.7%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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PROMISE Questionnaire at Baseline

All ParticipantsN=11469

Satisfied with ability to do leisure activities Not at all 522/7955 (6.6%) A little bit 683/7955 (8.6%) Somewhat 1605/7955 (20.2%) Quite a bit 1978/7955 (24.9%) Very much 3167/7955 (39.8%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/promise_baseline.sas

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Health Problems at Baseline

All ParticipantsN=11469

HeartCoronary artery disease 667/11454 (5.8%)Atrial fibrillation 495/11455 (4.3%)Heart attack or angina 650/11459 (5.7%)Congestive heart failure 264/11451 (2.3%)Implantable cardiac defibrillator (ICD) or pacemaker placement 128/11409 (1.1%)

CancerBreast cancer 287/11457 (2.5%)Colon cancer 85/11461 (0.7%)Lung cancer 37/11463 (0.3%)Prostate cancer 179/11450 (1.6%)Cervical cancer 134/11439 (1.2%)Melanoma 294/11453 (2.6%)Skin cancer, not melanoma 1199/11457 (10.5%)Oral cancer 17/11456 (0.1%)Other type of cancer 335/11443 (2.9%)

MetabolicDiabetes 1747/11451 (15.3%)High cholesterol 4388/11451 (38.3%)Thyroid disease 1351/11446 (11.8%)High blood pressure 4281/11447 (37.4%)Obesity 3077/11424 (26.9%)

Lung/RespiratoryAsthma 1446/11452 (12.6%)Emphysema or COPD 425/11442 (3.7%)

Bone/JointOsteoarthritis 1988/11443 (17.4%)Rheumatoid arthritis 814/11448 (7.1%)Other autoimmune disease 555/11437 (4.9%)Osteoporosis/Osteopenia 1154/11440 (10.1%)Gout 494/11450 (4.3%)

NeurologicalAlzheimer's disease 37/11456 (0.3%)Depression 2833/11453 (24.7%)Stroke 324/11453 (2.8%)Multiple sclerosis 794/11451 (6.9%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/health_baseline.sas

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Health Problems at Baseline

All ParticipantsN=11469

Gastrointestinal/RenalCrohn's disease/ulcerative colitis 196/11452 (1.7%)Liver disease 184/11459 (1.6%)Kidney disease 267/11453 (2.3%)

Family Medical HistoryHeart disease 5459/11449 (47.7%)Cancer 5254/11443 (45.9%)Mental illness 2785/11428 (24.4%)Dementia 1778/11431 (15.6%)Diabetes 4680/11443 (40.9%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/health_baseline.sas

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Lifestyle Habits at Baseline

All ParticipantsN=11469

Smoked at least 100 cigarettes Yes 4592/11459 (40.1%) No 6769/11459 (59.1%) Dont Know 98/11459 (0.9%)

Currently smoke cigarettes Yes, only some days 544/9680 (5.6%) Yes, everyday 759/9680 (7.8%) No 8377/9680 (86.5%)

Cigarettes/day N 4679 Mean (Std Dev) 14.2 (11.7) Median (25th, 75th) 10.0 (5.0, 20.0) (Min, Max) (0, 100)

Years have you smoked/did you smoke regularly Less than 1 year 367/9001 (4.1%) 1-5 Years 979/9001 (10.9%) 6-10 Years 702/9001 (7.8%) 11-15 Years 553/9001 (6.1%) 16-20 Years 576/9001 (6.4%) 21-25 Years 479/9001 (5.3%) More than 25 Years 1063/9001 (11.8%) N/A 4282/9001 (47.6%)

Tried any smokeless tobacco products Yes 1359/11449 (11.9%) No 10090/11449 (88.1%)

Currently use chewing tobacco or snuff Every day 166/10978 (1.5%) Some days 111/10978 (1.0%) Not at all 10701/10978 (97.5%)

Currently use cigars, pipes, bidis, kreteks, or other tobacco products Yes 264/11455 (2.3%) No 11191/11455 (97.7%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/lifestyle_baseline.sas

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Lifestyle Habits at Baseline

All ParticipantsN=11469

Exposure to tobacco smoke at indoor workplace I am currently exposed to tobacco smoke at work 323/11401 (2.8%) I have previously been exposed to tobacco smoke at work 4815/11401 (42.2%) I have never been exposed to tobacco smoke at work 6263/11401 (54.9%)

Exposure to tobacco smoke at home I am currently exposed to tobacco smoke at home 1062/11441 (9.3%) I have previously been exposed to tobacco smoke at home 4522/11441 (39.5%) I have never been exposed to tobacco smoke at home 5857/11441 (51.2%)

One drink of any alcoholic beverage during the past month Yes 6037/11457 (52.7%) No 5377/11457 (46.9%) Dont Know 43/11457 (0.4%)

Drink how many alcoholic beverages on an average day 0 318/6254 (5.1%) 1 3132/6254 (50.1%) 2 1765/6254 (28.2%) 3 515/6254 (8.2%) 4 255/6254 (4.1%) 5 74/6254 (1.2%) 6 95/6254 (1.5%) 7 11/6254 (0.2%) 8 25/6254 (0.4%) 9 1/6254 (0.0%) >=10 63/6254 (1.0%)

How many days per week alcoholic beverage consumed Less than 1 day per week/don't drink alcoholic beverages 6834/10255 (66.6%) 1-2 days per week 2031/10255 (19.8%) 3-4 days per week 779/10255 (7.6%) 5-7 days per week 611/10255 (6.0%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/lifestyle_baseline.sas

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Lifestyle Habits at Baseline

All ParticipantsN=11469

Years have drunk/did drink alcohol regularly Less than 1 year 582/11413 (5.1%) 1-5 Years 1156/11413 (10.1%) 6-10 Years 886/11413 (7.8%) 11-15 Years 599/11413 (5.2%) 16-20 Years 648/11413 (5.7%) 21-25 Years 541/11413 (4.7%) More than 25 Years 1658/11413 (14.5%) N/A 5343/11413 (46.8%)

Troubles with job, school, personal, or legal due to drinking Yes 396/11453 (3.5%) No 11015/11453 (96.2%) Dont Know 42/11453 (0.4%)

On-the-job activity during past year Not applicable 4883/11416 (42.8%) Sitting or standing with little exertion 4102/11416 (35.9%) Walking or using hands and arms with moderate exertion 1831/11416 (16.0%) Lifting or carrying heavy objects 470/11416 (4.1%) Hard physical labor 130/11416 (1.1%)

Leisure-time activity during past year Without very much physical activity 4078/11404 (35.8%) Few active things on weekdays / light exercise on weekends 2320/11404 (20.3%) Moderate activity three times per week on the average 3197/11404 (28.0%) Regular program of physical fitness at least three times per week 1104/11404 (9.7%) Regular program of physical fitness five or more times per week 705/11404 (6.2%)

Consume restaurant prepared meals Less than 1/week 3419/11442 (29.9%) 1-2/week 4284/11442 (37.4%) 3-6/week 2734/11442 (23.9%) 7-10/week 651/11442 (5.7%) 11-13/week 103/11442 (0.9%) 14 or more/week 91/11442 (0.8%) Dont Know 160/11442 (1.4%)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/lifestyle_baseline.sas

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Murdock 1.5 Page 22

Lifestyle Habits at Baseline

All ParticipantsN=11469

Read nutrition labels Always 1892/11441 (16.5%) Very Often 3341/11441 (29.2%) Sometimes 3262/11441 (28.5%) Rarely 1477/11441 (12.9%) Never 1149/11441 (10.0%) N/A 320/11441 (2.8%)

Fruits and vegetables N 9752 Mean (Std Dev) 2.6 (1.6) Median (25th, 75th) 2.0 (1.0, 3.0) (Min, Max) (0, 30)

Milk or dairy foods N 10065 Mean (Std Dev) 1.8 (1.2) Median (25th, 75th) 2.0 (1.0, 2.0) (Min, Max) (0, 16)

Protein foods N 10200 Mean (Std Dev) 2.6 (1.5) Median (25th, 75th) 2.0 (2.0, 3.0) (Min, Max) (0, 30)

Sweets N 9795 Mean (Std Dev) 1.2 (1.1) Median (25th, 75th) 1.0 (1.0, 2.0) (Min, Max) (0, 16)

Caffeinated drinks N 10459 Mean (Std Dev) 1.8 (2.0) Median (25th, 75th) 1.0 (0.0, 2.0) (Min, Max) (0, 40)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/lifestyle_baseline.sas

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Murdock 1.5 Page 23

Lifestyle Habits at Baseline

All ParticipantsN=11469

Sugar sweetened beverages N 10308 Mean (Std Dev) 1.0 (1.6) Median (25th, 75th) 0.0 (0.0, 1.0) (Min, Max) (0, 36)

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/lifestyle_baseline.sas

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Total Number of People Taking Specific Drugsat Baseline or Follow-up

All ParticipantsN=11469

ACETYLSALICYLIC ACID 2823 (24.6%)FISH OILS 2581 (22.5%)MULTIPLE VITAMINE 2510 (21.9%)VITAMIN DS 2458 (21.4%)LISINOPRIL 1411 (12.3%)CA CALCIUM 1346 (11.7%)OMEPRAZOLE 1156 (10.1%)SIMVASTATIN 1120 (9.8%)ASCORBIC ACID 846 (7.4%)METFORMIN 843 (7.4%)VITAMINE D3 814 (7.1%)LEVOTHYROXINE 742 (6.5%)HYDROCHLOROTHIAZIDE SULFATE 684 (6.0%)CYANOCOBALAMIN 644 (5.6%)IBUPROFEN 591 (5.2%)PRAVASTATIN 579 (5.0%)CRESTOR 571 (5.0%)LIPITOR 549 (4.8%)VITAMIN E 547 (4.8%)METOPROLOL 542 (4.7%)SYNTHROID 537 (4.7%)COENZYME Q10 513 (4.5%)AMLODIPINE 496 (4.3%)VITAMIN D3 (CHOLECALCIFEROL) 492 (4.3%)ATENOLOL 457 (4.0%)VITAMINS 454 (4.0%)CENTRUM SILVER 452 (3.9%)FUROSEMIDE 452 (3.9%)GABAPENTIN 442 (3.9%)MELOXICAM 442 (3.9%)NEXIUM 433 (3.8%)VIACTIV CALCIUM PLUS D 426 (3.7%)CITALOPRAM HYDROCHLORIDE 408 (3.6%)CALCIUM WITH VITAMIN D 390 (3.4%)MAGNESIUM 386 (3.4%)ZYRTEC 386 (3.4%)GLUCOSAMINE AND CHONDROITIN SULFATE 384 (3.3%)OMEGA 3 FATTY ACIDS 370 (3.2%)BIOTINE 359 (3.1%)MULTI VITAMINES 351 (3.1%)PRILOSEC 344 (3.0%)TRAMADOL, ACET 339 (3.0%)MECOBALAMIN 337 (2.9%)

Participant only counted once for each preferred drug nameMedications used by less than 1% of participants are not included in this reportData as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/drugprefterm.sas

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Total Number of People Taking Specific Drugsat Baseline or Follow-up

All ParticipantsN=11469

VITAMIN B WITH C 335 (2.9%)IRON 334 (2.9%)TYLENOL 330 (2.9%)LORATADINE HCL 329 (2.9%)LISINOPRIL AND HYDROCHLOROTHIAZIDE 328 (2.9%)GLUCOSAMINE 321 (2.8%)CLONAZEPAM 314 (2.7%)ATORVASTATIN 309 (2.7%)POTASSIUM 293 (2.6%)CYMBALTA 286 (2.5%)AMBIEN 285 (2.5%)B COMPLEX VITAMINS 284 (2.5%)ALEVE 282 (2.5%)HYDROCODONE 276 (2.4%)LOSARTAN HYDROCHLORIDE 272 (2.4%)AMLODIPINE BESYLATE 271 (2.4%)ASPIRIN LOW DOSE 270 (2.4%)ZOLPIDEM 254 (2.2%)PLAVIX 250 (2.2%)SINGULAIR 232 (2.0%)LEXAPRO 227 (2.0%)SERTRALINE 226 (2.0%)B- COMPLEX 225 (2.0%)CLARITIN 224 (2.0%)PREDNISONE ACETATE 224 (2.0%)MELATONIN 223 (1.9%)WARFARIN 221 (1.9%)PROBIOTIC 219 (1.9%)CELEBREX 217 (1.9%)FLUOXETINE 205 (1.8%)NIACIN 205 (1.8%)METFORMIN HYDROCHLORIDE 202 (1.8%)CYCLOBENZAPRINE 200 (1.7%)NASONEX 199 (1.7%)ALBUTEROL 198 (1.7%)ADVIL 197 (1.7%)NAPROXEN 193 (1.7%)RANITIDINE 193 (1.7%)FLAX SEED OIL 190 (1.7%)GLIPIZIDE 189 (1.6%)TRAZODONE 186 (1.6%)FLUTICASONE PROPIONATE 184 (1.6%)HYDROCODONE AND ACETAMINOPHEN 182 (1.6%)

Participant only counted once for each preferred drug nameMedications used by less than 1% of participants are not included in this reportData as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/drugprefterm.sas

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Total Number of People Taking Specific Drugsat Baseline or Follow-up

All ParticipantsN=11469

LANTUS 181 (1.6%)VITAMINS A 180 (1.6%)FLONASE 179 (1.6%)DIOVAN 178 (1.6%)ZOLOFT 177 (1.5%)ALENDRONATE 176 (1.5%)TRIAMTERENE AND HYDROCHLOROTHIAZIDE 176 (1.5%)ALLEGRA 175 (1.5%)POTASSIUM CHLORIDE 175 (1.5%)LORAZEPAM 172 (1.5%)ALENDRONATE SODIUM 170 (1.5%)ERGOCALCIFEROL, VITAMIN D2 168 (1.5%)METOPROLOL TARTRATE 168 (1.5%)CARVEDILOL 167 (1.5%)ADVAIR 166 (1.4%)FLUTICASONE 166 (1.4%)PRAVASTATIN SODIUM 166 (1.4%)ACETAMINOPHEN 165 (1.4%)CINNAMON 163 (1.4%)ESTRADIOL 163 (1.4%)CELEXA 162 (1.4%)KLOR CON 162 (1.4%)WELLBUTRIN 160 (1.4%)BUPROPION 159 (1.4%)ALLOPURINOL 156 (1.4%)RED RICE YEAST 153 (1.3%)ZETIA 151 (1.3%)FERROUS SULFATE, IRON 150 (1.3%)OYSCO D 149 (1.3%)SYMBICORT 149 (1.3%)FENOFIBRATE 148 (1.3%)FLAXSEED OIL 147 (1.3%)LOVASTATIN 144 (1.3%)LYRICA 144 (1.3%)CETIRIZINE 143 (1.2%)PROZAC 143 (1.2%)FEXOFENADINE 140 (1.2%)ZINC 139 (1.2%)ACTOS 137 (1.2%)BENADRYL 137 (1.2%)SPIRONOLACTONE 136 (1.2%)PRENATAL VITAMINS 135 (1.2%)ASPIRIN BAYER 134 (1.2%)

Participant only counted once for each preferred drug nameMedications used by less than 1% of participants are not included in this reportData as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/drugprefterm.sas

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Murdock 1.5 Page 27

Total Number of People Taking Specific Drugsat Baseline or Follow-up

All ParticipantsN=11469

AMITRIPTYLINE 133 (1.2%)LEVOXYL 133 (1.2%)ALPRAZOLAM 131 (1.1%)PREVACID 130 (1.1%)TAMSULOSIN 130 (1.1%)METHOTREXATE 129 (1.1%)PANTOPRAZOLE HCL 129 (1.1%)NITROSTAT 127 (1.1%)ZOCOR 127 (1.1%)FINASTERIDE 124 (1.1%)BACLOFEN 123 (1.1%)LOSARTAN POTASSIUM 123 (1.1%)METOPROLOL SUCCINATE ER 123 (1.1%)COUMADIN 121 (1.1%)DILTIAZEM 121 (1.1%)FOSAMAX 121 (1.1%)GARLIC EXTRACT 120 (1.0%)PREMARIN 119 (1.0%)SPIRIVA 119 (1.0%)NORVASC 118 (1.0%)OSTEO BI- FLEX 118 (1.0%)CALTRATE 117 (1.0%)PROTONIX 117 (1.0%)LEVOTHYROXINE SODIUM 116 (1.0%)TRAMADOL HYDROCHLORIDE 116 (1.0%)TUMS 115 (1.0%)ZOLPIDEM TARTRATE 115 (1.0%)

Participant only counted once for each preferred drug nameMedications used by less than 1% of participants are not included in this reportData as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/drugprefterm.sas

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Murdock 1.5 Page 28

Health Problems at Follow-Up

All ParticipantsN=11469

Follow-up* (years) N 8236 Mean (Std Dev) 3.2 (1.5) Median (25th, 75th) 3.0 (1.9, 4.2) (Min, Max) (0, 6)

HeartCoronary artery disease 320Atrial fibrillation 283Heart attack or angina 242Congestive heart failure 169Implantable cardiac defibrillator (ICD) or pacemaker placement 92

CancerBreast cancer 139Colon cancer 43Lung cancer 29Prostate cancer 104Cervical cancer 32Melanoma 166Skin cancer, not melanoma 819Oral cancer 7Thyroid disease 827

MetabolicDiabetes 1068High cholesterol 2400High blood pressure 2463Obesity 1380

Lung/RespiratoryAsthma 592Emphysema or COPD 348

Bone/JointOsteoarthritis 1396Rheumatoid arthritis 681Other autoimmune disease 346Osteoporosis/Osteopenia 879Gout 309

*For participants that withdrew, time to last follow-up, does not include time from last visit to withdrew date.

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/health_fu.sas

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Health Problems at Follow-Up

All ParticipantsN=11469

NeurologicalAlzheimer's disease 45Depression 1132Stroke 210Multiple sclerosis 305

Gastrointestinal/RenalCrohn's disease/ulcerative colitis 115Liver disease 101Kidney disease 185

*For participants that withdrew, time to last follow-up, does not include time from last visit to withdrew date.

Data as of 17APR2015 DRAFT: Analysis is not validatedProgram Name: /ct/murdock/murdock_1_5/tables/health_fu.sas