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nj īÝǶĵǰǗȆǒTĸʼnŜ@ǓǶƓĜǴ\ǟǯ nj ǚȋ-ĔĚôǶmħĤĭɉÍÄǶģŠ Ɗv| 4ċJĪ|Ĥĭ® ñÓ 201411Î28È İɆcǚȋÄŖƓĜșȼȱȚȎȳ

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Page 1: ß ï « Ì - kawamoto.frontier.kyoto-u.ac.jpkawamoto.frontier.kyoto-u.ac.jp/common/images/research_img/141226g... · tcr z .ctl ô Ú ¦ g t 8 i tcr z . å = zò ð Ô Ï . 8 i Ú

njƫ��īÝǶĵǰ�ǗȆǒTĸʼnŜ@ǓǶƓĜǴ\ǟǯƫnj�

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TĸʼnŜ@ȊŖ@ǶȃǖǴ±�ǦȆÊ�ǚÖȆ�

ŖǶêV� ċŖɁþÅŖdzDzɂ�

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4ċTĸʼnŜ@ȊǚȋòĚǴ čǦȆDZǕǖ­Ē�

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ǚȋǶ-ĔĚôǷÍſCĞǴƃèǤǪ�

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TCRƇ�z�.CTLĚô�ǚȋ¦Ň�

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ȓȴȶ²PȹȝȭȞȾĚô�ǚȋ¦Ň�

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DzǖǤǯǡȋdzŕFɁ?6ŃǏƇ�z¿sdzDzɂȊǦȆǶǙɊ�

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ǒ²PąēĞTĸʼnǓǫǟȊpȂǦǶǴǒ:ÑIǓǶ¯řȊ�ǖ�

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ES/iPSĸʼnǎ�

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TĸʼnȊ:ÑIǤǯESĸʼnǔȆǕǷiPSĸʼnȊǮǝȆDZǏ 4à«ǣȇǪȹȝȭȞȾƇ�zǚTǟĿǚȇȆǶǰǏ

ǩǶiPSĸʼnǙȄTĸʼnȊ4ċǣǨȆDZǏ[ǥR £ǶTĸʼnǚǮǝȇȆǐ�

VDJ 9ȅŵȅǣȇǪƇ�zǷTǟĿǚȇȆ ɁƇ�zǶàƁǷ ǎ:ÑIǣȇdzǕɂ�

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TĸʼnȹȝȭȞȾǎ�

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ȴȶȧȾȲǶMART-1²PąēĞ TĸʼnǶ4ċǴ«E�

[ǥWǴ×vǶƏzȽ�2Ȅȁ ȐȍȜȎȍȸț²PąēĞTĸʼnǶ4ċǴ«EDZn]�

Kyoko Masuda

Raul Vizcardo ǎǎ�

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[Z��}�_K���� �����hnr�,7; z{�#��z{'A��

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Vizcardo et al, Cell Stem Cell, 2013�

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抗CD3抗体添加

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0日 13日 35日

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��īÝ�

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4ċTĸʼn�

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��īÝ�

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TĸʼnǷ�ŒǴOƚdzǶǰ��īÝǰ�ǗdzǕ�

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[ǥHLAjǶǹDZǚ[ǥǚȋ²PȊ¸ǮǚȋǴdzǭǪoZ�

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��īÝǶȴȷȡȣ�Ƚ~�ǰ�ĽǰǛȆ�Ƚ_ŷǚ!ŨǣȇȆ�ȽÍĹĞǴǷ¶ľǣȇȆǶǰ~/�

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具体的な計画�

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WT1²PȊ�ǖ<Ā�

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�vŗøŌę2ĪǰǷWT1²PȊčǕǪãĆĸʼnĚôȊ¢£ƦƧ£ĝŗėǴ�ǤǯÆŘǤǪĻƥǚǔȆ�ƱƫDŽƽƷdžƺƫƲƮƲƲƷƫƸǀƾǂƾƸƷǀƫLJDžƾƷǀƫǃƻƫƾǁǁLjǂǃLJƽƺDžƷDŽNJƫƻǃDžƫƺǀƹƺDžǀNJƫDŽƷLJƾƺǂLJdžƫljƾLJƽƫƷƸLjLJƺƫǁNJƺǀǃƾƹƫǀƺLjƿƷƺǁƾƷƫLjdžƾǂƼƫƹƺǂƹDžƾLJƾƸƫƸƺǀǀdžƫƸǃƬDŽLjǀdžƺƹƫljƾLJƽƫƶƵƯƫDŽƺDŽLJƾƹƺƫƷǂƹƫNjǃǀƺƹDžǃǂƷLJƺƭ

Kitawaki et al, Br J Haematol, 2011 3��2�Ǵ-Ĕ|ĞR ǔȅ�

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WT-1²P�

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