CONTENTS

The MCDB News is pub-

lished by the Department of

Molecular, Cellular, and

Developmental Biology at

the University of Michigan,

Ann Arbor, MI 48109-1048.

Chair: Eran Pichersky

Editor: Steve Roper

Writer: Jennifer

Leadbetter

Layout and Design:

Wendy Everett

Photography: David Bay

Copyright 2003 by the

Regents of the University

of Michigan: David A. Bran-

don, Laurence B. Deitch,

Olivia P. Maynard, Rebecca

McGowan, Andrea Fischer

Newman, Andrew C.

Richner, S. Martin Taylor,

Katherine E. White, Mary

Sue Coleman, ex officio.

Wednesday, April 3, 2002 markedthe second year of the PriscillaConnell Memorial Lecture. Dr.Gerald Rubin, Vice President of theHoward Hughes Medical Institute(HHMI) and Professor of Genetics atthe University of California, Berke-ley, was this past year’s invitedspeaker. He presented his talk on“Biological and ComputationalAnnotation of the DrosophilaGenome Sequence.”

Dr. Rubin is one of the leadingresearchers in the field of develop-mental genetics, utilizing the fruitfly, Drosophila melanogaster. He firstreceived international acclaim in1982 for his work with AllanSpradling, describing a techniquefor the introduction of genes intothe germ line of fly. It remains theonly way to insert foreign or alteredgenes into the fly’s genome andhelped to usher in the “Drosophilarevolution” of the 1980s. His labora-tory went on to establish the fly eyeas one of the premier systems forstudying communication betweencells during development. Morerecently, he has been widely recog-nized as the leading force behindthe sequencing of the fly genome.

In 1991, Dr. Rubin and his col-leagues started the Berkeley Droso-phila Genome Project, whichintended to sequence the entiregenome of the fly and providegenetic tools to facilitate the analysisof individual genes. With the help ofCraig Venter from Celera Genomics,Inc., the sequence of the fly genomewas published in 2000. Analysis ofthe sequence revealed even moresimilarities between flies andhumans than had previously been

This lecture was made possible by a generous endowment by Mr. Paul Connell, inloving memory of his wife Priscilla Harrison Connell. Priscilla Connell was arenowned nature photographer whose work has appeared in Sierra Club and AudubonSociety magazines and calendars, as well as other notable publications. One of herphotographs has been featured on a U.S. postage stamp, and she has won the RogerTory Peterson award for her breathtaking simplicity in capturing the beauty of nature.

VICE PRESIDENT OF HHMISPEAKS AT SECOND ANNUALPRISCILLA CONNELLMEMORIAL LECTURE

continued on page 6

SPRING 2003

Chair’s Corner ................... 2

In Memorium ...........................2

Richard Hume and

Charles Yocum

Honored .................................3

Emeritus Honors ................ 4

External Grants

Awarded .................................4

Life Sciences Institute ..... 5

Mohammed Akaaboune ...... 5

MCDB’s New Website......... 5

MCDB Joins Biomedical

Sciences Program ............. 6

Honor Roll of Donors .....8

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Greetings! This is MCDB’s secondyear in existence, and it has certainlybeen as exciting as the first. On theUniversity level, we had the depar-ture of LSA’s dean Shirley Neuman, astrong champion of MCDB, and theappointment of Alan Saltiel as thenew director of the Life ScienceInstitute. Also, Mary Sue Colemanwas inaugurated as the thirteenthpresident of the University of Michi-gan. President Coleman has had along scientific career as a professorand researcher in the biomedical area.

With all these changes, and despitesome negative effects from the less-

than-perfect financial situation of thestate and the University, we havecontinued to develop the strengths ofour department. New faculty havebeen hired (see p. 5), and the numberof undergraduate students concen-trating in our programs (Cellular andMolecular Biology, and the jointlymanaged Biology) has continued toincrease. All our faculty, with theexception of those retiring this year,are currently conducting researchfunded by external sources, whichmeans that they are able to takeundergraduate and graduate stu-dents into their labs for hands-onexperience in molecular biology.

Indeed, our undergraduates consis-tently tell us that working in aprofessor’s lab is one of the high-lights of their undergraduate experi-ence at the University of Michigan,and that such experience is oftencrucial in shaping their future plansand careers.

The continued success of MCDBfaculty in teaching, research, andservice at the local, national, andinternational levels is a source ofsatisfaction for all of us. I am confi-dent that the years to come willsee even a better, more successfuldepartment.

CHAIR’S CORNERA MESSAGE FROM ERAN PICHERSKY

ALFRED S.SUSSMAN1919-2001On November 19, 2001 ProfessorEmeritus of Botany Alfred Sussmanpassed away at the U-M Hospital inAnn Arbor. The funeral was held onMarch 8, 2002 in the UniversityCommons. Shokrollah Manzoor, anIranian Jewish artist and a relative ofthe family, dedicated his Marchexhibit at the Washtenaw CountyJewish Center, entitled “Images of theHolocaust,” to the memory of Dr.Sussman.

Alfred Sussman began his career atthe University of Michigan in 1950,shortly after completing his Ph.D. atHarvard University. During the nextforty years, he served as Chair for theDepartment of Botany, Dean of theHorace H. Rackham School ofGraduate Studies, and as interim VicePresident for Academic Affairs andfor Graduate Studies and Research. In1972, Dr. Sussman received the

University of Michigan’s Distin-guished Faculty Achievement Award,and was acclaimed “a model of allthat is best in academic life.”

Although Alfred Sussman retired inJune of 1990, he continued to main-tain his research lab with the Depart-ment of Biology for several yearsafterward. His work at the Universityfocused primarily on the pink breadmold Neurospora and its regulation ofmetabolic processes based on chemi-cal and environmental factors.

Sussman was preceded in death byhis wife of 48 years, Selma. He issurvived by his second wife, Eleanor,daughter Jean, sons Paul and Harold,sister Evelyn Feit, and four grandchil-dren.

HOWARD A. CRUM1922-2002Howard Alvin Crum, ProfessorEmeritus of Botany, died at his homeon April 30, 2002. Known for hisenergetic teaching style and keen wit,Crum was a mentor for many gradu-ate students and a counselor to manyundergraduates.

IN MEMORIAM Howard Crum began studyingGerman at Western Michigan Univer-sity, and was called to serve as acryptographer for the U.S. Air Forceduring World War II. After the war,he spent a summer at the U-MBiological Station, and consequentlychanged his major to botany. Upongraduation from Western MichiganUniversity, Crum came to the Univer-sity of Michigan for his Ph.D., thenwent to Stanford University for threeyears of postdoctoral work.

Crum accepted a position as Curatorof Cryptograms for the NationalMuseum of Canada in Ottawa. In1965, Howard Crum returned to theUniversity of Michigan as AssociateProfessor of Botany, later to become afull professor and Chair of theDepartment of Botany.

During his career, he producedtreatments of both North and SouthAmerican mosses, publishing over100 taxa new to science. His researchculminated in the publication ofMosses of Eastern North America, acollaborative work with Dr. LewisAnderson of Duke University. Thecompilation took nearly 30 years to

continued on top of next page

3

complete, identifying over 750different species.

Howard Crum is survived by hiswife Irene, daughter Mary CrumScholtens, son Roger, and fourgrandchildren. Memorial contribu-tions may be made to the HowardA. Crum Memorial Fund at the U-MBiological Station, 501 E. University,Dennison Bldg., University of Michi-gan, Ann Arbor, MI 48109.

FRANCIS C. EVANS1914-2002Professor Emeritus of ZoologyFrancis Cope Evans passed away onAugust 16, 2002 following a shortillness. The memorial service washeld at St. Andrew’s EpiscopalChurch in Ann Arbor on September 28.

Dr. Evans was educated first atGermantown Friends School, thenHaverford College. After graduation,he went to study ecology as a RhodesScholar at Oxford University, and didpostdoctoral work at the Universityof California, Berkeley, the HooperFoundation in San Francisco, and theUniversity of California, Davis. In1943, Francis returned to Haverfordas a professor, and in 1944 he wasnamed acting dean.

Francis Evans came to the Universityof Michigan in 1948, and was ap-pointed Professor of Zoology in 1959.During the 34 years that Evans servedthe University, he acted as AssociateDirector of the E.S. George Reserve andeditor for publications of the Museumof Zoology. After his retirement in 1982,he served as President of the Ecologi-cal Society of America, from which hereceived a Distinguished Service Cita-tion in 1989.

Evans is survived by his wife Rachel,sons Kenneth and Richard, daughtersRachel and Rev. Katharine Cope Evans,and five grandchildren.

Two senior professors, Richard Humeand Charles Yocum, have beenhonored with prestigious awards fortheir research and work with stu-dents.

Neurobiologist Dr. Richard Hume hasbeen awarded the Margaret andHerman Sokol Award from theRackham Graduate School forpromoting excellence in the sciencesand graduate education. Over thepast several years, Dr. Hume hasplayed an active role in shaping theNeurobiology Graduate Program.Presently, he is the Director of theInterdepartmental NeuroscienceGraduate Program, and in the past hehas acted as Associate Chair forCurriculum of the Biology Depart-ment. He has also won the LS&AAward for Excellence in Teaching, aswell as the University of MichiganNeuroscience Faculty ExcellenceAward.

Dr. Hume follows the philosophy thatgraduate students should be treatedas “junior colleagues,” contributingtheir own research and ideas as anintegral part of the lab environment.He often recruits new students byholding potlucks at his home, and heschedules annual retreats wherestudents and faculty can interact in arelaxed, informal setting. Each year,

his students in the NeuroscienceProgram host a symposium wheregraduates choose their own guestspeakers.

Dr. Charles Yocum has been grantedthe John Simon Guggenheim Founda-tion Fellowship for research in cellbiology. The award is presented todistinguished professionals from theU.S. and Canada working in thehumanities, creative arts, naturalsciences, or social sciences. Dr.Yocum’s research focuses on the set ofproteins called photosystem II. Theprimary purpose of photosystem II isto harvest the energy of the sun,releasing oxygen as a byproduct ofthis reaction. In 1981, he developed aprocess to isolate this protein com-plex, and from this developmentstemmed his current research issues.This breakthrough is the basis formost research on photosynthesisaround the world, and his 1981 paperdescribing this process has been citedover a thousand times.

Each year, the John SimonGuggenheim Foundation receives3000-3500 applications and selectsapproximately 200 scholars andartists to receive one-year grants. Thisyear, Dr. Yocum was one of twoprofessors nominated from theUniversity of Michigan, and one of187 candidates selected overall.

RICHARD HUME AND CHARLES YOCUMHONORED FOR OUTSTANDINGCONTRIBUTIONS IN BIOLOGY

Charles Yocum

Richard Hume

4

Adams, Julian NIH Ciprofloxacin Resistance and Compensatory Mutations

Bardwell, James NIH Functional Analysis of a Protein Folding Catalyst

NIH How Are Disulfides Transported Across Membrances?

Bodmer, Rolf NIH Combinatorial Genetic Control of Cardiac Cell TypeSpecification: The Even-Skipped Lineage

Cadigan, Kennth NIH Tissue Specificity of Wingless Signaling in Drosophila

Denver, Robert NSF The Neuroendocrine Stress Axis in Amphibian Develop-ment and Physiology

Hay, Jesse NIH Neuronal Ykt6 Protein Interactions and Targeting

Jakob, Ursula NIH Functional Analysis of Hsp33-A Redox RegulatedChaperone

Klionsky, Daniel NIH Alternative Vacuolar Targeting Mechanisms in Yeast

Maddock, Janine NIH Characterization of the Vibrio harveyi CgtA Protein

NIH Proteomics of B anthracis Membrane and the SporeProteins

Olsen, Laura USDA The PTS2 Protein Import Pathway of Plant Peroxisomes

Pichersky, Eran NSF The Role of Terpene Synthases on Floral Scent inArabidopsis thaliana and Related Species

BARD/ Functional Genomics of Citral Biosynthesis in AromaticUSDA Plants: Pathway Elucidation and Applications

EXTERNAL GRANTS AWARDED TOMCDB FACULTY IN 2002EMERITUS

HONORSWesley M. Brown, Ph.D., retiredon May 31, 2002 and was namedby the Regents of the Universityas Professor Emeritus of Molecu-lar, Cellular, and DevelopmentalBiology and Professor Emeritus ofEcology and Evolutionary Biology.Dr. Brown was a founding mem-ber of the research field that usesDNA to identify individuals andinfer relationships betweenindividuals and species. He joinedthe University of Michigan facultyin 1980, and served as bothAssociate Chair and Chair of theDepartment of Biology. From1983-1998 he acted as an AssistantCurator, then Curator, in theMuseum of Zoology, and he waselected President of the Society ofMolecular Biology and Evolutionin 1995.

John P. Langmore, Ph.D., wasnamed Professor Emeritus ofMolecular, Cellular, and Develop-mental Biology and ResearchScientist Emeritus in the Biophys-ics Research Division upon hisretirement on December 31, 2002.Dr. Langmore is known for hisleading work in electron micros-copy and his models for nucleo-some structure. He also taught thefirst course in genomics at theUniversity of Michigan. Dr.Langmore became a member ofthe faculty at the University in1979, and has taught in both theBiology Department and theBiophysics Research Division.From 1989-1995 he served as Chairfor the Biophysics ResearchDivision and the BiophysicsGraduate Program, and in 1993 hecoordinated the move of Biophys-ics from its location on NorthCampus to its current place in thechemistry complex.

FACULTY HIGHLIGHTSJulian Adams was on sabbaticalthis past year. He acted as a reviewerfor the Howard Hughes MedicalInstitute’s Professor award and wasinvited to speak in Aussois, France,at the Symposium on Long TermExperimental Evolution with Mi-crobes.

Marc Ammerlaan was an invitedspeaker at the Provost’s Seminar onTeaching, 2002. He continued as theoverall director for the HowardHughes Outreach Program for HighSchool Teachers.

Robert Bender served as Chair Electof the Physiology and MetabolismDivision of the American Society forMicrobiology. He was asked to giverepeat talks of his “Tragic Tale ofTyphoid Mary” and was an invited

speaker on AIDS to the InternationalDevelopment and Health Association.

Ken Cadigan hosted this past year’sPriscilla Connell Memorial Lecture.

Robert Denver began serving asAssociate Chair for UndergraduateCurriculum.

Santha Jeyabalan was selected by theCollege as a Senior Lecturer.

Jianming Li was a lecturer for asummer course in plant molecularphysiology at Beijing University,China. He also was a member on anNSF Grant Panel.

Janine Maddock was elected Chair ofDivision J of the American Society forMicrobiology.

5

The Department of Molecular,Cellular, and Developmental Biologyis pleased to announce that ProfessorDaniel Klionsky has been named asone of the six charter members of theLife Sciences Institute.

The Institute has been undergoingconstruction since April 2001 and isscheduled to open Fall 2003. This 100million dollar complex will drawtogether some of the most talentedscientists from both the central andmedical campuses. Structured aroundan ideal of a “lab without walls,”

professors from the areas of genetics,biochemistry, cellular biology, andmany other disciplines in the lifesciences will share open lab spacesthat fluctuate as research projectschange.

As a charter member, Dr. Klionskywill be directly involved in launchingthe Life Sciences Institute. “It is agreat opportunity, but it can also beintimidating,” observes Klionsky.“The challenge is to merge twocultures, two different schools andmultiple departments, all run in

different ways.”Initially, he will beinvolved in theselection processfor new facultybrought into theinstitution. Thegoal is to identifyleading scientistswho welcome the

opportunity towork in a highlyinteractive envi-ronment. Includ-ing the six chartermembers and AlanSaltiel, Director ofthe Life SciencesInstitute, the LSIcomplex will eventually housebetween 20 and 30 faculty members,as well as over 300 graduates,postdoctoral fellows, and under-graduate researchers.

Although Dr. Klionsky will betransferring his laboratory facilities tothe Life Sciences Institute, he willcontinue to maintain his tenure andteach classes for the Department ofMolecular, Cellular, and Develop-mental Biology. In conjunction withhis move to the LSI facilities, Dr.Klionsky has also been awarded aCollegiate Professorship.

DISTINGUISHED PROFESSOR NAMED ASCHARTER MEMBER FOR LSI

HAVE YOU VISITEDMCDB’S NEW WEBSITE?

In conjunction with a new website for theCollege of Literature, Science, and theArts (LSA), the MCDB home page hasbeen redesigned and has many innova-tive features. The new site offers a cleaner,more consistent and professional look,including easier navigation and custom-ized pages for specific audiences, but thereal improvements go far beyondredesign. The engine behind the site’schanges is called a “content managementsystem” (CMS), which allows for quickand easy updates to pages by professorsand staff. LSA is one of the few colleges inthe country to have such a system, andMCDB is proud to be the first departmentin the College participating in this project.

Please visit our new home athttp://www.lsa.umich.edu/mcdb/

The new LSA website can be viewed athttp://www.lsa.umich.edu/

MOHAMMED AKAABOUNEDr. Mohammed Akaaboune is originally fromMorocco. He received his DEA and Ph.D. inneuroscience from the University of Pierre andMarie Curie in Paris, France, and his doctoratewas awarded with highest honors. His post-doctoral work was spent as a research associate atWashington University School of Medicine in St.Louis, Missouri. This past year Dr. Akaabounejoined our department as an Assistant Professor.

Dr. Akaaboune’s research focuses on synapticplasticity at the neuromuscular junction in living animals. Already in hiscareer, Dr. Akaaboune has distinguished himself by developing severalnew research techniques. He was awarded the highly prestigious HumanFrontier Science Program Postdoctoral Fellowship, and he was a finalist inthe 1999 James L. O’Leary Prize Competition in Neuroscience. He also hasbeen a National Institute of Health, French Medical Research, and FrenchMuscular Dystrophy Association Fellow.

WELCOME NEW FACULTY

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This past academic year, theDepartment of Molecular, Cellular,and Developmental Biology joined12 other departments participatingin PIBS, the Program in Biomedi-cal Sciences. PIBS is a gatewayprogram that permits students tofile a single application, whileallowing them access to Ph.D.programs in both the MedicalSchool and the College of Litera-ture, Science, and the Arts.

The primary goal of PIBS is to givestudents the opportunity toexplore the many diverse andcutting edge research ongoing atthe UM. During their first year,students rotate between labs oftheir choosing, immersing them-selves in hands-on research andtaking core courses in genetics,biochemistry, and cell biology.

After completing of the year, theywork with a mentor to finalizechoices of a Ph.D. program.

According to Dr. John Kuwada,Associate Chair of Graduate Studies,MCDB is one of the few departmentsin PIBS outside the Medical School.The Department benefits the programbecause much of the underlyingresearch for medicine comes from thegenetic, cellular and molecularanalysis of model organisms. As heexplains, “MCDB’s emphasis on theanalysis of genetic model organismssuch as the fruitfly, zebrafish, and theArabidopsis weed offers students theopportunity to examine the founda-tions of biological processes commonto many organisms.”

While students may still apply toindividual departments, PIBS allows

graduates to explore multipledisciplines and to change theirfields of study during the first yearwith minimal disruptions. “Itreally is an intellectual incubator,”remarks Mary Carr, Coordinatorof Graduate Studies for MCDB.Often, students apply who areunsure where they want to gowith their degrees and who wishto try more than one field beforepursuing a degree. PIBS allowsgraduates a certain amount offlexibility, and can help them seeconnections with other areas ofexpertise.

The admissions process to PIBS ishighly competitive. Of nearly 700applicants, fewer than 80 enteredthe program last year. The Depart-ment of Molecular, Cellular, andDevelopmental Biology admits upto six Ph.D. candidates from PIBS.

MCDB JOINS THE PROGRAM INBIOMEDICAL SCIENCES

suspected. For example, over 50human genes linked to a specificdisease have closely related genes inthe fly. Dr. Rubin hopes to use thepowerful genetic information avail-able in Drosophila to shed light onhow the genes function in humans.

Dr. Rubin’s seminar highlighted thehistorical context of his work, as wellas more recent research in progress.His presentation style was refresh-ingly self-effacing. For example, he

commented that during his Ph.D.work in the early 1970’s, it took himthree years to sequence one small flygene. He cheerfully added that at theheight of the fly genome sequencingeffort, his Ph.D. productivity wasbeing matched every ten seconds. Healso predicted that it would take 300years to accurately annotate the flygenome (i.e., fully understand thebiological role of each gene). Hefinished his talk by describing someof his lab’s recent studies usingbioinformatics and genomics tounderstand particular groups ofgenes.

Dr. Rubin graduated from the Massa-chusetts Institute of Technology in

VICE PRESIDENTOF HHMI SPEAKScontinued from page 1

1971. He received his Ph.D. fromCambridge in 1974 and went toStanford University School of Medi-cine for postdoctoral work. Afterjunior faculty positions at HarvardMedical School and the CarnegieInstitute, he arrived at the Universityof California, Berkeley in 1983.Currently he divides his time be-tween his laboratory and HHMIheadquarters in Chevy Chase,Maryland. Dr. Rubin has receivedmany awards, including theNewcomb Cleveland Prize from theAmerican Association for the Ad-vancement of Science (once in 1983and again in 2000). In 1987 he waselected a member of the NationalAcademy of Sciences.

7

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8

Dr. Nelda AlgerMs. Grace BaysingerMs. Janice E. BerryMr. Laird BloomBary J. & Emma Jean BowmanMr. Michael H. Buch, M.D.Dr. Gary J. BurinDr. Cynthia CareyMr. Paul ConnellMs. Nina L. ConsolattiMr. John CopleyMr. Earl R. CreutzburgMs. Jill J. DavisonJuan C. & Laura M. DawsonMr. Frank DennisMr. Richard DowdsMs. Deborah M. EldridgeDr. William S. EpsteinMs. Erin C. FitzgeraldDr. Catherine Delaney FreimanMr. Albert J. GrennanRuth & Frank GurdWilliam & Gertrude R. Healy

Dr. Lanny Ian HeckerMs. Dria S. HowlettPeter L. & Cheryle L. JolivetteFred & Janet KramerDavid & Hiejin KwonHoward & Liza LarkyAndrew & Katharine LeavittTamra & James LewisMr. Jordan G. LubahnWilliam A. & Mary D. LunkJoseph & Rennie MaddenJohn A. McAreeJ. Jay & Charlotte W. MeyersMs. Ann MishneMr. Melvin E. ModdermanWilliam G. & Hesed Padilla NashMrs. Sylvia NeivertMr. Patrick H. O’LearyRobert T. & Bonnie P. PainMr. & Mrs. Kenneth J. PetersDr. & Mrs. George H. ReazinDouglas & Sara W. RubyMr. Steven Fletcher Sands

2002 HONOR ROLL OF DONORSMr. Joseph R. SenkoMrs. Nancy Foster SmithJanet & Emerson SmithDorothy & James SymonsKathleen & Robert TarDr. Sarah Garvey TomlinsonMs. Kathryn R. WalterDr. & Mrs. Stanley C. WeckerSandra & Charles WestrinDr. Henry Miles WilburDr. Larry L. Wolf

Department Of Molecular, Cellular,

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through the University’s

Telefund and other cam-

paigns. Our apologies to

anyone we may have inadvert-

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