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7/30/2019 Spo Pengantar Silabus Gasl 2013
1/22
Sistem Penghantaran ObatMutakhir
(Advanced Drug Delivery)
Dr. Ahmad Kharis Nugroho, Apt.
Dr.rer.nat. Ronny MartienC.M. Ratna Rini N., M.Pharm., Apt.
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Drug delivery (system)?
Vehicle? Dosage form?
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Ultimate goal of drug
delivery ?To deliver the active pharmacological
ingredients to the site of action,
safely, efficiently and effectively
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2 aspects of controlled release
1. Spatial placement site specific
targeting delivery
2. Temporal delivery rate / time
efficiency
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Delivery design consideration
Disease/abnormalities determination Type and goal of therapy
Criteria for ideal system
Route of administration physiological
condition
Natural barrier anticipation
Possibility of modification or combinationof delivery
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Points to concern
Challenges (read: barriers) of delivery Ideal system
Technology development
Critical factors
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Type of drug delivery
Conventional drug delivery
Immediate - Continuous release
Advanced drug delivery Controlled release
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General purposes of study
To gain better understanding of advanceddrug delivery
To distinguish the delivery systems based
on the unique mechanisms
To identify the critical factors on thedelivery system studied
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Competence Indicators
Students can explain the role of drugdelivery system in encouraging patient-oriented therapy
Students are capable to distinguish theadvanced drug delivery systems based onthe mechanism of delivery and release
Students are able to identify the criticalfactors of the delivery systems learnt
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Conscience to develop
The objectiveness in accessing information Critical and logical thinking
The importance of communication and
team work/collaboration spirit
Self confidence to decide the right things
Imagination leading to creativity
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Compassion held
Willingly to contribute to the transfer ofcorrect information about drug deliverysystem
Highly motivated to design the drugdelivery system which fully concerns onpatients overall condition
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Menu
Week Agenda PIC
I-II Nanotechnology delivery Dr. Ronny
Martien
III-IV Nanotech on cancer
chemotherapy strategies
Dr. Ronny
Martien
V-VII Transdermal delivery Dr. AkhmadKharis, Apt.
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MenuWeek Agenda PIC to guide
Mid exam
VIII-X Pulmonary and nasal
delivery
Iin, M.Pharm,
Apt
XI-
XIII
Oral Modified Delivery Iin,
M.Pharm,Apt
Final exam
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Schedule description
Dr. Akhmad Kharis, Apt. and Dr. RonnyMartien will teach on weekdays schedule forall classes
Saturday classes are only carried out if Dr.Akhmad Kharis, Apt. is not available to givelectures on weekdays due to must-to-doagendas on Gadjah Mada University (there
will be notification)
Learning with Iin, M.Pharm will start aftermid exam for 6 weeks
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Distribution of assessment
I:K:R =50% : 25% : 25%
Description of I mark: Final exam : max 30
Assignment & presentation : max 20 (10 forpresentation, 10 for discussion)
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Learning together
guided by bu iin
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Activity class discussion
A class is divided into 9 groups@2assignments
Iin, M.Pharm:
Pulmonary drug delivery (3)
Nasal delivery (1)
Sustained delivery & Pulsatile delivery (2)
Oral macromolecular delivery (3)
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Iin, M.Pharm:
Pulmonary drug delivery (3) 2 meetings
Anatomy and physiology of lung, lung naturaldefense and physical factors affecting drugdisposition
Design of pulmonary delivery system
Exuberra review
Nasal delivery (1) 1 meeting
Anatomy of nose and reason behind delivery
Design of nasal delivery systemReview on pulmonary and nasal delivery
Sustained delivery & pulsatile delivery (2) 1
meeting
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Oral macromolecular delivery (3) 2
meetings (+review and reflection) Strategy to overcome enzymatic barriers
Role of penetration enhancers
Strategy to overcome efflux pump
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Aspects to discuss
Concept of deliveryDescription of either the anatomy and
physiology of the site of action or thephysiological barriers
The purpose of the delivery system
The unique mechanism of the system
What critical factors to concern and why?
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Handout
Use slides of Power Point (use 3 slides/page
no more than 8 pages)
No plagiarism!!!
If you refer to any articles or figures, always
refer on a right manner (with acknowledgement)and the statement of only for learningpurposes
Handout should be copied and distributed at
least one day before class If the handout needs to be revised, revision will
be done after class
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Recommended references
See the SPO folder on Filey!