SPINTRONIC NANOSENSORS for MEDICINEProf. Riccardo Bertacco

Centro LNESS Politecnico di Milano

Via Anzani 42, 22100 Como

riccardo.bertacco@polimi.it

Riccardo Bertacco

2Spintronic biosensors for molecular recognition

R

R’

No background

No bleaching

High stability

Molecule handling

High biological sensitivity

Tayloring the dinamic range

Lab on chip

Advantages

Disadvantages Not label free Impact of beads on the chemical affinity ?

biotin

streptavidin

target

probe

Riccardo Bertacco

SpinNanoMed FP7: NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info and/or cognitive)

3

End usersAntibody Microarrays C. Borrabaeck, Create

(Sweden)

User Interface, Data correlation and knowledge discovery

Database and Web Group – Bioinformatics Lab

P. Fraternali, S. Ceri, M. MasseroliPolitecnico di Milano (Italy)

Signal de-noising and data analysis

Digital Signal Processing Group- ISP Lab

M. TagliasacchiPolitecnico di Milano (Italy)

Signal read-out and LabOnChip electronics

Microfluidic transportInstitut fur Mikrotechnok Mainz GmbH

K. S. Drese (Germany)

Surface functionalization ICRM M. ChiariCNR (Italy)

Microfabrication of lab on chip micro arrays of spintronic biosensors

Spintronic group at LNESS

nanoGune

MIC - Copenhagen

R. Bertacco Politecnico di Milano (Italy)A. Berger, P. Vavassori (Spain)

M. F. Hansen (Denmark)

SPINTRONIC NANOSORS for MEDICINEPreventive medicine and diagnosis (in vitro diagnostic tests)Specific application:

Early detection of breast cancer via proteome profiling on the serum of patients

Lab on chip approach for point of care applications.

Riccardo Bertacco

Read out electronics (ASIC)

System layout

substrateInsulating layer

SiO2 + polymer

Microfluidics

AD conversion

DSP

Data mining

End user interface

Biomedical

validation

Riccardo Bertacco

Electronics

An ASIC, to be placed around the sensor chip, must be designed and realized with these functionalities:• front end electronics for the signal read out• analogical signal processing (filtering, amplification, ...)

A second external circuit will make the analog to digital conversion and provide suitable signal to an external PC for data acquisition and analysis.