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28/2/2014 Spin al manip ula tiv e thera py re duce s ce ntra l pain sensi tiza tio n -- Scie nce Da ily http://w ww .sci enceda il y .com/releases/2014/02 /1402 2512 2220.htm?utm_ source= feedb urner&utm_m edium=ema il &utm _camp aig n=Feed%3 A+s ci enceda il y%2… 1/1 Date: Source: MLA APA Chi cago  American Pain Soc iety . " Spinal manipulativ e therapy redu ces central pain sensi tiz ation." Sci enceDaily. ScienceDaily, 25 February 2014. <www.sciencedaily.com/releases/2014/02/140225122220.htm>. Spinal manipulative therapy reduces central pain sensitization February 25, 2014  American Pain S ociety The lessening of pain sensitivity achieved with spinal manipulation therapy (SMT) occurs as a result of the treatment and not as much from a placebo effect caused by the expectation of receiving SMT, according to a study published in The Journal of Pain. Spinal manipulative therapy has been shown to reduce the severity of low back pain in some patients. Improved understanding of its pain-relieving mechanisms could enhance clinic al eff ecti v eness. Chronic low back pain is associated with altered pain processing, suggesting a mechanism related to central sensitization of pain. Central sensitization is considered a factor in the progression of acute pain to chronic pain and in the maintenan ce of c hron ic pain. Resear chers fr om the Univ ersity of Florida inv estigated whether less ening of p ain sensi tivity at tributed to S MT is specific to the procedure itself or occurs as a placebo effect from treatment expectation. Studies have shown that placebo is associated with robust analgesia produced by anticipation of pain relief. Subjects for the study had low back pain and were recruited from the University of Florida campus. Participants underwent baseline pressure and thermal pain testing and were randomly assigned to SMT, placebo SMT, enhanced placebo SMT (same as placebo SMT except subjects wer e infor med they would get S MT or a placebo interv ention) or no intervention. The 110 study subjects had repeat mechanical and thermal pain sensitivity testing to measure immediate, within session, change in pain sensitivity. Results showed that significantly more participants receiving the enhanced placebo SMT indicated good to excellent outcomes than those receiving standar d placebo SMT or no treatment. A s ignificant diff erence was not foun d between subjects receiving SMT and the enhanced placebo. The authors concluded their findings reveal a mechanism of SMT unrelated to the expectation of receiving SMT, but from modulation of dorsal horn excitability and lessening of central sensitization. This suggests potential for SMT to be a cl inically bene ficial i nterv ention. Story Source: The above story is based on materials provided by American Pain Society. Note: Materials may be edited for content and length. Journal Reference : 1. Joe l E. Bialosk y, Stev en Z . George , Maggie E. Horn, Do nald D. Price, Roland Staud, Mic hael E. Robinson. Spinal Manipulative Therapy–Specific Changes in Pain Sensitivity in Individuals With Low Back Pain (NCT01168999) . The Journal of Pain, 2014; 15 (2): 136 DOI: 10.1016/j.jpain.2013.10.005 Cite This Page :

Spinal Manipulative Therapy Reduces Central Pain Sensitization

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 American Pain Society. "Spinal manipulative therapy reduces central pain sensitization." ScienceDaily.ScienceDaily, 25 February 2014. <www.sciencedaily.com/releases/2014/02/140225122220.htm>.

Spinal manipulative therapy reduces central pain sensitization

February 25, 2014

 American Pain Society

The lessening of pain sensitivity achieved with spinal manipulation therapy (SMT) occurs as a result of the treatmentand not as much from a placebo effect caused by the expectation of receiving SMT, according to a study publishedin The Journal of Pain.

Spinal manipulative therapy has been shown to reduce the severity of low back pain in some patients. Improvedunderstanding of its pain-relieving mechanisms could enhance clinical effectiveness.

Chronic low back pain is associated with altered pain processing, suggesting a mechanism related to centralsensitization of pain. Central sensitization is considered a factor in the progression of acute pain to chronic pain andin the maintenance of chronic pain.

Researchers from the University of Florida investigated whether lessening of pain sensitivity attributed to SMT isspecific to the procedure itself or occurs as a placebo effect from treatment expectation. Studies have shown thatplacebo is associated with robust analgesia produced by anticipation of pain relief.

Subjects for the study had low back pain and were recruited from the University of Florida campus. Participantsunderwent baseline pressure and thermal pain testing and were randomly assigned to SMT, placebo SMT, enhancedplacebo SMT (same as placebo SMT except subjects were informed they would get SMT or a placebo intervention)or no intervention. The 110 study subjects had repeat mechanical and thermal pain sensitivity testing to measureimmediate, within session, change in pain sensitivity.

Results showed that significantly more participants receiving the enhanced placebo SMT indicated good to excellentoutcomes than those receiving standard placebo SMT or no treatment. A significant difference was not found

between subjects receiving SMT and the enhanced placebo.The authors concluded their findings reveal a mechanism of SMT unrelated to the expectation of receiving SMT, butfrom modulation of dorsal horn excitability and lessening of central sensitization. This suggests potential for SMT tobe a clinically beneficial intervention.

Story Source:

The above story is based on materials provided by American Pain Society. Note: Materials may be edited for content and length.

Journal Reference:

1. Joel E. Bialosky, Steven Z. George, Maggie E. Horn, Donald D. Price, Roland Staud, Michael E. Robinson.Spinal Manipulative Therapy–Specific Changes in Pain Sensitivity in Individuals With Low Back Pain(NCT01168999). The Journal of Pain, 2014; 15 (2): 136 DOI: 10.1016/j.jpain.2013.10.005

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