Presidents

Marco Maria FontanellaGiannantonio Spena

Clinica di NeurochirurgiaUniversità degli Studi di BresciaSpedali Civili di BresciaP.le Spedali Civili, 1 – 25123 Brescia, Italy

Scientific Committee

Mitchel Berger (San Francisco, USA)Alberto Bizzi (Milan, Italy)Domenico D’Avella (Padova, Italy)Flavio Dell’Acqua (London, UK)Alessandro Ducati (Turin, Italy)Hugues Duffau (Montpellier, France)Roberto Gasparotti (Brescia, Italy)Nicola Latronico (Brescia, Italy)Stefano Magrini (Brescia, Italy)Gabriele Miceli (Turin, Italy)Carlo Miniussi (Brescia, Italy)Alessandro Padovani (Brescia, Italy)Pier Paolo Panciani (Turin, Italy)Nick F. Ramsey (Utrecht, Netherland)Miran Skrap (Udine, Italy)Alessandro Vercelli (Turin, Italy)

The structural and functional systems of the brain have complexnetworks in which connections play a prominent role. Gliomasare infiltrating tumors that can alter the normal function of theseconnections in different ways. Operating on and dealing withthese tumors requires a global approach that considers thetumor relative to the brain, and therapeutic goals are measuredin terms of quality of life and effective brain functioning.Consequently, neurosurgeons need to assemble a large amountof information before deciding to operate. As never before,modern neurosurgeons have the opportunity to enrich theircultural background through the translational flow of informationas a result of neuroscience research. Intraoperative brain mappingtechniques provide the unique opportunity to directly explorebrain function and represent an extraordinary integration withnon invasive methods. The aim of this congress is to gatherinternational leading experts from different neuroscience domainsto foster the exchange of knowledge between basic and clinicalneuroscientists. It will represent close interactions betweenneurosurgeons, neurologists, neurophysiologists, neuroradiologists,neuropsychologists and basic neuroscientists. Connections willbe the keyword of the congress, as the talks will exploreinteractions between the brain and gliomas, beginning with thenormal structure and function of the brain through fascinatingresearch in cortical and subcortical brain anatomy and theoreticbrain function modeling. Non-invasive brain mapping techniques,such as fMR (active and resting state), TMS and neuropsychologyexploration, will also be discussed, leading to a core feature ofthe congress, which includes the latest surgical techniques andintraoperative brain mapping. An entire section will be dedicatedto outcome measures, with a special emphasis on quality of lifefrom neurosurgical and neuropsychological perspectives. Indeed,connections between brain surgeons, neuroscientists,neuroimaging experts and neuropsychologists is definitely akeyword in modern glioma therapy. 

Marco Maria Fontanella Giannantonio Spena

WHEN THE CONNECTIONS ARE CRUCIALSeptember 24th – 26th, 2015

Auspices and Patronage

Italian Chapter International Societyfor Magnetic Resonance in Medicine

Invited Faculty

Barcia Juan (Madrid, Spain)

Bello Lorenzo (Milan, Italy)

Berger Mitchel (San Francisco, Usa)

Bergui Mauro (Turin, Italy)

Bizzi Alberto (Milan, Italy)

Buglione Di Monale Michela (Brescia, Italy)

Caleo Matteo (Pisa, Italy)

Carapella Carmine (Rome, Italy)

Caroli Manuela (Milan, Italy)

Carrabba Giorgio (Milan, Italy)

Castellano Antonella (Milan, Italy)

Cirillo Sossio (Naples, Italy)

D’Avella Domenico (Padova, Italy)

Delitala Alberto (Rome, Italy)

Dell’Acqua Flavio (London, UK)

Destrieux Christophe (Tours, France)

DiMeco Francesco (Milan, Italy)

Ducati Alessandro (Turin, Italy)

Duffau Hugues (Montpellier, France)

Esposito Vincenzo (Pozzilli, IS, Italy)

Fontanella Marco Maria (Brescia, Italy)

Garbossa Diego (Turin, Italy)

Gasparotti Roberto (Brescia, Italy)

Germano’ Antonino (Messina, Italy)

Giussani Carlo (Monza, Italy)

Hartwigsen Gesa (Kiel, Germany)

Innocenti Giorgio (Stockholm, Sweden)

Klein Martin (Amsterdam, Netherland)

Lo Russo Giorgio (Milan, Italy)

Magrini Stefano (Brescia, Italy)

Mandonnet Emmanuel (Paris, France)

Martino Gonzales Juan (Santander, Spain)

Miceli Gabriele (Rovereto, TN, Italy)

Miniussi Carlo (Brescia, Italy)

Missale Maria Cristina (Brescia, Italy)

Padovani Alessandro (Brescia, Italy)

Panciani Pier Paolo (Brescia, Italy)

Papagno Costanza (Milan, Italy)

Picht Thomas (Berlin, Germany)

Ramsey Nick (Utrecht, Netherland)

Rothwell John (London, UK)

Rouiller Eric (Fribourg, Swiss)

Rudà Roberta (Turin, Italy)

Sala Francesco (Verona, Italy)

Sganzerla Erik (Monza, Italy)

Skrap Miran (Udine, Italy)

Spena Giannantonio (Brescia, Italy)

Stefini Roberto (Brescia, Italy)

Stummer Walter (Munster, Germany)

Vercelli Alessandro (Turin, Italy)

Zona Gianluigi (Genova, Italy)

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14.00 Registration 15.00 Opening Ceremony15.25 Introduction15.30 I Session THE MICROSCOPIC BASIS OF PLASTICITY - 1st part16.30 Key Lecture Alessandro Vercelli (Turin, Italy)17.00

17.40 - 18.10 Coffee Break18.10 II Session THE MICROSCOPIC BASIS OF PLASTICITY - 2nd part19.00 Adjourn and Welcome aperitif

08.30 III Session FUNCTIONAL NEUROIMAGING NON-INVASIVEBRAIN MAPPING TECHNIQUE - 1st part

10.10 - 10.40 Coffee Break10.40 IV Session FUNCTIONAL NEUROIMAGING NON-INVASIVE

BRAIN MAPPING TECHNIQUE - 2nd part 10.40 Key Lecture John Rothwell (London, UK)11.1012.10 V Session FUNCTIONAL NEUROIMAGING NON-INVASIVE

BRAIN MAPPING TECHNIQUE- 3rd part 13.00 - 14.00 Buffet Lunch

14.00 VI Session FUNCTIONAL NEURO-ONCOLOGICAL SURGERY - 1st part15.20 Key Lecture Hugues Duffau (Montpellier, France)15.50

15.50 - 16.20 Coffee Break16.20 VII Session FUNCTIONAL NEURO-ONCOLOGICAL SURGERY - 2nd part16.20 Key Lecture Mitchel S. Berger (San Francisco, USA)16.5018.10 VIII Session FUNCTIONAL NEURO-ONCOLOGICAL SURGERY - 3rd part 19.00 Adjourn

08.30 IX Session OUTCOMES: QUALITY OF LIFE, SEIZURES, NEUROIMAGING - 1st part 10.10 - 10.40 Coffee Break

10.40 X Session OUTCOMES: QUALITY OF LIFE, SEIZURES, NEUROIMAGING - 2nd part10.40 Key Lecture Mitchel S. Berger (San Francisco, USA)11.1012.30 XI Session OUTCOMES: QUALITY OF LIFE, SEIZURES, NEUROIMAGING - 3rd part13.30 Closing Remarks13.40 End of the Meeting

AULA MAGNA

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14.00 Registration15.00

15.00 Opening CeremonyMarco M. Fontanella• Meeting PresidentSergio Pecorelli• Rector University of BresciaEzio Belleri• General Director Spedali Civili of BresciaMaurizio Memo• Dept. Molecular Medicine University of BresciaAlberto Delitala• SINch President

15.25 IntroductionGiannantonio Spena • Meeting Co-President

I SessionTHE MICROSCOPIC BASISOF PLASTICITY – 1st part

Moderators:Maria Cristina Missale (Brescia, Italy)Alessandro Ducati (Turin, Italy)

17’ presentation + 3’ discussion

15.30 CORTICAL AXONS, GEOMETRICAL AND TIMECOMPUTING PROPERTIESGiorgio Innocenti (Stockholm, Sweden)

15.50 POSTLESIONAL CORTICAL PLASTICITYEric Rouiller (Fribourg, Swiss)

16.10 GLIOMA-INDUCED PLASTICITY IN THE MOUSECEREBRAL CORTEXMatteo Caleo (Pisa, Italy)

16.30 Key LectureANATOMICAL CONNECTIVITY OF CORTICALPROJECTION NEURONSAlessandro Vercelli (Turin, Italy)

17.00 THE FIBRATLAS PROJECT: USING DISSECTION TOVALIDATE MR-TRACTOGRAPHYChristophe Destrieux, Ilyess Zemmoura(Tours, France)

17.20 CADAVER 3D FIBER DISSECTIONSJuan Martino Gonzalez (Santander, Spain)

17.40 Coffee Break

II SessionTHE MICROSCOPIC BASISOF PLASTICITY – 2nd part

Moderators:Diego Garbossa (Turin, Italy)Juan Martino Gonzalez (Santander, Spain)

7’ presentation + 3’ discussion

18.10 SELECTED ORAL COMMUNICATIONS19.00

18.10 CEREBELLUM CLUSTERING AND FUNCTIONALCONNECTIVITY  DURING PAIN PROCESSINGF. D’Agata, M. Diano, F. Cauda, T. Costa, K. Sacco,S. Duca, D.M. Torta, C.G. Geminiani (Turin, Italy)

18.20 SPECIFIC DISGUST PROCESSING IN THE LEFTINSULA: NEW EVIDENCE FROM DIRECTELECTRICAL STIMULATIONA. Pisoni, G. Mattavelli, A. Casarotti, A. Comi,F. Fumagalli, M. Vernice, E. Fava, M. Riva, L. Bello,C. Papagno (Milan, Italy)

18.30 FUNCTIONAL CONNECTIVITY CHANGES IN THEPRESENCE OF GLIOBLASTOMASN. Tuovinen1,2, F. de Pasquale1,2, C. Falletta Caravasso1,E. Giudice1, R. Miceli1, G. Ingrosso1, R. Santoni1,U. Sabatini1 (1Rome, Italy; 2Chieti, Italy)

18.40 EFFECTS OF KLINGLER'S PREPARATION ANDDISSECTION ON HUMAN WHITE MATTERULTRASTRUCTURE. AN ELECTRON MICROSCOPYSTUDYI. Zemmoura, E. Blanchard, P.I. Raynal, C. Rousselot-Denis, C. Destrieux, S. Velut (Tours, France)

18.50 LEFT FRONTAL ASLANT TRACT AND LANGUAGEFUNCTION: A CORTICAL-SUBCORTICALSTIMULATION MAPPING STUDYR. Lau, A. Fernández-Coello, J. Sierpowska, À. Camins,S. Castañer, M. Juncadella, A. Gabarrós (Barcelona, Spain)

19.00 Adjourn Welcome Aperitif

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IV SessionFUNCTIONAL NEUROIMAGINGNON-INVASIVE BRAIN MAPPINGTECHNIQUE – 2nd part

Moderators:Mauro Bergui (Turin, Italy)Roberto Gasparotti (Brescia, Italy)

17’ presentation + 3’ discussion

10.50 STUDYING BRAIN FUNCTION WITH TASK-FREEFMRINick F. Ramsey (Utrecht, Netherland)

11.10 MR DIFFUSION TRACTOGRAPHY: OVERCOMINGTHE LIMITS OF DTIFlavio Dell’Acqua (London, UK)

11.30 CLINICAL IMPACT OF PRESURGICAL MAPPINGIN ELOQUENT AREAS WITH FMRI AND MRDIFFUSION TRACTOGRAPHYAlberto Bizzi (Milan, Italy)

11.50 Discussion

V SessionFUNCTIONAL NEUROIMAGINGNON-INVASIVE BRAIN MAPPINGTECHNIQUE – 3rd part

Moderators:Giorgio Carrabba (Milan, Italy)Roberto Stefini (Brescia, Italy)

7’ presentation + 3’ discussion

12.10 SELECTED ORAL COMMUNICATIONS13.20

12.10 MAPPAGGIO PREOPERATORIO DELLACORTECCIA MOTORIA: CONFRONTO TRA fMRIBASATO SU COMPITO E fMRI A RIPOSOC. Rosazza1, D. Aquino1, L. D’Incerti1, R. Cordella1,A. Andronache1, D. Zacà2, M.G. Bruzzone1, G. Tringali1,L. Minati1,2 (1Milan, Italy; 2Trento, Italy)

III SessionFUNCTIONAL NEUROIMAGINGNON-INVASIVE BRAIN MAPPINGTECHNIQUE – 1st part

Moderators:Antonino Germanò (Messina, Italy)Alessandro Padovani (Brescia, Italy)

17’ presentation + 3’ discussion

08.30 TMS-EEG AND CONNECTIVITYCarlo Miniussi (Brescia, Italy)

08.50 HOW DOES TRANSCRANIAL MAGNETICSTIMULATION MODIFY NEURONAL ACTIVITYIN THE BRAIN?IMPLICATIONS FOR STUDIES OF COGNITIONGesa Hartwigsen (Kiel, Germany)

09.10 Key LectureTHERAPEUTIC NON-INVASIVE BRAINSTIMULATION: WHAT LIMITS TREATMENTSUCCESS?John Rothwell (London, UK)

09.40 INDUCING CORTICAL PLASTICITY WITHCORTICAL STIMULATIONJuan A. Barcia (Madrid, Spain)

10.00 TMS: USEFULNESS IN PRESURGICAL PLANNINGAND NAVIGATED TMSThomas Picht (Berlin, Germany)

10.20 Coffee Break

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13.10 PRESURGICAL MAPPING IN GLIOMAS: RESULTSOF THE ITALIAN DTI TRACTOGRAPHYCHALLENGEG. K. Ricciardi, G. Spena, A. Castellano, M. Caulo,T. Ius, M. Thiebaut de Schotten, A. Bizzi (Brescia, Italy)

13.20 Buffet Lunch14.00

Friday, September 25th, 2015

12.20 ADVANCED MAPPING OF THE CORTICO-SPINALTRACT IN BRAIN TUMORS: MR HARDI Q-BALLTRACTOGRAPHY OF THE DIFFERENTCOMPONENTS ACCORDING TO THEIRFUNCTIONAL ORIGIN AND VALIDATION WITHINTRAOPERATIVE STIMULATIONA. Castellano1, G. Cerri2, V. Blasi1, Paola Scifo1,M. Riva2, E. Caverzasi3, K. M. Jordan3, N. Papinutto3,E. Fava2, L. Fornia2, V. Ferpozzi2, M. Rossi2, A. Iadanza1,S.Crespi1, R. G. Henry1, L. Bello2, A. Falini1

(1Milan, Italy; 2Rozzano, Milan Italy; 3San Francisco, USA)

12.30 TRATTOGRAFIA CSD-BASED: UN‚AVANZATATECNICA DI RM NELLA VALUTAZIONEPRECHIRURGICA DEI GLIOMA DI ALTO GRADOC. Alafaci, F. Granata, E. Mormina, D. Marino,M. Longo, F. Tomasello (Messina, Italy)

12.40 NAVIGATED TRANSCRANIAL MAGNETICSTIMULATION FOR LANGUAGE MAPPINGINPATIENTS WITH BRAIN LESIONS IN DOMINANTPERYSILVIANAREAS: EVIDENCE OF LANGUAGEINTRA-HEMISPHERIC PLASTICITY AND IMPACTON OUTCOMEA. Germanò, A. Conti, G. Raffa, A. Scibilia,C. Sindorio, M. Quattropani, F. Tomasello (Messina, Italy)

12.50 NTMS-BASED DTI FIBER TRACKING OFLANGUAGE PATHWAYS IN BRAIN TUMORPATIENTS: A FEASIBILITY STUDYG. Raffa1, I. Bährend2, P. Vajkoczy2, T. Picht2 (1Messina, Italy; 2Berlin, Germany)

13.00 PREOPERATIVE PLANNING BASED ON NAVIGATEDTRANSCRANIAL MAGNETIC STIMULATIONIMPROVES SURGICAL TREATMENT OF BRAINLESIONS LOCATED NEAR THE MOTOR PATHWAYA. Germanò, A. Conti, G. Raffa, A. Scibilia,C. Sindorio, M. Quattropani, F. Tomasello (Messina, Italy)

VI SessionFUNCTIONAL NEURO-ONCOLOGICAL SURGERY – 1st part

Moderators:Carmine M. Carapella (Rome, Italy)Marco M. Fontanella (Brescia, Italy)

17’ presentation + 3’ discussion

14.00 PREOPERATIVE AND INTRAOPERATIVE COGNITIVEASSESSMENT IN GLIOMA PATIENTSGabriele Miceli (Rovereto, TN, Italy)

14.20 SURVIVAL AND FUNCTIONS IN LOW GRADEGLIOMASMiran Skrap (Udine, Italy)

14.40 A NEW PHILOSOPHY IN SURGERY FOR DIFFUSELOW-GRADE GLIOMAS: TOWARDS APROPHYLACTIC AND FUNCTIONAL NEURO-ONCOLOGYHugues Duffau (Montpellier, France)

15.00 TAILORING NEUROPHYSIOLOGICAL STRATEGIESIN GLIOMAS INVOLVING MOTOR PATHWAYSLorenzo Bello (Milan, Italy)

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15.20 Key LectureBRAIN PLASTICITY AND SURGICAL RESECTIONOF GLIOMASHugues Duffau (Montpellier, France)

15.50 Coffee Break

18.10 SELECTED ORAL COMMUNICATIONS19.20

18.10 SUBCORTICAL LANGUAGE AND NON-LANGUAGE MAPPING IN AWAKE BRAINSURGERY: THE USE OF MULTIMODAL TESTSE. Robert1, H. Colle1, E. De Witte2, D. Satoer3,E. Visch-Brink 4, P. Marien5 (1Ghent, Belgium; 2Brussels,Belgium; 3Groningen, Belgium; 4Rotterdam, TheNetherlands; 5Anversa, Belgium)

18.20 ELASTOGRAFIA STRAIN NELLA CHIRURGIA DEITUMORI GLIALIL. Mattei, F. Prada, A. Moiraghi, A. Rampini, M. Del Bene, F. DiMeco (Milan, Italy)

18.30 AWAKE CRANIOTOMY: XENON ANESTHESIAAND DEXMEDETOMIDINE SEDATION ASALTERNATIVES FOR PROPOFOLA. Kulikov, D. Sel’kov, G. Kobyakov, S. Buklina,A. Lubnin (Moscow, Russia)

18.40 INTRAOPERATIVE LANGUAGE MAPPING WITHNOUNS AND FINITE VERBSA. Rofes1, G. Spena2, A. Talacchi3, B. Santini3,A. Miozzo2, G. Miceli1 (1Trento, Italy; 2Brescia, Italy,3Verona, Italy)

18.50 THE NEGATIVE MOTOR NETWORK AND ITSASSESSMENT DURING AWAKE SURGERYF. Rech1, G. Herbet2, S. Moritz-Gasser2, H. Duffau2

(1Nancy, France; 2Montpellier, France)

19.00 CORRELAZIONE CLINICA TRA OUTCOMENEUROLOGICO E DIVERSE SOGLIE DI ALLARMEPER I POTENZIALI EVOCATI MOTORI DURANTEIL MONITORAGGIO NEUROFISIOLOGICO INTRAOPERATORIO NELLA CHIRURGIA DELLEAREE MOTORIEC. Parisi, V. Tramontano, G. Pinna, A. Pasqualin,M. Meglio, F. Sala (Verona, Italy)

19.10 5-AMINOLEVULINIC ACID-GUIDED SURGERY INPRIMARY AND RECURRENT MALIGNANTGLIOMAS. ITS RELATIONSHIP WITH THE AREAOF RESECTION AND APPEARANCE OF NEWPOSTOPERATIVE NEUROLOGICAL DEFICITSM. Carvi y Nievas (Traunstein, Germany)

19.20 Adjourn

VII SessionFUNCTIONAL NEURO-ONCOLOGICAL SURGERY – 2nd part

Moderators:Vincenzo Esposito (Pozzilli, IS, Italy)Giannantonio Spena (Brescia, Italy)

16.20 Key LectureFUNCTIONAL OUTCOME AFTER LANGUAGEMAPPING FOR GLIOMA RESECTIONMitchel S. Berger (San Francisco, USA)

17’ presentation + 3’ discussion

16.50 5-ALA UPDATEWalter Stummer (Münster, Germany)

17.10 INTRAOPERATIVE CONTRAST ENHANCEDULTRASOUND (CEUS) IN BRAIN TUMORSURGERYFrancesco DiMeco (Milan, Italy)

17.30 INTRAOPERATIVE NEUROPHYSIOLOGICALMONITORING FOR THE RESECTION OF BRAINTUMORS IN PEDIATRIC PATIENTSFrancesco Sala (Verona, Italy)

17.50 Discussion

VIII SessionFUNCTIONAL NEURO-ONCOLOGICAL SURGERY – 3rd part

Moderators:Manuela A. Caroli (Milan, Italy)Gianluigi Zona (Genova, Italy)

7’ presentation + 3’ discussion

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I IX SessionOUTCOMES: QUALITY OF LIFE,SEIZURES, NEUROIMAGING – 1st part

Moderators:Stefano Magrini (Brescia, Italy)Alberto Delitala (Rome, Italy)

17’ presentation + 3’ discussion

08.30 NEUROCOGNITIVE FUNCTION AND QUALITYOF LIFE IN GLIOMA PATIENTSMartin Klein (Amsterdam, Netherland)

08.50 THE ROLE OF NEUROCOGNITIVE ASSESSMENTIN THE FOLLOW-UP OF GLIOMASCostanza Papagno (Milan, Italy)

09.10 SEIZURE IN LOW GRADE GLIOMAS: A BIOMARKEROF TREATMENT RESPONSE AND AN END-POINTFOR CLINICAL TRIALSRoberta Rudà (Turin, Italy)

09.30 GLIOMAS SURGERY OR EPILEPSY SURGERY ?Giorgio Lo Russo (Milan, Italy)

09.50 DIRECT BRAIN MAPPING, INTRAOPERATIVESEIZURES AND ANTIEPILEPTIC DRUGPROPHYLAXIS: A SURVEY AMONG 18NEUROSURGICAL EUROPEAN CENTERSGiannantonio Spena (Brescia, Italy)

10.10 Coffee Break

Saturday, September 26th, 2015

10.40 Key LectureOPTIMIZING OUTCOMES FOR PATIENTS WITHGLIOMAS: A PERSONAL JOURNEYMitchel S. Berger (San Francisco, USA)

17’ presentation + 3’ discussion11.10 INCIDENTALLY DISCOVERED LGG: TIME FOR

SCREENING?Emmanuel Mandonnet (Paris, France)

11.30 RADIO-CHEMOTHERAPY OF GLIOMAS: DOSESAND THEIR CORRELATION WITH CLINICAL ANDFUNCTIONAL OUTCOMEMichela Buglione di Monale (Brescia, Italy)

11.50 ROLE OF DIFFUSION TENSOR MAGNETICRESONANCE TRACTOGRAPHY IN PREDICTINGTHE EXTENT OF RESECTION IN GLIOMA SURGERYAntonella Castellano (Milan, Italy)

12.10 Discussion

XI SessionOUTCOMES: QUALITY OF LIFE,SEIZURES, NEUROIMAGING – 3rd part

Moderators:Carlo G. Giussani (Monza, Italy)Pier Paolo Panciani (Brescia, Italy)Erik Sganzerla (Monza, Italy)

7’ presentation + 3’ discussion

12.30 SELECTED ORAL COMMUNICATIONS13.40

12.30 COGNITIVE OUTCOME AFTER AWAKE SURGERYFOR LEFT AND RIGHT HEMISPHERE TUMOURSE. De Witte1, D. Satoer2,3, E. Visch-Brink2, P. Mariën1,4

(1Brussels, Belgium; 2Rotterdam, The Netherlands;3Groningen, The Netherlands; 4Anversa, Belgium)

X SessionOUTCOMES: QUALITY OF LIFE,SEIZURES, NEUROIMAGING – 2nd part

Moderators:Sossio Cirillo (Naples, Italy)Domenico d’Avella (Padova, Italy)

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12.40 THE SHORTENED DULIP PROTOCOL:A STANDARDIZED TOOL TO EVALUATELANGUAGE PERFORMANCE BEFORE AND AFTERAWAKE GLIOMA SURGERYD. Satoer1,2, E. De Witte3, R. Bastiaanse2, P. Mariën3,4,E. Visch-Brink1 (1Rotterdam, The Netherlands; 2Groningen, TheNetherlands; 3Brussels, Belgium; 4Anversa, Belgium)

12.50 COMPARISON OF DYNAMIC SUSCEPTIBILITYCONTRAST- ENHANCED MR AND DYNAMICCONTRAST-ENHANCED MR IMAGING IN GLIOMAGRADINGC. Santarosa, A. Castellano, G. Conte, A. Iadanza,M. Cadioli, A.Franzin, M.R. Terreni, A. Falini, N. Anzalone(Milan, Italy)

13.00 PHYSICAL EXERCISE TO IMPROVE COGNITIVEFUNCTIONING IN GLIOMA PATIENTS: A PILOTRCTK. Gehring1, M.M. Stuiver2, G.J. Rutten1, M.J.B.Taphoorn3, N.K. Aaronson2, M.M. Sitskoorn1

(1Tilburg, The Netherlands; 2Amsterdam,The Netherlands; 3The Hague, The Netherlands)

13.10 HOW TO EXPLAIN COGNITIVE PROBLEMS TOA BRAIN TUMOR (BT) PATIENTM. Kallio (Helsinki, Finland)

13.20 TRAIETTORIE FUNZIONALI E SOPRAVVIVENZAIN PAZIENTI RIABILITATI DOPO TRATTAMENTOPER GLIOMAG. Cerina, L. Barulli, S. Ghirmai, C. Corsini,V. Colantonio, M. Pagani, B. Bernardini(Rozzano, Milan, Italy)

13.30 WHY GLIOMA PATIENTS SEIZE? ADDING GABAAND CHLORIDE TO THE GLUTAMATEHYPOTHESISJ. Pallud (Paris, France; Groland, France)

13.40 Closing Remarks

13.50 End of the Meeting

POSTERSP01 A CAUSE OF FOCAL EPILEPTIC SEIZURES:

GLIOMAF. Yakar (Ankara, Turkey)

P02 IMPACT OF HEADACHES UPON THE POST-RADIOTHERAPEUTIC QUALITY OF LIFE OFGLIOBLASTOMA MULTIFORME PATIENTS:

A QUALITATIVE STUDYS. Bennett, G. Cruickshank, A. Lindenmeyer,S. Morris (Birmingham, UK)

P03 SEGREGATING SURPRISE AND HAPPINESSPROCESSING NETWORKS IN THE LEFTHEMISPHERE: A VOXEL LESION SYMPTOMMAPPING STUDYG. Mattavelli1, A. Pisoni1, A. Casarotti2, A. Comi2,G. Sera1, M. Riva2, M. Rossi2, A. Bizzi2, L. Bello1,2,C. Papagno1 (1Milan, Italy; 2Rozzano, Milan, Italy)

P04 SPONTANEOUS SPEECH SEVEN MONTHS AFTERAWAKE GLIOMA SURGERYA. Rofes1,2,4, B. Santini3, A. Talacchi3, G. Pinna3,L. Nickels4, R. Bastiaanse5, G. Miceli2 (1Trento, Italy;Macquarie, Australia; Potsdam, Germany; Groningen,The Netherlands; Newcastle, UK; 2Trento, Italy;3Verona, Italy; 4Sydney, Australia; 5Groningen, TheNetherlands)

P05 PERFUSION WEIGHTED IMAGING IN THE STUDYOF BRAIN GLIOMAS: REPRODUCIBILITY ANDCOMPARISON OF DATA OBTAINED BY USINGTWO DIFFERENT SOFTWARE PLATFORMSG.M. Conte, A. Iadanza, M. Cadioli, A. Castellano,M.R. Terreni, A. Franzin, G. Calori, A. Falini, N. Anzalone(Milan, Italy)

P06 THE RELATIONSHIP BETWEEN THE MAGNITUDEOF ACTIVITY IN THE LEFT AND RIGHTHEMISPHERE AND THE LANGUAGELATERALIZATION INDEX AS DETERMINED WITHLANGUAGE FMRIJ.M. Jansma1,2, N.F. Ramsey2, G.J.M. Rutten1

(1Tilburg, The Netherlands; 2Utrecht, The Netherlands)

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P07 HIGH RESOLUTION 3T fMRI: PROTOCOLOPTIMIZATION FOR PRESURGICAL APPLICATION,WITH SINGLE FINGER SOMATOTOPY WITHINTHE PRIMARY MOTOR AREAP. Vitali, N. Anzalone, G. Germani, A. Faggioli,L. Casiraghi, G. Castellazzi, C. Wheeler-Kingshott(Pavia, Italy; Milan, Italy)

P08 PROTOCOL STUDY BY FMRI AND DTI INPATIENTS WITH LESIONS IN PREMOTOR REGION:WHEN, WHY AND HOW?S. Castañer, À Camins, J. Sierpowska, S. Ruth Lau,A. Fernández, A. Gabarrós, M. Juncadella, A. Rodríguez,C. Majós, C. Aguilera (Barcelona, Spain)

P09 THE INVOLVEMENT OF THE MIDDLE FRONTALAREAS IN LANGUAGE SWITCHING:INTRAOPERATIVE ELECTRICAL STIMULATIONEVIDENCEJ. Sierpowska, A. Gabarrós, A. Fernandez-Coello,À Camins, S. Castañer, M. Juncadella, A. Rodríguez-Fornells (Barcelona, Spain)

P10 LANGUAGE REORGANIZATION CAPACITY INPATIENTS WITH GLIOMAS IN THE FRONTAL ANDTEMPORAL LOBES OF THE LEFT HEMISPHEREA. Chrabaszcz, S. Buklina, V. Tolkacheva,A. Poddubskaya, O. Dragoy (Moscow, Russia)

P11 DEVELOPMENT OF READING AND WRITINGASSESSMENT IN AWAKE SURGERYF.C. Van Ierschot1, A. Miozzo1, G. Spena2,M.M. Fontanella2, G. Miceli1 (1Rovereto, TN, Italy;2Brescia, Italy)

P12 WHITE MATTER CONNECTIONS BETWEENSUPPLEMENTARY MOTOR AREA AND ANTERIORTEMPORAL LOBE IN FACE RECOGNITION ANDNAMING: A RETROSPECTIVE STUDYG. Bertani, B. Zarino, M. Minichiello, M. Caroli,M. Locatelli, P. Rampini, G. Carrabba (Milan, Italy)

P13 AWAKE SURGERY IN RECURRENT GLIOMASB. Zarino, G. Bertani, M. Caroli, M. Locatelli,P. Rampini, G. Carrabba (Milan, Italy)

P14 MAPPING OF VISUO-SPATIAL ABILITIES BY USINGNAVIGATED TRANSCRANIAL MAGNETICSTIMULATION: A FEASIBILITY STUDY IN HEALTHY SUBJECTS AND PATIENTS AFFECTEDBY NON- DOMINANT PARIETAL TUMORSA. Germanò, A. Conti, G. Raffa, A. Scibilia,C. Sindorio, M. Quattropani, F. Tomasello (Messina,Italy)

P15 THE ROLE OF PREOPERATIVE NEUROCOGNITIVEASSESSMENT FOR CORTICAL COGNITIVEMAPPING: ONE SIZE DOESN T FIT ALLC. Sindorio, M. Quattropani, G. Raffa, A. Scibilia,A. Conti, A. Germanò (Messina, Italy)

P16 NEUROPSYCHOLOGICAL ASSESSMENT IN LEFTFRONTAL GLIOMA PATIENT’S: THE ROLE OFEXECUTIVE FUNCTIONS AND MEMORY SKILLSFOR POSTOPERATIVE FUNCTIONAL OUTCOMEAND HEALTH RELATED QUALITY OF LIFEM. Quattropani, C. Sindorio, G. Raffa, A. Scibilia,A. Conti, A. Germanò (Messina, Italy)

P17 SOPRAVVIVENZA NEL TRATTAMENTO DEIGLIOMI AD ALTO GRADO CON WAFERS DICARMUSTINA: NOSTRA ESPERIENZA SU 112 PAZIENTI E CONFRONTO CON STUDIOMETA-ANALITICOL.A. Lattanzi, V. Fanelli (Taranto, Italy)

P18 5-ALA INTRAOPERATIVE FLUORESCENCE INLOW-GRADE GLIOMA SURGERY:A RETROSPECTIVE STUDY OF 27 PATIENTSS.A. Goryaynov, A.A. Potapov, M.F. Goldberg,L.V. Shishkina, M.V. Ryzhova, A. P. Chumakova,V.Y. Zhukov, V.A. Ohlopkov, T. Saveleva,M.D. Varuykhina (Moscow, Russia)

P19 FLUORESCENCE GUIDED RESECTION OFGLIOBLASTOMA. CORRELATION BETWEEN THEFLUORESCENCE INTENSITY AND THEPROPORTION OF MALIGNANT CELLS IN THETISSUET. Krcik, P. Buzrla (Ostrava, Czech Republic)

P20 IMAGING DI DIFFUSIONE E TRATTOGRAFIA;L’INFLUENZA DEI PARAMETRI DI ACQUISIZIONEC. Maffei1, F. Dell’Acqua2, J. Jovicich1 (1Trento, Italy;2London, UK)

POSTERS

AUDIOVISUAL EQUIPMENTPC Projection (only POWER POINT file on CD or on a memory stick, USB portor DVD) will be provided. Speakers are kindly requested to contact the SlideCenter, placed inside the Aula Magna, to upload their presentation(s), in orderto test all the audiovisual material at least one hour before the lecture. Thepresentation will be forwarded through Local Area Network (LAN) directly tothe Podium.The use of personal laptop (MAC/PC) is allowed but the speaker must check itwith the technician.Please, adhere strictly to the time allotted for each intervention.

ATTENDANCE CERTIFICATEAt the end of the meeting an attendance certificate will be given to alla registredparticipants.

OFFICIAL LANGUAGESThe official language of the meeting is English without simultaneous translation.

CALL FOR ABSTRACTSThe Organizing Committee invites You to partecipate actively at the Meeting.You are kindly invited to submit your abstracts in English for oral presentationusing the online form on www.mymeetingsrl.comThe receipt of abstract will be acknowledged automatically by e-mail to thepresenting author upon the on-line submission.Notification of acceptance/rejection will be notified not later than June 30th, 2015.

Deadline for abstract submission: May 31st, 2015Abstract submitted after the deadline might be not accepted.All participants must register for the Meeting in order to be accepted as speakerspresenters, unless invited.

Scientific Information

Topics of the meeting:

• Brain connections from ananatomical perspective

• The anatomical and microanatomicalbasis of plasticity

• Cadaver fiber dissection• Preoperative non invasive brain

mapping techniques• Functional connectivity on fMRI• fMRI and resting state in presurgical

planning• Diffusion tensor imaging: presurgical

usefulness and future developments• TMS in preoperative setting• TMS and mapping of functional and

effective connectivity• Therapeutic non invasive brain

stimulation• Pre, intra and follow-up

neuropsychological assessment• How gliomas alter brain connectivity• Intraoperative brain mapping: the

right technique for the right patient• Intraoperative Neurophysiological

monitoring• Intraoperative anesthesia protocols

to improve patients’ cooperation• New surgical tools to enhance

resection of gliomas• Quality of life assessment• Seizures and gliomas• New imaging techniques for the

diagnosis and follow-up of gliomas

VARIATIONSThe Scientific and the Organizing Secretariats reserve the right to make whateverchange to the program they deem necessary for scientific and/or technical reasons.

CME Accreditation

CME Accreditation is required for italian participant only.

Accreditamento NAZIONALE previsto A GIORNATA esclusivamente per legiornate di venerdì e sabato.My Meeting Provider provvisorio ECM n. 1396 ha assegnato all’evento formativo:• Venerdì 25 Settembre n. 4,5 crediti ECM, accreditamento per 9 ore di lavoroper 200 partecipanti - Codice evento n. 134997• Sabato 26 Settembre n. 2 crediti ECM, accreditamento per 4 ore di lavoroper 200 partecipanti - Codice evento n. 135014

Categorie AccreditateCategoria Medico Chirurgo discipline:-Neurologia-Neurochirurgia-Oncologia-Neuroradiologia-Radiodiagnostica-Radioterapia-Medicina Fisica E Riabilitazione-Neurofisiopatologia-Neuropsichiatria Infantile

Categoria PsicologoCategoria Tecnico Di NeurofisiopatologiaCategoria Tecnico Sanitario Di Radiologia MedicaCategoria Tecnico Della Riabilitazione Psichiatrica

I crediti formativi saranno certificati dal Provider Provvisorio My Meeting n. 1396secondo le normative della CNFC pubblicate sito www.agenas.itL’attestato conferente i crediti sarà spedito con posta certificata PEC solamenteai partecipanti che avranno frequentato l’intero percorso formativo accreditato(100% del monte ore) e riconsegnato il fascicolo E.C.M. debitamente compilatocon il raggiungimento del 75% delle risposte esatte del questionario di apprendimento.

Scientific Information

REGISTRATION FEES (VAT included)

Regular € 150,00EANS Members € 125,00Residents and Trainees°Accompanying person € 100,00Company Staff*

The Regular, Residents and Trainees registration fee includes:• Attendance to all Scientific Sessions • Entrance to the exhibition area• Attendance Certificate • Badge and Meeting Kit• Food & Beverage

The Accompanying Person registration fee includes:• Difference between single and double room• Food & Beverage

The Company Staff registration fee includes:• Entrance to the exhibition area • Food & Beverage

Registration Form will be available only on the dedicated websitehttp://www.mymeetingsrl.com/site/index.php?idsite=130

HOW TO REGISTER AND HOW TO PAYTo subscribe to this Meeting is necessary to fill the Registration Form andsend it together with payment to the Organizing Secretariat My Meeting(Fax +39 051/795270 - e-mail: info@mymeetingsrl.com).The registration will be confirmed by e-mail with a voucher.No registration will be processed unless accompanied payment.A receipt of payment for the total amount will be issued directly by My Meeting Srl.

Deadline for registration September 18th, 2015.After this date you can enroll only at the Meeting Venue

FOR ITALIAN PARTICIPANT ONLYISCRIZIONI A CARICO DI ASL E AZIENDE OSPEDALIEREIn caso di richiesta di emissione fattura nei confronti di enti esenti IVA, quali ad esempio A.S.L.o Aziende Ospedaliere, il partecipante dovrà farne richiesta al momento dell’invio della schedadi iscrizione (barrando l’apposita casella e apponendo il timbro dell’ente) ed effettuare il pagamentocontestualmente all’invio della scheda. Qualora l’A.S.L. o A.O. non riuscisse a fornire al partecipantecopia dell’avvenuto pagamento da allegare alla scheda di iscrizione, quest’ultimo dovrà anticiparnela quota. Sarà comunque emessa fattura quietanzata intestata secondo quanto riportato sullascheda di iscrizione da parte del partecipante. Una volta emesse le fatture non potranno esseremodificate. Per il pagamento chiediamo di attenersi scrupolosamente alle quote ESENTI IVA

VENUEAULA MAGNAFACULTY OF MEDICINE - UNIVERSITY OF BRESCIAViale Europa, 11 - 25123 Brescia • Italy - Ph. +39 030 2988201

General Information

°Proof must be providedby the ProgramDirector

* In addition to thoseincluded in thesponsorship agreement

MAIN DISTANCEAND HOW TO GET THEREDistance between venue and city center 4 km.

By air – Bergamo airport "Orio al Serio" atabout 53 Km.Verona Villafranca Airport "Valerio Catullo"about 60 Km.Milan Airport Linate at about 90 Km.Milan Malpensa Airport Malpensa at about 130 Km.

By car - From Highway A4 Milano - Veneziaexit Brescia Ovest. At the exit, take the RingRoad West continuing along the North Freeway.Follow the directions Stadium or hospital andcontinue to Via Oberdan. Going all the way, turnleft into the Triumplina and after about 800meters turn right for via Branze, the Faculty ofMedicine is located on the right, to enter theconference venue follow signs Emergency Hospital

By train - Brescia railway station is about 4.5 kmSchedules and costs on www.ferroviedellostato.it,Trenitalia number 892021

USEFUL NUMBERSRadiotaxi Brescia+39 030 35111Brescia Tourist Information+39 030 2400357

HOTEL ACCOMMODATIONOn the occasion of the Meeting have been provided agreements for special rateswith some hotels located near the Congress venue and the City centre.

Visit the dedicated websitehttp://www.mymeetingsrl.com/site/index.php?idsite=130to download the fact sheet of the hotels allottment.

To make your reservation, please contact the hotels directly referring to the MyMeeting convention and "The Brain and Gliomas" congress.It is advisable to make reservations in advance and no later than September 7th,2015. Reservations received after this date will be processed on the basis of theremaining availability.

INSURANCERegistration fees do not include insurance of any kind. It is strongly recommendedthat any time your register for the Meeting and book your travel you take outan insurance policy of your choice. The Organizing Secretariat cannot take anyresponsibility for any Participant failing to arrange their own insurance. Thisinsurance is to be purchased in your country of origin.

VISASome participants may need an entry VISA for Italy.Participants are requested to consult the Italian Embassy or Consulate in theirhome country or with their travel agency for specific details relating to visarequirements.It is the responsibility of the participant to obtain a visa if required.For more information see the web site of the Italian Ministry of Foreign Affairs:http://www.esteri.it/visti/index_eng.asp

PrivacyYour personal data, voluntarily provided on this occasion and collected by My Meeting Srl, shall bemanually and electronically processed, for the following purposes: keeping files on your participationin Congresses, Conferences, Meetings and other Events organized by My Meeting Srl and in compliancewith law provisions. Your personal data shall be communicated to suppliers and third parties involvedor participating in the Event as well as to relevant public authorities, in compliance with low provisions.Provision of requested personal data for the purposes listed above is compulsory for your participationin the Event. Personal data are kept by My Meeting Srl – Via 1° Maggio 33/35 – 40064 Ozzanodell’Emilia (BO) – Italy. You shall be entitled to exercise all the rights provided for by Title II ofLegislative Decree no. 196/2003. By signing the Registration Form of the Congress you declare thatyou read the information provided and give your consent to the processing and communication ofyour personal data for the purposes listed above.

General Information

Thanks to

Silver Sponsor

and

Update to 20/07/2015

Gold Sponsor

Platinum Sponsor

H8 - stampato Luglio 2015

My Meeting S.r.l.Via 1ºMaggio 33/35 - 40064 Ozzano dell’Emilia (BO), ItalyTel. +39 051 796971 - Fax +39 051 795270info@mymeetingsrl.com - www.mymeetingsrl.com

OrganizingSecretariat

WHEN THE CONNECTIONS ARE CRUCIAL

More details onwww.mymeetingsrl.com