Spectra Blend Color

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S E N S I E N T'M


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The Complete FilmCoating System

Spectrablend" film coating system is the answer to your film coat-

ing problems. Sensient's patented process is proven to be faster and

easier to use than competitive products. Spectrablend'" is the

complete film coating system - a prehydrated combination of poly-

mer, plasticizer and pigment It offers the user substantial benefits

when compared to other products of this type.

Thisunique processagglomerates particles,resulting in a dust-free

and free-flowingphysicalform Pre-hydration,another key property

of Spectrablend", is invaluable in reducing preparation time.

Spectrablend" is offered in both clear and colored formats. An

alternative option is to pigment Spectrablend'. clear using a color

dispersion.

SPECTRABLEND'MCLEAR

Polymer+

Plasticizer+

Water

SpectrablendTMadvantages

When comparing Spectrablend'" to alternatives, Spectrablend" was shown to be the superior product in all properties studied. The com-

bined features of Spectrablend'. result in easy handling and reduced processing time, thereby improving efficiency and reducing cost The

versatility of Spectrablend" allows the use of a wide range of plasticizers, film formers and natural or synthetic colors. This offers flexibility

to meet specific customer requirements.

Reduced Processing Time

Easy Handling

2 www.sensient-tech.com

. Agglomerated particles

. Dry granule. Free flowing

. Non-dusting

. Rapid Hydration

. Microbial Stability

. Lot-to-Lot Consistency


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SpectrablendTMPowder Properties

ParticleSizeDistributionThe particlesizeofSpectrablend'"is greaterwhen comparedto

competition.Thisnon-dustingnatureofSpectrablend'"resultsin an

increasedeaseof handling.

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-Spectrablend'. Competitor

A 200gm powder sample was screened sequentially via Roto-Tap Automaticsieve for 10 minutes.

DispersionPreparation

Rapid HydrationSpectrablend'"can be rapidlydispersedin water. This res

reducedprocessingtimes,therebyincreasingefficiency.

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Spectrablend'" HPMC

A 50gm powder sample was mixed at 700RPMin 450gm water. At time in

indicated, a 10gm sample was drawn, filtered using no. 1 Wratten fill

evaporated to dryness ayer 3 hours at 1100 Cto determine percent solid

TabletCoating Parameters

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Spectrablend'Mdispersionsaretypicallymadeat 12-15%solids

Tabletsaretypicallycoatedto a 0.5-3%weightgain

Typicalatomizingair pressurerangesfrom40-50PSI

Typicalair velocityranges200-400cu.ft./min.

Inletair temperatureis typically60-750C

Exhaustair temperatureis typically35-500C

Typicalpanspeedis 6-20RPM

(Theseare typical coating parametersand are subjectto equipmentefficiency,tablet type and

1. Pourwater into suitablevessel

2. Createvortex in water

3. PourSpectrablendintovortex

4. Reducespeedand mix for 30 minutesor untillump-free

5. Dispersionis now readyfor use.

TheCompleteFilm Coating System

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Coating Properties

Moisture Vapor TransmissionSpectrablend'"films are lesspermeableto water vaporthan the

competition.Thishelpsto protectthe activedrugfrom degradation.

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Spect"blend" Competitor

Filmsof the resultant dispersions were cast on glass, dried and tested for mois-tu re vapor transmission over a saturated NaClsolution.

Accelerated AgingSpectrablend'"films are morestablethan the competitionwhen

challengedby hightemperatureandhighhumidity

- Spect"blend" CompetitorTablets exposed to 400 C and 7S% relative humidity

Light StabilitySpectrablend'"films are more resistantto degradationby visiblelightthanthecompetition.Thishelpsto increasethe shelf-lifeof thecoatedtablet.

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ICHlight stability performed on tablets positioned 13" from a 2400 lux light

Film Strength and ElongationSpectrablend'"filmsaresignificantlystrongerwith greaterel

when comparedto thecompetition.

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-Spectrablend" Competitor

Films were studied using a Texture Technologies' texture analyzer

Disintegration TimeThe ability of Spectrablend'"to disintegratefaster increas

efficiencyof drugdelivery.

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Technical Support

Sensienr"PharmaceuticalTechnologiesoperatescustomerservice

and R&Dlaboratoriesstaffedby highlyexperiencedtechnicalteams

that canadviseon applicationformulation,new productdevelop-

mentand globallegislativerequirements.Ourskilledtechniciansare

availableto assistin solvingwhatevercoatingand color problems

youmayencounter.Asthe leadingglobalmanufacturerof high-

regulatedsyntheticand naturalcolors,we havemuchto offer

technicalserviceisconfidentialandwe welcomeinquiriesfrom

customers.

World leader in colors and film formers

Sensienr"hasbeentheworld leaderin colorsfor over90years.Wehavetakenour basiccolorknowledgeandgrown into a leadingt

coatingmanufactureroWith officesall overthe world,Sensienr"hasa broadknowledgeof the globalpharmaceuticalmarkets.Relyo

to find suitablecolorsand coatingsto salveyourtabletcoatingneeds.

. SpectracolSyntheticOyes,Lakesand Pigments

NaturalColors

Spectracel- Hypromellose(HPMC)

SpectracylTM- AcrylicPolymers

Colordispersions

Additionalfilm coatingsystems

---'Additional Products offered bySensienfMPharmaceuticalTechnologies:

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Documents

Spectra Blend Color