J. Indian Chem. Soc., Vol. 97, No. 8 Annual Subscription : ` 5000/US $ 600

August 2020 Retail Price : ` 500/US $ 65

Special Issue on “Medicinal Chemistry”

Published by Indian Chemical Society

92, Acharya Prafulla Chandra Road

Kolkata-700 009, India

J. Indian Chem. Soc., Vol. 97, August 2020

Th e I n d i a n C hem i c a l So c i e ty Office-Bearers (2020)

Advisors (Those who have filled the office of the President)

Suresh C. Ameta (Udaipur) Girjesh Govil (Mumbai) D. Banerjea (Kolkata) Jai P. Mittal (Navi Mumbai) D. S. Bhakuni (Lucknow) Dulal C. Mukherjee (Kolkata) Ramesh Chandra (Delhi) K. B. Pandeya (Allahabad) M. C. Chattapadhyaya (Allahabad) R. N. Prasad (Jaipur) Sukh Dev (Bhavnagar) Sunil Kumar Talapatra (Kolkata)

President G. D. Yadav (Mumbai)

Vice-President

R. D. Kaushik (Haridwar) Ashok Kr. Jha (President, Bhagalpur Branch) Hony. Secretary Hony. Treasurer

Chittaranjan Sinha (Kolkata) Sudip Kumar Das (Kolkata) Editor-in-Chief

G. D. Yadav (Mumbai)

Hony. Editors

A. C. Bhasikuttan (Mumbai) Sundargopal Ghosh (Chennai) Chhanda Mukhopadhyay (Kolkata)

Editor (Guest) Shivendu Ranjan (Lucknow/South Africa)

International Executive Editor Bimal K. Banik (USA )

International Editors

Takashiro Akitsu (Japan ) Anil Kumar (India ) Ebbe Nordlander (Sweden )

Members of the Council A. Anton Smith (Annamalai Nagar) K. Mohanan (Trivandrum) Anand S. Aswar (Amravati) Sheo Satya Prakash (Patna) Rakshit Ameta (Udaipur) Ch. Venkata Ramana Reddy (Hyderabad) Samir Biswas (Kolkata) Mahendra Nath Roy (Darjeeling) Nibedita Chakrabarti, Assistant Secretary (Kolkata) R. V. Singh (Jaipur) K. R. Genwa (Jodhpur) Scientist (To be nominated by the DST, New Delhi) R. N. Jadeja (Vadodara) R. K. Vatsa (Mumbai) Asok K. Mallick (Kolkata) Ranjit K. Verma (Munger)

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J. Indian Chem. Soc., Vol. 97, August 2020

Preface

Chemistry underpins everything that the advancement of modern science is associated with.

It plays the pivotal role in the health care system and particularly in the realm of pharmaceutical

sciences. In drug discovery and development, chemistry specifically organic synthesis holds the

central stage. The advancement in chemical research is the key indicator of the economic growth

and the societal development of any country. Chemical research has been one of the major

strengths of our country that earned India the status of the pharmacy of the world. Acharya

Prafulla Chandra Ray has been the doyen of chemical science in India showing it the path and

strength of entrepreneurship that laid the foundation of the pharma sector in the country. Thus, the

Indian Chemical Society has chosen appropriately to pay tribute to its founder Acharya Prafulla

Chandra Ray in organising the International Seminar on “Recent Advancements in Chemistry &

Material Sciences-2020 (RACMS-2020)” through the month of August 2020 to commemorate

his 159th Birth Anniversary. Under the scenario of COVID-19 pandemic and realising the

necessity of development of therapeutics to cope up such unprecedented adverse impact on the

healthcare system the decision of the Indian Chemical Society to dedicate a special issue of the

Journal of Indian Chemical Society on Medicinal Chemistry for the above International

Conference is the most fitting gesture to reflect the act and concern of Acharya Prafulla Chandra

Ray under such a need of the hour. It is our great pleasure that the Special Issue (August, 2020)

has been published with some invited contribution from the practicing medicinal chemists of the

country in various reputed institutes/universities. We cordially acknowledge with heartiest

admiration the scholastic contribution of the authors, who kindly responded promptly with their

articles. We believe that this token gesture of the Indian Chemical Society will further sensitize

the creative minds to focus their research endeavours towards new drug discovery and

development.

G D Yadav Chittaranjan Sinha Asit K. Chakraborti Debprasad Chattopadhyay

Chhada Mukhopadhyay

Sundargopal Ghosh President Honorary Secretary Tapas K. Hazra A C Bhasikuttan

Guest Editors

J. Indian Chem. Soc.,

Vol. 97, August 2020

Journal of the Indian Chemical Society

VOLUME 97 NUMBER 8 August 2020

C O N T E N T S

Article 1

Structure-based Optimization of 2,3-dioxopyrrolidines as Potential Inhibitors

of Flaviviral Methyltransferases

Prajakta Wangikar, Elvis A. F. Martis, Wahiba Aouadi, Santosh R Nandan*,

Etienne Decroly and Evans C. Coutinho*

Article 2

Pharmacophore Mapping and Virtual Screening for the Identification of New

PPARγ Agonists

Smriti Khanna, Sandeep Sundriyal,

and Prasad V. Bharatam*

Article 3

Functionalized Sulfamethoxazole and its metal complex : Structural

characterization, antibacterial and anticancer study of sulfamethoxazolyl-azo-

salicylic acid and its copper(II) complex

Nilima Sahu, Kunal Pal, Faruk Ahmed, Nayim Sepay, Kuladip Jana,

Alexandra M.Z. Slawin, Chittaranjan Sinha*

Article 4

2,4-Diaminotriazines as anti-infective agents

Suparna S. De, Siva K. Vogalu,

Nazima Ansari, Rajendra Patil, Dharmarajan

Sriram, and Mariam S. Degani*

Article 5

Anticancer activity of imidazole fused quinoxalines via human topoisomerase

inhibition

Gaurav Joshi and Raj Kumar*

Article 6

Design, Synthesis and Biological Evaluation of Novel DPP-IV Inhibitors

Chirag Karelia, Kailash Parmar, Divya Teli, Mahesh Chhabria*

Article 7

Design, Synthesis, Anti-cancer Screening, and Structure Activity Relationship

Studies of Biphenyl Linked Fused Imidazoles

Rahul Singh, Mallesh Pandrala, Sanjay V. Malhotra, Ganesh P. Pawar, Vinod

D. Chaudhari, Deepak B. Salunke*

Article 8

Drug Repurposing for Breast Cancer: Preliminary Medicinal Chemistry

Investigations and Future Perspectives

Prashant S. Kharkar*, Chetan P. Shah and Niteshkumar U. Sahu

Article 9

Synthesis and Biological Evaluation of Quinoline-Quinazolinones for

Antimicrobial and Antileishmanial Potential

Shweta Tiwari, Seema Kirar,

Uttam Chand Banerjee,

Neerupudi Kishore Babu,

Sushma Singh, Inder Pal Singh*

Article 10

Synthesis, biological evaluation, and enzyme assay of some 5-N-

substituted-2-N-(arylsulphonyl)-L(+)glutamines as potential anticancer agents

Tarun Jha,* Soma Samanta, Amit Kumar Halder, Nilanjan Adhikari, Sk.

Abdul Amin, Arpita Sanyal, Tanmoy Mukherjee

Article 11

Design, synthesis, and biological evaluation of O-alkyl umbelliferone

derivatives as pancreatic lipase inhibitors

Nisha Yadav, Prashant Auti, Ginson George, and Atish T. Paul*

Article 12

Study of Arginine Mimetic Benzamidine Urea Derivatives as PAD4 Inhibitors

Vadiraj Kurdekar, Satish N. Dighe, and Hemant R. Jadhav*

Article 13

In Silico Identification of a Potent Arsenic Based Lead Drug Di-phenyl

phenoxy roxarsone against SARS-CoV-2

Trinath Chowdhury, Joyita Dutta, Gourisankar Roymahapatra*, Santi M.

Mandal

Article 14

Zinc and copper homeostasis is crucial to maintain the cellular health and their

role in viral diseases

Sneha Mondal, Sounik Manna, Tarun Kr. Barik, Santi M. Mandal,*

Zn

incorporate

Inhibit

viral

replication

Inhibit RT (HIV),

DdDp

(SARC,HSV)

RdRp (influenza)

Inhibit viral

uncoting

NF-κB

Signalling

Inhibited

Article 15

Bioactivity of Azomethines Derived Mechanochemically from 2-Amino

Pyridine and Studies on the Effect of Substituents on the Reaction

Madhushree Das Sarma and Subhojit Ghosh*

Article 16

Ayurveda may play a preventive role against viral infections by the inactivation

of furin protease

Debarati Paul, Trinath Chowdhury, Santi M. Mandal*

Figure 2.

Oleanolic Acid Rosamarinic Acid Ursolic Acid (A)

(A’)

(B)

(B’)

(C)

(C’)

S253

D301 S302

W254

G255 P256

H194

D153

S368

N295

S253

W254

G255 P256

H194

D153

S368

N295

S253

W254

G255 P256

H194

D153

S368

N295

J. Indian Chem. Soc., Vol. 97, August 2020

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ISSN 0019-4522 August 08, 2020 RNI No. 2664/57 JICSAH 97 (8), (2020)

Edited, Printed and Published by the Honorary Secretary on behalf of Indian Chemical Society, Published

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