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SOUTHWEST RESEARCH INSTITUTE ASSISTANCETO NASA IN BIOMEDICAL AREAS OF THE
TECHNOLOGY UTILIZATION PROGRAM
%
CUMULATIVE QUARTERLY REPORT
Period Covered: 1 October 1967 - 31 March 1968
Contract No. NASW-1714
SwRI Project No. 14-2329
Prepared for
Chief, Dissemination Branch, Code (UT)
Technology Utilization Division
Office of Technology Utilization
NASA
Washington, D. C. 20546
April 15, 1968
Prepared by: Ray W. Ware, M. D.
Louis S. Berger
Southwest Research Institute8500 Culebra Road
San Antonio, Texas 78228
Approved:
William E. Cory, Director
Electronic Systems Research
https://ntrs.nasa.gov/search.jsp?R=19680013986 2018-05-15T01:30:03+00:00Z
TABLE OF CONTENTS
I.
II.
III.
IV.
V.
VI.
VII.
INTRODUC TION
A. General
B. Participating Personnel
NEW PROBLEMS
BIOMEDICAL PROBLEMS
A. Problem List and Status Summary
B. Problem Case Histories Status
C. Transfer Summaries
SUMMARY OF PROJECT ACTIVITIES
INSIGHTS INTO THE TRANSFER PROCESS
PROJECTIONS FOR THE NEXT QUARTER
DOCUMENTS FURNISHED TO PROGRAM PARTICIPANTS
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5
8
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ii
I. INTRODUCTION
_E_.EDI_(3 PAGB BEA_I¢, NOT W-tI_D.
I. INTRODUCTION
A. General
The aeronautical and space activities conducted by the National
Aeronautics and Space Administration (NASA) are creating an impressive
body of knowledge of great potential scientific and technological usefulness.
In carrying out its congressional mandate to disseminate this information
for ultimate benefit of the general public, NASA has engaged in an extensive
publications program; in particular, publications under the auspices of
NASA's Technology Utilization Division (TUD) are specifically aimed at
expeditiously transferring NASA developments to the scientific and
industrial community°
Special difficulties are encountered when it is attempted to transfer
NASA-derived technology, by means of TUD publications alone, to scientists
in the biomedical fields. These scientists are particularly overburdened
by the copious amounts of published biomedical material; additionally, they
are by and large unfamiliar with the language and symbology of the
physical and engineering sciences° As a result, technology in physical
science and engineering has often not been as effectively transferred to
biomedical applications as it deserves to be.
The TUD's investigations of the chain of events leading to the
introduction of new products, technological inventions, and methods into
medical practice have suggested that the biomedical research teams at
medical schools and similar biomedical research institutions play a key role
in this process. New discoveries, introduced by these groups, tend to
proceed naturally through stages of professional approval, manufacturing
interest and participation, on to the level of the practicing physicians,
bringing direct health benefits to the public° It would seem an attractive
goal to introduce NASA-derived advances at the level of the biomedical
research team, and thus to utilize the existing channels to the medical
practitioner and his patients for effective technological transfer.
As a result of these investigations, NASA's TUD has developed a
general methodology for the solution of this important and special technological
transfer problem. Prominently included in this methodology was the estab-
lishment of several strategically placed Biomedical Application Teams
consisting of appropriately cross-trained and broadly experienced physical
and biological scientists. It is the task of the Biomedical Application Team
to facilitate and improve the productive interaction between NASA centers
and biomedical research teams. Emphasis is on interpersonal contact, in
which the cross-trained members of the Biomedical Applications Team form
an active link between these two groups of scientists. A flexible system is
maturing in which both principal groups, NASA personnel and biomedicalresearchers, freely and effectively participate in mutually beneficialexchange of skills and knowledge.
Bm Participating Personnel
The following scientists are participating in the program:
Southwest Research Institute Biomedical Application Team,
Southwest Research Institute Personnel. _
Ray W. Ware, MoDo, Director
Louis S. Berger, Assistant Director
Raul San Martin, M. Do
Charles J. Laenger, Sro
Robert Jo Crosby
Chester Ao Heath
Felix St° Claire
Special Consultant_ Andre G. Buck
Key Coordinators at User Institutions:
Co W. Hall_ M. Do, Asst0 Professor_ Department of
Experimental Surgery, Baylor University
School of Medicine, Houston, Texas
F. Hermann Rudenberg_ Pho D., Associate Professor,
Department of Physiology, The University of Texas
Medical Branch, Galveston, Texas
Jack B. Johnson_ Assto Chief, Biomedical Instrumentation
Section_ Southern Research Support Center,
Veterans Administration, Little Rock, Arkansas
Mro John Hall_ Seattle Handicapped Center,
Seattle, Washington
Mrs Don Baker_ University of Washington, Department
of Bioengineering, Seattle_ Washington
Mro H. Ao Miller_ Stanford University School of Medicine
N. Po Thompson_ M.D._ Palo Alto Medical Research
Foundation
Joseph Canzoneri_ III, (SRS)_ Director, Biomedical
Engineering_ Texas Institute for Rehabilitation and
Research_ Houston_ Texas
V. Mooney_ M. Do_ (SRS)_ Rancho Los Amigos Hospital,
Downey_ California
Other Southwest Research Institute Staff consulted:
Leon M. Adams, Ph.D., Manager, Organic and PolymerChemistry
Wallace L. Anderson, Ph.I_.,, Senior Research Engineer
Robert Bond, Ph.D., Senior Research Physicist
J. Wray Fogwell, Manager, Electromechanical Research
Gerald Gardner, Ph.D., Senior Research Physicist
Stephen Juhasz, Ph.D., Editor, Applied Mechanics Review
Richard T. Mannheimer, Senior Research Engineer
Paul D. May, Senior Research Chemist
F_anl_ C. Milstead, Senior Research Engineer
4
II. NEW PROBLEMS
F| L., W'_;; ,_'.J•pI_,E_IEDING PAGE LANK NOT _''' _,r._
II. NEW PROBLEMS
HUV- 16
TITLE: Novel Joint Design Applied to Assistive Devices for
Human Limbs
SOURCE: Mr. Thorkild Engen, Department of Orthotics
Texas Institute for Rehabilitation and Research
This problem developed out of the "Reverse Problem Case History,
described on pages 106 and I07 of SwRI Final Report, NASr Contract
No. 94(09), 1 July 1966 through 31 October 1967. Mr. Engen, in his visit
of 20 September 1967 to Ames Research Center, was introduced to the new
joint design concepts developed in current hard spacesuit technology. He
requested that information be made available to him, so that he could
assemble joints of this type for his clinical evaluation.
COMMUNICATIONS WITH NASA CENTERS:
February 28, 1968--Mr. George G. Edwards, TU Officer,
Ames Research Center, furnished Mr. Engen a copy of a new technical
paper by Mr. H. C. Vykukal entitled, "Advanced Development s in Hard
Spacesuit Technology, " which is to be presented at the ASME (Aviation
and Space National Conference), Beverly Hills, California, June 16
through 18, 1968.
The bearings used b_ Mr. Vykukal are manufactured commercially
by the Kaydon Engineering Corporation, McCracken St., Muskegon,
Michigan, 49443. Typical item numbers are KA70X5 and KA55X5.
SRS-7
TITLE: Acoustic Pest Control Technology
DATE SUBMITTED: 8 March 1968
SOUR CE : James O. Wear, Ph.D., Acting Chief
Southern Research Support Center
Veterans Hospital
Little Rock, Arkansas
INITIAL DISPOSITION:
Because of previous activity in this problem area, several members
of the Biomedical Application Team were aware of existing commercial
technology. The commercial company (Bio-Sonic, Inc.) was contacted, and
it was learned that both Texas A&M and a government agency at Denver are
evaluating their method and equipment, which is protected by patents.
6
COMMUNICATIONS:
March 13, 1968--Mro C. J. Laenger, Sr. of the Biomedical
Application Team wrote a letter to the problem originator explaining
the existing commerciai_development programs.
March 19, 1968--Problem originator called to say that he was
following up Mro Laenger's information°
April i, 1968--Consultant called Mr. Laenger to inform him that
the problem originator had followed up the furnished inforn-_ation, that
further work was being considered in this problem area, but that for the
time being, no further Application Team activity was indicated. It was
requested that this problem be put on inactive status.
IIio BIOMEDICAL PROBLEMS
PREG'F.DING PAGE BLANK NOT IqLtv'l_,D.
III. BIOMEDICAL PROBLEMS
A* Problem List and Status Summary
I"_O o
HUV-I
HUV -2
HUV-3
HUV -4
HUV -5
HUV-6
HUV -7
HUV -8
HUV-9
HUV-I 0
Title Status
Texas Institute for Rehabilitation and Research
Reduced Workload Environment for
Physically Handicapped Patients
Phase i and Phase 2,
actual transfer
Advanced Computer Display and
Interface Technology
Inactive
Computer Scheduling Techniques Solution to staffing
problem is being
sought
Heart Sounds, Interval Analysis Second search results
are being evaluated
End Tidal Air Sampler Inactive
Ambulation Aid Problem Abstract
disseminated
Scheduling for Ward Patients Solution to staffing
problem is being
sought
Mechanisms of Onset of Orthostatic
Hypotension
Completed
Prosthetic Materials for Urinary
Tract
Staff consultation
planned with Biomed-
ical Application Team
specialist
Instrumented Prosthetic Leg The original, very
broad problem, has
been placed on the
inactive list; the pro-
ject has been funded
and will be used to
generate new problem
statements
No.
HUV-i I
HUV-I 2
HUV-I 3
HUV-14
HUV-1 5
HUV -1 6
RCU-I
SRS-I
SRS-Z
SRS-3
SRS-4
SRS-5
SRS-6
SRS-7
T itle
Improved Gas Sample Flow Control
and Measurement
Special Automobile Modifications for
Disabled Persons
Human Transfer Function Measure-
ments
Physical Space Utilization
Advanced Computer Terminal and
Display Technology
Novel Joint Design Applied to
Assistive Devices for Human Limbs
Status
Inactive
Inactive
Solution to staffing
problem is being
sought.
Transfer in progress
Closed Out
Transfer in progress
Rice University
"Artificial Heart" Control System
Technology
This problem has
been combined with
BLM-4
Veterans Administration Southern Research Support Center
Indirect Measurement of Blood
Pressure During Rest and Exercise
on Arms and Legs
Catheter Tip Transducer for Blood
Pressure and Flow Measurement
Locating Tip of Stomach Tube
Materials Suitable for Dry Elec-
trode Fabrication
Temperature Regulatory Mechan-
isms of the Body
Investigations of Cutaneous Stimuli
Acoustic Pest Control Technology
Periodic literature
review is requested
Periodic literature
review is requested
Status inactive
Periodic literature
review is requested
Periodic literature
review is requested
Closed out
New problem
10
No. Title Status
11
BLM-I
BLM-Z
BLM-3
BLM-4
BLM-5
BLM-6
BLM-7
BLM-8
BLM-9
GLM -I
GLM -2
Baylor University Medical School
Noiseless Gas Valves for "Artificial
Heart" Use
Support Slings for Postoperative
Care of Large Animals
Triggering on R Wave of ECG
Valve for Proportional Gas Flow
Control
Transthoracic Energy Coupling
Devices
Biocompatible Spray-On Plastics,
Impermeable to Bacteria
Telemetry of Cardiovascular Data
from Free-Ranging Animals
Miniature Tape Recorder for Bio-
logical Data
Cyclic Variation of Body Tempera-
ture in Mammals
Closed out
Closed out
Actual transfer
Technology tentatively
identified
No new information
Technology is being
evaluated by problem
originator
Contractor has been
informed of search
results
Technology tentatively
identified - unable to
obtain prototype for
evaluation
Information has been
furnished to problem
originator. Applica-
tion of this information
is as yet unspecified.
The University of Texas Medical Branch, Galveston
Analysis of Transitional Flow-Con-
vection/Diffusion
Transfer accomplished;
problem closed out
Monitoring of Blood Pressure by
Extra-Vascular Sensor, Using Wire-
less Telemetry of Information
Inactive
No.
GLM-3
GLM-4
GLM- 5
GLM-6
GLM-7
GLM-8
GLM-9
GLM -i0
GLM- 11
GLM -1Z
GLM-I 3
GLM-14
GLM -1 5
GLM- l 6
Title
Determination of Local Blood Flow,
Blood Gas Concentration, and Blood
pH in Small Portion of an Organ
Implanted Blood Pressure Transducer
Chronic Intracranial Pressure Mea-
surement in Man
A Model Vascular System
Viscosity Measurement of Minute
Samples of Blood
Computer Program for Electroen-
cephalograph: Period Analysis
Measurement of Local Tissue
Oxygen Consumption In Vivo
Computer Program for Flame
Spectrophotometry
Elimination of Electrostatic Charge
in Experimental Animals
Computer Selection and Elimination
of Artifacts
Multiple Co-Spectral Density
Analysis of Time-Series Data
Repetitive Measurement of Kidney
Mass in Intact Animal
Respiration Volume and Rate Mea-
surements in Unencumbered (Free)
Child
In-Situ Tumor Mass Determination
on Rat Leg
Status
Actual transfer
Unchanged
Unchanged
Reference documents
are being evaluated
Reference documents
are being evaluated
Reference documents
are being evaluated
Actual transfer
Technology tentatively
identified
Closed out; actual
transfer
Reference documents
are being evaluated
Problem Abstract
disseminated
References being
evaluated by prob-
lem originator
Problem originator
evaluating reference
material
Meeting is planned
for researcher and
Biomedical Applica-
tion Team members
for 1968
12
No. Title Status
The University of Texas Medical School at San Antonio
SNM- I Enhancement of X-Ray Contrast
Study Films
Enhancement proce-
dure has not yet been
successful. New
X-rays are being sent
to the Jet Propulsion
Laboratory.
B. Problem Case Histories Status
HUV-I--The grant application was approved, and a research project
initiated March 1968: Reduced Workload Environment for Physically Handi-
capped Patients.
COMMUNICATIONS WITH NASA CENTERS
February 15, 1968--Louis Berger called Mr. John Samos, Technology
Utilization Officer, Langley Research Center, and requested assistance with
technical drawings and possibly surplus hardware for the user institution.
Mr. Samos is going to be in touch with Mr. Canzoneri and work out arrange-
ments for furnishing the requested aid.
February 23, 1968--Mr. Samos and Mr. Canzoneri discussed Texas
Institute for Rehabilitation and Research needs for material and engineering
information. Mr. Samos is gathering appropriate materials and will be in
touch with Mr. Canzoneri.
February 28, 1968--Mr. John Samos called Mr. Joe Canzoneri. He
said that no further written information on the rehabilitation system sketch
is available, but Mr. Canzoneri should feel free to call Mr. Don Hewes, who
drew the sketch of application of the reduced gravity simulator (r.g.s. } to
biomedicine. Mr. Spady is looking into the question of obtaining surplus
equipment. It has been established that a J-bar is available, and probably
slings are available also. Mr. Samos is getting a reference for a possible
source of the helmet (possibly at Manned Spacecraft Center) and will get that
information to Mr. Canzoneri.
O THER COMMUNICATIONS
March 12, 1968--Literature search on medical data derived under
conditions of weightlessness was submitted to KASCenter following telephone
discussion with problem originator by preparers of search statement.
13
14
March 13, 1968--Mr. R. J. Crosby began review of NASA TTF-368,translation of Russian, "Problems of Space Biology," for articles relevantto Dr. Vallbona's interests in physiological parameters measured in reducedgravity or simulated reduced gravity environments.
March 2Z, 1968--Mr. R. J. Crosby verified by telephone call theproposed search strategy developed by the search specialist at KASCenter.
April 4, 1968--In response to an inquiry by Texas Institute forRehabilitation and Research researchers, Mr. Dave Bendersky, MidwestResearch Institute, was telephoned to obtain information on helmet respira-tory gases collecting scheme and triaxial accelerometer availability. Theinformation obtained was forwarded to the requesting researchers.
HUV-2 Advanced Computer Display and Interface Technology
February Z8, 1968--Problem originator stated in interview that herequests this problem to be put on inactive status. He has made his pur-chasin_ decisions on the basis of information submitted by search and feelsthat he is up-to-date on available information.
HUV-3 Computer Scheduling Techniques
CON/IMUNICAT IONS
February 28, 1968--Problem originator stated in interview that much
helpful information had been furnished by the Biomedical Application Program
on this problem. His main problem now is to find a staff member who would
be able to utilize this information and apply it to Texas Institute for Rehabili-
tation and Research scheduling problems. He inquired about the possibility
of usimg a NASA programmer or one of NASA's subcontractor's programmers
at Texas Institute for Rehabilitation and Research's expense for an extended
period of approximately 6 months be investigated.
February Z8, 1968--Problem originator stated in interview that Tech.
Brief 67-i0510, "Probabilistic Approach to Long Range Planning of Manpower"
is of interest to him and will request backup package from Manned Spacecraft
Center.
March 19, 1968--Inquiries were initiated as to potential programming
staff help by means of telephone call by Louis Berger to Mr. Paul Woytovich
of the NASA Office of Tracking and Data Acquisition. Mr. Woytovich advised
consultation with computer scientists at Ames, Jet Propulsion Laboratory,
and Manned Spacecraft Center to get their suggestions and recommendations
as to which contracting organizations might be consulted to furnish staffing
help as per problem originator's request.
HUV-4 Heart Sounds, Interval Analysis
Consultant is evaluating new search results and is also evaluatingTech. Brief 67-10598, for which he intends to obtain a backup package.
HUV-5 End Tidal Air Sampler
COMMUNICATIONS
December 8, 1967--Problem originator stated in interview that hedesired to drop this problem for the time being. It is placed on an inactivelist. No help was furnished on this problem by the program, except to con-firm the problem originator's impression that no applicable new technologywas readily available.
HUV-6 Ambulation Aid
No responses obtained from Problem Abstract dissemination to date.
HUV-7 Scheduling for Ward Patients
COMMUN ICAT IONS
March 19, 1968--Inquiries were initiated as to potential programmingstaff help by means of telephone call by Louis Berger to Mr. Paul Woytovichof the NASA Office of Tracking and Data Acquisition. Mr. Woytovich advisedconsultation with computer scientists at Ames, Jet Propulsion Laboratory
and Manned Spacecraft Center to get their suggestions and recommendations
as to which contracting organizations might be consulted to furnish staffing
help as per problem originator's request.
HUV-8 Mechanisms of Onset of Orthostatic Hypotension
COMMUNICATIONS
December 8, 1967--Problem originator stated that no new use had
been made of furnished information. It appears as a result of interviewing
the problem originator that no additional service can be provided by the
Team on this problem. The problem was therefore put on the "completed"
list.
HUV-9 Prosthetic Materials for Urinary Tract
C OMMUNIC AT IONS
November 8, 1967--Negative search appraisal returned from problem
originator. Iris planned to have0roblemorigin_tormeetwithaTeamspecialist
15
in synthetic materials to specify the problem in suitable physical scienceterms. Subsequently, a second literature search may be performed and/ora Problem Abstract prepared.
16
HUV-10 Instrumented Prosthetic Leg
C OMMUNICAT IONS
November 6, 1967--Dr. Ware called Dr. Sid P. Leverett, Biodynamics
Branch, USAF SAM, regarding availability of microspheres for conforming
interface. Dr. Leverett will try to obtain a sample for Texas Institute for
Rehabilitation and Research to evaluate.
December 8, 1967--Dr. Petersoninterviewed. He has sent for follow-
ups on Science Information Exchange and has not received material from
applicable project.
February 15, 1968--Gave to consultant two references for artificial
leg instrumentation: (1) Source for Microballoon Spheres, and (2) A Refer-
ence for Direct Casting of a Human in Rigid Polyurethane Foam.
February 28, 1968--Consultant stated in interview that a grant applica-
tion has been submitted. Four areas are likely to be in need of help: trans-
ducers, telemetry, pattern recognition, and casting problems. This problem
will be placed on an inactive list and will be used as a source to generate
focused problem statements in the four problem areas.
March 14, 1968--Dr. Spencer (Director, Texas Institute for Rehabili-
tation and Research) was interviewed concerning the grant application which
had been approved. He furnished the Biomedical Application Team with copies
of the grant application as a start toward specifying suitable problems for
problem statement submission.
March 18, 1968--Descriptive material and cover letter was received
from Michael McCally, M.D., Chief, Environmental Medicine Division,
Biomedical Laboratory, Wright-Patterson AFB. This material described
microballoon support restraint technology. Contract work performed by
Northrop Space Laboratory for Holloman AFB. This material was forwarded
to principal investigators of the newly funded grant on March 23, 1968.
March 28, 1968--Dr. Peterson acknowledged receipt of microballoon
technology description and requested information about availability of micro-
balloons for clinical trial.
HU_-ll Improved Gas Sample Flow Control and Measurement
December 8, 1967--After consultation with Texas Institute for Reha-
bilitation and Research staff, this problem was put on inactive list.
I-iUV-I2 Special Autompbile Modifications for Disabled Persons
COMMUNICATIONS
17
November Z9, 1967--Dr. Spencer informed Dr. Ware by telephone
that automobile assimulation hardware had recently been obtained. Dr.
Spencer was requested .to ask Mr. Canzoneri to furnish a description of the
recent acquisition, as well as the problem status in general.
December 8, 1967--AETNA simulator has been installed at facility;
mcetings scheduled to specify problem areas.
February 14, 1968--Louis Berger met with Mr. Canzoneri and Mr.
William Reese to discuss the status of the research and demonstration grant
application. It was agreed that this problem will be put on the inactive list
until the researchers decide what problem areas would specifically be appro-
priate for generation of well-specified problems.
HUV-13 Human Transfer Function Measurements
COMMUNICAT IONS
February 28, 1968--Problem originator stated in interview that Since
no personnel were available for implementing the system suggested by the
Langley development, this problem should be placed on the inactive list.
March 19, 1968--Inquiries were initiated as to potential programming
staff help by means of telephone call by L. Berger to Mr. Paul Woytovich
of the NASA Office of Tracking and Data Acquisition. Mr. Woytovich advised
consultation with computer scientists at Ames, Jet Propulsion Laboratory
and Manned Spacecraft Center to get their suggestions and recommendations
as to which contracting organizations might be consulted to furnish staffing
help as per problem o_iginator's request.
HUV-14 Physical Space Utilization
COMMUNICATIONS
February Z8, 1968--Problem originator was interviewed and stated
that a grant application has been submitted which will concern itself with live
simulation studies in the subject area. Should the grant be approved, there
would be a possibility of hiring a staff member to do parallel computer simu-
lation work, in which case the problem would be reactivated. For the time
beimg, this problem is being placed on the inactive list.
March 19, 1968--Inquiries were initiated as to potential programming
staff help by means of telephone call by L. Berger to Mr. Paul Woytovich
of the NASA Office of Tracking and Data Acquisition. Mr. Woytovich advised
consultation with computer scientists at Ames, Jet Propulsion Laboratory and
Manned Spacecraft Center to get their suggestions and recommendations as to
which contracting organizations might be consulted to furnish staffing help as
per problem originator's request.
HUV-15 Advanced Computer Terminal an_ Display Techno!o6y
SRS-I
This problem has been combined with HUV-2.
Indirect Measurement of Blood Pressure During Rest and Exercise
on Arms and Legs
C OMMUN IC AT IONS
December IZ, 1967--Problem originator stated in interview that the
problem should be put on the status of periodic literature review. A 6-month
cycle was requested.
SRS-2 Catheter Tip Transducer for Blood Pressure and Flow Measurement
C OMMUNIC AT IONS
December IZ, 1967--Problem originator stated in interview that the
problem should be put on the status of periodic literature review. A 6-month
cycle was requested.
SRS-3 Locating Tip of Stomach Tube
COMMUNICATIONS
December 8, 1967--Problem originator stated in postsearch status
form that no further action on this problem is required.
SRS-4 Materials Suitable for Dry Electrode Fabrication
C OMMUNIC AT IONS
December IZ, 1967--Probiem originator stated in interview that the
problem should be put on the status of periodic literature review. A 6-month
cycle was requested.
SRS-5 Temperature Regulatory Mechanisms of the Body
C OMMUN ICAT IONS
December 12, 1967--Consultant stated that the problem originator has
distributed the furnished information among his coworkers. He requested
18
19
that the problem be put on a 6-month cycle of periodic literature review
status.
SRS-6 Investigations of Cutaneous Stimuli
C OMMUN IC AT ION S
March I, 1968--Problem originator has left the staff of the participat-
ing institution and the problem is accordingly closed out. A follow-up of use
of references will be made.
BLM-I Noiseless Gas Valves for "Artificial Heart" Use
COMMUNICAT IONS
December 8, 1967--Status report furnished. Problem originator
stated in interview that this problem is being solved by a contractor who is
reengineering a commercially available solenoid valve. This problem is
accordingly considered withdrawn.
BLM-2 Support Slings for Postoperative Care of Large Animals
COMMUNICAT IONS
December 8, 1967--Problem originator stated that this problem has
been solved independently by the investigator and that no further information
is required. Accordingly, this problem is being withdrawn.
BLM-3 Triggering on R Wave of ECG
COMMUNICAT IONS
April 5, 1968--Dr. C. W. Hall stated in telephone conversation with
Dr. Ware that the R wave triggering device had been completed, used on
several experimental animals, and, finally, on 20 March 1968, used on a
human patient. The device worked very satisfactorily during the entire time
that the patient was on the artificial ventricular assist device, and will be
made a permanent addition to the De Bakey clinical artificial heart system.
BLM-4 Valve for Proportional Gas Flow Control
The most up-to-date technical fabrication information available on
a NASA developed control system is being sought from Lewis ResearchCenter.
BLM-5 Transthoracic Energy Coupling Devices
C OMMUNICA TIONS
December 8, 1967--Problem originator stated in interview that infor-
mation obtained through the program was interesting, but no specific informa-
tion was submitted on coupling through the chest wall. No investigation has
been undertaken concerning the energy transfer methods that were brought to
the problem originator's attention through this program.
BLM-6 Biocompatible Spray-On Plastics, Impermeable to Bacteria
C OMMUNICA TIONS
Dr. Hall stated in telephone conversation with Dr. Ware that the
polyamino acid film treated nylon velour material, prepared by Southwest
Research Institute's Department of Chemistry and Chemical Engineering,
was used on a pig experimentally to cover an area of third degree burn as a
skin substitute° Results were stated to be excellent.
With regard to a second film (irradiated polyethylene), Dr. Hall
stated that the testing machine under construction was leaking and that,
pending receipt of O-ring seals to correct this condition, continuation of
test trials would not be possible.
BLM-7 Telemetry of Cardiovascular Data from Free-Ranging Animals
December 8, 1967--Problem originator stated that this problem was
turned over to a commercial instrument company in Houston° They have been
working on the system for about 3 months and are testing prototypes° Infor-
mation collected by the Application Team will be made available to the com-
mercial contractor.
January 9, 1968--Computer search results forwarded to H. D. Millar,
who is subcontracting telemetry work for problem originator.
February 5, 1968--L. Berger called Mr. H. Millar for follow-up of
use n__ade of search results. Mr. Millar stated that the references so far
appeared to be extremely useful for general background information. They
have been given to a new project engineer, with instructions that the engineer
should select references of particular interest and request full documents as
indicated.
BLM-8 Miniature Tape Recorder for Biological Data
COMMUNICATIONS
No change.
2O
BLM-9 Cyclic Variation of Body Temperature in Mammals
COMMUNICATIONS
March 31, 1968--Descriptive material on NASA project 15G-B2299
(A System of Monitoring of Deep Brain Temperatures) was received from the
Technology Utilization Officer, NASA headquarters. This material was
forwarded to problem originator with cover letter.
March 26, 1968--Problem originator returned a positive evaluation of
information sent on the NASA Franklin Institute Research Project.
GLM-1 Analysis of Transitional Flow-Convection/Diffusion
Transfer accomplished.
GLM-2 Monitoring of Blood Pressure by Extra-Vascular Sensor, Using
Wireless Telemetry of Information
C OMMUNICAT IONS
February 16, 1968--Consultant has notified Application Team that
problem originator is too involved with other matters to continue work on
this problem at the present. The problem is therefore being placed on the
inactive list.
GLM-3 Determination of Local Blood Flow, Blood Gas Concentration, and
Blood pH in Small Portion of an Organ
Unchanged.
Implanted Blood Pressure TransducerGLM-4
COMMUNICATIONS WITH NASA CENTERS
January ii, 1968--Mr. C. J. Laenger called Mr. E. Edwards,
Technology Utilization Officer, Ames Research Center, and was advised
that the status of availability of capacitance transducers (Mr. Coon's devices)
is unchanged. Requested references are being furnished to problem
originator.
GLM-5 Chronic Intracranial Pressure Measurement in Man
COMMUNICATIONS WITH NASA CENTERS
January ii, 1968--Mr. C. J. Laenger called Mr. G. Edwards,
Technology Utilization Officer, Ames Research Center, and was advised
that the status of availability of capacitance transducers (Mr. Coon's devices)
is unchanged. Requested references are bein_ furnished to problem
originator.
21
GLM®6 A Model Vascular System
Requested references have been furnished to problem originator,and are being evaluated by him.
GLM-7 Viscosity Measurement of Minute Samples of Blood
Requested references have been furnished to problem originator,and are being evaluated by him.
GLM®8 Computer Program for Electroencephalograph
Requested references have been furnished to problem originator,
and are being evaluated by him.
GLM_9 Measurement of Local Tissue Oxygen Consumption In Vivo
No new information has been furnished on this problem.
GEM-10 Computer Program for Flame Spectrophotometry
COMMUNICATIONS
February 29, 1968--Problem originator was interviewed and furnished
detailed and specific descriptions of the procedures that had been used to
date in the flame spectrophotometry analysis. It was decided that since a
ready-made computer program seems to be unavailable, further analysis of
the mathematics of the problem needs to be undertaken. Preparation of a
problem abstract draft is in progress.
March Z1, 1968--Problem Abstract draft was prepared by Dr. C. Go
Gardner, submitted to NASA March 21, 1968.
GLM-II Elimination of Electrostatic Charge in Experimental Animals
Closed out; actual transfer.
GLM-1Z Computer Selection and Elimination of Artifacts
Requested references have been furnished to problem originator,
and are being evaluated by him.
GLM-13 Multiple Co-Spectral Density Analysis of Times -Series Data
C OMMUNICATIONS
December 7, 1967--Problem originator was interviewed. He is still
evaluating reference articles furnished to him, and he also stated that he was
Z2
23
familiar with the approach suggested by Mr. Peter Mengert, ElectronicsResearch Center, in Mr. Mengert's response to the disseminated ProblemAbstract.
GLM-14 Repetitive Measurement of Kidney Mass in Intact Animal
COMMUNICATIONS
Problem originator is evaluating computer search results.
GLM-15 Respiration Volume and Rate Measurements in Unencumbered
(Free) Child.
C OMMUNICAT IONS
February 15, 1968--Louis Berger spoke with Dr. Rudenberg who
informed him that problem originator valued the package concerning
research on remote sensors which was furnished by Electronics Research
Center on November Z0, 1967.
February Z9, 1968--Problem originator indicated in interview that he
will furnish his evaluation of documents and other search results with
recommendation for priorities for the order in which applicable research
program should be investigated.
GLM-16 In-Situ Tumor Mass Determination on Rat Leg
C OMMUNICAT IONS
Problem originator is planning a trip to Southwest Research Institute
to evaluate potentially identified aerospace technology.
RCU-I "Artificial Heart" Control System Technology
C OMMUNICATIONS
February 15, 1968--Problem originator was forwarded five refer-
ences furnished by Mr. Harrison Allen of Lewis Research Center in
response to Problem Abstract RCU-I which overlaps BLM-4.
Z4
SNM-I Enhancement of X-Ray Contrast Study Films
COMMUNICATIONS WITH NASA CENTERS
March 27, 1968--Mr. Berger contact Dr. R. Nathan by telephone to
to verify the status of processing of X-ray films previously submitted.
Dr. Nathan stated that the films had been scanned and digitized and
attempts had been made to obtain enhanced visualization of gall stones. The
results of these attempts were considered by jPL personnel to be poor;
nevertheless, these results will be provided for Dr. Zanca's evaluation.
Dr. Nathan stated that he hopes to obtain funding with which to continue the
biomedical applications of $PL enhancement techniques in June 1968, and
that he would, at that time, welcome submission of additional films.
Co Transfer Summaries
Actual Transfer
Transfers in
Progress
Technology Tentatively
Identified
HUV-1 HUV-14 HUV-3
GLM- 1 (completed) HUV-16 HUV-7
GLM- 3 HUV- 1 3
GLM-9 BLM-8
SNM-I GLM-Z
SRS- 6 GEM -4
BLM- 3 GEM- 5
BLM - 6
GLM- I i (completed) GEM-10
25
IV. SUMMARY OF PROJECT ACTIVITIES
PRECEDING PAGE BLANK NOT I:II,_D.
IV. SUMMARY OF PROJECT ACTIVITIES
26
The work performed during this period in connection with previously
submitted problems and the specification of two newly submitted problems
is reported in Section III of this report. Site visits by members of the
Application Team, performed in connection with submitted problems, were
as follows:
1 November 1967: Mr. Re J. Crosby, and Mr. F. St. Claire--
Texas institute for Rehabilitation and Research;
7,8 December 1967: L. Berger--Texas Institute for Rehabilitation
and Research and the University of Texas Medical Branch at
Galveston;
15, 16 December 1967: Dro Quentin Hartwig, Dr. Ray W. Ware,
and Louis Berger--Texas Institute for Rehabilitation and
Research (meeting with Dro W. Spencer, Director) and
Baylor University College of Medicine (Michael DeBakey, M.D. );
15 February 1968: Dr. Ray W. Ware, Mr. A. G. Buck, and
g. So Berger--Texas Institute for Rehabilitation and Research;
Z8 February 1968: L. So Berger--Texas Institute for
Rehabilitation and Research;
29 February 1968: L. S. Berger--The University of Texas
Medical Branch at Galveston; and
14 March 1968: L. S. Berger--Texas Institute for
Rehabilitation and Research.
In addition to conducting business directly related to submitted
problems, the above trips routinely included discussion about improved
procedures, new approaches, and the generation of new problem state-
ment submission, as well as in most instances including briefings of staff
members at the participating institutions who had not yet been made
thoroughly familiar with the program.
Trips were also taken in connection with briefing of key researchers
and administrators at institutions which are being added to the program.
Upon the acquisition of the services of our special consultant for the
West Coast region, Mr. A. G. Buck, the following trips were taken:
I-4 March 1968: Dr. Ray W. Ware and Mr. A. G. Buckvisited the Palo Alto Medical Research Foundation, theRancho Los Amigos Hospital, and Ames Research Center;
27-29 March 1968: Mro L. S. Berger and Mr. A. G. Buckvisited the following institutions--Rancho Los Amigos Hospital,University of Washington, Seattle (Biomedical EngineeringDepartment), and the Seattle Handicapped Center.
Miscellaneous conferences attended were:
31 October-i November 1967: Dro Ware and Mr. Bergerattended a joint Application Team meeting hosted by theResearch Triangle Institute;
12, 13 February 1968: Dro Ware and Mr_ Berger attended aconference on the utilization of space technology in mentalretardation research, sponsored by NASA and The NationalInstitute of Child Health and Human Development. On thisoccasion, the Southwest Research Institute Team presenteda paper titled "Search Strategy in Communication Networksin the Biomedical Application Program. "
(Work concerning new problem solicitation was minimal during thisreporting period, since the program operated at a reduced level,pending completion of contract negotiations. )
27
28
V. INSIGHTS INTO THE TRANSFER PROCESS
PRECEDING pAGE BLANK NO'T FIL,M_D,
V. INSIGHTS INTO THE TRANSFER PROCESS
29
The conclusions that were expressed in the last Final Report
regarding thoughtful consideration of potential new problems were applied
in communications with the new as well as the older participating research
institutions. In order to improve the program efficiency, a number of
problem areas of interest to newly participating researchers at the
University of Texas Medical Branch were prescreened, and resulting
information was furnished to these researchers, together with suggestions
about potentially fruitful problem areas, as a guide to planning problem
statement submission.
Preliminary discussions were initiated at the Texas Institute for
Rehabilitation and Research for the purpose of developing new problem
statements. It was agreed that particularly favorable conditions for
problem statement submission existed in the case of two newly funded
research projects which had available funds, personnel, and which
involved specific and pressing problem areas. These funded projects
will be important sources of new problem statements. Team members
will work closely with the research program investigators in developing
problem statements from these projects.
The need for careful approach to problem statement acceptance was
discussed also at some length during briefing sessions with key adminis-
trative and research personnel at three of the new member institutions:
Rancho Los Amigos Hospital, University of Washington, Department of
Biomedical Engineering, and Seattle Handicapped Center.
During the first year of program performance, we frequently found
that researchers and administrators at participating institutions had stereo-
typed misconceptions about the aims and mechanisms of the NASA program.
Frequently, staff members believe the program to be essentially a
literature search and information retrieval program; perhaps this mis-
conception was engendered by some of the terminology which frequently
crops up in the program execution, such as information transfer, technology
transfer, technology utilization. The assumption also was sometimes made
that the program would routinely furnish hardware on request, and that its
function was similar to that of a hardware surplus disbursing agency. It
seemed indicated, in the light of these misconceptions, to emphasize in
initial briefing interviews the things that the program was not primarily
concerned with, as well as describing the program function in positive.
terms. It remains to be seen whether this approach will significantly
reduce the researchers' misconceptions about the ongoing program.
3O
VI. PROJECTIONS FOR THE NEXT QUARTER
_ING PAGE BLANK, NQT FIEfg_E_.
VI. PROJECTIONS FOR THE NEXT QUARTER
31
The next quarter's effort will be concentrated in two major areas:
(1) Implementing the program at the institutions on the West Coast which
have recently been added to the program; this will include continued
briefings of the special consultant who will primarily be responsible for
communications with these institutions, to make him thoroughly familiar
with the procedures and practices which have been developed in conjunction
with this program over the past year and a half. In addition, as this
consultant has extensive administrative experience within NASA, and,
since he is looking at the program with a fresh and unbiased viewpoint, his
suggestions and recommendations for improving program efficiency will be
solicited. (2) The institutions who have participated since the program
inception will continue to be serviced.
In connection with the new participating member institutions, interest
profile development will continue, and problem submission will be simulated,
subject to the considerations discussed in Section V. Essentially, these
institutions are at the stage that our old member institutions were in the
beginning of the program, and the work to be performed in this phase of
institutional development will parallel the work performed at the old
institutions a year and a half ago, with the benefit of application of the
skills and insights gained in institutional development during the first
18 months of project performance°
Regarding the older institutions, most of the previously submitted
problems have either become inactive or have resulted in actual or potential
transfers; in the latter case, Team activity will center about aiding
completion of transfer activity as required, including complete documenta-
tion. The approaches to new problem submissions from the Texas Institute
for Rehabilitation and Research, Baylor University School of Medicine, and
The University of Texas Medical Branch, which have been discussed in
Section V, will be followed during the next quarter.
Some changes in staff utilization of institutions in the Houston/
Galveston area have been planned: Mrs. Sarah Garrison, Information
Specialist at Texas Institute for Rehabilitation and Research, will take over
much of the document dispersal and records keeping function previously
executed by Mr. Joe Canzonerio It is planned to spend sufficient time with
Mrs. Garrison to work out efficient procedural details. It is also planned
to have two members of the Biomedical Application Team take on increasingly
more of the Team contacts at Texas Institute for Rehabilitation and Research
and The University of Texas Medical Branch at Galveston, in order to
utilize the Team's capabilities more efficiently° Mr. C. J. Laenger, Sr.,
and Mr. Robert J. Crosby have technological backgrounds and interestswhich will be especially useful in the problem areas of intense activity inthe two last mentioned member institutions.
Besides frequent site visits to the participating member institutions,a program review meeting is planned at Southwest Research Institute forlate May, and a Technology Utilization Division staff meeting will beattended at Langley Research Center in early June.
3Z
33
VII. DOCUMENTS FURNISHED TO PROGRAM PARTICIPANTS
PRECEDING PAGE BLANK NOT EILt_.
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