Society for Hematopathology/ European Association for Haematopathology

October 29 – 31, 2015Long Beach Convention CenterLong Beach, California

Immunodeficiency and Dysregulation

2015 Workshop

NEW!ASCP/SH DAYWednesday, Oct. 28See p.5 for details.

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Program Overview

Immunodeficiency and dysregulation can predispose to as well as mimic hematolymphoid malignancy. Recognition of an underlying immune defect can pose significant challenges to the pathologist and be instrumental in guiding workup and therapy of affected pa-tients. The intersection of immunologic dysfunction and pathologic diagnosis is rapidly evolving as a result of recent advances in high-throughput genomic and proteomic technologies. The objectives of this workshop are to improve understanding of primary and secondary immunodeficiencies and disorders of immune regulation and refine diagnostic criteria surrounding immunodeficiency-related hematopoietic malignancy and their separation from immune-medi-ated morphologic mimics. This forum will specifically focus on pri-mary and secondary immunodeficiency and associated neoplasms, immune dysregulation including autoimmune, iatrogenic and viral-related lymphoproliferative disorders and post-transplant lym-phoproliferative disorders. In addition, distinguished speakers will share their insights into human immune senescence, hematopoietic stem cells and aging and high throughput strategies to interrogate lymphocyte repertoires in inherited and acquired immunodeficiency.

Program Committee

Yaso Natkunam, MD, PhD (Chair)

Dita Gratzinger, MD, PhD

Scott Boyd, MD, PhD

Department of Pathology Stanford University Sch of MedicineStanford, California, USA

Workshop Review Panel

Amy Chadburn, MD

John K.C. Chan, MD, FRCPath

Daphne de Jong, MD, PhD

Elaine S. Jaffe, MD

John Goodlad, MD, FRCPath

Dita Gratzinger, MD, PhD

Yaso Natkunam, MD, PHD

Jonathan Said, MD

October 29 – 31, 2015Long Beach Convention CenterLong Beach, California

Immunodeficiency and Dysregulation

2015 Workshop

This year the SH workshop is being held in conjunction with the ASCP annual meeting. This allows you to attend certain ASCP meeting functions in addition to this workshop. Please see schedule and additional registration option details enclosed.

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Faculty

Scott Boyd, MD, PhDStanford University Sch of MedicineStanford, CA

Ethel Cesarman, MD, PhDWeill Medical College of Cornell UniversityNew York, NY

Amy Chadburn, MDWeill Medical College of Cornell UniversityNew York, NY

John K.C. Chan, MD, FRCPathQueen Elizabeth HospitalHong Kong

Mark Davis, PhDStanford University School of MedicineStanford, CA

Daphne de Jong, MD, PhDNetherlands Cancer InstituteAmsterdam, The Netherlands

John Goodlad, MD, FRCPathUniversity of EdinburghUnited Kingdom

Dita Gratzinger, MD, PhDStanford University Sch of MedicineStanford, CA

Elaine S. Jaffe, MDNational Institutes of HealthBethesda, MD

Katherine Yudeh King, MD, PhDBaylor College of MedicineHouston, TX

Yaso Natkunam, MD, PHDStanford University Sch of MedicineStanford, CA

Stefania Pittaluga, MD, PhDNational Institutes of HealthBethesda, MD

Jonathan Said, MDUCLA Medical CenterLos Angeles, CA

Steven H. Swerdlow, MDUniversity of PittsburgPittsburg, PA

Educational Objectives

After attending the conference, partici-pants should be able to: • Appraise current WHO catego-

ries of immunodeficiency-related lymphoproliferative disorders, and identify areas of diagnostic difficulty (Knowledge, Competence, Performance)

• Correlate advances in molecular diag-nostics and the molecular pathogenesis of primary (congenital), post-trans-plant, infection-related, aging, autoim-mune and iatrogenic immunodeficien-cies and related lymphoproliferative disorders (Knowledge, Competence)

• Connect new clinical approaches to treatment and monitoring of patients with immunodeficiency-related lym-phoproliferative disorders to hemato-pathology practice (Knowledge, Com-petence, Performance, Patient Outcomes)

Target Audience

This conference is designed for physi-cians and other health professionals in hematopathology, pathology, hematology and oncology.

Educational Methods

Lectures, Case Studies, Questions and Answers, Audience Response System

Evaluation

A course evaluation form will provide participants with the opportunity to comment on the value of the program content to their practice decisions, performance improvement activities, or possible impact on patient health status. Participants will also have the opportu-nity to comment on any perceived com-mercial bias in the presentations as well as to identify future educational topics.

Accreditation/ Credit Designation

The Society for Hematopathology in partnership with the American Society for Clinical Pathology designates this live activity for a maximum of 20 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensu-rate with the extent of their participa-tion in the activity.

The American Society for Clinical Pathology is accredited by the Accredita-tion Council for Continuing Medical Education to provide continuing medical education for physicians.

CME Certificates and Attendance

Verification CertificatesCertificates awarding AMA PRA Category 1 CreditTM or certificates docu-menting attendance will be distributed to participants when the participant departs the conference. To obtain a CME certificate, physicians must submit a completed evaluation questionnaire and a CME Verification Form. Upon request, a record of attendance (certificate) will be provided on–site to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

5.0 SAM CreditsThe Society for Hematopathology is partnering with the American Society for Clinical Pathology to provide American Board of Pathology (ABP)-approved Self-Assessment Module (SAM) credits. SAM credits are necessary to meet the ABP maintenance of certification require-ments. SAM credits will be available for this conference.

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Types of Cases Featured in the Workshop

Lymphoproliferative disorders of primary (congenital) immunodeficiency• Lymphoproliferative neoplasms in the setting of chronic variable im-

munodeficiency (CVID), severe combined immunodeficiency (SCID), hyper-IgM syndrome, CD40/CD40 ligand deficiency, ataxia telangi-ectasia, autoimmune lymphoproliferative syndrome (ALPS), X-linked lymphoproliferative syndrome (XLP), chronic granulomatous disease (CGD), Nijmegen breakage syndrome (NBS) and related entities.

• Morphologic abnormalities or mimics of lymphoma in the setting of primary immunodeficiency or inherited immune disorders.

Post-transplant lymphoproliferative disorders (PTLD) • Particular focus will be given to uncommon categories or controversial areas of

PTLD with the goal of achieving better definitions and criteria for diagnosis• Early lesions• Polymorphic PTLD and the border with monomorphic PTLD• EBV-negative PTLD• T-cell PTLD• Classical Hodgkin and Hodgkin-like PTLD

Infection-related lymphoproliferative disorders (excluding PTLD)• Lymphoproliferative disorders related to HCV,

HHV8 and other oncogenic viruses• HIV-associated lymphoma, with a focus on less common manifestations

(e.g. Burkitt with plasmacytoid differentiation, plasmablastic lymphoma)• Chronic active EBV (CAEBV)• EBV-positive T and NK cell lymphoproliferative disorders of childhood • Non-neoplastic complications of infection/ immunodeficiency-

related lymphoproliferative disorders (e.g. hemophagocytic lymphohistiocytosis, macrophage activation syndrome)

Lymphoproliferative disorders related to autoimmunity, non-transplant iatrogenic conditions and aging • Autoimmune conditions including systemic lupus erythematosus, rheu-

matoid arthritis, and IgG4-related systemic sclerosing disease• Manifestations related to drugs (e.g. methotrexate) or biologic response

modifiers (e.g. interferon, TNF-alpha, G-CSF, monoclonal antibodies)• Other predisposing conditions (e.g. breast implants/seroma, lymphoma)• Aging and immune senescence (e.g. EBV+ lymphoproliferations

of the elderly)

Featured Guest Speakers & Topics

Mark Davis, PhD Human Immune Senescence: Insights into Immunodeficiency of Aging

Stefania Pittaluga, MD, PhD Primary Immunodeficiency Disorders

Steven Swerdlow, MD Posttransplant Lymphoproliferative Disorders

Ethel Cesarman, MD, PhD Human Oncogenic Herpesviruses

John K. Chan, MD, FRCPath IgG4-Related Systemic Sclerosing Disorders

Scott Boyd, MD, PhD High-Throughput DNA Sequencing Studies of Lymphocyte Repertoires in Inherited and Acquired Immunodeficiency

Katherine Yudeh King, MD, PhD Inflammation Regulates Hematopoietic Stem Cell Function

Robert H. Schiestl, PhD Intestinal microbiota involved in genetic instability, genotoxicity, latency of lymphoma and longevity in Atm deficient mice

Registration Open

ascp.org/2015SHmeeting

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WEDNESDAY, OCTOBER 28TH - ASCP/SH DAY AT ASCP 2015

6:30 am – 6:00 pm Registration at Long Beach Convention Center Open8:00 am – 9:30 am ASCP Educational Sessions9:45 am – 11:15 am ASCP Educational Sessions

Including a 90 minute program on The Diagnosis, Classification and Clinical Care of Peripheral T‐cell Lymphoma (PTCL)

1:00 pm – 4:10 pm ASCP Educational Sessions Including a 3-hour program on The Spectrum of Non-Neoplastic Hematologic Disease

4:30 pm Poster Presentation Viewing5:00 pm – 6:30 pm ASCP Grand Opening General Session6:15 pm – 8:00 pm ASCP Grand Opening Reception in Science Connection

Central

Schedule

NEW – Join us 1 day early for ASCP/SH Day! For only $199 additional, get full access to all of ASCP 2015, including ASCP/SH day on Wednesday, featuring a full day of hematopathology content presented by both organizations.

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THURSDAY, OCTOBER 29, 2015

7:00 am – 8:00 am Continental Breakfast8:00 am – 8:05 am Welcome

Yaso Natkunam8:05 am – 8:35 am Post-Transplant Lymphoproliferative Disorders: Clinicopathologic

Spectrum and Diagnostic ChallengesLecture: Steven Swerdlow

Session One, Part 1: EBV-Associated Proliferations of Varied Malignant PotentialPanelists: John Goodlad and Yaso Natkunam8:40 am – 8:50 am Session Introduction8:50 am – 10:10 am Oral Presentations10:10 am – 10:30 am Break10:30 am – 12:00 pm Oral Presentations continued12:00 pm – 12:20 pm Session Summary

12:20 pm – 1:30 pm Lunch

Session One, Part 2: IgG4 DiseasePanelists: John Goodlad and John Chan1:30 pm – 2:00 pm Oral Presentations2:00 pm – 2:30 pm IgG4-Related Systemic Sclerosing Disorders

Lecture and Summary: John Chan

Session Two: B-Cell and Classical Hodgkin Lymphomas Associated with ImmunodeficiencyPanelists: John Chan and Daphne de Jong2:30 pm – 2:35 pm Session Introduction2:35 pm – 3:50 pm Oral Presentations3:50 pm – 4:10 pm Break4:10 pm – 5:50 pm Oral Presentations continued5:50 pm – 6:10 pm Session Summary6:15 pm SH Program Ends for the Day (Dinner on Your Own)

ASCP Schedule for Add-On Registrants5:30 pm – 6:30 pm ASCP Exhibitor Attendee Mixer (Reception in Hall)6:40 pm – 8:10 pm ASCP Educational Sessions6:40 pm – 8:30 pm ASCP Poster Platform Oral Abstract Sessions

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FRIDAY, OCTOBER 30

7:00 am – 8:00 am Continental Breakfast

Session Three: HHV8/KSVH-Related Lymphoproliferative Disorders and the Spectrum of Plasmablastic/Plasma Cell NeoplasmsPanelists: Amy Chadburn and Jonathan Said8:05 am – 8:35 am Human Oncogenic Herperviruses: Role in Immunodeficiency and

LymphomagenesisLecture: Ethel Cesarman

8:35 am – 8:40 am Session Introduction8:40 am – 10:10 am Oral Presentations10:10 am – 10:30 am Break10:30 am – 11:40 am Oral Presentations continued11:40 am – 12:00 pm Session Summary12:00 pm – 12:30 pm Intestinal microbiota involved in genetic instability, genotoxicity,

latency of lymphoma and longevity in ATMdeficient miceLecture: Robert Schiestl

12:30 pm – 2:00 pm Roche/Ventana Lunch Symposium: Studies of the Checkpoint Immune System in Neoplasia

Perspectives on Hematopoietic Stem Cells and Immume SensecencePanelists: Brent Tan and Scott Boyd2:00 pm – 2:30 pm Hematopoietic Stem Cells and Inflammation

Lecture: Katherine Yudeh King2:30 pm – 3:30 pm Immune Senescence: Insights into immunodeficiency of aging

Keynote Lecture: Mark M. Davis

3:30 pm – 3:45 pm Break

Session Four: T-Cell and NK-Cell Lymphomas Associated with ImmunodeficiencyPanelists: Dita Gratzinger and Daphne de Jong3:35 pm – 3:50 pm Session Introduction3:50 pm – 5:10 pm Oral Presentations5:10 pm – 5:30 pm Session Summary

6:00 pm – 10:00 pm SH Halloween Gala Dinner Reception at the WESTIN hotel (Costumes highly encouraged!)

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SATURDAY, OCTOBER 31

7:00 am – 8:00 am Continental Breakfast

Session Five, Part 1: Systemic EBV+T and NK Cell Lymphoproliferative DisordersPanelists: Dita Gratzinger and Elaine Jaffe8:00 am – 8:05 am Session Introduction8:05 am – 9:05 am Oral Presentations9:05 am – 9:20 am Session Summary9:20 am – 9:50 am High-throughput DNA sequencing studies of lymphocyte

repertoires in inherited and acquired immunodeficiencyLecture: Scott Boyd

9:50 am – 10:10 am Break

Session Five, Part 2: Primary/Congenital ImmunodeficiencyPanelists: Dita Gratzinger and Elaine Jaffe10:10 am – 10:40 am Primary/Congenital Immunodeficiency Disorders

Lecture: Stefania Pittaluga10:40 am – 10:45 am Session introduction10:45 am – 12:20 pm Oral Presentations12:20 pm – 12:40 pm Session Summary

12:40 pm – 12:55 pm Workshop SummaryYaso Natkunam

12:55 pm – 1:00 pm Closing RemarksSherrie Perkins

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Airports & Ground TransportationLong Beach area is served by two main airports

• John Wayne, Orange County Airport, Santa Ana/ Anaheim (22mi/30minutes from Long Beach)

• LAX Los Angeles International Airport, Los Angeles (23mi/40minutes)

Taxicabs and Shuttle Transportation to the Westin Hotel Long Beach can be arranged upon arrival at either airport

Meeting FacilityThe SH-EAHP 2015 Workshop will be held Thursday – Saturday, October 29-31, 2015 in Long Beach, California, USA at the Long Beach Convention & Entertainment Center. See visitlongbeach.com.

The ASCP Annual meeting will also be held at this location from Wednesday – Friday this same week.

AccommodationsThe host hotel for the 2015 SH//EAHP Workshop is the WESTIN Long Beach. The Westin Long Beach is located at 333 East Ocean Blvd in Long Beach, California. See westinlongbeachhotel.com.

It is conveniently located halfway between Los Angeles International Airport and Orange County Airport. Only a mile from the beach, and a few minutes from the new Aquarium of the Pacific, guests can experience the best of California.

Room ReservationWe have secured a room block to accommodate our SH/EAHP guests. It is very important that you stay at the WESTIN to receive the preferential pricing we have secured. The Westin hotel group rate pricing will be available until October 8, 2015, so please book early to assure your reservation using the link on the Workshop website.

Reception & DinnerA Gala Reception and Halloween themed dinner will be held at the Westin Long Beach SH/EAHP host hotel on Friday evening, October 30, 2015.

One ticket to this event is complimentary with your workshop registration.

Guests may be added at the cost of $125 each.

Workshop WebsitePlease continue to visit the SH/EAHP 2015 Workshop website at ascp.org/2015shmeeting for continuously updated information about this meeting, including information about: Educational program; registration; conference faculty; hotel and gala dinner.

6:00pm - 7:00 pm Cocktails

7:00pm - 9:00 pm Dinner

9:00pm - 10:00 pm Dancing

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Registration InformationThe American Society for Clinical Pathology - ASCP, see ascp.org, is managing and hosting the SH/EAHP 2015 Workshop in association with the ASCP 2015 Annual Meeting. ASCP is providing an option to add-on access to the ASCP program for activities outside of SH Workshop times.

For more information about any aspect of the SH/EAHP 2015 Workshop, please contact Jennifer Clark, SCT(ASCP)CMMBCM at 1.312.541.4999 x3901 or by email at jennifer.clark@ascp.org

Early registration pricing is available until 8/31/2015. Advance registration is encouraged.

The full conference registration fee includes the tuition, conference materials, breaks, lunches, and one gala dinner. Guests may be added to the gala dinner for an additional fee.

There are three ways to register for the workshop:1. Online registration at ascp.org/services/Organization/

OrgMeetingInfo?Org=SH is preferred. You will receive immediate email receipt confirmation.

2. Mail to: The Society for Hematopathology, C/O ASCP, 3462 Eagle Way, Chicago, IL 60678

3. Call ASCP Customer Service at: 1.800.267.2727 (Toll-free) 312.541.4848 (International Customer Service) Fax 312.541.4472

We accept the following forms of payment:

• Check (payable through U.S. banks only)• Money Order• Credit Cards (MasterCard, VISA, and American Express)

Refund/Cancellation PolicyA full refund will be issued for cancellations received in writing no later than October 10, 2015. Refunds are not issued for cancellations after this date. ASCP reserves the right to cancel a program due to circumstances beyond its control or for insufficient registration. Registrants will be notified immediately and allowed to substitute a session or obtain a full refund. The Society is not responsible for penalties incurred as a result of cancelled transportation. Please notify us in advance by contacting ASCP Customer Service at 800.267.2727, option 2; international callers: 312.541.4890; or ascp.org/feedback.

Registration Open

ascp.org/2015SHmeeting

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PARTICIPANT INFORMATIONLast Name First MI

Highest Degree

Department (include box no.)

Specialty

Physician

Institution

Street

City State Zip or Mail Code

E–mail Address

Daytime Phone (with area code) Cell Phone (with area code)

Fax (with area code) Emergency Contact Phone (with area code)

PAYMENT INFORMATIONCharge the following: VISA MasterCard American ExpressCredit Card Number Expiration Date

Credit Card Holder Name (First/Last)

Credit Card Holder Billing Address

IDT Approver Name (First/Last)

IDT Approver E–mail

Authorized Signature (REQUIRED)

2015 Workshop Registration – October 29-31, 2015 This is not a self-mailer

Address to:The Society for HematopathologyC/O ASCP3462 Eagle WayChicago, IL 60678

Make check or money order payable to:The Society for Hematopathology

Registration FeesSH/EAHP Members

$649 Rate until 8/31/15 $699 Rate on or after 9/1/15

Non–Members $699 Rate until 8/31/15 $749 Rate on or after 9/1/15

Trainees $449 Rate until 8/31/15 $499 Rate on or after 9/1/15

Dinner Guest FeeGuests for Gala Reception and Dinner

$125 per Guest # of Guests

ASCP/SH Day – Wed, October 28 (New!)For only $199 additional, get full access to ASCP 2015, also located at the Long Beach Convention Center. Includes access to ASCP/SH Day on Wednes-day, October 28, featuring a full day of hematopathology sessions, including:

• The Spectrum of Non-Neoplastic Hematologic Disease: Important Non-Malignant Conditions in Lymph Nodes, Bone Marrow, and Flow Cytometry

• The Diagnosis, Classification and Clinical Care of MDS II• The Diagnosis, Classification and Clinical Care of T-Cell Lymphoma

TOTAL Payment

$

ASCP 2015 RegistrationIncludes access to ASCP/SH Day and all ASCP 2015 sessions, keynotes, exhibits, and the Opening Reception.

$199