Small Animal Ventilator for Hyperpolarized Helium MRI

Ashley Anderson III, Micah Brown, Matt Smith, Chris Wegener

Client: Dr. Sean FainAdvisor: Dr. Willis Tompkins

MRI compatible ventilator system Deliver 20% O2 and 80% He-3 in

same breath Allows constant scanning of the He-3 in

MRI rather than every 4 breaths

Client Requirements

Background - Helium MRI

Newer technique Same MRI scanner

Convention is H Here, tuned to Helium

(48.6 MHz) Breath of Helium Displays respiratory

channels

Project Concept

• Each syringe feeds off of independent gas reservoirs

• Gas mixing occurs right before entering small animal

First Generation Prototype

Currently in use in animal studies Only using one syringe Not compatible with small syringes

for mouse studies

Modifications to G1

Reinforced syringe clips

Larger motor Eliminated

O2 chaser breath

Calibration

Results using manometer testing. Graph shows small deviation from entered volumes.

Second Generation Concept

Second Generation Prototype

Created in Solidworks

Smaller components

Interchangeable syringes

Adjustable axle support

Second Generation Prototype

Large motor Motor shielding Precision

machining Can be

disassembled

From Solidworks to Reality

Does it move?

Did we meet client requirements?

Gear ratios allow the appropriate 80/20 gas output ratio

MRI Safe materials Motor shielded for RF Rat/Mouse

compatible

Future Work

Calibration testing Volume delivery Timing

Software development Simultaneous 3He/O2 delivery Inspired time based on %Insp and RR Valve switching

Mixing testing (imaging)

Questions?