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Enabling Research with Infrastructure:From Alzheimer’s to Tinnitus to Big Bird

Ardoth HasslerAssociate Vice PresidentUniversity Information Services

With Collaborators: Steve Moore, Director Research TechnologiesScott Allen, Director Network ServicesClay Shields, Professor, Computer Science

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Overview

• CC-NIE – Network Infrastructure: Enabling Big-Data Science Collaboration at Georgetown

• CC*IIE – NWIRED - Network Innovation for Research and Education at Georgetown: Science DMZ and Cloud Services

• CC*DNI – Engineer: CRaNE – Cyberinfrastructure Research Network Engineer (pending)

Scientific Research – Over 22 use cases from researchers from both Main Campus and the Medical Center were cited in these proposals.

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CC-NIE Award: Network Infrastructure: Enabling Big-Data Science Collaboration

• Georgetown upgraded high-end networking across Hilltop campuses • Improvements enabled end-to-end 10 Gbps connectivity among GU's

science buildings, campus backbone, off-campus data center, Mid-Atlantic Crossroads (MAX) Gigapop, and Internet2.

• 1Gbps or 10Gbps connections were provided to select departmental locations including:

Programs• Biology • Chemistry • Computer

Science • Medicine • Neuroscience • Pharmacology • Physics

Centers• Center for Brain Plasticity • Center for Functional and Molecular Imaging • Georgetown-Howard Center for Clinical and

Translational Science • Innovation Center for Biomedical Informatics• Lombardi Cancer Center Shared Resources • Universal Protein Resource • Others

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Enhanced ResearchInfrastructure

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CC*IIE: Create Science a DMZNWIRED - Network Innovation for Research and Education at Georgetown: Science DMZ and Cloud Services

• Goals/Plans:– Provide a friction-free, high-speed network for Big

Science and Big Data– Create a network for scientific collaboration internally

and with external researchers – Leverage GU's extant plan for Multi-Processing Label

Switching deployment on campus

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CC*IIE: Create Science a DMZ

Science DMZ:• Creates “Friction Free” IP networks on and off campus• Leverages GU’s10Gbps network enhancements on

campus and to Internet2 (via CAAREN) • Securely extends the network into cloud services via

encrypted Layer-2/3 connection at GU’s Virginia Data Center (VDC)

• Benefits Access to:– HPC and Storage at GU’s at Laurel Data Center (LDC)– Services at VDC including access to Amazon Web

Services, Internet2 Net+, and compute and storage resources at National Labs, XSEDE, et al 

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GU’s Science DMZ

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Alzheimer’s Research Research

GU’s 10 Gbps network upgrade allowed Dr. Federoff’s team the ability to store, manage, and analyze over 16 TBs of data from blood tests from 525 participants, age 70, over a 5-year observational period using and validating 10 plasma phospholipid biomarkers.

The results identified a potential blood test for cognitive decline that is now moving to commercialization.

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Georgetown and Howard universities received notification of a $27 million Clinical and Translational Science Award (CTSA) from the NIH.

The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a multi-institutional consortium of medical research institutions forged from a desire to promote clinical research and translational science. The members of the GHUCCTS consortium are: Georgetown University (GU), Howard University (HU), MedStar Health Research Institute (MHRI), Oak Ridge National Laboratory (ORNL), and the Washington Veteran’s Affairs Medical Center (VAMC).

Through multiple partnerships and collaborations among the member institutions, GHUCCTS is transforming clinical research and translational science in order to bring new scientific advances to health care. - See more at: http://georgetownhowardctsa.org/about-us#sthash.IY5n8cRL.dpuf

Research

GU

•EHR•LAB•Registries•Research

MedStar

•EHR•LAB•Registries•Research

HUH

•EHR•Lab•No Std.

VA DC

•Project based•EHR

GU

•EHR•LAB•Registries•Research

MedStar

•EHR•LAB•Registries•Research

HUH

•Project based•EHR•i2b2

VA DC

•Project based•EHR

GU

•EHR•LAB•Registries•Research

MedStar

•EHR•LAB•Registries•Research

HUH

•EHR•LAB•Registries•Research

VA DC

•Project based•EHR

• SHRINE• CTSAs• Friction Free research

Network• Patient engagement

• Coalitions• Team science• Underserved Pop

• Common IRB• BAA & DUA• Dashboard• CTMS

• Cohort Discovery

• BI Services• i2b2

• Common IRB• BAA & DUA• Dashboard

• Cohort Discovery

• BI Services• i2b2

Available Patients’ Records:3.4 Million

GovernanceFederationWorkflowsCompliance

Pre-CTSA

Research Network

Now

Next

No Access

Access to High-Scale Research Data - CTSA

Hybrid Cloud Computing solution for researchBuilt on UIS LDC & AWS’s Virtual Private Cloud Architecture

GUAmazon Classic Web Services CloudSecure VPN

Connection over the Internet

Subnets

Isolated AWS resources

RouterVPN

Gateway

NAT

VPC

Source: Amazon Web Services VPC Architecture

Internet

Internet

Investigator͛�s Desktop10 Gig LAN10 Gig

• Science as Service• Elastic environment• Storage and

computing at scale

Globus Genomics Project: Leveraging High Speed Bandwidth at GU:

• Globus Genomics (GG):ICBI and Genomics Shared Resource at Georgetown University Medical Center initiated a joined pilot project with the University of Chicago. The project is introducing and implementing high efficiency tools and capabilities to transfer large data sets to the cloud, and use pipelines and software applications developed by the Center. – Data Management SaaS– Next-gen sequence analysis pipelines– Flexible, scalable, cost effective

Globus Genomics Pilot

Current

Projects 8

Users 6

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Neuroscientists Discover Brain Abnormalitiesfor Tinnitus and Chronic Pain

Josef Rauschecker, PhD, DSc

GUMC and Germany’s Technische Universität München have uncovered the brain malady responsible for tinnitus and for chronic pain. The scientists describe how the neural mechanisms that normally “gate” or control noise and pain signals can become dysfunctional, leading to a chronic perception of these sensations. They traced the flow of these signals through the brain and showed where “circuit breakers” should be working — but aren’t.

https://gumc.georgetown.edu/news/Neuroscientists-Uncover-Brain-Abnormalities-Responsible-for-Tinnitus-and-Chronic-Pain

Research

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Measureable OutcomesCenter for Brain Plasticity and Recovery

454 MB Brain Image File

Before CC-NIE: 39 seconds to upload to Data CenterAfter CC-NIE: 19 seconds

http://cbpr.georgetown.edu/

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Measureable OutcomesChildren’s Digital Media Center: Understanding Digital Media’s Influence on Children

Sandra L. Calvert, Ph.D., is Professor of Psychology at Georgetown University (G.U.) and a co-founder and the Director of the Children’s Digital Media Center a multi-institution interdisciplinary research center that has received funding primarily from four collaborative grants from the National Science Foundation.

Dr. Calvert’s lab is connected to the 10 GBs campus network. She wrote:

“Just wanted to thank you for getting my office and Center into the digital age!”

- Sandyhttp://cdmc.georgetown.edu/

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Approaches: Two Examples

• AWS– Connected to Amazon Cloud using site-to-site VPN– Proteomics Information Resource Center was satisfied

with test results– More to come with Science DMZ

• Results of Prior Work for Notice for Prospective PIs

Networking Infrastructure Enhancements: Georgetown University is the recipient of NSF CC-NIE award #1340971, Enabling Big-Data Science Collaboration at Georgetown (2013, $379,018) and CC*IIE award #1440743, NWIRED - Network Innovation for Research and Education at Georgetown (2014, $425,373). These awards enabled campus network infrastructure upgrades to 10 Gbps with 1 Gbps uplinks for most researchers, increased the speed of our connection to Internet2, and enabled implementation of a Science DMZ (in progress). When completed in 2015, the Science DMZ portion of the network will be optimized for high performance scientific applications rather than for general purpose business systems. [Ardoth A. Hassler, PI]

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Summary

• What’s Ahead– BIG Data

• AvesTerra infrastructure: force migration, HIV/AIDS – http://avesterra.georgetown.edu/

• McCourt School of Public Policy Massive Data Institute– http://mccourt.georgetown.edu/massive-data-institute/research

– Much more…• Computer Science Collaborations • Neuroscience is GU’s most externally funded research• Tinnitus Research is one of many projects that will benefit from a

CC*DNI award

Results of CC-NIE and CC*IIE awards are enabling research at Georgetown

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Questions?

Contact• Ardoth Hassler

hasslera@georgetown.edu• Steve Moore

moores@georgetown.edu• Scott Allen

Scott.Allen@georgetown.edu• Clay Shields

clay@cs.georgetown.edu