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Sleep and Wakefulness (and Circadian Rhythms). What is Sleep?. Minimal Behavioral Activity. A rapidly reversible state of quiescence. Increased Arousal Threshold. Species-Specific Posture. Tobler and Stadler , 1988. Measurement of Sleep. Two Types of Sleep. - PowerPoint PPT Presentation
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Sleep and Wakefulness (and Circadian Rhythms)
What is Sleep? Minimal Behavioral Activity
A rapidly reversible state of quiescence
Increased Arousal Threshold
Species-Specific PostureTobler and Stadler, 1988
Measurement of Sleep
Two Types of SleepNon-rapid eye movement (NREM) sleepFour different stages (1 [lightest] 4 [deepest])Mixed-frequency EEGlow amplitude, high frequency or high amplitude, low frequencyRelatively little muscle movements
Rapid eye movement (REM) sleepLow-amplitude, high frequency EEGSynchronous eye movementshttp://www.youtube.com/watch?v=AZ6I9N7t7VcParalysisNarcolepsy: http://www.youtube.com/watch?v=nvMyuZKGKAY
Time Course of Sleep
Ontogeny of Sleep
Neural Control of Sleep
Neural Control of (NREM) Sleep
Bottom-Up ProcessingFlip-Flop CircuitCliff Saper, Bob McCarley, Jerome Siegel
Neural Control of (REM) SleepPGO waves pons-geniculate-occipital areas ORBrainstem-Thalamus-Occipital Cortex
Brain-Spinal Cord Induction of Paralysis During REM sleep
Neural Control of Spindles
Really Cool Probing of Sleep-Regulatory Areas With Optogenetics
Circadian Rhythms
Basic Criteria of Circadian RhythmsAny physiological or behavioral process that oscillates predictably across 24 hrsThis rhythm can be shifted by environmental factors (light, drugs, mating)Persist even with the removal of environmental factors (light, seasons)Some Out-of-Phase Physiological Rhythms
Rhythms in HumansNathaniel Kleitman and Eugene Aserinsky
Neural (SCN) Control of Rhythms
SCN: Suprachiasmatic NucleusBeyond the SCN: Molecular Control of Rhythms
Real-Time Recording of Molecular Feedback in the SCN
Working in TandemInteraction between sleep and circadian brain systems characterized as the two-process model
More Questions?You can stop by for a lab visit