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Siver sulfadiazine

Introduction: Silver sulfadiazine is a sulfa derivative topical antibacterial usedprimarily as a topical burn cream on second- and third-degree burns.

Mechanism of action: Acts upon the bacterial cell wall and cell membrane.Bactericidal for many gram-negative and gram-positive bacteria and is effectiveagainst yeast. Active against Pseudomonas aeruginosa, Pseudomonasmaltophilia, Enterobacterspecies, Klebsiellaspecies, Serratiaspecies, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri,Proteusvulgaris, Providenciaspecies, Citrobacterspecies,Acinetobactercalcoaceticus,Staphylococcus aureus, Staphylococcusepidermidis, Enterococcusspecies, Candida albicans, Corynebacteriumdiphtheriae, and Clostridium perfringens.

Pharmacology:

Absorption: Significant percutaneous absorption of silver sulfadiazine can occurespecially when applied to extensive burns

Half-life elimination:10 hours; prolonged with renal impairment

Time to peak, serum: 3-11 days of continuous therapy

Excretion:Urine (?50% as unchanged drug)

Indications: Silver sulfadiazine 1% (silver sulfadiazine) is a topical antimicrobialdrugindicated as an adjunct for the prevention and treatment of wound sepsis inpatients with second- and third-degree burns

Dosage:Children and Adults: Topical: Apply once or twice daily with a sterile-gloved hand; apply to a thickness of 1/16; burned area should be covered with

cream at all times

Administration: Topical

Apply with a sterile-gloved hand. Apply to a thickness 1/16. Burned area should

be covered with cream at all times.

Side effects: Check with your doctor as soon as possible if any of the followingside effects occur:

Rare Blistering, peeling or loosening of skin Bloody or cloudy urine Chills or fever Cough Decreased amount of urine or less frequent urination Increased sensitivity of skin to sunlight, especially in patients with burns

on large areas

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Intense itching of burn wounds Pain at site of application Painful or difficult urination Red skin lesions, often with a purple center Shortness of breath

Sore throat Sores, ulcers or white spots on lips or in mouth Swollen glands Unusual bleeding or bruising Unusual tiredness or weakness

More common Burning feeling on treated area(s)

Less common or rare Brownish-gray skin discoloration

Itching or skin rash

Precautions:General: If hepatic and renal functions become impaired and elimination of drugdecreases, accumulation may occur and discontinuation of Silver sulfadiazine1% (silver sulfadiazine) should be weighed against the therapeutic benefit beingachieved. In considering the use of topical proteolytic enzymes in conjunctionwith Silver sulfadiazine 1%, the possibility should be noted that silver mayinactivate such enzymes.Pregnancy: Teratogenic Effects. Pregnancy Category B.: this drug should beused during pregnancy only if clearly justified, especially in pregnant womenapproaching or at term.

Nursing Mothers: It is not known whether silver sulfadiazine is excreted inhuman milk. However, sulfonamides are known to be excreted in human milk,and all sulfonamide derivatives are known to increase the possibilityof kernicterus. Because of the possibility for serious adverse reactions in nursinginfants from sulfonamides, a decision should be made whether to discontinuenursing or to discontinue the drug, taking into account the importance of the drugto the mother.

Geriatric Use: No overall differences in safety or effectiveness were observedbetween these subjects and younger subjects, and other reported clinicalexperience has not identified differences in responses between the elderly andyounger patients, but greater sensitivity of some older individuals cannot be ruledout.

Pediatric Use: Safety and effectiveness in pediatric patients have not beenestablished.

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Contraindications: Silver sulfadiazine is contraindicated in patients who are

hypersensitive to silver sulfadiazine or any of the other ingredients in the

preparation.

How supplied: Customized as per request.