Water Technologies & Solutions

Laboratory TOC Analyzer and Autosampler RT12Sievers* 860

www.sieversinstruments.com

Sievers membrane conductometric TOC technology The Sievers 860 Analyzer uses the Sievers Membrane Conductometric Detection method, which has proven to be an extremely reliable technique for measuring TOC. It uses a gas-permeable membrane that selectively passes only the CO2 produced from the oxidation of organics. By preventing compounds such as acids, bases, and halogenated compounds from interfering with the measurement, the Membrane Conductometric Method delivers unmatched sensitivity, selectivity, stability, accuracy, and precision. This technique also can tolerate higher conductivity and remove inorganic carbon more effectively than TOC analyzers that use the direct conductometric technology.

DataPlus software The Sievers 860 can operate standalone via the instru- ment’s keypad or with a PC. When using a PC, the innovative, easy-to-use DataPlus software allows users to operate the Sievers 860, manage and analyze water sample data, and comply with pharmaceutical water testing regulations. The most robust laboratory TOC data management tool available, DataPlus lets you:

• Set up sampling protocols in just minutes

• Create trending charts for a single sample point for internal quality control and troubleshooting

• Export data as .csv or .xls files and print reports and trending charts in pdf format

• Perform calibration and verification with a single mouse click

• Track consumables usage and conduct routine maintenance easily

firmware upgrades Firmware can be updated easily using a USB. You can take advantage of the latest features and optimize performance without changing hardware.

high performance at an affordable cost for general pharmaceutical water testing requirements The Sievers 860 Laboratory Total Organic Carbon (TOC) Analyzer was designed specifically for pharmaceutical applications. Based on the Sievers technology used in the best-selling M9 Laboratory model, the Sievers 860 provides excellent analytical performance at an affordable price. It offers a streamlined feature set designed to meet general pharmaceutical water testing requirements. Like other Sievers TOC analyzers, the Sievers 860 is easy to set up, operate, and maintain and requires no special operator training. The Sievers 860 needs no internal reagents, which minimizes cost of operation. The innovative DataPlus software features an intuitive PC-based interface, the software lets you easily manage the data sample points in your water system and comply with global TOC monitoring requirements, such as the US, European, Chinese, Indian, and Japanese Pharmacopeias (USP, EP, ChP, IP, and JP). Sievers TOC Analyzers bring a strong tradition of innova- tion, quality, and reliability. When regulatory compliance and public safety is critical, partnering with an estab- lished, trusted manufacturer is essential to control risks. Sievers is the leading pharmaceutical TOC analyzer brand, and more than 10,000 Sievers TOC Analyzers have been installed throughout the world. applications The Sievers 860 TOC Analyzer was designed for general pharmaceutical water testing, including Water for Injection (WFI) and Purified Water (PW). It has a linear range of 0.3 ppb to 1.5 ppm and offers a more robust alternative to the direct conductivity method.

Sievers 860 highlights• Proven Sievers Technology — Uses the proven Sievers

Membrane Conductometric TOC technology that pro- vides unsurpassed analytical performance and reliability.

• Regulatory Compliance — The Sievers 860 complies with major global pharmacopeia requirements.

• Affordability — The Sievers 860’s streamlined feature set was carefully designed to reduce costs, while still offering high performance for select pharmaceutical applications.

• Easy Operation — The Sievers 860 can operate stand- alone via the instrument’s keypad or with a PC.

• Best-in-Class Software — DataPlus enables easy analyzer operation, data management, water quality trending, document creation, and regulatory compliance.

• Low Maintenance — Features one-year calibration stability and needs just a few hours of annual preventive maintenance.

options and accessories for the 860 DataGuard Software Sievers DataGuard software offers comprehensive sup- port for compliance with the USFDA’s 21 CFR Part 11 requirements. DataGuard provides an administratively controlled user access system, complete audit trail functionality, and electronic signature management.Autosampler RT12 The Autosampler RT12 is a highly-automated, com- pact accessory for the Sievers 860 designed to increase laboratory productivity. Extremely reliable, the RT12 requires little maintenance or adjustment. Key features and benefits include: Single-line connection and operation via DataPlus The RT12 can connect to both the Sievers 860 TOC Analyzer and the power supply with just one cable. Using a computer and the DataPlus software you can operate the Autosampler easily. High sampling capacity and simultaneous in-vial sparging The RT12 can handle up to twelve 40-mL vials. Its rotary design makes it easy to set up the sampling sequence according to the vial position in the rack. The RT12 enables overnight calibration and verification to ensure the Sievers 860 is ready to go the next day.

The RT12 has the same sipper needle design as the Sievers 860, enabling it to conduct in-vial sparging before sampling. When IC is high—especially when it is involatile IC—acidification is needed. Sparging effec- tively reduces the inorganic carbon and enhances mea- surement accuracy. Compact, space-saving size The RT12’s slim 23.1-cm wide profile requires minimal bench space. When operated side-by-side with the 21.5-cm wide Sievers 860 Laboratory Analyzer, the two units occupy just 46.6 cm of horizontal space. The RT12 requires only three connections—a sample inlet tube, a gas liquid waste outlet tube, and a power cable to the Sievers 860—keeping the lab bench neat and clean. Sievers certified standards and TOC vials Sievers Certified Reference Materials are available, including calibration and verification standards for the Sievers 860, as well as reliable and economical 40-mL TOC vials. Some of the most frequently used Sievers Standards for the 860 include: 74403 - System Suitability Set 74405 - Single-point Calibration Set 4406 - Linearity Set 74407 - Accuracy, Precision and Verification Set

Sievers 860 laboratory system specifications1

Find a contact near you by visiting www.sieversinstruments.com and clicking on “Contact Us”.* Trademark of SUEZ; may be registered in one or more countries.2017 © Copyright SUEZ. All rights reserved.

This information herein may be subject to change without notice and is provided for general guidance only. The dimensions and performance of systems, products and services may vary. Pictures are for example purposes and not to scale. All legal obligations are exclusively as set out in contractual documents. Nothing contained herein constitutes a representation, warranty or undertaking.

300 00240 Rev B

ISO

9001:2008QUALITY

MANAGEMENT SYSTEM

The UV lamp inside this product contains mercury and must be recycled or disposed of in accordance with local, state, and federal laws.

Hg6060 Spine Road Boulder, CO 80301-3687 USA T +1 800 255 6964 T +1 303 444 2009 F +1 303 527 1797www.sieversinstruments.com

total organic carbon Linear Range Precision Accuracy Analysis Time Sample Flow Rate (nominal) Sample pH Sampling Method Operation

0.3 ppb–1.5 ppm TOC 0.1 ppb or 1%, whichever is greater ± 5% at 500 ppb C of sucrose 6 minutes Analysis mode: 0.25 mL/min Fast Flush (between samples): 0.5 mL/min <3 Grab sampling PC or standalone operation; one PC can control up to four analyzers

analyzer specifications Power Requirements Fuses Ambient Temperature Normal Operating Environment Maximum Relative Humidity Maximum Altitude2 Sparge Gas (if used) Sparge Gas Flow Rate Calibration Stability Outputs Installation/Overvoltage Category Safety Certifications Pollution Degree Display Dimensions Weight

100–240 ±10% VAC, 60 W, 50/60 Hz T1.6 A, 250 VAC (SloBlo), size 5 x 20 mm (appliance inlet) 10 °C to 40 °C Intended for indoor use only Up to 95%, non-condensing 3,000 m (9,843 ft) Inlet pressure: 30 psig to 50 psig 120 mL/min to 150 mL/min Typically stable for 12 months One USB port to support printer or Flash drive, and one Ethernet port II CE, ETL listed. Conforms to UL Std. 61010-1. Certified to CSA C22.2 No. 61010-1 2 Color LCD H: 43.0 cm (16.9 in); W: 21.5 cm (8.5 in); D: 40.5 cm (15.9 in) 10.5 kg (23.0 lb)

1. Stated analytical performance is achievable under controlled laboratory conditions that minimize operator and standards errors.2. Known to meet performance specifications.

Autosampler RT12 Specifications1

Capacity Power Supply Ambient Temperature Normal Operating Environment Maximum Relative Humidity Maximum Altitude2 Dimensions Weight Safety Certifications

Twelve (12) 40-mL vials Power supplied by the Sievers 860 Laboratory TOC Analyzer 10 °C to 40 °C Intended for indoor use only Up to 95%, non-condensing 3,000 m (9,843 ft) H: 36.8 cm (14.5 in); W: 23.1 cm (9.1 in); D: 25.4 cm (10.0 in) 3.9 kg (8.6 lb) CE