Si M. Pham, MD

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CURRICULUM VITAE 1. Date: 12/4/2008 I.- PERSONAL Name: Si M. Pham, M.D. Office 305-355-5070 Current Academic Rank: Professor of Surgery, Director of Heart/Lung Transplant and

Artificial Heart Section Primary Department: Surgery Secondary or Joint Appointments: Citizenship: U.S.A. Visa Type: N/A II.- HIGHER EDUCATION 11.- Institutional

University of Saigon, School of Pharmacy Vietnam Sept. 1973 - April 1975 Lebanon Valley College B.S. (Magna Cum Laude) Annville, PA (Chemistry) September 1975 - May 1979 University of Pittsburgh M.D. Pittsburgh, PA September 1979 - May 1983 University of Pittsburgh Intern and Resident Pittsburgh, PA General Surgery (Director: Henry T. Bahnson, MD) July 1983 - June 1986 University of Pittsburgh Research Fellow Pittsburgh, PA Cardiothoracic Surgery July 1986 - June 1987 (Mentors:Bartley Griffith, Harvey Borovetz) University of Pittsburgh Senior and Chief Resident Pittsburgh, PA General Surgery (Director: Richard L. Simmons, MD) July 1987 - June 1989 University of Pittsburgh Resident (July1989-June 1991; Chief Resident July 1991-

June 92) Pittsburgh, PA Cardiothoracic Surgery (Henry T. Bahnson, Bartley Griffith) July 1989 - June 1992

12.- Non-Institutional: N/A 13.- Certification, licensure:

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Certification: American Board of Surgery (Certificate Number 35668)

Certified: 11/5/90; Recertification on 10/22/99; valid until 7/1/11

American Board of Thoracic Surgery (Certificate Number 5398) Certified: 6/4/93; Recertification on 12/3/01; valid until 12/31/13

American Board of Surgery-Added Qualifications in Surgical Critical Care (Certificate Number 1254)

Certified: 10/22/93; Recertification on 10/19/01; valid until 7/1/14 Licensure: State of Pennsylvania License Number MD 032420E 1984 State of Florida License Number ME 0076694 September 1998

III.- EXPERIENCE 14.- Academic:

University of Miami School of Medicine Miami, FL Professor of Surgery (June 2002 - present) Associate Professor of Surgery (October 1998 - May 2002; Tenured June 2001) Director of Cardiothoracic Transplant Section October 1998 - Present University of Pittsburgh School of Medicine Assistant Professor of Surgery Pittsburgh, PA July 1992 - September 1998 Presbyterian University Hospital Director of Extracorporeal Membrane Oxygenation Pittsburgh, PA July 1993 - September 1998 University of Pittsburgh School of Medicine Director, Adult Cardiac Transplant Program Pittsburgh, PA 15213 July 1993 - September 1997 UPMC Health System Director, Cardiothoracic Transplant Research Laboratory Pittsburgh, PA 15213 July 1997 - September 1998

15. Hospital Appointments: Jackson Memorial Hospital, Miami, FL, Attending Physician October 1998-present VA Medical Center, Miami, FL, Attending Physician July 2000-present University of Miami Hospital and Clinics, Miami, FL, Attending Physician October 1998-present

Presbyterian University Hospital, Pittsburgh, PA, Attending Physician July 1992-September 1998

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Children's Hospital of Pittsburgh, Pittsburgh, PA, Attending Physician July 1992-September 1998 Oakland Veterans Administration Medical Center, Pittsburgh, PA, Attending Physician July 1992- September 1998 Montefiore University Hospital, Pittsburgh, PA, Attending Physician July 1992-September 1998 Westmoreland Hospital, Pittsburgh, PA, Attending Physician July 1995-July 1997

15a.- Non-Academic: N/A

16.- Military Branch: N/A IV.- PUBLICATIONS (in my field, the last author is generally considered the senior author) 17. Books and monographs: 17 a. Books

1. A textbook of Congenital and Acquired Diseases of the Aorta. Liotta D, del Rio M, Cooley DA, Cabrol C, Griepp RB, Safi H, Fraser Jr CD, Pham SM, Bachet J, Elefteriades J, Bonser RS, Kato M, eds. Buenos Aires, Domingo Liotta Foundation Medical, 2003.

17 b. Monographs and book chapters

1. Katariya K, Tehrani H, Cohn SM, Salerno TA, Pham SM. "Traumatic injury to the thoracic aorta" in “Congenital and acquired diseases of the aorta: Liotta D, del Rio M, Cooley DA, Cabrol C, Griepp RB, Safi H, Fraser Jr. CD, Pham SM, Bachet J, Elefteriades J, Bonser RS, Kato M, eds. Buenos Aires, Domingo Liotta Foundation Medical, Chapter 39; pp 497-508, 2003.

2. Louis LB, Qi X, Pham SM. “Myocardial preservation in clinical cardiac transplantation: An update” in

Modern Myocardial Protection. Salerno T, Ricci M, eds., Blackwell Publishing/Futura, New York, Chapter 31; pp., 2003.

3. Fertel DP, Qi X, Pham SM. Treatment strategies for obliterative bronchiolitis. Curr Opin Organ

Transplant, 6:231-238, 2001.

4. Pham SM, Mitruka SN, Li S. Cytokines in pulmonary transplantation. Lung Biology in Health Disease. Nelson S, Martin TR, eds., Marcel Dekker, Inc., New York, Chapter 16, pp365-402, 2000.

5. Gammie JS, Pham SM. Simultaneous donor bone marrow and cardiac transplantation: Can tolerance be

induced with the development of chimerism. Current Opinion in Cardiology, 14:126-132, 1999. 6. Demetris AJ, Murase N, Lee RG, Randhawa P, Zeevi A, Pham SM, Duquesnoy R, Fung JJ, Starzl TE.

Chronic rejection. A general overview of histopathology and pathophysiology with emphasis on liver, heart and intestinal allografts. Annals of Transplantation, 2(2):27-44, 1997.

7. McCurry KR, Iacono AT, Dauber JH, Grgurich WF, Pham SM, Hattler BG, Keenan RJ, Griffith BP.

Lung and heart-lung transplantation at the University of Pittsburgh. Clinical Transplants 1997. Cecka and Terasaki, eds. UCLA Tissue Typing Laboratory, Los Angeles, Chapter 20, 209-218, 1997.

8. Pham SM, Ildstad ST. New concepts in immunobiology. Seminars in Anesthesia, 14(2):73-84, 1996.

9. Pham SM, Keenan RJ, Griffith B. New approaches to achieve immunologic acceptance of lung

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allografts. Semin Respir Crit Care Med, 17(2):197-205, 1996.

10. Gammie JS, Pham SM. Tacrolimus (FK506) in thoracic organ transplantation. The Transplantation and Replacement of Thoracic Organs (2nd ed). Cooper DKC, Miller LW, Patterson GA, eds. Dordrecht: Kluwer Academic Publishers, Chapter 10, pp89-95, 1996.

11. Kawai A, Pardis IL, Keenan RJ, Hardesty RL, Hattler BG, Pham SM, Griffithy BP. Lung

Transplantation at the University of Pittsburgh: 1982 to 1994. Clinical Transplants 1994. Terasaki P, Cecka T, eds. UCLA Tissue Typing Laboratory, Los Angeles, Chapter 8, pp111-120, 1995.

12. Pham SM, Kormos RL, Murali S, Kawai A, Demetris AJ, Hattler BG, Williams PA, McNamara D,

Rosenblum W, Griffith BP. Cardiac Transplantation at the University of Pittsburgh: 1994 Update. Clinical Transplants 1994. Terasaki P, Cecka T, eds. UCLA Tissue Typing Laboratory, Los Angeles, Chapter 9, pp121-125, 1995.

13. Thompson, ME, Paradis I, Dummer JS, Uretsky BF, Pham S. Cardiac and Cardiopulmonary

Transplantation. Cardiology. Parmley WW, Chatterjee K, eds. J.B. Lippincott Co., Philadelphia, Chapter 8, pp1-47, Vol. 3 1994.

18.- Juried or refereed journal articles or exhibitions:

18 a. Published: 1. Eddie W. Manning III, Mayur B. Patel, Lisardo Garcia-Covarrubias, Amir A. Rahnemai-Azar, Si M.

Pham, Matthias Majetschak. Proteasome peptidase activities parallel histomorphological and functional consequences of ischemia-reperfusion injury in the lung. Exp Lung Res (In Press, December 2008).

2. Roberto I. Vazquez-Padron, Si M. Pham, Dania Mateu, Sheik Khan, Abdelouahab Aitouche. An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase β2 mRNA translation. FEBS J, 2008, 275:3598-3607.

3. H. Layman, Marianne Sacasa, Ashley E. Murphy, Amy M. Murphy, Si M. Pham, Fotios M.

Andreopoulos, “Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model”, Acta Biomaterialia, (accepted July 2008).

4. Garcia-Covarrubias L, Manning E.W. III, Sorell LT, Pham SM, Majetschak M. Ubiquitin enhances the Th2 cytokine response and attenuates ischemia-reperfusion injury in the lung. Crit Care Med, 2008, 36:979-982

5. Majetschak M, Patel MB, Liotta C, Sorell LT, Li S, Pham SM. Cardiac proteasome dysfunction during

cold ischemic storage and reperfusion in a murine heart transplantation model. Biochem Biophys Res Commun, 2008, 365:882–888.

6. Li S, Salgar SK, Kurimoto Y, Yousem S, Pham SM. Mixed chimerism achieved by nontoxic conditioning regimen induces donor-specific tolerance to lung allografts. J Surgical Research. (J Surg Res. 2008;146(2):289-97

7. Layman H, Spiga MG, Brooks T, Pham S, Webster KA, Andreopoulos FM. The effect of the controlled

release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model. Biomaterials. 2007 28(16):2646-54

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8. Earle SA, El-Haddad A, Patel MB, Ruiz P, Pham SM, Majetschak M. Prolongation of skin graft survival

by exogenous ubiquitin. Transplantation 2006; 82(11):1544-6. 9. Li S, Salgar S, Thanikachalam M, Murdock A, Gammie J, Demetris A, Zeevi A, Pham SM. CTLA4-Ig-

Based conditioning regimen to induce tolerance to cardiac allografts. J Surg Research 2006; 136, (2):238-246.

10. Calfa M, Aitouche A, Vazquez-Padron R, Gay-Rabinstein C, Lasko D, Badell J, Farji A, El-Haddad A,

Liotta C, Louis LB, Pestana IA, Pang M, Li S, Pham SM. Aging and transplant arteriosclerosis in absence of alloreactivity and immunosuppressive drugs: Recipient age’s contribution in a rat aortic graft model. Transplantation. 2005; 79(12):1683-90.

11. Jimenez J, Edwards LB, Higgins R, Bauerlein J, Pham S, Mallon S. Should stable UNOS status 2

patients be transplanted? J Heart Lung Transplantation, 2005; (24); 2: 178-182. 12. Vernon SE. Acar BC. Pham SM. Fertel D. Acanthamoeba infection in lung transplantation: report of a

case and review of the literature. Transplant Infectious Disease. 2005; 7(3-4):154-7. 13. Cervino C. Nasini V. Sroka A. Diluch A. Caceres M. Sellanes M. Malusardi A. del Rio M. Pham SM.

Liotta D. Novel left ventricular assist systems I and II for cardiac recovery: the driver. Texas Heart Institute Journal. 2005: 32(4):535-40.

14. Pestana IA, Vazquez-Padron RI, Aitouche A, Pham SM. Nicotinic and PDGF-receptor function are

essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells. J Cellular Biochemisty, 2005; 96(5):986-95.

15. Gattas-Asfura KM. Weisman E. Andreopoulos FM. Micic M. Muller B. Sirpal S. Pham SM.

Leblanc RM. Nitrocinnamate-functionalized gelatin: synthesis and "smart"hydrogel formation via photo-cross-linking. [Journal Article] Biomacromolecules. 2005: 6(3):1503-9.

16. Masroor S. Tehrani H. Pham S. Neijman T. Martinez-Ruiz R. McKenney M. Salerno T. Extracorporeal

life support in pulmonary failure after traumatic rupture of the thoracic aorta: a case report. J Trauma-Injury Infection & Critical Care. 2004; 57(2):389-91.

17. Vazquez-Padron RI, Pham SM, Pang M, Li S, Aiouche A. Molecular dissection of mouse soluble

guanylyl cyclase α1 promoter. Biochemical and Biophysical Research Communications, 2004; 314; 208-214.

18. Vazquez-Padron RI, de la Riva G, Agüero G, Silva Y, Pham SM, Soberón M, Bravo A and Aïtouche A.

Cryptic endotoxic nature of Bacillus thuringiensis Cry1Ab insecticidal crystal protein. Febs Letters 2004; 570:30-6.

19. Vazquez-Padron R, Lasko D, Li S, Louis LB, Pestana I, Pang M, Liotta C, Alessia Fornoni, Aïtouche A,

Pham S. Aging exacerbates neointimal formation, and increases proliferation and reduces susceptibility to apoptosis of vascular smooth muscle cells in mice. J Vasc Surg 2004; 40:1199-1207.

20. Vazquez-Padron R, Lasko D, Li S, Louis LB, Pestana I, Pang M, Liotta C, Fornoni A, Aitouche A, Pham

SM. Aging exacerbates neointimal formation, increases the proliferation, and reduces susceptibility to

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apoptosis, of vascular smooth muscle cells in mice. J Vasc Surg; 2004, (40):1199-1207. 21. Li S, Louis LB, Kawaharada N, Yousem S, Pham SM. Intrathymic Inoculation of donor bone marrow

induces long-term acceptance of lung allografts. Ann Thorac Surg 2003; 75: 257-63. 22. Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S,

Lanciotti RS, Lance-Parker SE, DiazGranados CA, Winquist AG, Perlino CA, Wiersma S, Hillyer KL, Goodman JL, Marfin AA, Chamberland ME, Petersen LR. Transmission of West Nile Virus from an organ donor to four transplant recipients. N. England J Med, 2003; 348:2196-203.

23. Foster RD, Pham S, Li S, Aitouche A. Long-term acceptance of composite tissue allografts through

mixed chimerism and CD28 blockade. Transplantation, 2003; 76:988-994. 24. Kaplon R, Nejman A, Andreopoulos F, Katariya K, Bolooki H, Kanevsky A, Parpard M, Qi X, Pham S.

Novel use of an FDA-approved BiVAD for total cardiopulmonary support. J Card Surg, 2003; 18:411-414.

25. Zheng Y, Orbulescu J, Ji X, Andreopoulos FM, Pham SM, Leblanc RM. Development of fluorescent

film sensors for the detection of divalent cooper. J American Chemical Society, 2003; 125(9):2680-2686. 26. Gattas-Asfura KM, Zheng Y, Micic M, Snedaker MJ, Ji X, Sui G, Orbulescu J, Andreopoulos FM, Pham

SM. Immobilization of quantum dots in the photo-cross-linked poly(ethylene glycol)-based hydrogel. J Phys Chem B, 2003; 107; 10464-10469.

27. Zheng Y, Gattas-Asfura KM, Li C, Andreopoulos FM, Pham SM, Leblanc RM. Design of a membrane

fluorescent sensor based on photocrosslinked PEG hydrogel. J of Physical Chemistry, 2003; 107:2; 483-488.

28. Kaplon RJ, Pham SM, Salerno TA. Beating-heart valvular surgery: A possible alternative for patients

with severely compromised ventricular function. J Cardiac Surg, 2002: 17(2):170-2. 29. Pham SM, Qi SX, Mallon SM, Kaplon RJ, Bauerlein EJ, Katariya K, Sequeira RF, Bolooki H,

Rosenkranz E, Loo AF, Lee PC, Jimenez J, Salerno TA. Sirolimus and tacrolimus in clinical cardiac transplantation. Transplantation Proceedings 2002; 34:1839-1842.

30. Zheng Y, Micic M, Mello SV, Mabrouki M, Andreopoulos FM, Konka V, Pham SM, Leblanc RM.

PEG-based hydrogel synthesis via the photodimerization of anthracene groups. Macromolecules 2002; 35:5228-5234.

31. Webber SA, Bentlejewski C, Boyle GJ, Miller SA, Law Y, Murali S, Pham S, Park A, Griffith BP,

Duquesnoy R, Zeevi A. Propagation of activated T lymphocytes from endomyocardial biopsy samples of cardiac allografts: influence of the addition of recombinant interleukin-4 to the culture environment. Pediatric Transplantation 2002; 6(2): 119-23.

32. Fukada J, Schena S, Tack I, Ruiz P, Kurimoto Y, Pang M, Aitouche A, Abe T, Striker LJ, Pham SM.

Nitric oxide donor FK409 attenuates the development of neointimal hyperplasia in a rat aortic allograft model. Transplant Proceedings 2001; 33(1-2):536-7.

33. Pham SM, Louis L, Li S, Peel RL. Acute aortic dissection in a patient with Turner’s Syndrome. Viet

Med J 2001; 1:37-40.

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34. Li S, Thanikachalam M, Pang M, Kawaharada N, Aitouche A, Pham SM. A clinically relevant CTLA4-

Ig-based regimen induces chimerism and tolerance to heart grafts. Ann Thorac Surg 2001; 72:1306-1310. 35. Kaplon RJ, Qi X, Andreopoulos FM, Anderson MB, Bauerlein E, Nejman A, Pham SM. Tricuspid

valvectomy for right ventricular outflow cannula occlusion with the Thoratec ventricular assist device. J Thoracic Cardiovasc Surg 2001; 121:812-3.

36. Zheng Y, Andreopoulos FM, Micic M, Huo Q, Pham SM, Leblanc RM. A novel photoscissable PEG-

based hydrogel. Advanced Functional Materials, 2001;11 (1): 37-40. 37. Li S, Thanikachalam M, Carreno MR, Pang M, Calfa M, Aitouche A, Pham SM. Combined host-

conditioning with CTLA4Ig, Tacrolimus and anti-lymphocyte serum leads to stable mixed hematopoietic chimerism in rats at lower doses of radiation. Experimental Hematology, 2001; 29(4): 534-541.

38. Sileri P, Schena S, Morini S, Rastellini C, Pham S, Benedetti E, Cicalese L. Pyruvate inhibits hepatic

ischemia-reperfusion injury in rats. Transplantation 2001; 72(1):27-30. 39. Vega DJ, Ochsner JL, Jeevanandam V, McGiffin DC, McCurry KR, Mentzer RM, Stringham JC, Pierson

RN, Frazier OH, Menkis AH, Staples ED, Modry DL, Emery RW, Piccione W, Carrier M, Hendry PJ, Aziz S, Furukawa S, Pham SM. A multicenter, randomized, controlled trial of Celsior for flush and hypothermic storage of cardiac allografts. Ann Thorac Surg 2001;71:1442-7.

40. Li S, Thanikachalam M, Pang M, Kawaharada N, Aitouche A, Pham SM. A clinically relevant CTLA4-

Ig-based regimen induces chimerism and tolerance to heart grafts. Ann Thorac Surg 2001;72:1306-10. 41. Fukada J, Kurimoto Y, Aitouche A, Zeevi A, Ruiz P, Kubota T, Li S, Pham SM. Long-term survival

of rat cardiac allografts by intrathymic and portal venous injections of donor bone marrow cells. Transplant International 2001;14:311-319.

42. Zheng Y, Huo Q, Kele P, Andreopoulos FM, Pham SM, Leblanc RM. A new fluorescent chemosensor

for copper ions based on tripeptide glycyl-histidyl-lysine (GHK). Organic Letters, 2001;21 (3): 3277-3280.

43. Pham SM, Rao AS, Zeevi A, McCurry KR, Keenan RJ, Vega JD, Kormos RL, Hattler BG, Fung JJ,

Starzl TE, Griffith BP. Effects of donor bone marrow infusion in clinical lung transplantation. Ann Thorac Surg 2000; 69:345-50.

44. Pham SM, Rao AS, Zeevi A, Kormos RL, McCurry KR, Hattler BG, Fung JJ, Starzl TE, Griffith BP. A

clinical trial combining donor bone marrow infusion and heart transplantation: intermediate-term results. J Thorac Cardiovasc Surg, 2000; 119:673-81.

45. Fukada J, Schena S, Tack I, Pang M, Ruiz P, Kurimoto Y, Aitouche A, Abe T, Striker LJ, Pham SM.

FK409, a spontaneous nitric oxide releaser, attenuates allograft vasculopathy in a rat aortic transplant model. Circ Res 2000; 87: 66-72.

46. Taylor DO, Farhoud HH, Kfoury G, Pham SM, Pigula FA, Kormos RL, Renlund DG. Cardiac

transplantation in survivors of lymphoma: a multi-institutional survey. Transplantation 2000; 69(10):2112-5.

47. Kawaharada N, Shears, LL, Li S, Pham SM. Mixed hematopoietic chimerism prevents allograft

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vasculopathy. J Heart Lung Transplant 1999; 18:532-541. 48. Rao AS, Shapiro R, Corry R, Dodson F, Abu-Elmagd K, Pham SM, Jordan M, Salgar S, Zeevi A,

Rastellini C, Ostrowski L, Aitouche A, Keenan R, Reyes J, Griffith B, Starzl TE, Fung JJ. Immune modulation in organ allograft recipients by single or multiple donor bone marrow infusions. Transplantation Proceedings 1999; 31(1-2):700-1.

49. Pham SM, Mitruka SN, Youm W, Li S, Kawaharada N, Yousem SA, Colson YL, Ildstad ST. Mixed

hematopoietic chimerism induces donor-specific tolerance for lung allografts in rodents. American Journal of Respiratory & Critical Care Medicine 1999; 159(1):199-205.

50. Zeevi A, Spichty K, Banas R, Morel P, Iacono A, Dauber J, Yousem S, Pham SM, Keenan R,

Duquesnoy R, Griffith B. Two types of CMV-specific memory responses in lung transplant recipients. Transplantation Proceedings 1999; 31(1-2):173-4.

51. Neipp M, Gammie JS, Exner BG, Li S, Chambers WH, Pham SM, Ildstad ST. A partial conditioning

approach to achieve mixed chimerism in the rat: depletion of host natural killer cells significantly reduces the amount of total body irradiation required for engraftment. Transplantation 1999; 68(3):369-78.

52. Salgar SK, Shapiro R, Dodson F, Corry R, McCurry K, Zeevi A, Pham SM, Abu-Elmagd K, Reyes J,

Jordan M, Keenan R, Griffith B, Sesky T, Ostrowski L, Starzl TE, Fung JJ, Rao AS. Infusion of donor leukocytes to induce tolerance in organ allograft recipients. Journal of Leukocyte Biology 1999; 66(2):310-4.

53. Gammie JS, Banks MC, Fuhrman CR, Pham SM, Griffith BP, Keenan RJ, Luketich JD. The pigtail

catheter for pleural drainage: a less invasive alternative to tube thoracostomy. Society of Laparoendoscopic Surgeons 1999; 3(1):57-61.

54. Neipp M, Exner BG, Maru D, Haber M, Gammie JS, Pham SM, Ildstad ST. T-cell depletion of

allogeneic bone marrow using anti-alphabeta TCR monoclonal antibody: prevention of graft-versus-host disease without affecting engraftment potential in rats. Experimental Hematology 1999; 27(5):860-7.

55. Tagusari O, Kormos RL, Kawai A, Yamazaki K, Pham SM, Hattler BG, Murali S, Griffith BP. Native

heart complications after heterotopic heart transplantation: insight into the potential risk of left ventricular assist device. Journal of Heart and Lung Transplantation 1999; 18(11):1111-9.

56. Gammie JS, Stukus DR, Pham SM, Hattler BG, McGrath MF, McCurry KR, Griffith BP, Keenan RJ.

Effect of ischemic time on survival in clinical lung transplantation. Annals of Thoracic Surgery 1999; 68(6):2015-9; discussion 2019-20.

57. Gammie JS, Li S, Kawaharada N, Colson YL, Yousem S, Ildstad ST, Pham SM. Mixed allogeneic

chimerism prevents obstructive airway disease in a rat heterotopic tracheal transplant model. J Heart Lung Transplant 1998;17:801-8.

58. Zaldonis DB, Keenan RJ, Pham SM, Kormos RL, Griffith BP. Neoral conversion in stable thoracic

transplant patients leads to dose reduction. Transplant Proc 1998;30:1158-59. 59. Li S, Liu K, Yousem SA, Pham SM. Intrathymic inoculation of donor bone marrow at the time of

transplantation plus a short course of tacrolimus induces long-term acceptance to rat lung allografts. Transplant Proc 1998;30:1065-66.

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60. Pham SM, Shears LL, Kawaharada N, Li S. Venkataramanan R, Sehgal S. High local production of nitric oxide as a possible mechanism by which rapamycin prevents transplant arteriosclerosis. Transplant Proc 1998;30:953-954.

61. Gammie JS, Li S, Colson YL, Demetris AJ, Neipp M, Ildstad ST, Pham SM. A partial conditioning

strategy for achieving mixed chimerism in the rat: tacrolimus and anti-lymphocyte serum substantially reduce the minimum radiation dose for engraftment. Exp Hematol 1998;26:1-9.

62. Gammie JS, Keenan RJ, Pham SM, McGrath MF, Hattler BG, Khoshbin E, Griffith BP. Single-versus

double-lung transplantation for pulmonary hypertension. J Thorac Cardiovasc Surg 1998;115:397-403. 63. Reis SE, Bhoopalam V, Zell KA, Counihan PJ, Smith AJC, Pham SM, Murali S. Conjugated estrogens

acutely abolish abnormal cold-induced coronary vasoconstriction in male cardiac allografts. Circulation 1998;97(1):23-5.

64. Mitruka SN, Pham SM, Zeevi A, Li S, Cai J, Burckart GJ, Yousem SA, Keenan RJ, Griffith BP. Aerosol

cyclosporine prevents acute allograft rejection in experimental pulmonary transplantation. J Thorac Cardiovasc Surg 1998;115:28-37.

65. Gammie JS, Li S, Zeevi A, Demetris AJ, Ildstad ST, Pham SM. Tacrolimus-based partial conditioning

produces stable mixed lymphohematopoietic chimerism and tolerance for cardiac allografts. Circulation 1998; 98(19 Suppl):II163-8; discussion II168-9.

66. Gammie JS, Shah AS, Hattler BG, Kormos RL, Peitzman AB, Griffith BP, Pham SM. Traumatic aortic

rupture: diagnosis and management. Annals of Thoracic Surgery 1998; 66(4):1295-300. 67. Webber SA, Bentlejewski C, Park A, Fricker FJ, Griffith C, Boyle GJ, Miller SA, Pham SM, Murali S,

Griffith BP, Duquesnoy R, Zeevi A. Clinical relevance of in vitro propagation of activated lymphocytes from endomyocardial biopsy samples of pediatric heart transplant recipients. Pediatric Transplantation 1998; 2(3):200-5.

68. MacGowan GA, Kormos RL, McNamara DM, Alvarez RJ, Rosenblum WD, Pham SM, Feldman AM,

Murali S. Predicting short-term outcome in severely ill heart failure patients: implications regarding listing for urgent cardiac transplantation and patient selection for temporary ventricular assist device support. Journal of Cardiac Failure 1998; 4(3):169-75.

69. Gammie JS, Cheul Lee J, Pham SM, Keenan RJ, Weyant RJ, Hattler BG, Griffith BP. Cardiopulmonary

bypass is associated with early allograft dysfunction but not death after double-lung transplantation. Journal of Thoracic & Cardiovascular Surgery 1998; 115(5):990-7.

70. Zeevi A, Morel P, Spichty K, Dauber J, Yousem S, Williams P, Grurich W, Pham SM, Iacono A, Keenan

R, Duquesnoy R, Griffith B. Clinical significance of CMV-specific T helper responses in lung transplant recipients. Human Immunology 1998; 59(12):768-75.

71. Shears LL 2d, Kawaharada N, Tzeng E, Billiar TR, Watkins SC, Kovesdi I, Lizonova A, Pham SM.

Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. J Clin Invest 1997;100:2035-42.

72. Mitruka SN, Griffith BP, Kormos RL, Hattler BG, Pigula FA, Shapiro R, Fung JJ, Pham SM. Cardiac

operations in solid-organ transplant recipients. Ann Thorac Surg 1997;64:1270-8.

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73. Mandarino WA, Winowich S, Gasior TA, Pham SM, Griffith BP, Kormos RL. Assessment of timing right ventricular assist device withdrawal using left ventricular assist device filling characteristics. ASAIO J 1997;43:M801-05.

74. Randhawa PS, Jenkins FJ, Nalesnik MA, Martens J, Williams PA, Ries A, Pham SM, Demetris AJ.

Herpesvirus 6 variant A infection after heart transplantation with giant cell transformation in bile ductular and gastroduodenal epithelium. Am J Surg Pathol 1997; 21(7):847-53.

75. Iacono A, Dauber J, Keenan R, Spichty K, Cai J, Grugrich W, Burckart G, Smaldone G, Pham SM,

Ohori NP, Yousem S, Williams P, Griffith B, Zeevi A. Interleukin 6 and interferon- gene expression in lung transplant recipients with refractory acute cellular rejection: Implications for monitoring and inhibition by treatment with aerosolized cyclosporine. Transplantation 1997; 64(2):263-69.

76. Tsamandas AC, Pham SM, Seaberg EC, Pappo O, Kormos RL, Kawai A, Griffith BP, Zeevi A,

Duquesnoy R, Fung JJ, Starzl TE, Demetris AJ. Adult heart transplantation under tacrolimus (FK506) immunosuppression: Histopathologic observations and comparison to a cyclosporine-based regimen with lympholytic (ATG) induction. J Heart Lung Transplant 1997; 16(7):723-34.

77. Nalesnik MA, Rao AS, Furukawa H, Pham SM, Zeevi A, Fung JJ, Klein G, Gritsch A, Elder E,

Whiteside TL, Starzl TE. Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients. Transplantation 1997; 63(9):1200-05.

78. Demetris AJ, Murase N, Ye Q, Galvao FHF, Richert C, Saad R, Pham SM, Duquesnoy RJ, Zeevi A,

Fung JJ, Starzl TE. Analysis of chronic rejection and obliterative arteriopathy: Possible contributions of donor antigen-presenting cells and lymphatic disruption. Am J Pathol 1997; 150(2):563-78.

79. Gammie JS, Pham SM, Colson YL, Kawai A, Keenan RJ, Weyant RJ, Griffith BP. Influence of panel-

reactive antibody on survival and rejection after lung transplantation. J Heart Lung Transplant 1997;16(4)408-15.

80. Rao AS, Fontes P, Iyengar A, Shapiro R, Dodson F, Corry R, Pham SM, Jordan M, Zeevi A, Rastellini

C, Aitouche A, Egidi F, Gritsch HA, Reyes J, Fung JJ, Starzl TE. Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: A forty-four month follow-up. Transplant Proc 1997;29(1-2):184-5.

81. Zeevi A, Pavlick M, Banas R, Bentlejewski C, Spichty, Rao AS, Fontes P, Iyengar A, Shapiro R, Dodson

F, Jordan M, Pham SM, Keenan R, Griffith B, Corry R, Egidi F, Fung JJ, Starzl TE. Three years of follow-up of bone marrow augmented organ transplant recipients: The impact on donor specific immune modulation. Transplant Proc 1997;29(12):1205-6.

82. Horn KD, Becich MJ, Rhee RY, Pham SM. Left atrial myxoma with embloization presenting as an acute

infrarenal aortic occlusion. J Vasc Surg 1997;26(2):341-5. 83. Nalesnik MA, Rao AS, Zeevi A, Fung JJ, Pham SM, Furukawa H, Gritsch A, Klein G, Starzl TE.

Autologous lymphokine-activated killer cell therapy of lymphoproliferative disorders arising in organ transplant recipients. Transplant Proc 1997;29(3):1905-6.

84. Griffith BP, Hattler BG, Hardesty RL, Kormos RL, Pham SM, Bahnson HT. The need for accurate risk

adjusted measures on outcome in surgery: Lessons learned through coronary artery bypass. Ann Surg 1996;222(4):593-99.

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85. Labadie RF, Antaki JF, Williams JL, Katyal S, Ligush J, Watkins SC, Pham SM, Borovetz HS. Pulsatile

perfusion system for ex vivo investigation of biochemical pathways in intact vascular tissue. Am J Physiol 1996;270:H760-H768.

86. Pham SM, Kormos RL, Kawai A, Murali S, Hattler BG, Demetris AJ, Griffith BP. Tacrolimus (FK506)

in clinical cardiac transplantation: A five-year experience. Transplant Proc 1996;28(2):1002-04. 87. Pham SM, Kormos RL, Hattler BG, Kawai A, Tsamandas AC, Demetris AJ, Murali S, Fricker FJ, Chang

HC, Jain AB, Starzl TE, Hardesty RL, Griffith BP. A prospective trial of tacrolimus (FK506) in clinical heart transplantation: Intermediate term results. J Thorac Cardiovasc Surg 1996;111(4):764-72.

88. Kormos RL, Gasior TA, Kawai A, Pham SM, Murali S, Hattler BG, Griffith BP. Transplant candidate's

clinical status rather than right ventricular function defines need for univentricular verses biventricular support. J Thorac Cardiovasc Surg 1996;111(4):773-83.

89. Gammie JS, Colson YL, Griffith BP, Pham SM. Chimerism and thoracic organ transplantation. Semin

Thorac Cardiovasc Surg 1996;8:149-55. 90. Komatsu K, Youm W, Koniski H, Kawaharada N, Yousem SA, Murase N, Griffith BP, Pham SM.

Prolonged survival of hamster-to-rat pulmonary xenografts by tacrolimus (FK506) and cyclophosphamide. J Heart Lung Transplant 1996;15:722-27.

91. Macha M, Griffith BP, Keenan R, Kawai A, Hattler BG, Fabrizio C, Kormos RL, Hardesty RL,

Boujoukos A, Pham SM. ECMO support for adult patients with acute respiratory failure. ASAIO J 1996;42:M841-4.

92. Zenati M, Pham SM, Keenan RJ, Griffith BP. Extracorporeal membrane oxygenation for lung transplant

recipients with primary severe donor lung dysfunction. Transpl Int 1996;9:227-30. 93. Pham SM, Kormos RL, Griffith BP. Native cardiectomy in a heterotopic heart transplant recipient. J

Thorac Cardiovasc Surg 1996;112(4):1109-11. 94. Zeevi A, Pavlick M, Lombardozzi S, Banas R, Pappo O, Rao AS, Fontes P, Demetris J, Shapiro R,

Dodson F, Trucco M, Carroll P, Pham SM, Fung JJ, Starzl TE. Immune status of recipients following bone marrow-augmented solid organ transplantation. Transplantation 1995;50:616-20.

95. Bando K, Paradis IL, Keenan RJ, Yousem SA, Komatsu K, Konishi H, Guilinger RA, Masciangelo TN,

Pham SM, Armitage JM, Hardesty RL, and Griffith BP. Comparison of outcomes after single and bilateral lung transplantation for obstructive lung disease. J Heart Lung Transplant 1995;14(4):692-8.

96. Moe OA, Jr., Pham SM, Selinsky B, Dang T. A kinetic study of the effect of cobalt(2+), cadmium(2+),

copper (2+), and nickel(2+) on yeast pyrophosphatase. Biochem Biophys Acta 1995;827(3):207-14. 97. Pham SM, Armitage JM, Griffith BP. Left atrial thrombus after lung transplantation. Ann Thorac Surg

1995;59:513-15. 98. Moliterno R, Woan M, Bentlejewski C, Qian J, Zeevi A, Pham SM, Griffith BP, Duquesnoy RJ. Heat

shock protein-induced T-lymphocyte propagation from endomyocardial biopsies in heart transplantation. J Heart Lung Transplant 1995;14:329-37.

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99. Rao AS, Fontes P, Zeevi A, Trucco M, Dodson FS, Rybka WB, Shapiro R, Jordan M, Pham SM, Rilo HL, Seskey T, Todo S, Scantlebury V, Vivas C, Demetris AJ, Fung JJ, Starzl TE. Augmentation of chimerism in whole organ recipients by simultaneous infusion of donor bone marrow cells. Transplant Proc 1995;27:210-2.

100. Pham SM, Keenan RJ, Rao AS, Fontes PA, Kormos RL, Abu-Elmagd K, Zeevi A, Kawai A, Hattler BG,

Hardesty RL, Demetris AJ, Trucco M, Rosner G, Fung JJ, Starzl TE, Griffith BP. Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients. Ann Thorac Surg 1995;60:1015-20.

101. Glassman LR, Keenan RJ, Fabrizio C, Sonett JR, Bierman MI, Pham SM, Griffith BP. ECMO as an

adjunct treatment for primary graft failure in adult lung transplant recipients. J Thorac Cardiovasc Surg 1995;110(3):723-7.

102. Mandarino WA, Gorcsan J III, Gasior TA, Pham SM, Griffith BP, Kormos RL. Estimation of left

ventricular function in patients with a left ventricular assist device. ASAIO J 1995;41(3) M544-7. 103. Muluk SC, Steed DL, Makaroun MS, Pham SM, Kormos RL, Griffith BP, Webster MW. Aortic

aneurysm in heart transplant recipients. J Vasc Surg 1995;22:689-96. 104. Pham SM, Kormos RL, Landreneau RJ, Kawai A, Gonzalez-Cancel I, Hardesty RL, Hattler BG, Griffith

BP. Solid tumors after heart transplantation: Lethality of lung cancer. Ann Thorac Surg 1995;60:1623-6. 105. Schwartz RE, Pham SM, Bierman MI, Lee KW, Griffith BP. Tension pneumoperitoneum after heart-

lung transplantation. Ann Thorac Surg 1994;57(2):478-81. 106. Worsey J, Pham SM, Newman B, Park SC, del Nido PJ. Left main bronchus compression after arterial

switch for transposition. Ann Thorac Surg 1994;57(5):1320-2. 107. Reddy SC, Katz WE, Medich GE, Gasior TA, Quinlan JJ, Pham SM, Ziady GM, and Kormos RL.

Infective endocarditis of the pulmonary artery conduit in a recipient with a heterotopic heart transplant: Diagnosis by transesophageal echocardiography. J Heart Lung Transplant 1994;13(1):139-41.

108. Kawai A, Morita S, Kormos RL, Mandarino WA, Gasior TA, Pham SM, Armitage JM, Hardesty RL,

and Griffith BP. A clinical trial comparing University of Wisconsin solution and cold cardioplegia with load-independent mechanical parameters. J Heart Lung Transplant 1994;13(1):150-156.

109. Hattler, BG, Madia, C, Johnson, C, Armitage, JM, Hardesty, RL, Kormos RL, Pham, SM, Payne, DN,

Griffith, BP. Risk stratification using the Society of Thoracic Surgeons Program. Ann Thorac Surg 1994;58(5):1348-52.

110. Griffith BP, Bando K, Hardesty RL, Armitage JM, Keenan RJ, Pham SM, Paradis IL, Yousem SA,

Komatsu K, Konishi H, Fung JJ, Starzl TE. A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. Transplantation 1994;57(6):848-51.

111. Rao PN, Zeevi A, Snyder J, Spichty K, Habrat T, Warty V, Dauber J, Paradis I, Duncan S, Pham SM,

Griffith B. Monitoring of acute lung rejection and infection by broncoalveolar lavage and plasma levels of hyaluronic acid in clinical lung transplantation. J Heart Lung Transplant 1994;13(6):958-62.

112. Hattler BG, Reeder GD, Sawzik PJ, Walters FR, Pham SM, Kormos RL, Keenan RJ, Griffith BP,

Armitage JM, Hardesty RL, Borovetz HS. Development of an intravenous membrane oxygenator: A new

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concept in mechanical support for the failing lung. J Heart Lung Transplant 1994;13(6):1003-8. 113. Yoshida Y, Iwaki Y, Pham SM, Dauber JH, Yousem SA, Zeevi A, Morita S, Griffith BP. Benefits of

post-transplant monitoring of interleukin-6 in lung transplantation. Ann Thorac Surg 1993;55:89-93. 114. Griffith BP, Hardesty RL, Armitage JM, Hattler BG, Pham SM, Keenan RJ, Paradis I. A decade of lung

transplantation. Ann Surg 1993;218(3):310-320. 115. Keenan RJ, Uknis ME, Pham SM, Spichty K, Duquesnoy RJ, Griffith BP, Zeevi A. Mitogen responses

of lymphocytes from lung transplant recipients: Correlation with rejection and infection. Transplantation 1992;54(2):241-245.

116. Greisler HP, Joyce KA, Kum DU, Pham SM, Berceli SA, Borovetz HS. Spatial and temporal changes in

compliance following implantation of bioresorbable vascular grafts. J Biomed Materials Research 1992;26:1449-1461.

117. Pham SM, Yoshida Y, Aeba R, Hattler BG, Iwaki Y, Zeevi A, Hardesty RL, Griffith BP. Interleukin-6,

a marker of preservation injury in clinical lung transplantation. J Heart Lung Transplant 1992;11:1017-24.

118. Hung TC, Pham SM, Steed DL, Webster MW, Butter DB. Alterations in erythrocyte rheology in

patients with severe peripheral vascular disease: 1. Cell volume dependence of erythrocyte rigidity. Angiology 1991;210-217.

119. Pham SM, Johnson R, Durham SJ, Peitzman AB, Griffith BP. Hemodynamic consequences of foley

catheter control in experimental penetrating cardiac wounds. Surg Gynecol Ob 1989;169:247-50. 120. Greisler HP, Endean ED, Klosak JJ, Ellinger J, Henderson SC, Pham SM, Durham SJ, Showalter DP,

Levine J, Borovetz HS. Hemodynamic effects of endothelial cell monolayer detachment from vascular prostheses. Arch Surg 1989;124:429-33.

121. Warty VS, Calvo WJ, Berceli SA, Pham SM, Durham SJ, Tanksale SK, Klein EC, Herman IM, Borovetz

HS. Hemodynamics alter arterial low-density lipoprotein metabolism. J Vasc Surg 1989;10(4):392-99. 122. Moe OA, Jr., Pham SM, Dang T, Styer L. Kinetic analysis of the effect of zinc ion on the inorganic

pyrophosphatase reaction. Arch Biochem Biophys 1979;196:73-78.

18 b. Submitted: 1. Hans Layman, Marianne Sacasa, Ashley E. Murphy, Amy M. Murphy, Si M. Pham, Fotios M.

Andreopoulos, “Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model”. Acta Biomaterialia, (in revision) 2008.

2. Vazquez-Padron RI, Pham SM, Wei Y, Rodriguez-Menocal L, Khan S, Calfa M, Striker G. Post Injury

Neointima Cells are Predominantly of Local Origin rather than from Circulating Progenitors. Submitted to American Journal of Pathology (2008)

19.- Other works, publications, and abstracts:

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Abstracts: 1. Roberto I. Vazquez-Padron, Luis Rodriguez-Menocal, Danea Mateu, Yuntao Wei, Sashi Salgar, Sen

Li, Si M. Pham. Vascular Injury Causes Early-Onset Apoptosis of Medial Vascular Smooth Muscle Cells. Journal of Surgical Research; 2008;144 (2): 414.

2. Pamboukian SV, Pham SM, Higgins RSD, Czerska B, Clemson BS, Kirklin JK, Brown RN, White-Williams C: 392: Infection and Rejection Risk Using Induction with Interleukin II Receptor Blockers vs. Antithymocyte Globulin vs. No Induction: A Multi-Institutional Study. J. Heart Lung Transplantation, 2008, 27:S202.

3. Ganz SS, Gaynor JJ, Levi DM, Moon JI, Nishida S, Osorio M, Pham SM: Donor Predictors of

Successful Lung Recovery for Transplantation. American J. Transplantation. 2007, 7(Supplement 2):386.

4. Garcia-Covarrubias L, Pham, SM, Majetschak M: Ubiquitin Attenuates Ischemia-Reperfusion Injury

of the Lung. American J. Transplantation.2007, 7(Supplement 2):435.

5. Ganz SS, Levi DM, Nishida S, Moon JI, Gaynor JJ, Osorio M, Pham SM: Pulmonary Function Is Preserved during Prolonged Donor Management When the Link™ Is Used. American J. Transplantation. 2007, 7(Supplement 2):244.

6. Salgar S, Li S, Wei Y, Hernandez M, Mateu D, Vazquez-Padron R, Matthew J, Pham S:

Mesenchymal Stem Cell Therapy for Immunosuppression and Vascular Regeneration in Organ Transplantation. American J. Transplantation. 2007, 7(Supplement 2):204.

7. Salgar S, Li S, Hernandez M, Wei Y, Mateu D, Mathew J, Pham S: Viral interleukin-10 gene therapy

via mesenchymal stem cells prolonged cardiac transplant survival, The Journal of Heart and Lung Transplantation. 2007, 26:S219-S220.

8. Majetschak M, Patel MB, Liotta C, Li S, Busby LT, Pham SM: Proteasome dysfunction during cold

ischemia and reperfusion in a murine heart transplantation model, The Journal of Heart and Lung Transplantation. 2007, 26:S81.

9. Calfa M., Vazquez-Padron RI, Li S, Salgar S, and Pham SM. Young bone marrow as

opposed to aging bone marrow attenuates intimal formation promotes re-endothelialization and diminishes the inflammatory response associated with the vascular response to injury. Journal of Surgical Research 2007; 137(2):209.

10. Vazquez-Padron RI, Wei Y, Mateo D, Hernandez M, Pestana I, Li S, Salgar S, Pham SM: Nicotine

Activates p44/42 MAPK Signaling in Vascular Smooth Cells and Exacerbates Vascular Inflammation and Neointimal Formation after Vascular Injury. Circulation (Supplement II), 2006, 114(18):II-179.

11. Earle SA, Patel MB, Pham S, Majetschak M. Prolongation of allogenic skin graft survival by

exogenous ubiquitin. Journal of Surgical Research 2006; 130(2):273. 12. Vazquez-Padron RI, Farji A, Aitouche A, Pham SM. Aging exacerbates stress-induced senescence

in vascular smooth muscle cells during vascular remodeling. Journal of Surgical Research 2006; 130(2):313.

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13. Layman H, Li S, Pham SM, Andreopoulos FM. Therapeutic angiogenesis in critical limb ischemia

via the localized delivery of BFGF from ionic hydrogels. Journal of Surgical Research 2006; 130(2):265.

14. Pang M, Li S, Salgar S, Liotta C, Aitouche A, Vazquez-Padron R, Matthew J, Pham SM. Donor

bone marrow infusion reduces the infiltration of recipient-derived CD4 and dendritic cells in lung allograft. Journal of Surgical Research 2006; 130(2):176.

15. Pham SM, Jimenez J, Bednar BM, Panos A, Futterman L, Bauerlein EJ, Ricci M, Mallon SM,

Rosenkranz, Rusconi P. Campath-1H in clinical heart transplantation. J Heart-Lung Transplant 2006: 25(25):5126.

16. Pang M, Li S, Salgar S, Liotta C, Vazquez-Padron R, Matthew J, Pham SM. Donor bone marrow

modulates the host immune responses to lung allografts. J Heart-Lung Transplant, 2006; 25(25):5156.

17. Jimenez J, Edwards LB, Mallon S, Panos A, Pham S. What is the fate of temporary inactive patients

listed for heart transplantation? J Heart-Lung Transplant, 2006; 25(25):5141.

18. Salgar S, Li S, Hernandez M, Mathew J, Pham S. Engineered mesenchymal stem cell therapy prolonged cardiac allograft survival. Amer J Transplant, 2006; 6(s2):188.

19. Pang M, Li S, Salgar S, Liotta C, Vazquez-Padron R, Mathew J, Pham S. Donor bone marrow

infusion modulates host immune response in allogeneic lung transplant model. Amer J Transplant, 2006: 6(s2):189.

20. Pham SM, Jimenez J, Panos AL, Bauerlein EJ, Mallon SM, Bednar BM, Patel S, Ricci M,

Rosenkranz EE. The combined use of Tacrolimus and Sirolimus in clinical heart transplantation: Intermediate-term results. Amer J of Transplantation, 2005; 5(supplement 11): 170.

21. Thanikachalam M, Simmonds A, Cheung M, Vazquez-Padron R, Liotta CA, Gambotto A, Aitouche

A, Pham SM. p53 plays a significant role in the pathogenesis of allograft vasculopathy. J Heart Lung Transplant 2004; 23 (Suppl 1), S125.

22. Pestana IA, Vazquez-Padron RI, Aitouche A, Pham SM. Nicotinic and PDGF-receptor function are

essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells. Circulation, 2004; 110 (17), 366.

23. Thanikachalam M, Pang M, Li S, Vazquez-Padron R, Aitouche A, Grotendorst GR, Pham SM.

Expression of connective tissue growth factor is upregulated in post-transplant obliterative airway disease. J Heart Lung Transplantation 2003; 22 (1S): 101.

24. Webber SA, Pereira JR, Pigula FA, Gandhi S, Murase N, Woodward JE, Boyle GJ, Law YM, Pham

S, Zeevi A, Griffith BP, Fung JJ. A novel technique for donor bone marrow procurement for clinical tolerance trials in children. Am J Transplantation 2003; 23 (Suppl 5), 528.

25. Webber SA, Boyle GJ, Law YM, Pereira JR, Bentlejewski C, Pigula FA, Gandhi S, Miller SA,

Woodward JE, Murase N, Fung JJ, Martell J, Pham S, Griffith BP, Zeevi A. A clinical trial of intrathymic inoculation of donor bone marrow with pediatric heart transplantation. Am J Transplantation 2003; 23 (Suppl 5), 167.

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26. Simmonds A, Thanikachalam M, Lasko D, Vasquez R, Aitouche A, Li S, Pang M, Gambotto A,

Liotta C, Cheung M, Pham S. Nitric oxide induces apoptosis in vascular smooth muscle cells by upregulating the expression of p53 gene. Am J Transplantation 2003; 23 (Suppl 5), 195.

27. Qi X, Lee P, Kaplon R, Loo A, Mallon S, Katariya K, Bauerlein E, Pham SM. Sirolimus and

tacrolimus in heart transplantation. J Heart Lung Transplant 2002; 121(21):I.

28. Feinberg L, Mallon S, Mitrani R, Jara J, Bauerlein J, Sequeira R, Bednar B, Pham S, Jimenez J. Safety of continuous intravenous home inotrope plus defibrillator in patients awaiting heart transplantation. American J Transplantation 2002; 2(suppl. 3):271.

29. Calfa M, Aitouche A, Vazquez R, Li S, Pang M, Louis LB, Pham SM. Recipient’s age plays a more

important role than donor’s age in determining the severity of vascular neointimal hyperplasia. American J Transplantation 2002; 2(suppl. 3): 271.

30. Cabana ER, Fertel D, Qi X, Gerity S, Pham S, Ruiz P. Cytofluorographic analysis of

bronchoalveolar lavage (Bal) hematopoietic cell subpopulations correlates with histologic acute rejection (AR) grade in lung transplants. American J Transplantation 2002; 2(suppl. 3): 271.

31. Calfa M, Aitouche A, Gay-Rabinstein C, Vazquez RI, Li S, Pang M, Thanikachalam M, Lasko D,

Simmonds A, El-Haddad A, Louis LB, Pham SM. What matters more in transplant arteriosclerosis: The age of the donor or the age of the recipient? Transplantation 2002; 74 (4): 141.

32. Qi XS, Lee PC, Kaplon R, Mallon S, Loo AF, Katariya K, Bauerlein EJ, Pham SM. Sirolimus and

tracrolimus in clinical heart transplantation. J Heart Lung Transplant 2002; 21 (1): 121.

33. Cabana ER, Fertel D, Qi XS, Gerity S, Pham S, Ruiz P. The immunophenotypic profile of bronchial veolar lavage (BAL) cells correlates with histologic acute rejection grade in lung transplants. Transplantation 2002; 74 (4): 548.

34. Thanikachalam M, Pang M, Vazquez-Padron R, Li S, Aitouche A, Grotendorst GR, Pham SM.

Connective tissue growth factor may play an important role in the development of obliterative bronchiolitis. J Surg Research 2002; 107: 284.

35. Calfa M, Aitouche A, Vazquez R, Pang M, Lasko D, Simmonds A, El-Haddad A, Pham S. Effects

of bone marrow on the exaggerated vascular response to injury associated with aging. Circulation 2002; (Suppl 11), 106 (19): 151.

36. Qi X, Lee P, Kaplon R, Loo A, Mallon S, Katariya K, Bauerlein E, Pham SM. Sirolimus and

tacrolimus in clinical cardiac transplantation: A pilot study. American J of Transplantation 2001; 1(Suppl 1):432.

37. Calfa M, Aitouche A, Vazquez R, Li S, Pang M, Gay-Rabinstein C, Louis L, Pham S. Aging milieu,

not the intrinsic property of the aging vessel, determines the exaggerated vascular response to injury associated with aging. Circulation (supplemental) 2001; 104:17.

38. Schena S, Kurimoto Y, Fukada J, Tack I, Ruiz P, Pang M, Aitouche A, Striker LJ, Pham SM.

Ventricular unloading is not associated with adoptosis of myocardiocytes. Transplantation 2000; 69(8):S273.

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39. Thanikachalam M, Li S, Carreno MR, Pang M, Calfa M, Aitouche A, Pham SM. Costimulatory blockage with CTLA4Ig significantly reduces the dose of total body radiation (200 cGy) to achieve mixed chimerism in rats. Transplantation 2000; 69(8):S355.

40. Calfa MT, Aitouche A, Gay-Rabinstein C, Li S, Pham SM. Effects of aging on vascular response to

injury: Aging milieu versus vessel senescence. Journal of Surgical Research 2000; 93:343.

41. Thanikachalam M, Li S, Murdock AD, Kurimoto Y, Gammie JS, Zeevi A, Yousem S, Pham SM. Tacrolimus-based nonlethal conditioning leads to stable mixed chimerism and donor-specific tolerance to lung allografts in rats. Journal of Surgical Research 2000; 93:345.

42. Thanikachalam M, Fukada J, Calfa M, Perez M, Grotendorst GR, Pham SM. Increased expression

connective tissue growth factor (CTGF) in posttransplant obliterative arteriopathy. Journal of Surgical Research 2000; 93:372.

43. Thanikachalam M, Li S, Carreno M, Pang M, Calfa M, Aitouche A, Pham SM. Co-stimulatory

blockage with CTLA4-Ig leads to stable mixed chimerism in rats at 200 cGy and donor-specific tolerance to heart allografts. Circulation 2000; 102(18):II-764.

44. Fukada J, Schena S, Tack I, Pang M, Ruiz P, Kurimoto Y, Aitouche A, Abe T, Striker LJ, Pham SM.

The effect of FK409 on allograft vasculopathy in a rat aortic transplant model. Circulation 2000; 102(18):II-819.

45. Fukada J, Aitouche A, Zeevi A, Ruiz P, Kubota T, Kurimoto Y, Li S, Pham SM. A combination of

intrathymic and portal venous injection of donor bone marrow cells produces long-term survival of cardiac allografts in high responder rat strains. Transplantation 1999; 67 (9): A256.

46. Weber SA, Pham SM, Zeevi A, Rao AS, Byle GJ, Bentlejeweski, McCurry K, Pigula F, Fung JJ,

Griffith BP. A clinical trial of intrythymic inoculation of donor bone marrow cells with concomitant pediatric heart transplantation: Preliminary observations. Transplantation 1999; 67(7): S33.

47. Sileri P, Schena S, Rastellini C, Pham SM, Cicalese L. Pyruvate inhibits hepatic ischemia-

reperfusion (I/R) injury. Transplantation 1999; 67(7): S265.

48. McCurry KR, Pham SM, Zeevi A, Webber S, Rao A, Ostrowski L, Salgar S, Starzl TE, Bentlejewski C, Keena RJ, Fung J, Griffith BP. Immunomodulatory effects of donor bone marrow infusion in heart or lung transplantation: Five-year experience. J Heart Lung Transplant 1999; 18(1): 72.

49. Murdock A, Li S, Kurimoto Y, Shears L, Demtris A, Billiar TR, Kovesdi I, Lizonova A, Pham SM.

Attenuation of cardiac allograft vasculopathy by adenoviral gene transfer of inducible nitric oxide synthase. Transplantation 1999; 67(9): S590.

50. Tagusari O, Kormos RL, Kawai A, Yamazaki K, Pham SM, Hattler BG, Murali S, Griffith BP.

Native heart complications after heterotopic heart transplantation: Insight into the potential risk of left ventricular assist device. J Heart Lung Transplant 1999; (18) 11.

51. Johnson B, Li S, Pham SM, Pitt B. Efficiency of adenoviral gene transfer to rat lung

allograft is increase by using a recirculated perfusion system. Am J Respir Crit Care Med 1998; 157(3):A332.

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52. Pham SM, Li S, Yousem SA. Induction of donor-specific tolerance to rat lung allografts

using mixed bone marrow chimerism. Am J Respir Crit Care Med 1998; 157(3):A332.

53. Iacono A, Dauber J, Keenan R, Smaldone G, Burckart G. Ohori P, Mccurry K, Delgado E, Pham SM, Rapp T, Grugrich W, Williams P, Nunley D, Vega R, Griffith B. Aerosolized cyclosporine given as prophylaxis for acute rejection after lung transplantation: Safety and peripheral lung deposition following early administration. Am J Respir Crit Care Med 1998; 157(3):A328.

54. Tagusari O, Pham SM, Kawai A, Yamazaki K, Hattler BG, Murali S, Griffith BP, Kormos RL.

Native heart outcome after heterotopic heart transplantation: Insight into native heart complications on left ventricular assist device for chronic use. J Heart Lung Transplant 1998; 17(1):94.

55. Pham SM, Li S, Gammie JS, Linsley PS, Demetris AJ. Costimulatory blockage with CTLA4Ig

significantly reduces the dose of radiation required to achieve mixed bone marrow chimerism and donor-specific transplantation tolerance. J Heart Lung Transplant 1998; 17(1):74.

56. Li S, Yousem SA, Pham SM. Mixed bone marrow chimerism achieved by non-myeloablative

conditioning induces donor-specific tolerance to rat lung allografts. J Heart Lung Transplant 1998; 17(1):73.

57. Gammie JS, Pham SM, Zeevi A, Duquesnoy RJ, Vega R, Hattler BG, Griffith BP, Keenan RJ.

Effect of HLA matching in lung transplantation. J Heart Lung Transplant 1998; 17(1):58.

58. Zeevi A, Banas R, Donnenberg AD, Donnenberg VS, Spichty K, Logar A, Morel P, Pham SM, Keenan R, Iacono A, Dauber J, Griffith B, Starzl TE. Functional and phenotypical analysis of two distinct CMV-specific T helper memory cells. J Heart Lung Transplant 1998; 17(1):55.

59. Webber SA, Bentlejewski CA, Par A, Boyle GJ, Miller SA, Law Y, Murali S, Pham SM, Zeevi A.

Propagation of activated lymphocytes from endomyocardial biopsy samples (EMB) of heart transplant recipients: Influence of addition of rlL4 to the culture environment. J Heart Lung Transplant 1998; 17(1):54.

60. Nastala CJ, Kormos RL, Winowich S, Pham SM, Hattler BG et al. Profile of blood pump related

infections in bridge to transplant patients: A ten year experience. J Heart Lung Transplant 1998; 17(1):93.

61. Shears LL, Kawaharada N, Tzeng E, Billiar TR, Pham SM. Endogenous inducible nitric oxide

synthase expression attenuates the development of allograft arteriosclerosis. Surg Forum 1997; XL VIII:503-5.

62. Pham SM, Shears LL, Kawaharada N. Rapamycin prevents allograft arteriosclerosis by permitting

the endogenous expression of inducible nitric oxide synthase in the allograft. Surg Forum 1997; XL VIII:497-500.

63. Pham SM, Gammie JS, Li S. Mixed bone marrow chimerism and donor-specific tolerance for

cardiac allografts can be achieved in rats with nonlethal conditioning. Circulation 1997; 96(Suppl I):I-510.

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64. Bozkurt B, Alvarez RJ Jr, McNamara DM, Rosenblum WD, Pham SM, Kormos RL, Murali S. Restrictive physiology late after cardiac transplantation adversely affects survival. Circulation 1997; 96(Suppl I):I-14.

65. Mitruka SN, Pham SM, Pigula F, Kormos RL, Hattler BG, Shapiro R, Fung JJ, Griffith BP. Cardiac

surgery in solid organ transplant recipients. Asian Cardiovas Thorac Ann 1997; 5:30A.

66. Mandarino WA, Winowich S, Gasior TA, Pham SM, Griffith BP, Kormos RL. Assessment of timing right ventricular assist device withdrawal using left ventricular assist device filling characteristics. ASAIO 1997; 43:54.

67. Farhoud H, Taylor DO, Kfoury AG, Pigula F, Pham SM, Renlund DG. Cardiac transplantation in

survivors of lymphoma: A multicenter survey. J Heart Lung Transplant 1997; 16:108.

68. Pham SM, Li S, Kawaharada N, Yousem SA, Griffith BP. Donor-specific tolerance for lung allografts by thymic inoculation of donor bone marrow. J Heart Lung Transplant 1997; 16:81.

69. Zeevi A, Spichty K, Morel P, Waldman J, Dauber J, Iacono A, Keenan R, Pham SM, Duquesnoy R,

Griffith B. Two types of CMV-specific memory responses: Potential role of donor infected target cells in recruitment of activated T cells to the graft. J Heart Lung Transplant 1997; 16:81.

70. Zeevi A, Pham SM, Pavlick M, Keenan R, Rao A, Fontes P, Dauber J, Iacono A, Yousem S, Fung J,

Starzl TE, Griffith B. Donor-specific bone marrow infusion in lung transplant recipients: The impact on immune modulation and delayed graft rejection. J Heart Lung Transplant 1997; 16:69.

71. Pham SM, Zeevi A, Rao A, Keenan RJ, Fontes P, Kormos RL, Hattler BG, Kawai A, Dyke C,

Demetris AJ, Yousem A, Fung JJ, Starzl TE, Griffith BP. Three year experience on combined donor bone marrow infusion and thoracic organ transplantation. J Heart Lung Transplant 1997; 16:69.

72. Pham SM, Kawaharada N, Shears L, Gammie JS, Li S, Ildstad ST. Mixed bone marrow chimerism

prevents allograft arteriopathy. J Heart Lung Transplant 1997; 16:51.

73. Shears LL, Kawaharada N, Tzeng E, Billiar TR, Lizonova A, Kovesdi I, Pham SM. Inhibition of allograft arteriosclerosis using a nitric oxide gene transfer strategy. J Heart Lung Transplant 1997; 16:51.

74. Gammie JS, Ildstad ST, Li S, Kawaharada N, Colson YL, Kaufman CL, Pham SM. Nonlethal

conditioning to achieve stable mixed chimerism in the rat: Treatment of recipients with ALS and tacrolimus substantially reduces the dose of radiation sufficient for donor engraftment. Blood 1996; 88 (10):601.

75. Shears LL II, Pham SM, Tzeng E, Kawaharada N, Billiar TR. Cyclosporine inhibits inducible nitric

oxide synthase (NOS-2) expression in aortic allografts: An etiology for allograft vasculopathy. Circulation (Supplement I) 1996; 94:I-648.

76. Kormos RL, Pham SM, Gasior TA, Murali S, Kawai A, McNamara DM, Rosenblum WD, Hattler

BG, Griffith BP. Resolution of pulmonary hypertension in patients receiving a left ventricular assist device (LVAD). Circulation (Supplement I) 1996; 94:I-293.

77. Pham SM, Keenan RJ, Rao A, Fontes P, Zeevi A, Kormos RL, Kawai A, Hattler BG, Trucco M,

Yousem SA, Demetris AJ, Fung JJ, Starzl TE, Griffith BP. A trial of donor bone marrow infusion

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and thoracic organ transplantation. J Heart Lung Transplant 1996; 15:S34.

78. Kawai A, Kormos RL, Pham SM, Griffith BP. Impact of arrhythmias for patients on left ventricular assist devices (LVAD). J Heart Lung Transplant 1996; 15:S31.

79. Zeng Q, Pham SM, Todo S, Zang S, Tsamandas AC, Starzl TE. Maximal myocardial preservation

with increased hydrostatic pressure in coronary circulation. J Heart Lung Transplant 1996; 15:S28.

80. Kawaharada N, Li S, Komatsu K, Thai N, Colson YC, Gammie JS, Yousem SA, Griffith BP, Ildstad ST, Pham SM. Cytokine mRNA activity in rat lung allografts: Effects of bone marrow mixed chimerism and tacrolimus. J Heart Lung Transplant 1996; 15:S25.

81. Li S, Kawaharada N, Gammie JS, Colson YC, Yousem SA, Griffith BP, Ildstad ST, Pham SM.

Mixed bone marrow chimerism prevents obstructive airway disease (OAD) in a heterotopic tracheal transplant model in rats. J Heart Lung Transplant 1996; 15:S25.

82. Pham SM, Keenan RJ, Kawai A, Vega JD, Boyle GJ, Webber SA, Iaocono A, Nunley D, Dauber J,

Kurland G, Nalesnik M, Williams P, Yousem SA, Griffith BP. Post-transplant lymphoproliferative disease after lung transplantation. J Heart Lung Transplant 1996; 15:S15.

83. Tsamandas AC, Pham SM, Kormos RL, Griffith BP, Starzl TE, Fung JJ, Demetris AJ. Heart

allograft pathology under tacrolimus immunosuppression. J Heart Lung Transplant 1996; 15:S10.

84. Gammie JS, Kawai A, Pham SM, Keenan RJ, Colson YL, Weyant RJ, Griffith BP. Influence of panel-reactive antibody on survival and rejection after lung transplantation. J Heart Lung Transplant 1996; 15:S9.

85. Mandarino WA, Winowich S, Gorscan J III, Gasior TA, Pham SM, Griffith BP, Kormos R L. Right

ventricular performance and left ventricular assist device filling. ASAIO 1996; 42:47.

86. Macha M, Griffith B, Keenan R, Kawai A, Hattler B, Fabrizio C, Kormos R, Hardesty R, Pham SM. ECMO support for adult patients with respiratory failure. ASAIO 1996; 42:69.

87. Webber SA, Bentlejewski CA, Boyle GJ, Miller SA, Murali S, Pham SM, Zeevi A. Propagation of

activated lymphocytes under differing culture conditions from endomyocardial biopsy samples of heart transplant recipients. Pediatric Research 1995; 37 (Part II):37A.

88. Pham SM, Kormos R. L. Kormos, M.D., Hattler BG, Tsamandas AC, Demetris AJ, Fricker FJ,

Starzl, TE, Griffith BP. Phase I trial of FK506 in clinical heart transplantation: Immediate term results. Asian Cardiovasc Thorac Ann 1995; 3:41A.

89. Komatsu K, Youm W, Konishi H, Yousem SA, Murase N, Griffith BP, Pham SM. Survival of

hamster-to-rat lung xenografts is prolonged by FK506 and cyclophosphamide. J Heart Lung Transplant 1995; 14:S94.

90. Murali S, Kormos RL, Pham SM, Bhoopalam V, Griffith B. Gender differences in outcome after

cardiac transplantation. J Heart Lung Transplant 1995; 14:S80.

91. Zeevi A, Pham SM, Keenan R, Griffith B, Rao A, Fontes P, Demetris A, Fung J, Shapiro R, Kormos R, Hattler B, Hardesty R, Starzl TE. Sequential immune studies in bone marrow augmented solid organ transplant recipients: Heart and lung and other solid organ transplants. J Heart Lung Transplant

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1995; 14:S63.

92. Pham SM, Tsamandas AC, Griffith BP, Kormos RL, Pappo O, Hattler BG, Murali S, Kawai A, Fung JJ, Starzl TE, Demetris AJ. Comparison between FK506 and cyclosporine-based immunosuppressions in clinical cardiac transplantation. J Heart Lung Transplant 1995; 14:S50.

93. Pham SM, Kormos R, Murali S, Kawai A, Hattler BG, Fung JJ, Demetris AJ, Starzl TE, Griffith BP.

Reversal of intractable rejection with FK-506 in cardiac transplant recipients. J Heart Lung Transplant 1995; 14:S50.

94. Murase N, Pham SM, Fung JJ, Starzl TE, Demetris AJ. Hematolymphoid microchimerism, quilty

lesions, and chronic cardiac allograft rejection. J Heart Lung Transplant 1995; 14:S44.

95. Wagner W, Wilhelm C, Gartner M, Fabrizio C, Pham SM. Thrombus deposition and flow modeling in extracorporeal membrane oxygenation circuits. ASAIO; 1994 Abstracts Issue.

96. Wook Y, Colson YL, Komatsu K, Ildstad ST, Yousem SA, Griffith BP, Pham SM. Mixed

chimerism to achieve donor-specific transplantation tolerance for lung allografts in rats. Surg Forum 1994; 45:271-3.

97. Kormos RL, Glassman LR, Pham SM, Hattler BG, Griffith BP. Long-term outcome in a randomized

trial of rabbit antithymocyte globulin vs. OKT3 immunophophylaxis. J Heart Lung Transplant 1994; 13(1, Part 2):S42.

98. Hattler BG, Reeder GD, Sawzik PJ, Walters FR, Pham SM, Kormos RL, Keenan RJ, Griffith BP,

Armitage JM, Hardesty RL, Borovetz HS. Development of an intravenous membrane oxygenator (IMO): A new concept in mechanical support for the failing lung. J Heart Lung Transplant 1994; 13(1, Part 2):S36.

99. Magee MJ, Pham SM, Suwan S, Zeevi A, Hattler BG. Characterization of the immune response to

cardiac myxomas. Surg Forum 1993;44:218-219.

100. Pham SM, Armitage JM, Kormos RL, Hattler BG, Hardesty RL, and Griffith BP. Rescue therapy with FK 506 in cardiac transplantation. Circulation 1993; 88(4):I-94.

101. Komatsu K, Pham SM, Konishi H, Bando K, Yousem S, Murase N, Griffith BP. Lung xenograft

rejection in hamster-to-rat model. Chest 1993; 104:127S.

102. Pham SM, Kormos RL, Armitage JM, Zerbe TR, Hattler BG, Murali S, Hardesty RL, Griffith BP. Cardiac transplantation in patient with active myocarditis. J Heart Lung Transplant 1993; 12(1):S101.

103. Pham SM, Kormos RL, Armitage JM, Kawai A, Morita S, Stein K, Hattler BG, Hardesty RL, del

Nido P, Faber J, Griffith BP. Long term outcome of human cardiac allografts preserved with University of Wisconsin solution. J Heart Lung Transplant 1993; 12(1):S83.

104. Kormos RL, Armitage JM, Hattler BG, Hardesty RL, Pham SM, Murali S, Griffith BP.

Differential analysis of risk factors following heart transplantation: The utility of the hazard function. J Heart Lung Transplant 1993; 12(1):S82.

105. Kawai A, Morita S, Kormos RL, Mandarino WA, Gasior TA, Pham SM, Armitage JM, Hardesty

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RL, Griffith BP. A clinical trial comparing University of Wisconsin solution and cold cardioplegia with load-independent mechanical parameters. J Heart Lung Transplant 1993; 12(1):S70.

106. Konishi H, Komatsu K, Bando K, Yoshida Y, Keenan RL, Stein KL, Paradis IL, Pham SM,

Armitage JM, Hardesty RL, Griffith BP. Bilateral lung transplantation for cystic fibrosis: University of Pittsburgh experience. J Heart Lung Transplant 1993; 12(1):S69.

107. Bando K, Guilinger RA, Paradis IL, Stein KL, Komatsu K, Konishi H, Keenan RJ, Yousem SA,

Pham SM, Armitage JM, Hardesty RL, Griffith BP. Comparison of outcomes after single (SLT) and bilateral lung transplantation (BLT) for obstructive lung disease (OLD). J Heart Lung Transplant 1993; 12(1):S68.

108. Pham SM, Morris E, Sawzik P, Klein M, del Nido PJ, Hattler BG. The Role of Aspartate and Glutamate in Myocardial Metabolism during Clinical Cardiac Surgery. Surg Forum 1002;XLIII:195-7.

109. Pham SM, Durham SJ, Johnson R, Showalter D, Endean ED, Vorp DA, Borovetz HS, Greisler

HP. Compliance change in bioresorbable vascular prostheses after implantation. Surg Forum 1988;39:330-32.

110. Pham SM, Durham SJ, Calvo WJ, Berceli SA, Warty VS, Borovetz HS. Effects of hemodynamics

and de-endothelialization on the intramural metabolism of low-density lipoprotein in canine carotid artery. Surg Forum 1987;38:355-57.

20. Other works: 20 a: Non-peer review journal publications:

1. Moosa HH, Shapiro SP, Pham SM, Miller RJ, Schachter AB. Isolated inflammatory hypogastric artery aneurysm with ureteral obstruction. Contemporary Surg 1990; 36:31-37.

20 b. Works listed in GeneBank:

1. Vazquez RI, Pham SM, Pang M., Aitouche A. Mus musculus strain C57BL/6J soluble guanylyl cyclase alpha subunit gene, 5' UTR (bases 1 to 278). http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Nucleotide. ACCESSION Number AY170850 (VERSION AY170850.1 GI:27466732). Submitted on 30-OCT-2002.

2. Vazquez-Padron, RI, Pham SM, Pang M, Aitouche A. Characterization of the mouse soluble guanylyl

cyclase alpha 5' flanking region (bases 1 to 1613). http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Nucleotide. ACCESSION NUMBER: AY116663 (VERSION AY116663.1 GI:21724200); Submitted on 31-MAY-2002.

V. PROFESSIONAL 21. Funded Research Performed: 21. Funded Research Performed:

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PAST GRANTS: 1) Title: "Augmentation of pulmonary blood flow with an electrically-conditioned latissimus dorsi muscle flap in Fontan operations" Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: Children's Hospital of Pittsburgh Amount: $7,500 Date: 1/1/87-12/30/87 2) Title: “Augment heart output by skeletal muscle in Fontan operation” Role: Co-Investigator Principal Investigator: Alfredo Trento, MD Agency: American Heart Association Amount: $15,675 Date: 7/1/87–6/30/88 3) Title: "Augmentation of right heart output by skeletal muscle in Fontan operation". Role: Role: Co-investigator Principal Investigator: Alfredo Trento, MD Agency: Presbyterian University Hospital, Pittsburgh, PA. Amount: $21,000 Date: 7/1/87-6/30/89 4) Title: "Induction of donor-specific tolerance for lung allografts using nonlethal conditioning" (Research Fellowship to James S. Gammie, MD) Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American Heart Association, Pennsylvania Affiliate Amount: $22,000 Date: 7/1/95-6/31/96 5) Title: “Mixed chimerism to achieve donor-specific transplantation tolerance for lung allografts” Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American College of Surgeons Amount: $60,000 Date: 7/1/94–6/30/96 6) Title: “Donor-specific tolerance induction in lung transplantation” Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American Heart Association Amount: $69,912 Date: 7/1/94-6/30/96 7) Title: “Induction of donor-specific tolerance for lung allografts using nonlethal conditioning Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American Heart Association (National) (#96014590) Direct cost: $ 120,000

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Indirect cost: $ 12,000 Duration: 7/1/96-6/30/99 8) Title: “Nitric oxide in allograft vasculopathy” Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: Thoracic Surgery Foundation Direct cost: $ 60,000 Indirect cost: None Duration: 7/1/96-6/30/98 9) Title: “Autologous LAK cell immunotherapy for PTLD” Role: Co-Investigator Principal Investigator: Abdul Rao, MD Agency: Cancer Treatment Research Foundation Support: $ 262,262 Duration: 12/1/96-11/30/98 10) Title: “Thymic tolerance in lung transplantation” Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American Lung Association (Dalsemer Research Scholar Award) (DA-0020-N) Direct cost: $ 50,000 Duration: 7/1/97-6/30/99 11) Title: “Prevention of allograft vasculopathy with inducible nitric oxide synthase gene therapy” Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: American Heart Association (Pennsylvania Affiliate) Direct cost: $70,000 Indirect cost: $7,000 Duration: 7/1/97-6/30/99 12) Title: “Aging and responses to vascular injury” Role: Co-Investigator Principal Investigator: Abdelouahab Aitouche, PhD Agency: NIH Direct cost: $50,000 Indirect cost: $25,000 Dates: 7/1/00-6/31/03 Status: Funded but declined because of overlapping support 13) Title: “Role of p53 in vascular remodeling” Role: Mentor Principal Investigator: Mohan Thanikachalam, MD (Post-doc fellow) Agency: American Heart Association Direct cost: $69,000 Indirect cost: none Dates: 7/1/00-6/31/02 Status: (Score: 1.3 {2.6 percentile}). Funded but declined.

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14) Title: “Combined bone marrow and organ transplantation in humans” Role: Co-Investigator Principal Investigator: John J. Fung, MD (University of Pittsburgh) Agency: NIH (#AI40329-02) Support: $ 184,970 (direct cost)/year Duration: 4/1/97-3/31/01 15) Title: “Pathogenesis and treatment of chronic rejection” Role: Co-Investigator Principal Investigator: Noriko Murase, MD (University of Pittsburgh) Agency: NIH Support: $175,054 (direct cost)/year Duration: 12/1/97-11/30/03 16) Title: “The role of p53 in the nitric oxide synthase-mediated inhibition of cardiac allograft vasculopathy” Role: Mentor Principal Investigator: Mohan Thanikachalam, MD (Post-doc fellow) Agency: Thoracic Surgery Foundation Direct cost: $70,000 Indirect cost: None Dates: 7/1/20–6/30/02 17) Title: “Severity and reversibility of arteriosclerosis during vascular remodeling. Influence of age and estrogen milieu” Role: Co-Investigator Principal Investigator: Abdelouahab Aitouche, PhD Agency: American Heart Association Direct cost: $ 204,546 Indirect cost: $ 20,454 Dates: 7/1/00-6/31/03 18) Title: “Nitric oxide in allograft vasculopathy” (R01) Role: Principal Investigator Principal Investigator: Si Pham, MD Agency: NIH Direct cost: $625,164 (total) Indirect cost: $326,321 (total) Dates: 1/1/99-12/31/03 19) Title: “Ex-vivo co-stimulatory blockade for tolerance induction and GVHD prevention” Role: Co-Investigator Principal Investigator: Sen Li Agency: American Heart Association (Beginning Grant-in-Aid) Direct cost: $204,600 Indirect cost: $20,400 Dates: 7/01/01–6/30/04 20) Title: “Donor Treatment with The LinkTM to Improve Airway Clearance and Increase the Number of Lungs Recovered for Transplantation” Role: Co-Investigator

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Principal Investigator: Susan Ganz Agency: Dept of Health and Human Services, Health Resources and Services Administration (# 1 H39 OT 00126-01) Direct cost: $ 820,049 Indirect cost: $ 421,473 Dates: 9/30/02-9/30/05 Status: Completed 21) Title: Immunoregulation role of donor bone marrow in lung transplantation” Role: Mentor Principal Investigator: Manhui Pang Agency: American Heart Association (Beginning Grant-in-Aid) Direct cost: $218,184 Indirect cost: $21,816 Dates: 7/01/03–6/30/06 22) Title: “Donor bone marrow and immunoregulation in lung transplantation” Role: PI Principal Investigator: Si M. Pham, MD Agency: NHLBI (Number 1 R01 HL079446-01) Direct cost: $300,000 (total) Indirect cost: $154,500 (total) Dates: 2/01/04–3/31/07 (including 1-year no cost extension) 23) Title: “The role of p53 Oncogen in Allograft Vasculopathy” Grant-in-Aids (Pham) Role: PI Principal Investigator: Si M. Pham, MD Agency: American Heart Association (Florida/Puerto Rico Affiliate) Direct Cost: $109,090 Indirect Cost: $10,910 Dates: 7/01/04–6/30/06 24) Title: “Biomimetic scaffolds for multiple growth factor delivery” Role: Co-Investigator Principal Investigator: Fotios Andreopoulos Agency: MIH/NIAMS Direct cost: $150,000 Indirect cost: $77,250 Dates: 6/01/04–5/30/07 25) Title: “Retrospective comparison of outcome of heart transplant recipients receiving either tacrolimus, sirolimus, and steroids or tacrolimus, mycophenolate mofetil, and steroids” Role: PI Principal Investigator: Si M. Pham Agency: Fujisawa Healthcare, Inc. Total cost: $60,000 Dates: 9/1/04-8/31/06

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26) Title: “DeBakey Ventricular Assist Device Project” Role: PI Principal Investigator: Si M. Pham Agency: Jackson Memorial Foundation Total cost: $190,000 Dates: 12/1/04-12/31/06 ACTIVE GRANTS: 1. American Heart Association Grant #: 0755568B (PI: Pham, Si) 07/01/2007-06/31/10 EFFECTS OF AGING AND BONE MARROW STEM CELLS ON NEOINTIMAL FORMATION The central hypothesis of this application is that the aging process exhausts the pool of bone marrow vascular progenitor cells needed for vascular repair, resulting in exaggerated neointimal formation after injury in the aged. The purposes of this study are: 1) to investigate the mechanisms by which young bone marrow attenuates the exaggerated neointimal formation after vascular injury in the aged, and 2) to determine whether young bone marrow or its components attenuate neointimal formation after vascular injury in aging mice. Total support: $240,000/3 years) 2. Florida Department of Health. Team Science Project # 07KT-02 (Webster, K) 07/01/2007-06/31/09 Cellular Therapeutics and Mechanisms of Vascular Dysfunction in Heart and Kidney Disease Role: Project Leader of Project #3: MECHANISMS RESPONSIBLE FOR EXACERBATED NEOINTIMAL FORMATION BY NICOTINE Summary: The hypothesis of this project is that nicotine exaggerates neointimal formation by augmenting the recruitment of vascular progenitor cells to the site of injury, and by enhancing the proliferation of neointimal VSMC via the PDGF-receptor/ligand signaling pathway. We will test our hypothesis in the following two specific aims. In AIM I, we will determine the intracellular signaling pathways by which nicotine stimulates PDGF-BB production in vascular smooth muscle cells. In AIM II, we will determine whether nicotine increases the recruitment of vascular progenitor cells to the site of vascular injury, and increases the differentiation of these cells in the neointima by stimulating the production of PDGF-BB by VSMC. Total support for the Project: $125,000/yr for 2 years. 3. Transplantation Foundation of South Florida. (PI= Pham,S) Project Title: Adult Stem Cell Therapy in Lung Transplantation 7/01/07-6/31/08 The Aim of the study is to determine whether bone marrow derived Mesenchymal Stem Cells can prevent ischemia/reperfusion injury and graft rejection following lung transplantation. Total support: $ 63,850 for 1 year 4.NIH U54HL081028-01 (PI: Marban) 09/01/05 - 08/31/10 (Project 1, Miami Site, PI: Hare, J) Title of Grant: Cellular Cardiomyoplasty for Acute and Chronic Ischemia GOALS: This Specialized Center for Cell Therapeutics proposal aims to develop cellular cardiomyoplasty for the treatment of ischemic heart disease, both post-myocardial infarction left ventricular dysfunction as well as chronic ischemic cardiomyopathy. Role: Dr. Pham is Co-Investigator with 10% of effort

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5. “The Role of Vascular Senescence in Age-Related Vasculopathy” (PI= Roberto Vazquez-Padron, Ph.D) Role: Mentor Agency: American Heart Association (Florida/Puerto Rico Affiliate) Total Cost: $ 240,000 Dates: 7/01/05–6/30/08 Status: Active 6. Title: “The role of nicotine in smoking-related vascular diseases” (PI= Roberto Vazquez-Padron) Role: Mentor Agency: Florida Department of Health Total cost: $450,000 Dates: 7/1/06-6/31/09 Status: Active 7. “A prospective study using humanized monoclonal antibody against CD52 (Campath-1H) and Tacolimus in heart transplant recipients Role: PI Principal Investigator: Si M. Pham Agency: Astellas Pharmaceutical Co. Total cost: $73,800 Dates: 8/1/05-7/31/07 Status: Active Pending Grants: 1. NIH-1R21HL088176-01 (PI: Fotios Andreopoulos) “Bioengineered tissue-responsive angiogenic strategies” Your role: Significant contributor Direct costs: $275,000 Date: 4/01/07-3/31/09 2. Title: “Bone-marrow derived mesenchymal stem cell to promote tolerance to heart graft” (PI= S. Salgar, Ph.D) Role: Co-Investigator Agency: NIH Total Cost: $ 240,000 Status: Pending 22. Editorial Responsibilities: Reviewer for:

Annals of Thoracic Surgery Journal of Thoracic and Cardiovascular Surgery American Society of Artificial Internal Organs Journal Asian Cardiovascular & Thoracic Annals Transplantation Journal of Heart and Lung Transplantation Circulation Research European Respiratory Journal

23. Professional and Honorary Organizations: Diplomate, American Board of Surgery, 11/90

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Society of Critical Care Medicine, 1992 International Society for Heart and Lung Transplantation, 1992 American Society of Artificial Internal Organs, 1993 American Association for the Advancement of Science, 1993 Extracorporeal Life Support Organization, 1993 Diplomate, American Board of Thoracic Surgery, 6/93 American Society of Transplant Surgeons, 1994 American College of Surgeons (Fellow, 1995) Society of Thoracic Surgeons, 1995 Association of Academic Surgery, Senior Member, 1996 American Association for Thoracic Surgery, 2001 Fellow of the American Heart Association, 2002

24. Honors and Awards: Marquis Who’s Who in Science and Engineering, 2006 Ad hoc reviewer for NHLBI Winter Hematology Program Project, January 27-28, 2005, Columbia, MD “Year 2004 Award for Excellent Sciences Award.” Vietnamese American Medical Research Foundation. James H. Nakano Citation from The National Centers for Infectious Diseases, of Centers for Disease Control and Prevention, (Atlanta, Alabama) for the paper entitled “Transmission of West Nile Virus from an Organ Donor to Four Transplant Recipients”, The New England Journal of Medicine 2003;348(22):2196-203. Reviewer, Site Visitor for Dr. Anversa’s Program Project Grant entitled “Stem Cells and Cardiac Aging” (By The National Institute of Aging), New York Medical College, Valhalla, New York, July 7-8, 2003 Doctor “Honoris Causa”, University of Moron, Argentina, October 31, 2002 Panelist, Special Emphasis Panel for RFA-AI-00-013: Immunopathogenesis of Chronic Graft Rejection; NIH (NIAID, NHLBI); Bethesda, Maryland; February 7-9, 2001 American Lung Association Dalsemer Research Scholar Award, 1997-1999 American College of Surgeons Faculty Fellowship Award, 1994-1996 Marquis Who's Who in Science and Engineering, 1997-present Honors Convocation, University of Pittsburgh, 2/97 Marquis Who's Who in Medicine and Healthcare, 1996-present Marquis Who's Who in America, 1995-present Marquis Who's Who in the East, 1995-1999 Marquis Who's Who in the South East, 2000-present Marquis Who’s Who in the World, 2007 Alumni Citation, Lebanon Valley College, 1994 Radiology Award, University of Pittsburgh, School of Medicine, 1983 Phi Alpha Epsilon (Scholarship Society), Lebanon Valley College, 1979 Department Honors Program, Lebanon Valley College, 1979 American Chemical Society Award, 1979 Magna Cum Laude, 1979 Valedictorian, 1973 (Ninh Hoa High School, Ninh Hoa, Khanh Hoa, Viet Nam)

25. Post-Doctoral Fellowships: N/A 26. Other Professional Activities:

a) Research Experiences:

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1) 1997: Molecular Biology Summer Workshop, Smith College, Northampton, MA. 2) 1987-1988: Cardiothoracic Research Fellow, Department of Surgery, University of Pittsburgh. (under Harvey Borovetz, Ph.D., Bartley P. Griffith, M.D.). 3) 1980: Participated in the study of the pathogenesis of Yellow Hyaline Membrane Disease, Department of Pathology, Magee Women's Hospital, Pittsburgh, PA. (under Bernard Klionsky, M.D.). 4) 1980: Pittsburgh-West African Medical Scientist Summer Exchange Program, University of Pittsburgh, School of Medicine - University of Benin Teaching Hospital, Nigeria. (under Robert Glew Ph.D). 5) 1977 and 1978: Participated in the study of the effects of divalent metal ions on yeast pyrophosphatase, Lebanon Valley College (under Owen Moe, Jr., Ph.D).

b) Invited Speaker/Visiting Professor:

1. March 27, 2008: “Effects of Donor Bone Marrow on Thoracic Organ Recipients”, Visiting Professor, Hershey Medical Center, Penn State University, Hershey, Pennsylvania (March 26-31, 2008).

2. January 30, 2006: “Effect of Donor Bone Marrow on Solid Organ Recipients”, Visiting Professor,

University of Kentucky, Louisville, KY. 3. February 19, 2006: “Heart Transplantation: Outcomes”, International Conference – Heart Failure:

Comprehensive Management, Chennai, India.

4. February 28, 2006: “Ventricular Assist Devices and Cardiac Transplantation”, First Miami Joint Symposium: Mechanisms Involved and Management Innovation in Heart Failure, Miami, Florida.

5. May 8, 2006: “Current Status of Lung Transplantation”, Visiting Professor, Harbin Medical

University, Harbin, China (May 8-11, 2006).

6. September 17, 2006: “Pulmonary Arterial Hypertension and Lung Transplantation”, Invited Speaker and Moderator, 51st Tri-State Conference on Lung Disease, Florida Thoracic Society/American Lung Associate of Florida, Ponte Vedra Beach, Florida (September 15-17, 2006).

7. December 8, 2005: “Recent Advances in Heart Transplantation.” Scientific Forum XV-International

Congress of Cardiovascular Sciences, Rio de Janeiro, Brazil.

8. December 12, 2005: “Current Status of Heart Transplant and Heart Assist Device”, Visiting Professor, University of Moron, Buenos Aires, Argentina.

9. September 21, 2004: “Current Status of Heart and Lung Transplantation.” South Miami Hospital,

Miami, FL.

10. October 21, 2003: “Intraabdominal Malignancies after Thoracic Transplantation and the Incidence, Treatment and Outcome.” American College of Surgeons 89th Annual Clinical Congress. Chicago, IL.

11. January 4, 2000: Current Status of Heart Transplantation. Grand Rounds at Holy Cross Hospital, Fort

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Lauderdale, FL.

12. January 27, 2000: “Induction of Tolerance to Lung Allografts.” Research Seminar. Division of Pulmonary Medicine, University of Miami School of Medicine. Miami, FL.

13. September 6, 2000: “Approaches to Induce Long-Term Acceptance to Transplant Organs.” Research

Seminar. Institute for Cellular Therapeutics. Louisville, KY.

14. September 26, 2000: “Management of the Pediatric Patient Post-Transplant: Diagnosis and Management of Rejection and Other Complications.” IX Congress of the Latin Society of Pediatric Cardiology and Cardiovascular Surgery. Key Biscayne, FL.

15. October 14, 2000: “Cardiothoracic Diseases.” Transplant Forum 2000. Florida International

University. Miami, FL.

16. November 21, 2000: “Heart Transplant.” Pediatrics Grand Rounds. University of Miami School of Medicine. Miami, FL.

17. February 24, 1999: Current Status in Lung Transplantation. South Miami Hospital’s Annual

Symposium on Cystic Fibrosis, Miami, FL.

18. May 22, 1999: Current Status of Heart and Lung Transplantation. University of Miami, School of Medicine, Department of Surgery Grand Rounds, Miami, FL.

19. January 21, 1998: Induction of Donor-Specific Transplantation Tolerance by Intrathymic Inoculation

of Donor Cells. University of Pittsburgh, School of Medicine, Department of Pathology Research Conference, Pittsburgh, PA.

20. January 22, 1998: Novel Approaches to Prevent Rejection in Transplanted Hearts. University of

Pittsburgh, School of Medicine, Division of Cardiology, Cardiovascular Research Conference, Pittsburgh, PA.

21. September 25-27, 1998: Ex-Vivo Donor Manipulation Results of Inducible Nitric Oxide Synthase

Gene Transfection. International Society for Heart and Lung Transplantation 1st Annual Fall Education Meeting on Coronary Allograft Vasculopathy, Washington D.C.

22. March 18, 1997: Novel Approaches to Prevent Acute and Chronic Rejection in Organ Allografts.

Institute of Cellular Therapeutics, Allegheny University of the Health Sciences, Philadelphia, PA.

23. May 23, 1997: Ventricular Assist Device as a Bridge to Cardiac Transplantation. Thomas E. Starzl Transplantation Institute Conference, Pittsburgh, PA.

24. October 31, 1997: Induction of Donor-Specific Transplantation Tolerance by Intrathymic Inoculation

of Donor Cells: Experimental and Clinical Studies. Children's Hospital of Pittsburgh, Pittsburgh, PA.

25. April 11, 1996: Chimerism in Thoracic Organ Transplant Recipient. Pittsburgh Transplantation

Institute Conference, 1996. Pittsburgh, PA.

26. May 21, 1996: Chimerism in Thoracic Organ Transplantation. Buffalo General Hospital, Buffalo, NY.

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27. August 7, 1996: Tacrolimus in Clinical Heart Transplantation. Cleveland Clinic Foundation,

Cleveland, OH.

28. October 4, 1996: Outcome in Heart Transplantation. State of the Art Treatment of Ischemic Heart Disease at the University of Pittsburgh Medical Center. Station Square, Pittsburgh, PA.

29. October 22, 1996: New Immunosuppressive Agents in Heart Transplantation. Temple University

Hospital, Philadelphia, PA.

30. April 13, 1995: Simultaneous Infusion of Donor-Specific Bone Marrow and Heart Lung Transplantation. Transplantation Grand Rounds, University of Pittsburgh, School of Medicine, Pittsburgh, PA.

31. December 12, 1995: Tacrolimus in Clinical Heart Transplantation. Fairfax Hospital, Falls Church,

VA.

32. March 2, 1994: Current Status on Lung Transplantation; Surgical Grand Rounds, Western Pennsylvania Hospital, Pittsburgh, PA.

33. April 7, 1993: Update in Cardiac Transplantation; Medical Grand Rounds, St. Francis Hospital,

Pittsburgh, PA.

c) Presentations At National And International Meetings

1. Salgar S, Sen Li, Yuntao Wei, James Mathew, Si Pham.Interleukin-10 Gene Delivery Via Mesenchymal Stem Cells For Immunosuppression In Organ Transplantation, Accepted for presentation (oral) International Society for Cell Therapy, May 2008, Miami, FL.

2. A. Rahnemai-Azar, A. Gomez, T. Reiner, G. D’Ippolito, S. Salgar, P. Schiller, S. Pham. Marrow-

Isolated Adult Multilineage Inducible (MIAMI) Cells have the Potential to Promote Vascularization and Function in a Mouse Limb Ischemia Model, Accepted for presentation at International Society for Cell Therapy, May 2008, Miami, FL.

3. Pamboukian SV, S.M. Pham, R.S.D. Higgins, B. Czerska, B.S. Clemson, J.K. Kirklin, R.N. Brown, C.

White-Williams, Cardiac Transplant Research Database. Infection and Rejection Risk Using Induction with Interleukin II Receptor Blockers vs. Antithymocyte Globulin vs. No Induction: A Multi-Institutional Study. Oral Presentation at 28th Annual Scientific Meeting of the Society of Heart and Lung Transplantation, April 9-12, 2008, Boston MA

4. Vazquez-Padron RI, Wei Y, Menocal-Rodriguez L, Mateo D, Salgar S, Li S and Pham SM. Post Injury

Neointima Cells are Predominantly of Local Origin rather than from Circulating. Poster Presentation at the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008 in Atlanta, Georgia, April 15-19, 2008.

5. Sheik K, Wei Y., Mateo D, Li S, Fletcher T, Pham S and Vazquez-Padron RI. Aging Increases Oxidative

Stress-Induced Senescence Suring Vascular Remodeling. Poster Presentation at the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008 in Atlanta, Georgia, April 15-19, 2008.

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6. Salgar S., S. Li, M. Hernandez, D. Mateu, Y. Wei, J. Mathew, S. Pham. Interleukin-10 Gene Delivery Via Mesenchymal Stem Cells To Prevent Cardiac Allograft Rejection. Cardiovascular Research Symposium. Cardiovascular Research Symposium, March 13, 2008

7. A. Rahnemai-Azar, A. Gomez, T. Reiner, G. D’Ippolito, S. Salgar, P. Schiller, S. Pham. MIAMI

(Marrow-Isolated Adult Multilineage Inducible) Cells Promote Vascularization and Function in a Mouse Limb Ischemia Model, Cardiovascular Research Symposium, March 13, 2008

8. E Manning, S Pham, S Li, R Vazquez-Padron, J Mathew, P Ruiz, S Salgar*. Interleukin-10 Delivery Via

Mesenchymal Stem Cells (MSC): A Novel Approach To Prevent Lung Ischemia/Reperfusion Injury, Accepted for presentation at American Transplant Congress 2008.

9. Manning E, Salgar S, Hernandez M, Mateu D, Vazquez-Padron R, Li S, Mathew J, Pham S.

Mesenchymal Stem Cell Therapy Prevents Ischemia/Reperfusion Injury and Promotes Tissue Regeneration. American Heart Association Scientific Sessions 2007 meeting in Orlando, Florida. Nov 6, 2007.

10. Salgar S, Li S, Wei Y, Hernandez M, Mateu D, Vazquez-Padron R, Mathew J, Pham Si. Recipient

conditioning with mesenchymal stem cells and interleukin-10 prolonged allograft survival. American Association of Immunologists Meeting, May 18-22, 2007, Miami, Florida. J. Immunol., Apr 2007; 178: 102.1.

11. Salgar S, Li S, Hernandez M, Wei Y, Mateu D, Mathew J, Pham S. Viral Interleukin-10 Gene Therapy

Via Mesenchymal Stem Cells Prolonged Cardiac Transplant Survival. The Journal of Heart and Lung Transplantation, 2007, 26, 2S: 219. *Oral presentation at 27th International Society of Heart and Lung Transplantation meeting, April 25-28, 2007, San Francisco, CA.

12. Garcia-Covarrubias L, Pham, SM, Majetschak M: Ubiquitin Attenuates Ischemia-Reperfusion

Injury of the Lung. *Poster presentation at the American Transplant Congress 2007 meeting, May 5-9, 2007, San Francisco, California. American Journal of Transplantation 2007, 7S2:1120.

13. Ganz SS, Gaynor JJ, Levi DM, Moon JI, Nishida S, Osorio M, Pham SM. Donor Predictors of

Successful Lung Recovery for Transplantation. *Poster presentation at the American Transplant Congress 2007 meeting, May 5-9, 2007, San Francisco, California. American Journal of Transplantation 2007, 7S2:927.

14. Ganz SS, Levi DM, Nishida S, Moon JI, Gaynor JJ, Osorio M, Pham SM. Pulmonary Function

Is Preserved during Prolonged Donor Management When the Link™ Is Used. *Oral presentation at the American Transplant Congress 2007 meeting, May 5-9, 2007, San Francisco, California. American Journal of Transplantation 2007, 7S2:377.

15. Salgar S, Li S, Wei Y, Hernandez M, Mateu D, Vazquez-Padron R, Mathew J, Pham Si. Mesenchymal

Stem Cell Therapy for Immunosuppression and Vascular Regeneration in Organ Transplantation. *Oral presentation at the American Transplant Congress 2007 meeting, May 5-9, 2007, San Francisco, California. American Journal of Transplantation 2007, 7S2:221

16. Calfa M., Vazquez-Padron RI, Li S, Salgar S, and Pham SM. Young bone marrow as opposed to aging

bone marrow attenuates intimal formation promotes re-endothelialization and diminishes the inflammatory response associated with the vascular response to injury. Oral presentation at the 2nd Annual Academic Surgical Congress in Phoenix, AZ, February 6-9, 2007.

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17. Vazquez-Padron RI, Wei Y, Mateo D, Rodriguez-Menocal L, Li S, Salgar S and Pham MS. Aging

Increases the Inflammatory Response After Vascular Injury, Leading to an Exaggerated Neointimal Formation. Poster Presentation at the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2007 in Chicago, Illinois, April 19-21, 2007.

18. Vazquez-Padron RI, Wei Y, Mateo D, Hernandez M, Pestana I, Li S, Salgar S, Pham SM. Nicotine

Activates p44/42 MAPK Signaling in Vascular Smooth Cells and Exacerbates Vascular Inflammation and Neointimal Formation after Vascular Injury. Presentation at the American Heart Association Scientific Sessions 2006 in Chicago, IL November 12 – 15, 2006. Circulation (Supplement II), 2006, 114(18):II-179.

19. Salgar S, Li S, Hernandez M, Vazquez-Padron R, Wei Y, Liotta C, Mathew J, Pham S. Engineered

Mesenchymal Stem Cell Therapy: A Novel Approach to Prolong Cardiac Allograft Survival. The Annual Meeting of the American Association of Immunologists, May 12-16, 2006, Boston, MA.

20. Earle SA, Patel MB, Pham S, Majetschak M. Prolongation of allogenic skin graft survival by exogenous

ubiquitin. Poster presentation at 1st Annual Academic Surgical Congress (Society of University Surgeons) in San Diego, CA, February, 2006.

21. Vazquez-Padron RI, Farji A, Aitouche A, Pham SM. Aging exacerbates stress-induced senescence in

vascular smooth muscle cells during vascular remodeling. Poster presentation at 1st Annual Academic Surgical Congress (Society of University Surgeons) in San Diego, CA, February, 2006.

22. Layman H, Li S, Pham SM, Andreopoulos FM. Therapeutic angiogenesis in critical limb ischemia via

the localized delivery of BFGF from ionic hydrogels. Poster presentation at 1st Annual Academic Surgical Congress (Society of University Surgeons) in San Diego, CA, February, 2006.

23. Pang M, Li S, Salgar S, Liotta C, Aitouche A, Vazquez-Padron R, Matthew J, Pham SM. Donor bone

marrow infusion reduces the infiltration of recipient-derived CD4 and dendritic cells in lung allograft. Oral presentation at 1st Annual Academic Surgical Congress (Society of University Surgeons) in San Diego, CA, February, 2006.

24. Pang M, Li S, Salgar S, Liotta C, Vazquez-Padron R, Matthew J, Pham SM. Donor bone marrow

modulates the host immune responses to lung allografts. Poster presentation at the International Society of Heart and Lung Transplantation 26th Annual Meeting and Scientific Sessions, Madrid, Spain, April, 2006.

25. Pham SM, Jimenez J, Bednar BM, Panos A, Futterman L, Bauerlein EJ, Ricci M, Mallon SM,

Rosenkranz EE, Rusconi P. Campath-1H in clinical heart transplantation. Oral presentation at the International Society of Heart and Lung Transplantation 26th Annual Meeting and Scientific Sessions, Madrid, Spain, April, 2006.

26. Jimenez J, Edwards LB, Mallon S, Panos A, Pham S. What is the fate of temporary inactive patients

listed for heart transplantation? Poster presentation at the International Society of Heart and Lung Transplantation 26th Annual Meeting and Scientific Sessions, Madrid, Spain, April, 2006.

27. Vazquez-Padron RI, Pestana I, Li S, Liotta C, Pham SM. Nicotine increases vascular smooth muscle

proliferation and intimal hyperplasia after vascular injury. Poster Presentation at Keystone Symposia of Molecular Biology of the Vascular in Keystone, Colorado, April, 2006.

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28. Vazquez-Padron RI, Pestana I, Li S, Aitouche A, Pham SM. Aging increases p16 INK4a expression in vascular tissue. Poster Presentation at the 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, Denver, Colorado, April, 2006.

29. Pham SM, Jimenez J, Mallon S, Bauerlein EJ, Panos A, Bednar B, Patel S. The combined use of

tacrolimus and sirolimus in clinical heart transplantation; Intermediate-term results (Poster). American Transplant Congress 2005, Seattle, Washington, May 2005.

30. Thanikachalam M, Li S, Simmonds A, Cheung M, Vazquez-Padron R, Liotta CA, Aitouche A, Pham

SM. p53 plays a significant role in the pathogenesis of allograft vasculopathy. Oral presentation, International Society for Heart & Lung Transplantation 24th Annual Meeting and Scientific Sessions, San Francisco, CA, April 2004.

31. Pestana IA, Vazquez-Padron RI, Aitouche A, Pham SM. Nicotinic and PDGF-receptor function are

essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells. Oral presentation, American Heart Association Scientific Sessions, New Orleans, LA, November 2004.

32. Pham SM, Jimenez J, Mallon S, Bauerlein EJ, Panos A, Bednar B, Patel S. The combined use of

tacrolimus and sirolimus in clinical heart transplantation. Oral presentation, 3rd International Congress on Immunosuppression, San Diego, CA, December 2004.

33. Thanikachalam M, Pang M, Li S, Vazquez-Padron R, Aitouche A, Grotendorst GR, Pham SM.

Expression of connective tissue growth factor is upregulated in post-transplant obliterative airway disease. (Poster). International Society of Heart Lung Transplant Meeting, Vienna, Austria, April 2003.

34. Webber SA, Pereira JR, Pigula FA, Gandhi S, Murase N, Woodward JE, Boyle GJ, Law YM, Pham S,

Zeevi A, Griffith BP, Fung JJ. A novel technique for donor bone marrow procurement for clinical tolerance trials in children. Presented at American Transplant Congress, Washington, DC, May 2003.

35. Webber SA, Boyle GJ, Law YM, Pereira JR, Bentlejewski C, Pigula FA, Gandhi S, Miller SA,

Woodward JE, Murase N, Fung JJ, Martell J, Pham S, Griffith BP, Zeevi A. A clinical trial of intrathymic inoculation of donor bone marrow with pediatric heart transplantation. (Poster). Presentated at American Transplant Congress, Washington, DC, May 2003.

36. Simmonds A, Thanikachalam M, Lasko D, Vasquez R, Aitouche A, Li S, Pang M, Gambotto A, Liotta

C, Cheung M, Pham S. Nitric oxide induces apoptosis in vascular smooth muscle cells by upregulating the expression of p53 gene. Presented at American Transplant Congress, Washington, DC, May 2003.

37. Li S, Louis LB, Kawaharada N, Yousem S, Pham SM. Intrathymic Inoculation of donor bone marrow

induces long-term acceptance of lung allografts. The Society of Thoracic Surgeons Annual Meeting, Ft. Lauderdale, FL, January 28-30, 2002.

38. Louis LB, Li S, Kawaharada N, Yousem S, Pham SM. Intrathymic inoculation of donor bone marrow

at the time of transplantation induces long-term acceptance of lung allografts. 38th Annual Meeting of the Society of Thoracic Surgeons, Fort Lauderdale, FL, January 28-30, 2002.

39. Qi X, Lee P, Kaplon R, Loo A, Mallon S, Katariya K, Bauerlein E, Pham SM. Sirolimus and tacrolimus

in heart transplantation. International Society for Heart and Lung Transplantation, 22nd Annual Meeting and Scientific Sessions, Washington, D.C., April 10-13, 2002.

40. Calfa M, Aitouche A, Vasquez RI, Li S, Pang M, Louis L, Pham SM. Recipient’s age plays a more

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important role than donor’s age in determining the severity of vascular neointimal hyperplasia. American Transplant Congress, Transplant 2002, Washington, D.C., April 26-May 1, 2002.

41. Cabana ER, Fertel D, Qi XS, Gerity S, Pham S, Ruiz P. The immunophenotypic profile of bronchial

veolar lavage (BAL) cells correlates with histologic acute rejection grade in lung transplants. XIX International Congress of the Transplantation Society, Miami, FL, August 25-30, 2002.

42. Calfa M., Aitouche A, Gay-Rabinstein C, Vazquez RI, Li S, Pang M, Thanikachalam M, Lasko D,

Simmonds A, El-Haddad A, Louis LB, Pham SM. What matters more in transplant arteriosclerosis: The age of the donor or the age of the recipient? XIX International Congress of the Transplantation Society, Miami, FL, August 25-30, 2002.

43. Thanikachalam M, Pang M, Vazquez-Padron R, Li S, Aitouche A, Grotendorst GR, Pham SM.

Connective tissue growth factor may play an important role in the development of obliterative bronchiolitis. Association for Academic Surgery 36th Annual Meeting, Boston, MA, November 8, 2002.

44. Calfa M, Aitouche A, Vazquez R, Pang M, Lasko D, Simmonds A, El-Haddad A, Pham S. Effects of

bone marrow on the exaggerated vascular response to injury associated with aging. American Heart Association Scientific Meeting, Chicago, IL, November 17-20, 2002.

45. Qi X, Lee PC, Kaplon R, Loo AF, Mallon S, Katariya K, Bauerlein E, Pham SM. Sirolimus and

tacrolimus in clinical cardiac transplantation: A pilot study. (Poster) Transplantation 2001, the Joint American Transplant Meeting, Chicago, IL, May 11-16, 2001.

46. Calfa M, Aitouche A, Vasquez R, Li S, Pang M, Gay-Rabenstein C, Louis L, Pham SM. “Aging

Milieu, Not the intrinsic property of the aging vessel, determines the exaggerated vascular response to injury associated with aging. (Poster) American Heart Association Scientific Sessions 2001, Anaheim, CA, November 9–10, 2001.

47. Qi X, Lee PC, Kaplon R, Loo AF, Mallon S, Katariya K, Bauerlein E, Pham SM. Sirolimus and

tacrolimus in clinical heart transplant. (Oral Presentation) The 2nd International Congress on Immunosuppression, San Diego, CA, December 6-8, 2001.

48. Thanikachalam M, Li S, Pham SM. Mixed chimerism by non-lethal conditioning induces donor-

specific tolerance to lung allografts in rats. 11th Annual Resident, Intern & Student Surgical Research Forum, South Florida Chapter of the American College of Surgeons, Hollywood, FL, May 3, 2000.

49. Fukada J, Schena S, Tack I, Ruiz P, Kurimoto Y, Pang M, Aitouche A, Striker G, Striker LJ, Pham SM.

Exogenous nitric oxide (FK409) attenuates transplant arteriosclerosis in rat aortic allograft model. 11th Annual Resident, Intern & Student Surgical Research Forum, South Florida Chapter of the American College of Surgeons, Hollywood, FL, May 3, 2000.

50. Dowdy L, Thurer R, Pinna A, Pham S, Morcos J, Tzakis A, Miller J. Successful combined medical

surgical treatment of disseminated fungal infection in transplant recipients. Transplant Infectious Disease, Stockholm, Sweden, May 25-27, 2000.

51. Fukada J, Schena S, Tack I, Ruiz P, Kurimoto Y, Pang M, Aitouche A, Abe T, Pham S. Exogenous

nitric oxide attenuates allograft vasculopathy. XVIII International Congress of the Transplantation Society, Rome, Italy, August 27 to September 1, 2000.

52. Fukada J, Kurimoto Y, Schena S, Aitouche A, Ruiz P, Zeevi A, Kubota T, Pham S. Long-term survival

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of rat cardiac allografts by intrathymic plus portal venous injections of donor bone marrow cells and short-term tacrolimus immunosuppression. First Congress of the International Pediatric Transplant Association, Venice, Italy, August 23-25, 2000.

53. Calfa M, Aitouche A, Gay-Rabinstein C, Li S, Pham SM. Effects of aging on vascular response to

injury: Aging milieu versus vessel senescence. Association for Academic Surgery 34th Annual Meeting of the Association, Tampa, FL, November 2-4, 2000.

54. Thanikachalam M, Li S, Murdock AD, Kurimoto Y, Gammie JS, Zeevi A, Yousem S, Pham SM.

Tacrolimus-based nonlethal conditioning leads to stable mixed chimerism and donor-specific tolerance to lung allografts in rats. Association for Academic Surgery 34th Annual Meeting of the Association, Tampa, FL, November 2-4, 2000.

55. Thanikachalam M, Fukada J, Calfa M, Perez M, Grotendorst GR, Pham SM. Increased expression

connective tissue growth factor (CTGF) in posttransplant obliterative arteriopathy. Association for Academic Surgery 34th Annual Meeting of the Association, Tampa, FL, November 2-4, 2000.

56. Thanikachalam M, Li S, Carreno M, Pang M, Calfa M, Aitouche A, Pham SM. Co-stimulatory

blockage with CTLA4-Ig leads to stable mixed chimerism in rats at 200 cGy and donor-specific tolerance to heart allografts. American Heart Association Annual Meeting, New Orleans, LA, November 22-24, 2000.

57. Fukada J, Schena S, Tack I, Pang M, Ruiz P, Kurimoto Y, Aitouche A, Abe T, Striker LJ, Pham SM.

The effect of FK409 on allograft vasculopathy in a rat aortic transplant model. (Poster) American Heart Association Annual Meeting, New Orleans, LA, November 22-24, 2000.

58. Pham SM, Rao A, Zeevi A, et al. Five-year experience on combined donor bone marrow infusion and

lung transplantation. 1999 Annual Meeting of the Society of Thoracic Surgeons, San Antonio, TX, January 27.

59. Gammie JS, Stukrs Dr, Pham SM, Hattler BG, McGrath MF, McCurry KR, Griffith BP, Keenan RJ.

Effect of ischemic thime on survival in clinical lung transplantation. Annual Meeting of the Society of Thoracic Surgeons, San Antonio, TX, January 27, 1999.

60. Pham SM, Rao AS, Zeevi A, McCurry KR, Kormos RL, Fontes P, Hattler BG, Fung JJ, Starzl TE,

Griffith BP. A clinical trial combining donor bone marrow infusion and heart transplantation: Intermediate-term results. International Conference of the American Association for Thoracic Surgery, New Orleans, LA, April 18-21, 1999.

61. McCurry KR, Pham SM, Zeevi A, Webber S, Rao A, Ostrowski L, Salgar S, Starzl TE, Bentlejewski C,

Keenan RJ, Fung JJ, Griffith BP. Immunodulatory effects of donor bone marrow infusion in heart or lung transplantation: a five-year experience. International Conference of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 21-24, 1999.

62. Sileri P, Schena S, Rastellini C, Pham SM, Cicalese L. Pyruvate inhibits hepatic ischemia-reperfusion

(I/R) injury. Annual Meeting of the American Society of Transplantation, Chicago, IL, May 15-19, 1999.

63. Weber SA, Pham SM, Zeevi A, Rao AS, Boyle GJ, Bentlejewski C, McCurry K, Pigula F, Fung JJ,

Griffith BP. A clinical trial of intrythymic inoculation of donor bone marrow cells with concomitant pediatric heart transplantation: preliminary observations. Annual Meeting of the American Society of

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Transplantation, Chicago, IL, May 15-19, 1999. 64. Murdock A, Li S, Kurimot Y, Shears L, Demtirs A, Billiar TR, Kovesdi I, Lizonova A, Pham SM.

Attenuation of cardiac allograft vasculopathy by adenoviral gene transfer of inducible nitric oxide synthase. Annual Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 19-21, 1999.

65. Fukada J, Aitouche A, Zeevi A, Ruiz P, Kubota T, Kurimoto Y, Li S, Pham SM. A combination of

intrathymic and portal venous injection of donor bone marrow cells produces long-term survival of cardiac allografts in high responder rat strains. Annual Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 19-21, 1999.

66. Zeevi A, Banas R, Donnenberg AD, Donnenberg VS, Spichty K, Logar A, Morel P, Pham SM, Keenan

R, Iacono A, Dauber J, Griffith B, Starzl TE. Functional and phenotypical analysis of two distinct CMV-specific T helper memory cells. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

67. Gammie JS, Pham SM, Zeevi A, Duquesnoy RJ, Vega R, Hattler BG, Griffith BP, Keenan RJ. Effect of

HLA matching in lung transplantation. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

68. Li S, Yousem SA, Pham SM. Mixed bone marrow chimerism achieved by nonmyeloablative

conditioning induces donor-specific tolerance to rat lung allografts. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

69. Pham SM, Li S, Gammie JS, Linsley PS, Demetris AJ. Costimulatory blockage with CTLA4Ig

significantly reduces the doses of radiation required to achieve mixed bone marrow chimerism and donor-specific transplantation tolerance. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

70. Nastala CJ, Kormos RL, Winowich S, Pham SM, Hattler BG, Dyke CM, Griffith BP. Profile of blood

pump related infections in bridge to transplantation patients: A ten year experience. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

71. Tagusari O, Pham SM, Kawai A, Yamazaki K, Hattler BG, Murali S, Griffith BP, Kormos RL. Native

heart outcome after heterotopic heart transplantation: Insight into native heart complications on left ventricular assist device for chronic use. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

72. Iacono A, Dauber J, Keenan R, Smaldone G, Burckart G, Ohori P, McCurry K, Delgado E, Pham SM,

Rapp T, Grugrich W, Williams P, Nunley D, Vega R, Griffith B. Aerosolized cyclosporine given as prophylaxis for acute rejection after lung transplantation: Safety and peripheral lung deposition following early administration. International Conference of the American Thoracic Society, Chicago, IL, April 24-29, 1998.

73. Pham SM, Li S, Yousem SA. Induction of donor-specific tolerance to rat lung allografts using mixed

bone marrow chimerism. International Conference of the American Thoracic Society, Chicago, IL, April 24-29, 1998.

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74. Johnson B, Li S, Pham S, Pitt B. Efficiency of adenoviral gene transfer to rat lung allografts is increased by using a recirculated perfusion system. International Conference of the American Thoracic Society, Chicago, IL, April 24-29, 1998.

75. Webber SA, Bentlejewski CA, Park A, Boyle GJ, Miller SA, Law Y, Murali S, Pham SM, Zeevi A.

Propagation of activated lymphocytes from endomyocardial biopsy samples (EMB) of heart transplant recipients: Influence of addition of rlL4 to the culture environment. 18th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, Chicago, IL, April 15-18, 1998.

76. Mitruka SN, Pham SM, Pigula F, Kormos RL, Hattler BG, Shapiro R, Fung JJ, Griffith BP. Cardiac

surgery in solid-organ transplant recipients. 33rd Annual Meeting of the Society of Thoracic Surgeons, San Diego, CA, February 1-5, 1997.

77. Shears LL, Kawaharada N, Tzeng E, billiar Terri Rapp, RN, Lizonova A, Kovesdi I, Pham SM.

Inhibition of allograft arteriosclerosis using a nitric oxide gene transfer strategy. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

78. Pham SM, Kawaharada N, Shears L, Gammie JS, Li S, Ildstad ST. Mixed bone marrow chimerism

prevents allograft arteriopathy. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

79. Pham SM, Zeevi A, Rao A, Keenan RJ, Fontes P, Kormos RL, Hattler BG, Kawai A, Dyke C, Demetris

AJ, Yousem A, Fung JJ, Starzl TE, Griffith BP. Three year experience on combined donor bone marrow infusion and thoracic organ transplantation. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

80. Zeevi A, Pham SM, Pavlick M, Keenan R, Rao A, Fontes P, Dauber J, Iacono A, Yousem S, Fung J,

Starzl TE, Griffith B. Donor-specific bone marrow infusion in lung transplant recipients: The impact on immune modulation and delayed graft rejection. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

81. Zeevi A, Spichty K, Morel P, Waldman J, Dauber J, Iacono A, Keenan R, Pham SM, Duquesnoy R,

Griffith B. Two types of CMV-specific memory responses: Potential role of donor infected target cells in recruitment of activated T cells to the graft. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

82. Pham SM, Li S, Kawaharada N, Yousem SA, Griffith BP. Donor-specific tolerance for lung allografts

by thymic inoculation of donor bone marrow. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

83. Farhoud H, Taylor DO, Kfoury AG, Pigula F, Pham SM, Renlund DG. Cardiac transplantation in

survivors of lymphoma: A multicenter survey. 17th Annual Meeting & Scientific Sessions of The International Society for Heart and Lung Transplantation, London, England, April 2-5, 1997.

84. Mitruka SN, Zeevi A, Pham SM, Li S, Cai J, Burchard GJ, Yousem SA, Keenan RJ, Griffith BP. The

effect of aerosol cyclosporine on local and systemic cytokine and iNOS gene expression in experimental pulmonary transplantation. 16th Annual Meeting of the American Society of Transplant Physicians, Chicago, IL, May 10-14, 1997.

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85. Pham SM, Kawaharada N, Shears L, Gammie JS, Li S, Ildstad ST. Mixed bone marrow chimerism prevents allograft arteriopathy. 16th Annual Meeting of the American Society of Transplant Physicians, Chicago, IL, May 10-14, 1997.

86. Gammie JS, Neipp M, Li S, Pham SM, Chambers W, Ildstad ST. In vivo depletion of recipient natural-

killer cells yields reliable mixed allogeneic bone marrow chimerism at sublethal radiation doses and induces tolerance to donor-specific cardiac allografts in the rat. 23rd Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 14-16, 1997.

87. Rao AS, Fontes P, Shapiro R, Corry R, Dodson F, Jordan M, Pham SM, Zeevi A, Rastellini C, Aitouche

A, Gritsch HA, Keenan R, Abu-Elmagd K, Reyes J, Griffith B, Fung JJ, Starzl TE. Outcome analysis of a clinical trial involving adjuvant bone marrow infusion in clinical organ transplant recipients. 23rd Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 14-16, 1997.

88. Gammie JS, Li S, Ildstad ST, Pham SM. A tacrolimus-based nonlethal conditioning regimen produces

stable multilineage mixed bone marrow chimerism and donor-specific tolerance for cardiac allografts in the rat. 23rd Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 14-16, 1997.

89. Pham SM, Shears LL, Kawaharada N. Rapamycin permits inducible nitric oxide synthase expression

during chronic rejection. 23rd Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 14-16, 1997.

90. Nalesnik MA, Rao AS, Zeevi A, Pham SM, Aitouche A, Rogers J, Braun M, Ionellie J, Furukawa H,

Abu-Elmagd K, Reyes J, Fung JJ, Starzl TE. Autologous lymphokine activated killer (LAK) cell therapy for refractory lymphomas arising in organ transplant patients. 23rd Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 14-16, 1997.

91. Pham SM, Li S, Kawaharada N, Yousem SA, Griffith BP. Donor-specific tolerance for lung allografts

by thymic inoculation of donor bone marrow. (Poster) Fifth Basic Sciences Symposium of the Transplantation Society, Chautauqua, NY, September 6-11, 1997.

92. Shears LL, Kawaharada N, Tzeng E, Billiar TR, Pham SM. Endogenous inducible nitric oxide synthase

expression attenuates the development of allograft arteriosclerosis. 83rd Annual Clinical Congress of the American College of Surgeons, Chicago, IL, October, 1997.

93. Pham SM, Shears LL, Kawaharada N. Rapamycin prevents allograft arteriosclerosis by permitting the

endogenous expression of inducible nitric oxide synthase in the allograft. 83rd Annual Clinical Congress of the American College of Surgeons, Chicago, IL, October, 1997.

94. Pham SM, Gammie JS, Li S. Mixed bone marrow chimerism and donor-specific tolerance for cardiac

allografts can be achieved in rats with nonlethal conditioning. (Poster) American Heart Association 70th Scientific Sessions, Orlando, FL, November 9-12, 1997.

95. Kawaharada N, Li S, Komatsu K, Thai N, Colson YC, Gammie Josh Sonett, M.D., Yousem SA, Griffith

BP, Ildstad ST, Pham SM. Cytokine mRNA activity in rat lung allografts: Effects of bone marrow mixed chimerism and tacrolimus. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

96. Pham SM, Keenan RJ, Kawai A, Vega JD, Boyle GJ, Webber SA, Iaocono A, Nunley D, Dauber J,

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Kurland G, Nalesnik M, Williams P, Yousem SA, Griffith BP. Post-transplant lymphoproliferative disease after lung transplantation. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

97. Li S, Kawaharada N, Gammie JS, Colson YC, Yousem SA, Griffith BP, Ildstad ST, Pham SM. Mixed

bone marrow chimerism prevents obstructive airway disease (OAD) in a heterotopic tracheal transplant model in rats. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

98. Gammie JS, Kawai A, Pham SM, Keenan RJ, Colson YL, Weyant RJ, Griffith BP. Influence of panel-

reactive antibody on survival and rejection after lung transplantation. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

99. Tsamandas AC, Pham SM, Kormos RL, Griffith BP, Starzl TE, Fung JJ, Demetris AJ. Heart allograft

pathology under tacrolimus immunosuppression. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

100. Zeng Q, Pham SM, Todo S, Zang S, Tsamandas AC, Starzl TE. Maximal myocardial preservation with

increased hydrostatic pressure in coronary circulation. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

101. Kawai A, Kormos RL, Pham SM, Griffith BP. Impact of arrhythmias for patients on left ventricular

assist devices (LVAD). International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

102. Pham SM, Keenan RJ, Rao A, Fontes P, Zeevi A, Kormos RL, Kawai A, Hattler BG, Trucco M,

Yousem SA, Demetris AJ, Fung JJ, Starzl TE, Griffith BP. A trial of donor bone marrow infusion and thoracic organ transplantation. International Society for Heart and Lung Transplantation, New York, NY, March 15-18, 1996.

103. Zeevi A, Pavlick M, Banas R, Bentlejewski C, Spichty K, Rao AS, Fontes P, Demetris AJ, Shapiro R,

Jordan M, Dodson F, Pham SM, Keenan R, Griffith B, Corry R, Egidi F, Fung JJ, Starzl TE. Three years of follow-up bone marrow augmented organ transplant recipients: The impact on donor specific immune modulation. 15th Annual Meeting of the American Society of Transplant Physicians, Dallas, TX, May 26-30, 1996.

104. Nalesnik M, Pham SM, Rao A, Zeevi A, Elder E, Whiteside T, Rybka W, Keenan R, Griffith B, Rowe

D, Fung J, Starzl TE. Cellular therapy of post-transplant lymphoproliferative disorders (PTLD) arising in solid organ allograft recipients. 15th Annual Meeting of the American Society of Transplant Physicians, Dallas, TX, May 26-30, 1996.

105. Gammie JS, Pham SM, Colson YL, Chambers WH, Ildstad ST. An incompletely myeloablative

approach to mixed chimerism in the rat: Depletion of recipient natural killer cells significantly reduces the amount of radiation sufficient for donor engraftment. (Poster) 15th Annual Meeting of the American Society of Transplant Physicians, Dallas, TX, May 26-30, 1996.

106. Pham SM, Li S, Kawaharada N, Gammie JS, Colson YC, Yousem SA, Griffith BP, Ildstad ST. Mixed

bone marrow chimerism prevents obstructive airway disease (OAD) in rats. (Poster) 15th Annual Meeting of the American Society of Transplant Physicians, Dallas, TX, May 26-30, 1996.

107. Shears L, Pham SM, Tzeng E, Kawaharada N, Billiar TR. Cyclosporine inhibits inducible nitric oxide

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synthase expression in aortic allografts: An etiology for allograft vasculopathy. 82nd Annual Clinical Congress of the American College of Surgeons, San Francisco, CA, October, 1996.

108. Labadie RF, Severyn D, Pham SM, Watkins SC, Borovetz HS. Hemodynamic induction of the nitric

oxide pathway in human saphenous veins perfused ex vivo under arterial condition. 82nd Annual Clinical Congress of the American College of Surgeons, San Francisco, CA, October, 1996.

109. Kormos RL, Pham SM, Gaisor TA, Murali S, Kawai A, McNamara DM, Rosenblum WD, Hattler BG,

Griffith BP. Resolution of pulmonary hypertension in patients receiving a left ventricular assist device (LVAD). 69th Scientific Sessions of the American Heart Association, New Orleans, LA, October 1996.

110. Shears LL, Pham SM, Tzeng E, Kawaharada N, Billiar TR. Cyclosporine inhibits inducible nitric oxide

synthase expression in aortic allografts. 69th Scientific Sessions of the American Heart Association, New Orleans, LA, October 1996.

111. Pham SM, Keenan RJ, Rao AS, Fontes PA, Kormos RL, Abu-Elmagd K, Zeevi A, Hattler BG, Hardesty

RL, Demetris AJ, Trucco M, Rosner G, Fung JJ, Starzl TE, Griffith BP. Donor bone marrow on infusion augments chimerism in heart and lung transplant recipients. Society of Thoracic Surgeons 31st Annual Meeting, Palm Springs, CA, January 30, 1995 - February 1, 1995.

112. Murase N, Pham SM, Fung JJ, Starzl TE, Demetris AJ. Hematolymphoid microchimerism, quilty

lesions and chronic cardiac allograft rejection. The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

113. Pham SM, Kormos RL, Murali S, Kawai A, Hattler BG, Fung JJ, Demetris AJ, Starzl TE, Griffith BP.

Reversal of intractable rejection with FK506 in cardiac transplant recipients. The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

114. Pham SM, Tsamandas AC, Griffith BP, Kormos RL, Pappo O, Hattler BG, Murali S, Kawai A, Fung JJ,

Starzl TE, Demetris AJ. Comparison between FK506- and cyclosporine- based immunosuppression in clinical cardiac transplantation. The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

115. Zeevi, A, Pham SM, Keenan R, Griffith B, Rao A, Fontes P, Demetris A, Fung J, Shapiro R, Kormos R,

Hattler B, Hardesty R, Starzl TE. Sequential immune studies in bone marrow augmented solid organ transplants recipients: Heart and lung and other solid organ transplants. The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

116. Murali S, Kormos RL, Pham SM, Bhoopalam V, Griffith B. Gender differences in outcome after

cardiac transplantation. The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

117. Komatsu K, Youm W, Konishi H, Yousem SA, Murase N, Griffith BP, Pham SM. Survival of hamster-

to-rat lung xenografts is prolonged by FK506 and cyclophosphamide. (Poster). The Fifteenth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Francisco, CA, April 5-8, 1995.

118. Pham SM, Kormos RL, Hattler BG et al. A prospective trial of tacrolimus (FK506) in clinical heart

transplantation: Intermediate term results. The 75th Annual Meeting of the American Association for

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Thoracic Surgery, Boston, MA, April 23-26, 1995. 119. Kormos RL, Pham SM, Gasior TA, Murali S, Hattler BG, Griffith BP. Transplant candidate's clinical

status rather than right ventricular function defines need for univentricular vs. biventricular support. The 75th Annual Meeting of the American Association for Thoracic Surgery, Boston, MA, April 23-26, 1995.

120. Pham SM, Kawai A, Kormos RL, et al. Comparison between tacrolimus- and cyclosporine-based

immuno-suppression in clinical cardiac transplantation. 21st Annual Scientific Meeting of the American Society of Transplant Surgeons, Chicago, IL, May 17-19, 1995.

121. Pham SM, Kormos RL, Kawai A, Murali S, Hattler BG, Demetris AJ, Griffith BP. Tacrolimus (FK506)

in clinical cardiac transplantation: A five year experience. International Congress on New Immunosuppressive Drugs, Minneapolis, MN, August 27-30, 1995.

122. Pham SM, Kormos RL, Gonzalez I, Armitage JM, Hardesty RL, Griffith BP. Mortality of solid tumors

after heart transplantation: Lethality of Lung Cancer. (Poster) Society of Thoracic Surgeons Thirtieth Annual Meeting, New Orleans, LA. January 31 - February 2, 1994.

123. Hattler BG, Reeder GD, Sawzik PJ, Walters FR, Pham SM, Kormos RL, Keenan RJ, Griffith BP,

Armitage JM, Hardesty RL, Borovetz HS. Development of an intravenous membrane oxygenator (IMO): A new concept in mechanical support for the failing lung. The Fourteenth Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation, Venice, Italy, March 24-26, 1994.

124. Kormos RL, Glassman LR, Pham SM, Hattler BG, Griffith BP. Long-term outcome in a randomized

trial of rabbit antithymocyte globulin vs OKT3. The Fourteenth Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation, Venice, Italy, March 24-26, 1994.

125. Wook Y, Colson YL, Komatsu K, Ildstad ST, Yousem SA, Griffith BP, Pham SM. Mixed chimerism to

achieve donor-specific transplantation tolerance for lung allografts in rats. American College of Surgeon's 80th Annual Clinical Congress, Chicago, IL, October 9 - October 14, 1994.

126. Bando K, Dowling RD, Paradis IL, Stein KL, Keenan RJ, Magee MJ, Pham SM, Armitage JM, Shah A,

Hardesty RL, Bahnson HT, Griffith BP. "The impact of pulmonary hypertension on clinical outcome of single lung transplantation" (Poster) Twenty-ninth Annual Meeting of the Society of Thoracic Surgeons, San Antonio, TX, January 23-25, 1993.

127. Pham SM, Kormos RL, Armitage JM, Kawai A, Morita S, Stein K, Hattler BG, Hardesty RL, del Nido

P, Faber J, Griffith BP. "Long term outcome of human cardiac allografts preserved with University of Wisconsin solution". (Poster) Thirteenth Annual Meeting and Scientific Sessions, The International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

128. Pham SM, Kormos RL, Armitage JM, Zerbe TR, Hattler BG, Murali S, Hardesty RL, Griffith BP.

"Cardiac transplantation in patient with active myocarditis". (Poster) Thirteenth Annual Meeting and Scientific Sessions, The International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

129. Bando K, Paradis IL, Keenan RJ, Yousem SA, Komatsu K, Konishi H, Guilinger RA, Pham SM,

Armitage JM, Hardesty RL, Griffith BP. Comparison of outcome after single and bilateral lung transplantation for obstructive lung disease. Thirteenth Annual Meeting and Scientific Sessions,

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International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

130. Konishi H, Komatsu K, Bando K, Yoshida Y, Keenan RL, Stein KL, Paradis IL, Pham SM, Armitage JM, Hardesty RL, and Griffith BP. Bilateral lung transplantation for cystic fibrosis: University of Pittsburgh Experience. Thirteenth Annual Meeting and Scientific Sessions, International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

131. Kawai A, Morita S, Kormos RL, Mandarino WA, Gasior TA, Pham SM, Armitage JM, Hardesty RL,

Griffith BP. A clinical trial comparing University of Wisconsin solution and cold cardioplegia with load-independent mechanical parameters. Thirteenth Annual Meeting and Scientific Sessions, International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

132. Komatsu K, Pham SM, Konishi H, Bando K, Yousem S, Murase N, and Griffith BP. Lung xenograft

rejection in hamster-to-rat model. (Poster) American College of Chest Physicians, 59th Annual International Scientific Assembly, Orlando, FL, October 24-28, 1993.

133. Kormos RL, Armitage JM, Hattler BG, Hardesty RL, Pham SM, Murali S, Griffith BP. Differential

analysis of risk factors following heart transplantation: The utility of the hazard function. Thirteenth Annual Meeting and Scientific Sessions, International Society for Heart and Lung Transplantation, Boca Raton, FL, March 31 - April 3, 1993.

134. Durham SJ, Pham SM, Kormos RL, Armitage JM, Hardesty RL, Griffith BP. Vascular anastomotic

complications in heart and heart-lung transplantation. Fortieth Annual Meeting, American College of Angiology, Orlando, FL, October 3-8, 1993.

135. Pham SM, Armitage JM, Kormos RL, Hattler BG, Hardesty RL, and Griffith BP. Rescue therapy with

FK 506 in cardiac transplantation. American Heart Association's 66th Scientific Sessions, Atlanta, GA; Nov 8-11, 1993.

136. Pham SM, Yoshida Y, Aeba R, Hattler BG, Iwaki Y, Hardesty RL, Griffith BP. "Interleukin-6 is a

marker of preservation injury in lung transplant". (Poster) Twelfth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Diego, CA, April 2-4, 1992.

137. Rao P, Zeevi A, Synder J, Habrat T, Warty V, Dauber J, Paradis I, Duncan S, Pham SM, Griffith BP.

"Monitoring of acute pulmonary rejection and infection by bronchoalveolar lavage and plasma levels of hyaluronic acid in clinical lung transplantation". Twelfth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, San Diego, CA, April 2-4, 1992.

138. Pham SM, Morris E, Sawzik P, Klein M, del Nido PJ, Hattler BG. "The role of aspartate and glutamate

in myocardial metabolism during clinical cardiac surgery". Am College of Surgeons Clinical Congress, New Orleans, LA, October 1992.

139. Pham SM, Hattler BG. "Observations on intracardiac air bubbles during open heart surgery including

right to left shunting by way of the pulmonary capillary bed". Pittsburgh Cardiothoracic Surgery Society, Pittsburgh, PA, November 1990.

140. Pham, SM. "MCV-independent decreases in erythrocyte filterability in patients with severe peripheral

vascular disease". 7th International Congress of Biorheology, Nancy, France, June 1989.

141. Pham, SM. "Hemodynamic effects of balloon catheter control of hemorrhage in penetrating cardiac

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wounds". Society of University Surgeons, San Antonio, TX, February 1988.Pham, SM. "Compliance changes in bioresorbable vascular prostheses after implantation". Clinical Congress, American College of Surgeons, Chicago, IL, October 1988.

142. Pham, SM. "Effects of hemodynamics and de-endothelialization on intramural metabolism of low-

density lipoproteins in canine carotid artery". Clinical Congress, American College of Surgeons, San Francisco, CA, October 1987.

VI. TEACHING 27. Teaching Awards Received: N/A 28. Teaching Specialization:

Harvey Cardiology Lectures to Medical Students Teaching, residents, clinical fellows in the operating room, hospitals wards, and clinical conferences.

29. Thesis and Dissertation Advising/Post-doctoral student/fellow supervision: a) Member of Thesis committee for:

1. John Thompson, Candidate for Ph.D; Department of Molecular and Cellular Pharmacology (2004-Present)

2. Eric Weisman, Masters in Bioengineering; Department of Biomedical Engineering, (December 2005) 3. Agnieska Sroka, Masters in Bioengineering, (July 2005); Department of Biomedical Engineering b) Research Mentor for junior faculty.

Adel Aitouche, Ph.D., Research Assistant Professor of Surgery, University of Miami, (1999-2004) Fotios Andreopoulous, Ph.D., Research Assistant Professor of Biomedical Engineering and Surgery, University of Miami, (1999-present). Sen Li, M.D., Research Assistant Professor of Surgery, Univ. of Miami, (1999-present) Roberto Vazquez-Padron, Ph.D., Research Assistant Professor of Surgery, University of Miami, (2003-present).

c) Research Fellows In-Training:

Years in Lab Current/Subsequent Position 1. Yuntao Wei, MD 2005-present Post-doctoral Research Fellow Department of Surgery University of Miami, Miami, FL 2. Eddie Manning, MD 2006-present Post-doctoral Research Fellow Department of Surgery University of Miami, Miami, FL c) Research Fellows Trained:

Years in Lab Current/Subsequent Position 1. Kanshi Komatsu, MD, PhD 1992-1994 Assistant Professor

Dept. of Surgery Sapporo University, Hokaido, Japan

2. Wook Youm, MD, PhD 1993-1994 Clinical Associate Professor

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of Thoracic & Cardiovascular Surgery Seoul National University Seoul, Korea

3. James S. Gammie, MD 1995-1996 Assistant Professor Dept. of Surgery University of Massachusetts Worster, MA

4. Surindra Mitruka, MD 1996-1997 Cardiothoracic Surg. Fellow Dept. of Surgery Univ of California at San Diego, San Diego, CA

5. Kim Michele Bechard, MD 1996-1997 Resident, Pathology Bringham & Women's Hospital, Boston, MA

6. Nobuyoshi Kawaharada, MD, PhD 1994-1997 Assistant Professor Dept. of Surgery Sapporo Medical University, Sapporo, Hokkaido, Japan

7. Sen Li, MD 1994-1998 Research Assistant Professor Dept. of Surgery University of Miami, Miami, FL

8. Yu-qing Zhang, MD 1997-1998 Research Associate Dept. of Surgery University of Pittsburgh, Pittsburgh, PA

9. Yoshihiko Kurimoto, MD, PhD 1997-1999 Assistant Professor Department of Surgery Sapporo Medical University Sapporo, Hokkaido, Japan

10. Stefano Schena, MD 1998-2000 Resident Cardiothoracic Surgery

University of Bari Bari, Italy

11. Johji Fukada, MD 1997-2000 Assistant Professor Sapporo Medical University Sapporo, Hokkaido, Japan

12. Carlota Gay Rabenstein, MD 2000-2001 Rochester, Minnesota 13. Mohan Thanikachalam, MD 1999-2002 Assistant Professor

Department of Surgery Christian Medical College, Velore, India

14. Marian Calfa, MD 1999-2002 Resident Department of Surgery University of Miami, Miami, FL

15. Louis Louis, MD 2000-2002 Cardiothoracic Surg Resident Department of Surgery Ohio State Univ Columbus,OH 16. Roberto Vasquez-Padron, PhD 2000-2003 Assistant Professor Department of Surgery Univ. of Miami, Miami, FL 17. David Lasko, MD 2001-2003 Resident Department of Surgery

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Univ. of Miami, Miami, FL 18. Alric Simmonds, MD 2001-2003 Resident Department of Surgery Howard University Medical

Center, Washington, DC 19. Ahmed El-Haddad, MD 2002-2003 Resident Jackson Memorial Hospital Univ. of Miami, Miami, FL 20. Ivo Pestana, MD 2002 – 2004 Surgical Resident Department of Surgery Univ. of Miami, Miami, FL 21. Arie Farji-Cisneros, MD 2004-2005 Surgical Resident Caritas St. Elizabeth Med Center Boston, MA 22. Carlos Liotta, MD 2002–2006 Family Practice Resident Saint Elizabeth Hospital Chicago, IL d) College students Mentored: 1. Michael Riflin (Premed student from UCLA); July-August 2006 2. Alex Vosky (Premed student from Duke University): June-July 2006 3. Palmer Rosemont (Pre med student from MIT) July-August 2006

VII. SERVICE 30. University Committee and Administrative Responsibilities:

Director, Heart/Lung Transplant and Artificial Heart Services, of University of Miami/Jackson Memorial Hospital A founding member of Vascular Biology Institute, University of Miami (an institute dedicated to basic and translational researches in vascular diseases)

31. Community Activities:

Advisory Board Member, Transplant Foundation Inc., Miami, Florida Community Board Member, American Heart Association, Miami-Dade Division, Miami, Florida

32. Others: o Member of Grant Review Committee of The Thoracic Surgery Research and Education

Foundation (a national organization) o Chair of Scientific Session: Immunobiology in Lung Transplantation, 25th Anniversary Meeting

and Scientific Sessions, International Society of Heart and Lung Transplant, April 7, 2005, Philadelphia, PA

o External assessor for academic promotions and/or tenure:

I have assisted the following academic Institutions in the assessment of faculty for promotion and/or tenure: University of California, San Francisco, The University of Maryland, The University of Pittsburgh, The University of Miami, Cornell University, New York University, The University of Louisville (Kentucky), The University of California, San Diego., University of Florida (Gainesville, Florida)

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Clinical Research Current IRB Approved Studies:

1. A prospective study using humanized monoclonal antibody against CD52 (Campath-1H) and tacrolimus in heart transplant recipients.

a. Role: PI. 2. Myocardial bridging and cardiomyopathies (PI = M. Morales, MD)

a. Role Co-Investigator 3. Adult cardiac transplant research database (CTRD): an ongoing study of adult heart transplant

and the major clinical events after transplantation a. Role: PI

4. The Debakey VAD child for humanitarian use in pediatrics a. Role; PI

5. Clinical investigation of the Debakey VAD with a comparison to a performance goal to establish safety and effectiveness of the device as a left ventricular support in patients awaiting cardiac transplantation.

a. Role: PI 6. ECG Gated Cardiac MDCT for Preoperative and Postoperative Assessment of Orthotopic Heart

Transplant Patients: Retrospective Analysis. (PI= Ghersin, E) a. Role; Co-Investigator

7. Interangency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Database a. Role: PI