Heart Failure and Cardiomyopathies A846 JACC April 1, 2014 Volume 63, Issue 12 SEX DIFFERENCES IN HEART FAILURE HOSPITALIZATIONS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY Poster Contributions Hall C Saturday, March 29, 2014, 3:45 p.m.-4:30 p.m. Session Title: Heart Failure and Cardiomyopathies: Diagnostic, Prognostic and Therapeutic Strategies in Cardiomyopathies Abstract Category: 12. Heart Failure and Cardiomyopathies: Clinical Presentation Number: 1147-200 Authors: Oludamilola Oluleye, Sue Duval, Renuka Jain, Lillehei Heart Institute, Minneapolis, MN, USA, University of Minnesota Medical School, Minneapolis, MN, USA Background: The incidence of heart failure in hypertrophic cardiomyopathy (HCM) is reported to be low (2-5%). Little is known about demographic characteristics and outcomes of heart failure in HCM patients, but women with HCM have been reported to have worse outcomes. Methods: We compiled all hospitalizations in the Nationwide Inpatient Sample (NIS) in years 2003-2010 with HCM as a diagnosis. We examined demographics, clinical characteristics, and hospitalization outcomes amongst those with acute hospitalization for heart failure (CHF). Results: Amongst 31236 admissions, heart failure was the primary diagnosis in 34.8% in patients with HCM. In-hospital mortality improved from 7% in 2003 to 4.9% in 2010. Overall, women constituted 71.4 % (7,766) of all cases. Compared to men, women were more likely to be hypertensive (58.9% vs. 54.9%, p=<0.0001) and older (74.2 vs. 63.7 years, p=<0.0001). Women were less likely to have atrial ﬁbrillation (41.4% vs. 48.3%, p=<0.0001), coronary artery disease (36.7% vs. 38.9%, p=0.03), diabetes (21.2% vs. 23.9%, p=0.002) and chronic kidney disease (11.2% vs.16.4%, p=<0.0001). Women with CHF had increased in-hospital mortality (5.9%, n=461) than men with CHF (4.8%, n=151) p=0.03. However, after adjustment for co morbidities (age, race, hypertension, atrial ﬁbrillation, coronary artery disease, diabetes mellitus, chronic kidney disease), women with HCM and CHF did not have increased mortality (OR: 1.07; 0.86-1.35). Conclusion:CHF accounts for a third of all hospitalizations in patients with HCM. Though women constitute nearly three-quarters of these admissions, they do not have an increased risk of mortality when adjusted for age and other comorbidities.

SEX DIFFERENCES IN HEART FAILURE HOSPITALIZATIONS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

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Page 1: SEX DIFFERENCES IN HEART FAILURE HOSPITALIZATIONS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

Heart Failure and Cardiomyopathies

A846JACC April 1, 2014

Volume 63, Issue 12

Sex differenceS in heart failure hoSpitalizationS in patientS with hypertrophic cardioMyopathy

Poster ContributionsHall CSaturday, March 29, 2014, 3:45 p.m.-4:30 p.m.

Session Title: Heart Failure and Cardiomyopathies: Diagnostic, Prognostic and Therapeutic Strategies in CardiomyopathiesAbstract Category: 12. Heart Failure and Cardiomyopathies: ClinicalPresentation Number: 1147-200

Authors: Oludamilola Oluleye, Sue Duval, Renuka Jain, Lillehei Heart Institute, Minneapolis, MN, USA, University of Minnesota Medical School, Minneapolis, MN, USA

background: The incidence of heart failure in hypertrophic cardiomyopathy (HCM) is reported to be low (2-5%). Little is known about demographic characteristics and outcomes of heart failure in HCM patients, but women with HCM have been reported to have worse outcomes.

Methods: We compiled all hospitalizations in the Nationwide Inpatient Sample (NIS) in years 2003-2010 with HCM as a diagnosis. We examined demographics, clinical characteristics, and hospitalization outcomes amongst those with acute hospitalization for heart failure (CHF).

results: Amongst 31236 admissions, heart failure was the primary diagnosis in 34.8% in patients with HCM. In-hospital mortality improved from 7% in 2003 to 4.9% in 2010. Overall, women constituted 71.4 % (7,766) of all cases. Compared to men, women were more likely to be hypertensive (58.9% vs. 54.9%, p=<0.0001) and older (74.2 vs. 63.7 years, p=<0.0001). Women were less likely to have atrial fibrillation (41.4% vs. 48.3%, p=<0.0001), coronary artery disease (36.7% vs. 38.9%, p=0.03), diabetes (21.2% vs. 23.9%, p=0.002) and chronic kidney disease (11.2% vs.16.4%, p=<0.0001). Women with CHF had increased in-hospital mortality (5.9%, n=461) than men with CHF (4.8%, n=151) p=0.03. However, after adjustment for co morbidities (age, race, hypertension, atrial fibrillation, coronary artery disease, diabetes mellitus, chronic kidney disease), women with HCM and CHF did not have increased mortality (OR: 1.07; 0.86-1.35).

conclusion:CHF accounts for a third of all hospitalizations in patients with HCM. Though women constitute nearly three-quarters of these admissions, they do not have an increased risk of mortality when adjusted for age and other comorbidities.