Setting Specific Proposed Levels for bioactive compounds: … · Dietary Allowances Dietary Reference Intake RDA DRIs PI, >36 ... Components of the Dietary Reference Intakes. Component

Setting

Specific Proposed Levels

for bioactive compounds

Recent experiences in China

Prof Yang Yuexin

China CDC

Chinese Nutrition society

yxyangcnsocorg

Key information

bull Developing SPL for phytochemicals

bull Defining the process of SPL

bull Key elements amp results

bull Limitations amp Challenges

History of RDA in China

as the Minimum Nutrient

Requirement for Chinese

people including 6 nutrients

protein carbohydrate and

vitamins

1938 1955 1976 1988 2000 2013

First MNR

RDA

DRIs

6 8 20 3215

the Recommended

Dietary Allowances Dietary Reference Intake

RDA

DRIs PI

gt36

bull Goals of the DRI Expert Committee

1) Revised and Setting Recommended Intake Values ndash RNI

and AI

-Both RNI and AI are intended to be used as goals in

planning nutritious diets

2) Facilitating Nutrition Research and Policy ndash EAR

-EAR values for the scientific basis upon which the RNI

values are set

3) Establishing Safety Guidelines ndash UL

-Identify potentially hazardous levels of nutrient intake

-Indispensable to consumers who take supplements or

consume foods or beverages to which vitamins or

minerals have been added

4)

4) Preventing Chronic Diseases

The DRI committee takes into account chronic disease

prevention wherever appropriate

-PI ( preventing intake -NCD)

the committee set lifelong intake goals for Na K VitC

at levels believed in the later years

-- Acceptable macronutrient Distribution Ranges (AMDR)

AMDR for FAT CHO and Protein

- Specific Proposed Level( SPL) a diet that provides

adequate Non - Nutrients Substance while reducing the

risk of chronic diseases

The DRI committee has made separate

recommendations for specific sets of people (specific

age ranges)

Expert Review Panels 87 experts in 7 groups

bull E CHO Fat and fat acids DHA EPA n-3

bull ProteinMacronutrient

bull Vit A Vit E

bull Vit D Vit K

fat-soluble vitamins 4

bull VitB1 B2 B6 B12 Folic acid

bull Vit C NiacinCholine Biotin Pantothenic acid

water -soluble vitamins 10

bull Zinc Iron I se cobalt

bull Cu Mn Mo Cr FTrace Elements 10

bull Ca P Mg K Na

bull chlorideMacro-elements 6

bull Water Fiber

bull 18 Phytochemicals Non-nutrient 21

Introduction Definition methods formula application

DRI component Description

Estimated Average

Requirement (EAR)

Reflects the estimated median requirement and is

particularly appropriate for applications related to

planning and assessing intakes for groups of

people

Recommended Nutrient

Intake (RNI)

Derived from the EAR and intended to cover the

requirements for 97ndash98 percent of the population

Adequate Intake (AI) Used when an EARRNI cannot be developed

average intake level based on observed or

experimental intakes

Tolerable Upper Intake

Level (UL)

Tolerable Upper Intake Level (UL) Highest

average intake that is likely to pose no risk

Estimated Energy

Requirement (EER)

Average dietary energy intake predicted to maintain

energy balance in a healthy adult of defined age

gender weight height and level of physical activity

that is consistent with good health

Components of the Dietary Reference Intakes

Component Description

Acceptable Macronutrient

Distribution Range (AMDR)

An intake range for an energy source

associated with reduced risk of chronic

disease

Fat fat acid CHO Ca

Proposed intake (PI) Dietary Goal for Preventing

Non-communicable Chronic Disease

Na K

Specific proposed level (SPL)

---non nutrients components

(phytochemicals)

Dietary level for Preventing Specific chronic

Disease

SPL predicted to maintain health in a healthy

adult

New Concepts Developed

Tolerable Upper Intake Level

(UL)



most from NOAEL or LOAEL or ADI

What is SPLs

SPLs Specific Proposed

Level (abbreviations SPLs)

bull SPL and UL are a

comprehensive set of

phytochemical

values for healthy

populations that can

be used for a guide

for the diet

Principles The

SPLs reflect the

current state of

scientific knowledge

with respect to non-

nutrient guide and

are published as a

series of reports by

the CNS

WHY Setting SPL and UL for Non ndashnutrients components

Foods consist of thousands of different chemicals

- each has the potential of being beneficial neutral or

harmful to the body

-some may be beneficial in some ways and harmful in other

-some chemical may exert different effects on different

people or when taken at differing doses or at different

life stages

When considering concentrated supplements of

phytochemicals

-Be aware that any normally beneficial substance even

water can be toxic when taken in too high a dose

-Though most naturally occurring substances are safe for

most healthy people when consumed in foods

--adequate and safe dosages been established by

research evidence

Why use novel concept SPL

Difference with nutrient and non nutrient

bull Definition Essential nutrient for body with the lack

of symptoms And non-nutrient are not maybe just

lifespan essential

bull Substantial scientific database

science required for DRI value

digestion absorption metabolism interactionhellip

bull Established process

EAR -----X---- RNI or RDA

Intake ----X---- AI lack FC database

Age group ---X limitation for infants children

woman

DRIs working Structure

DRIs

2013

ScientificAdvisory

Committee

DRI Scientific Board Committee

The Secretary

GroupExpert Review

ampworking

Panels

from literature

Non-nutrient substances

bull Non-nutrient bioactive substances

非营养素生物活性物质

bull bioactive substances 生物活性物质

bull Dietary ingredient 膳食成分

bull Photochemical 植物化合物

bull Botanical 植物药 deriving from plants

bull Botanical ingredient 植物有效成分

bull Extract 提取物

Screening conditions for Non-nutrients components

bull Research data accumulated the abundant firsthand

materials

bull in natural foodstuffs

bull The use of large amounts of food industry

bull Others

After setting the definition for non-nutrients

components and SPL

non-nutrients substances list

水 water

膳食纤维Dietary fiber

低聚果糖 FOS

花色甙anthhoyanin

白藜芦醇 Resveratrol

儿茶酚（儿茶素Catechol

榭皮素（角黄素）Quercetin

姜黄素 Curcumin

绿原酸 Chlorogenic acid

叶黄素Lutin

Zeaxanthin

番茄红素 Lycopene

原花青素 Proanthocyanidins

大豆异黄酮 Isoflavones

植物固醇 Phytosterol

异硫氰酸盐 Isothiocyanates

大蒜素 Allicin Gallic

氨基葡萄糖 Glucosamine

r ndash氨基丁酸 GABA

a-硫辛酸 alpha-Lipoic Acid (LA)

L-肉碱 L-carnitine

Types of study used as a basis for Specific Proposed Level

Hierarchy of evidence

Meta-analyses

(Cochrane Collaboration)

(Health Assessment)

(Cohort studies)

(RCT）

Scientific data

Approach of Expert Review Panels

The expert panels are responsible for

1 reviewing the scientific literature concerning specific food

component under study for each life-stage especially adult

2 considering the roles of nutrients in decreasing the risk of chronic

diseases and health conditions

3 evaluating possible criteria or indicators of adequacy and providing

a rationale for the choice of each criterion

4 estimating the average requirement(s) for each nutrient reviewed

for each life-stage

5 interpreting the current data on nutrient intakes of population

groups

6 reviewing the food resource for each nutrient or component

bull NOEL(no observed effect level)

bull LOEL(lowest observed effect level)

bull OSL(the observed safe level)

bull HOI(the highest observed intake)

UL approaches

How to document an effect

物质作用的不同阶段

毒性

治疗

稳态

营养

临界

Phytochimecals Specific Proposed Level

SPL obtained by observation or experiment

non-nutrient dietary ingredients that have

beneficial effect in the prevention of chronic

diseases for healthy adults

Based Substantial Evidence and detary Intakes (if )

Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data

summary on Curcumin RCT -meta analysis

Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8

7d T1 姜黄素500mgdT2姜黄素1gd

C 维生素E200IUd

血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr

Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20

2 m T 姜黄素500mgd

C 0mgd

与对照组相比血清TGF-βdarrIL-8darr

尿蛋白排出darr

Usharani P

2008

印度糖尿病病人

T 36

C 36


C 0mgd

与对照组相比血清IL-6TNF-a等

炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90

2m T 姜黄素45mg-6gd

C 阿托伐他汀维生素E或安慰剂

血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义

Hanai H

2006

日本静止期肠炎病人

T 45

C 44

6m T 姜黄素2gd

C 0mgd

肠炎活动指数内镜检查指数改善

Example

carotenoids and reduce risk of breast cancer

Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)

End point relative risk(RR95CI)

Larsson

2010

Sweden

prospective

Postmenopau

sal women1008 94 ge3160 vs lt1422 活检确诊

095

(078-116)

Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093

(080-107)

Cho2003 美国前瞻性绝经前妇女 714 80 5939 vs 1006 临床确诊096

(075-122)

Terry2002 加拿大前瞻性绝经前妇女1452病例

5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-

Ross2002美国前瞻性

绝经前和

绝经后妇女711 20 ge1782 vs lt576 临床确诊

12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)

表3 叶黄素与乳腺癌发生风险研究

retrospective or prospective cohort

Evidences evaluation

Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L

白藜芦醇生物学功能证据等级

Resveratrol SPL not specific recommended

bull Examples Not approved due to lack of substantiation

UL recommended for adults (draft )

Group ANot necessary

Group BUL 值的建议

Group C 5资料限制Information

insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd

Proanthocyanin 800mg

phytosterol l 24g-39g

Fruit -oligosaccharide 15d

Soy lsoflavone 80mg

L- carnitine 2000mgd

Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid

Specific Proposed Level ( SPL) for adults only draft

Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin

A model to understand for DRIs

PI --Preventing Lifestyle-related

Diseases SPL for phytochemicals

PI

Scientific significance

1)First time to evaluate data of phytochemicals

2)Further understanding of the absorptiond metabolism

function

3)Establish the procedure method puts forward the

guiding value first suggested a new concepts

Temporary Guidence Levels

Social amp practical significance

1)To avoid overeating

2)To prevent lifestyle-related diseases

3)To increase the natural life-span of healthy humans

Evidence based PL

The importance of SPLs and UL of Phytochemicals

Limitations and Challenges

1 Limited human data regarding Phyto-chmicals in global

2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip

such as Soy lsoflavone

3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups

4 Limited data on food composition database

food composition are not sufficiently available for assessment of some phyto-nutrients intake

For lifespan

to quantify a healthy diet should be not only including

essential nutrients but also others

Acknowledgements

ProfChenyx prof Zhaify profYangxg

SPL expert penal 16 experts

Scientific Committee 15 experts

All experts in working panel 80 more

2010mdash2013

bull Thanks for your attention

Primary Uses of DRIs

The four primary uses of the DRIs are

bull To assess the intakes of individuals

bull To assess the intakes of population groups

bull To plan diets for individuals

bull To plan diets for groups

Some of the dietary planning activities that are most

relevant to DRI use include dietary guidance institutional

food planning military food and nutrition planning

planning for food-assistance programs food labeling

food fortification developing new or modified food

products and food-safety assurance

SPLs put on evaluating scientific evidence for the role

played by hellip that could contribute to the prevention of the

major diet-related chronic diseases

Oo perspective has been accounted for in setting the

recommendation

The primary uses of the SPLs and UL are

bull In the prevention of major diet-related chronic diseases


bull For food-safety assurance during new or functional food

product development

Primary Uses of SPL and UL

Purpose

bull To maintain and promote health

bull To prevent lifestyle-related diseases and

illnesses due to insufficient and excessive

consumption of energy and nutrients

Target population Healthy individuals and groupsIncl those who have some mild ailments but do not

need dietary restrictions or prescribed diets

eg hypertension hyperlipidemia

DRIs

amp SPL

Key information

bull Developing SPL for phytochemicals

bull Defining the process of SPL

bull Key elements amp results

bull Limitations amp Challenges






vitamins

1938 1955 1976 1988 2000 2013

First MNR

RDA

DRIs

6 8 20 3215

the Recommended


RDA

DRIs PI

gt36



and AI





values are set






4)














age ranges)




bull Vit A Vit E

bull Vit D Vit K







bull Ca P Mg K Na


bull Water Fiber




Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL






vitamins

1938 1955 1976 1988 2000 2013

First MNR

RDA

DRIs

6 8 20 3215

the Recommended


RDA

DRIs PI

gt36



and AI





values are set






4)














age ranges)




bull Vit A Vit E

bull Vit D Vit K







bull Ca P Mg K Na


bull Water Fiber




Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL



and AI





values are set






4)














age ranges)




bull Vit A Vit E

bull Vit D Vit K







bull Ca P Mg K Na


bull Water Fiber




Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL














age ranges)




bull Vit A Vit E

bull Vit D Vit K







bull Ca P Mg K Na


bull Water Fiber




Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL




bull Vit A Vit E

bull Vit D Vit K







bull Ca P Mg K Na


bull Water Fiber




Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Estimated Average

Requirement (EAR)




people


Intake (RNI)







Level (UL)



Estimated Energy

Requirement (EER)











disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL






disease

Fat fat acid CHO Ca



Na K



(phytochemicals)


Disease


adult



(UL)




What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL

What is SPLs





phytochemical

values for healthy


be used for a guide

for the diet

Principles The

SPLs reflect the

current state of



nutrient guide and

are published as a


the CNS




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL




harmful to the body




life stages


phytochemicals






research evidence





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL





lifespan essential








woman


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


DRIs

2013

ScientificAdvisory

Committee


The Secretary

GroupExpert Review

ampworking

Panels

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL

from literature












materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL



materials



bull Others


components and SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


水 water


低聚果糖 FOS





姜黄素 Curcumin


叶黄素Lutin

Zeaxanthin













Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL



Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL










for each life-stage


groups






UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL





UL approaches



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL



毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


毒性

治疗

稳态

营养

临界







Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Meta-analyses


(Health Assessment)

(Cohort studies)

(RCT）

Scientific data


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Author and

yearCountr

y Subjects N (TC)

durati

on

Dose amp

methods

Biomarker

Results

Pungcharoenkul K

2009

泰国 healthy

adults

24

T1 8

T28

C 8


C 维生素E200IUd


Khajehdehi P

2011伊朗

糖尿病病人

T 20

C 20


C 0mgd


尿蛋白排出darr

Usharani P

2008


T 36

C 36


C 0mgd


炎症因子darr

Sahebkar A

2013

Meta分析

不同人群 T 133

C 90




Hanai H

2006


T 45

C 44

6m T 姜黄素2gd

C 0mgd


Example


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Author Long term

study Subjects

N duratio

n (y)

uplower intake

(microgd)


Larsson

2010

Sweden

prospective

Postmenopau


095

(078-116)


(080-107)


(075-122)


5239对照95 6838 vs1219 临床确诊

117

(090-153)

Horn-


绝经前和


12

（090-160）

Zhang

1999美国前瞻性

绝经前和

绝经后妇女2697 140

绝经前8796

vs1376绝经后

8796vs 1376

临床确诊

079

(063-099)

095

(082-110)




Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Cardiovascular

protective

effects

Anti-

inflammatory

activity

Anti -

Cancer

diabetes

Evidence

grading

M L L L








insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL





insufficient

Water

Catchiness

r-GABA

Anthocyanin

Lutein 60 mgd

Lycopene 50mgd

curcumin 180 mgd

Resveratrol 25gd




Soy lsoflavone 80mg


Allicin

Glucosamine

DF

Isothiocyanates

Quercetin

Lipoic acid

Chlorogenic acid


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


Group A

AI

Group B

SPL

Group C

Information

insufficient

Water 15-17L

Fiber 25-30 g

Soy lsoflavone

Lutein

Lycopene

phytosterol

Glucosamine

Anthocyanin

Proanthocyanin

50mg

6 mg

18 mgd

08gd 13gd()

1gd 15g

50mgd

200mgd

L-carnitine

Resveratrol

R -GABA

curcumin

Allicin

Chlorogenic acid

LA

Catechins

Iso thiocyanates

FOS

Quercetin




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL




PI




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL




function








Evidence based PL









For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL








For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL

For lifespan



Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL

Acknowledgements





2010mdash2013


















recommendation





product development


Purpose








DRIs

amp SPL


















recommendation





product development


Purpose








DRIs

amp SPL

















recommendation





product development


Purpose








DRIs

amp SPL





recommendation





product development


Purpose








DRIs

amp SPL

Purpose








DRIs

amp SPL

Documents

Setting Specific Proposed Levels for bioactive compounds: … · Dietary Allowances Dietary Reference Intake RDA DRIs PI, >36 ... Components of the Dietary Reference Intakes. Component