Copyright © 2011 Neural Essence, LLC. All Rights

Sensory Overload & Your Brain: Understanding & Overcoming Autism

By Dr. Joel Pardee

Updated 12/16/2011

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual outcomes will vary.

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I. What is Sensory Overload? Overcoming an Overwhelming Environment II. Understanding Sensory Overload “Disco Fever,” Relating to the Autistic Experience III. How the Brain Controls Sensory Overload The Physiology of Sensory Overload—How the Brain Controls Fearful Emotions IV. Defeating Sensory Overload How Calming Neurotransmitters in the Brain Balance Emotions V. What is Natural Metabolic Enhancement Therapy Balancing Metabolism to Achieve a Better Quality of Life VI. Summary VII. What’s in N-MET? Is it safe? N-MET Ingredients and Supplement Facts VIII. On the Inventor: Who is Joel Pardee? IX. A Note From Joel

Table of Contents

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I. What is Sensory Overload? Overcoming an Overwhelming Environment

In her pioneering work identifying the root cause of autism, Dr. Temple Grandin determined that

autism ultimately stems from Unchecked Sensory Overload. She discovered that the autism she her-

self experienced, and that is characteristic of the general autistic population, is due to a mental condi-

tion that generates an overpowering fear of the environment.

Autism sufferers have a chronic fear of their surroundings from which they cannot es-

cape. Their endless attempts to isolate themselves by retreating into familiar surroundings, repetitive

behaviors, avoidance of eye contact, and angry panic attacks induced by noise, crowds, light shows,

etc. all result from an uncontrollable fright of their surroundings.

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II. Understanding Sensory Overload “Disco Fever,” Relating to the Autistic Experience

To understand sensory overload let's revisit for a moment our younger days when we enjoyed the

club scene. Remember the thrill of entering a dance club and being immersed in sensations. Pulsat-

ing music heavy on a pounding beat, swirling lights reflected off a mirrored ball, crowding shoulder to

shoulder sweating with sheer delight and animal togetherness, losing touch with the "real world" and

swimming in a sensory world of pure emotion. It's time to grab a drink and swing. Wonderful!—for a

t ime. But we cannot take th is great sensat ion for too long.

After an hour or two of sensory overload, we have to get out. The pounding beat starts to irritate

and I'm getting dizzy from the flashing strobes. Time to take a break, get out for some cool air and

quiet. And herein lies the rub. An autistic child wakes up in that disco every morning and

can't get out. Sensory overload is on them at all times. All their behaviors are attempts to escape

a w o r l d g o n e m a d w i t h s o u n d a n d f u r y .

We are all too familiar with the behaviors: panic attacks, explosive anger, repetitive movements,

mild seizures, sleep abnormalities, gastrointestinal irregularities, silence, repeated words, and physical/

social isolation. All are attempts to make sense of a chaotic world and gain self-control. Autistics

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III. How the Brain Controls Sensory Overload The Physiology of Sensory Overload—How the Brain Controls Fearful Emotions

In our brain fearful emotions are controlled by a tiny organ called the amygdala. It is often re-

ferred to as the Anger Management Center.

Here, sensory inputs such a sights, sounds and touch are analyzed for their "danger quotient" and

appropr iate responses are mounted to escape any perceived danger.

Unless the reasoning part of the brain instructs the amygdala that the sensation is not dangerous,

t h e a m y g d a l a a u t o m a t i c a l l y t r i g g e r s a " f i g h t o r f l i g h t " r e s p o n s e .

We have all experienced the effects of being startled and scared. It's an adrenalin rush. In an in-

stant we are on high alert. We panic and are overpowered with an intense urge to fight or run. At

that instant we perceive danger, we are thrust into a state of Acute Sensory Overload.

Fig. 1. Location of the Amygdala in the Brain. The tiny amygdala is located on top of the spinal cord. Nerve signals from the eyes, ears and skin are trans-mitted to the amygdala where they are analyzed for potential danger.

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The image below shows how the amygdale is activated by fear and environmental inputs. This activa-

tion manifests itself in people with autism as overpowering fear and uncontrolled emotions.

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III. How the Brain Controls Sensory Overload...continued The Physiology of Sensory Overload—How the Brain Controls Fearful Emotions

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Then the "reasoning" part of the brain sends a signal to the amygdala to shut down. The shut down signals are two inhibitory neurotransmitters called Serotonin and L-Glycine. If we have sufficient quantities of Serotonin and L-Glycine available in our brain, the shut down is rapid and complete. If we do not have enough, the shut down is slow and partial. In this case, the continual sensations we receive from the outside world are never completely inhibited, and we are left in a perpetual state of low level "fight or flight". It is not as intense as a full-blown panic attack, but it is constantly there. In this case we remain in a perpetual state of anxiety. We are experiencing Chronic Sensory Overload. Persons with low lev-els of Brain Serotonin and L-Glycine are constantly fighting to get back to normal. That is the case with those with autism, chronic anxiety, extreme nervousness and uncontrollable anger.

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When we see a smile, the amydala is quiet. When we see a frown, it is activated. The level of activity is de-termined by the intensity of the threat. In the example shown here, smile = low activity (yellow line), frown = higher activity (blue line), fright = highest activity of the amygdala (red line). When the perceived danger passes, we slowly get

back into control as normal reason prevails over emotion.

This happens when the brain has analyzed the situation

and has determined that all is OK.

III. How the Brain Controls Sensory Overload...continued The Physiology of Sensory Overload—How the Brain Controls Fearful Emotions

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IV. Defeating Sensory Overload How Calming Neurotransmitters in the Brain Balance Emotions

There are two ways to combat Chronic Sensory Overload.

1.) Remove or lower the sensations causing overload (isolation)

2.) Elevate levels of Brain Serotonin and Brain L-Glycine

The first is accomplished by putting ourselves into a calm, peaceful environment. Lower the

lights, turn down the sound, be by yourself, and slow down. It's what we all do when we want to relax or

think or sleep. In fact, it is also precisely the classic behavior pattern recognized in autistics. They

withdraw into their own private space, away from the bustle, noise and bright lights of our frenetic mod-

ern world. In a very real sense, they are self medicating, attempting to achieve a semblance of nor-

malcy by isolation.

The second way to remove sensory overload is to elevate levels of Serotonin and L-Glycine in the brain. This is precisely how N-MET works.

However, this is not easy to accomplish, since Serotonin (also known as 5-HT) when taken as a

dietary supplement cannot get into the brain due to the blood brain barrier.

As for L-Glycine, the brain uses about 10 times more Glycine than can be taken in by eating pro-

tein or taking dietary supplements containing Glycine.

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Serotonin and L-Glycine must be made on site in the brain. Consequently, it is absolutely necessary to provide the brain with natural starting materials (precursors) that can be converted into Serotonin and L-Glycine in the brain itself.

Directly ingesting common Serotonin (5-HT) supplements will not elevate serotonin levels in the brain. The same is true for Glycine.

N-MET gives the brain exactly what it needs to produce Serotonin and L-Glycine on site,

giving the amygdala (Anger Management Center) the neurotransmitters it needs to regulate

fearful emotions.

Other conditions resulting from Chronic Sensory Overload, such as depression, hyperactivity and low energy, are also effectively treated by the components supplied in N-MET.

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KEY CONCEPT:

IV. Defeating Sensory Overload…continued How Calming Neurotransmitters in the Brain Balance Emotions

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V. What is Natural Metabolic Enhancement Therapy? Balancing Metabolic to Achieve a Better Quality of Life

Metabolic Enhancement Therapy identifies and targets metabolic pathways involved in chronic dis-eases or disorders. The identified pathways are then treated by giving natural dietary supplements that enhance

production of the metabolite made by the affected pathway; thereby balancing metabolism.

N-MET is a formulation that works with the nervous system to reduce a number of detrimental behav-iors often associated with autism, ADD, ADHD and chronic anxiety syndromes. Those who suffer from these dis-

orders are typically over stimulated by the sights, sounds and contacts in their environment. The result is a loss of mental focus and emotional control.

N-MET works by enhancing the synthesis of inhibitory neurotransmitters that normally regulate emo-tion, excitability, fear, anger and anxiety. The dietary supplements provided by N-MET stimulate metabolic path-

ways that produce these inhibitory neurotransmitters. As a result, nervous impulses are modulated and regulated,

allowing users to more fully control their emotions and relieve stress.

Furthermore, N-MET contains natural metabolites that build and sustain the optimum energy levels re-

quired for peak mental focus and productivity. The combined effects of mental calm and sustained energy promote

a positive and confident mood.

This novel N-MET formula (Patent Pending) has never before been made available to the public, and is not

presumed to cure disease. It is offered as an effective dietary supplement that helps release individuals from emo-

tional overload and mental confusion. Because excessive emotional stress can be experienced by anyone, N-MET

can help rebalance the emotional state of anyone experiencing chronic anxiety, anger, nervous stress and persis-

tent fatigue.

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• Sensory Overload is the root cause of many Autistic behaviors

• Autistic behavior is caused by an unrelenting fear of the environment

• Fearful emotions are controlled by the amygdala

• When the amygdala is activated it causes fearful, anxious and stressful emotions

• The two neurotransmitters responsible for controlling the amygdala are Serotonin and L-Glycine

• Low quantities of Serotonin and L-Glycine result in insufficient shutdown of the amygdala, causing Chronic Sensory Overload

• Serotonin CANNOT enter the brain due to the blood brain barrier

• Sufficient amounts of Glycine CANNOT be obtained from diet or supplements to serve brain function

• BOTH SEROTONIN AND L-GLYCINE MUST BE MADE ON-SITE IN THE BRAIN

• N-MET’s patent pending, proprietary formula is the only available supplement that provides the brain with the natural starting materials necessary to produce the required calming neurotransmitters

• N-MET’s formula contains all the necessary ingredients to provide relief from sensory overload, calm, focus, and energy

VI. Summary

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VII. What’s in N-MET? Is it safe? N-MET Ingredients and Supplement Facts

N-MET is composed of natural metabolites regularly used by the body and brain. It is hypoallergenic.

N-MET works with gluten free diets.

N-MET DOES NOT CONTAIN: Gluten, casein, milk, yeast, sucrose, soy, gelatin, herbal extracts, artifi-cial preservatives, flavorings, colorings, sugars, or sweeteners. There are no known adverse side ef-fects.

All of the ingredients work in harmony to produce the desired effect by providing the brain with the starting materials it needs to produce calming neurotransmitters on site. Please see the supplement facts below. Please see our website for recommended doses. Always strive to achieve the minimum effective dose.

Supplement Facts Serving Size 3 tsp (15mL)

Please see dosing guidelines

A Proprietary Liquid Blend

Trimethylglycine 500 mg *

L-Glycine 500 mg *

L-Serine 500 mg *

L-Glutamine 500 mg *

L-Tryptophan 500 mg *

Acetyl-L-Carnitine 12 mg *

Vitamin B6 (as pyridoxine hydro- 9.37 mg 721%

Folate (as folinic acid from calcium 300 mcg 75%

Vitamin B12 (as cyanocobalamin) 15 mcg 625%

Biotin 55.5 mcg 222%

Thiamin (as thiamin hydrochloride) 9.37 mg 781%

* Daily value not established.

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Joel D. Pardee is the Founder and Chief Executive Officer of Neural Essence, LLC.

To help his autistic son, he invented Metabolic Enhancement Therapy and developed the N-MET

formula together with Dr. Alexander Birk.

Until 2009 Dr. Pardee was on the Cell & Developmental Biology faculty at Weill Cornell Medical

College of Cornell University, where he served as a research professor, medical school lecturer, Associ-

ate Dean of the Weill Cornell Graduate School of Medical Sciences (1997-2007) and Associate Dean of

Research (2007-2009).

Dr. Pardee has taken a leadership role in medical education both as a lecturer and director of

graduate school and medical school courses. He is the recipient of several Excellence in Teaching

Awards by the medical student body.

His medical science researches in the fields of cell motility and cancer cell metastasis have pro-

duced a number of original research papers and patents, most recently for Metabolic Enhancement

Therapy. He is currently Editor in Chief of the Cell Biology of Medicine lecture series published by Mor-

gan and Claypool.

VIII. On the Inventor: Who is Joel Pardee?

Joel & Son Danny

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Learning and Understanding are the first steps to Overcoming Autism.

And if you’ve made the decision to read this report you’ve done just that.

But with all the promises out there from companies that claim to offer relief for Autistics you’re smart for being skeptical. After all you’re here to help your child, yourself, or a loved one.

All of us have been skeptical. We’re all frightened for the future of our children or loved ones because in this amazing technological world there is no cure for us.

So what do we do? Do we give up?

No. We cannot. These are our children.

So we try everything.

And there’s no way to know if something is going to work for you until you try it.

I know the real risk of trying new products focused on Autism: that it won’t work, it’s just another failure, your hope is crushed like mine was so many times before.

But we all know the alternative is to do nothing.

Even if you’re trying other therapies right now, as I did with my child for 15 years, please take me up on my offer and try N-MET. I believe you will experience the same results I and hundreds of others have.

If I’m wrong, and you see no positive results from N-MET, so what?

Send me an email and I will refund your money, no questions asked. That will be the end of it. You have nothing to lose.

If you have any questions at all please feel free to email me directly at this email address: DrJoel@N-MET.com, or visit the Contact Us page at www.N-MET.com. All emails are forwarded directly to me and Dr. Birk.

IX. A Note From Joel

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