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OS18
Y. Qiu1, R. Abila1, H.H.Win2
1. OIE SRR-SEA
2. Myanmar LBVD
SEACFMD Vaccination Campaign in Central Myanmar
OS18
Central Myanmar- the significant role in regional FMD control
Cattle density map, FAO
Major movement pathways of large ruminants
Myanmar
Thailand
Laos
Cambodia
Vietnam
China
OS18
Central Myanmar- the significant role in regional FMD control
• FMD outbreak hotspots (dark orange)(2011-2014: O/SEA/Myanmar-98)
• Significant socio-economic burden - USD 5-20 per drought cattle- USD 81 per infected cow
• PCP progression requirement
OS18
FMD Vaccination Project
February and March 2015:
• 18 townships in Central Myanmar
• 1127 villages vaccinated
• Benefiting >54,000 owners
• >210,000 large ruminants vaccinated 2x
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FMD Vaccination Project
Parallel FMD education campaign:
• FMD recognition and reporting
• Biosecurity
• Outbreak responses
• Cleaning and disinfection
• Benefits of vaccination
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Post-Vaccination Monitoring
0
100
200
300
400
0 30 60 90 120 150 180 210 Days
1st 2nd Vacc
LP E
LISA
Ab
tit
er (
GEM
)
NSP negative throughout the study period Tested against a Thai reference strain O189/87
– antigenically equivalent to O/3039 Protective threshold not defined
N=53
N=50
N=37
Vaccine: O1/Manisa + O/3039>6PD50
Moderate antibody level at 5 months after the boost vaccination
OS18
Village with type O FMD Village with type A FMDVillage with untyped FMD
Post-Vaccination Monitoring
O/Ind2001
O/Mya-98A/SEA-97
• FMD was reported in 226 villages in 2015
• 75% outbreaks occurred during Aug-Oct (after flooding)
• Outbreaks in close proximity to major rivers/roads
• (re)emergence of new strains (A/SEA-97, O/Ind2001)
0
20
40
60
80
Jan
Fe
b
Ma
r
Ap
r
Ma
y
Jun
Jul
Aug
Se
p
Oct
No
v
De
c
No. o
f o
utb
reaks
RoadRiverBoundary
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14 out of 226 outbreaks occurred in vaccinated villages (n=1127):
• waned immunity (>5 months after the last vaccination)
• serotype A virus
• antigenically variant viruses
• vaccination coverage
• vaccination failure
Post-Vaccination MonitoringVaccinated villageVillage with type O FMD Village with type A FMDVillage with untyped FMD
The majority of vaccinated villages were clinically protected against FMD
OS18
Expanded Vaccination Campaign
• Additional 5 rounds of vaccinations implemented since 2016
• Expanded to another 6 townships
• Updated vaccine composition:+ A/Malaysia/97 and A22/Iraq in 2016 + Asia 1/Shamir in 2017/18
• Vaccination coverage
• Public awareness campaign
• Animal identification and tracing
• VAHW capacity building
• Biosecurity
• Outbreak response
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Trade opportunities stimulate FMD Control
220,000
365,000
74,000
• >1 million large ruminants from SEA enter China annually
• Significant costs associated with unofficial movements (500 USD/head in Myanmar)
• 3 pilot trade zones to be established between China-Myanmar/Laos borders
• Vaccinate-to-move: reduce risks along movement pathways
• Challenges:- steady supply of high-quality vaccines- increase buy-in from farmers & traders- infrastructure- monitoring
Proposed trade zones and estimated annual trade volumes
OS18
Acknowledgement
Co-workers: Donors:
• Myanmar LBVD
• Corissa Miller
• Phillipe Widders
• Karan Kukreja
• Scott Zaari
• Ian Dacre
• Polly Smith
• Bolortuya Purevsuren
OS18
Thank you for your
attention12, rue de Prony, 75017 Paris, France