Screening for Hematologic Disorders

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  • 8/17/2019 Screening for Hematologic Disorders

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    Phospholipids 80%SaturatedPhosphatidylcholine 60%UnsaturatedPhosphatidylcholine 25%Phosphatidylglycerol andPhosphatidylinositol 15%

    Protein 12%

    Neutral Lipids 8%

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    PREVENTION

    !

    TREATMENT

    Prophylactic

    PreVentilation

    PostVentilation

    EarlyRescue Late

    Rescue

    ) ( 44 5 62 ( 5 1 % " 45 7 % " 44 583 %

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    No clinically significant difference in outcome

    between immediate administration of prophylacticsurfactant and administration at 10 min after birthafter a brief period of stabilization

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    Early surfactant with brief ventilation Vsselective surfactant and MV for pretermwith or at risk for RDS

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    - 10C2-8 C2-8 CStorage

    3/ 5 ml1.5 ml4 / 8 mlVial size

    Bovine liquidPorcine lungBovine lungSource

    Slowly warm toroom temp

    Wait for 30min

    Warm atroom temp

    for 10minOr in hand

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    334Max. doses

    5 cc/kg2.5 cc/kg4 cc/kgInitial doseYesYesYesTreatment

    NoNoYesProphylaxis

    NeosurfCurosurfSurvanta

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    1990 2006

    Exosurf Survanta Infasurf Curosurf1991 1998 1999

    Surfaxin

    Animal derived proteincontaining surfactants

    In two trials of protein containing synthetic surfactants

    compared to animal derived surfactant extract,no statistically different clinical differencesin death and chronic lung disease were noted.

    Cochrane Database Syst Rev. 2008

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    Thermoregulation Infection

    Nutrition

    R D S

    Hostresponse

    Ventilation

    Supportivecare

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    U i i b bbl i i

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    Using microbubble test in gastric

    aspirates for surfactant ( < 31 w) 5 " - -- ( A >"" ' '!( * F ; G 5 A >"" # (

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