5-8.2.2014Dan E i lat Hotel

SCIENTIF IC PROGRAM

ANNUAL MEETING OF ISRAELI ASSOCIATION OF GASTROENTEROLOGY AND LIVER DISEASE

From Functional to Cutting Edge TechnologyPost Graduate Course: 2014Course Directors: Nadir Arber, Zamir Halpern

SESSION 1 | 14:00-16:00 | Functional GI Disorders. Chairs: Ran Dikman, Yishai Ron

14:00-14:20 IBS – Making the diagnosis Prof. Brennan M. R. Spiegel, M.D, MSHS, David Geffen School of

Medicine, UCLA, USA14:20-14:40 Pathophysiology of IBS – Central and Peripheral Mechanisms Prof. Douglas Drossman, M.D, University of North Carolina School

of Medicine, USA14:40-15:00 Functional abdominal pain syndrome Prof. Ami Sperber, M.D, MSPH, Faculty of Health Sciences, Ben-

Gurion University of the Negev, Beer Sheba15:00-15:20 Treating IBS – Doctor – Patient Relationship Prof. Douglas Drossman, M.D, University of North Carolina School

of Medicine, USA15:20-15:40 Treating IBS – What works? Prof. Brennan M. R. Spiegel, M.D, MSHS, David Geffen School of

Medicine, UCLA, USA 15:40-16:00 Panel discussion

16:00-16:30 Coffee break and Visit the Medical Exhibition

WEDNESDAY | 5.2.2014

WEDNESDAY | 5.2.2014

SESSION 2 | 16:30-18:30 | New challenges in Endoscopy Chairs: Ori Segol, Ian Garlenk

16:30-16:50 Endoscopic management of acute upper GI bleeding Ian Granlek, MD, Chair, Division of Ambulatory Services, Institute of Gastroenterology, Rambam Medical Center,

Technion, Haifa16:50-17:10 Esophageal stenting (malignant and benign diseases) Peter Siersema, MD, PhD, Department of Gastroenterology and

Hepatology, University Medical Center Utrecht, Netherland17:10-17:30 Capsule endoscopy Rami Eliakim, Head Department of Gastroenterology, Sheba

Medical Center, Ramat Gan, Tel-Aviv, University17:30-17:50 Therapeutic EUS – where? When? What Yael Kopelman, MD, Department of Gastroenterology, Hilel Yaffe

Medical Center17:50-18:10 Stenting elsewhere in the GI tract Iyad Khamaysi, MD, Department of Hepatology and

Gastroenterology, Rambam Medical Center, Technion, Haifa18:10-18:30 Biliary cannulation - Tips and tricks Dr. Erwin Santo, Director of Invasive Endoscopy Department

of the Institute of Gastroenterology and Liver Diseases, Tel Aviv Souraski Medical Center, Tel Aviv

18:30-18:50 The large colonic polyp Ori Segol, Chief of Gastroenterology Unit, Carmel Medical

Center, Haifa18:50-19:10 Enhanced Vision and Better detection Zamir Halpern, Head of Digestive Disease Center, Tel Aviv

Sourasky Medical Center, Tel Aviv 19:10-19:30 Panel Discussion

SESSION 3 | 08:30-10:30 | Motility GI Disorders Chairs: Ram Dikman, Ami Sperber

08:30-08:50 Pathophysiology of GERD Prof. Ronnie Fass, MD, Chairman of the Division of

Gastroenterology and Hepatology and Director of the Esophageal and Swallowing Center, Metro Health Medical Center, Cleveland Ohio.

08:50-09:10 Functional dyspepsia Prof. Nick Talley, Dean (Health) University of Newcastle Callaghan,

NSW, Australia09:10-09:30 The Refractory GERD patient Prof. Ronnie Fass, MD, Chairman of the Division of

Gastroenterology and Hepatology and Director of the Esophageal and Swallowing Center, Metro Health Medical Center, Cleveland

09:30-09:50 Gastroparesis Prof. Nick Talley, Dean (Health) University of Newcastle Callaghan,

NSW, Australia09:50-10:10 Understanding pain in the gut Dr. Marc Beer Gabel, MD, Department of Gastroenterology,

Sheba Medical Center, Tel Hashomer Ramat Gan10:10-10:30 Panel Discussion

10:30-11:00 Coffee Break and Visit the Medical Exhibition

THURSDAY | 6.2.2014

THURSDAY | 6.2.2014

SESSION 4 | 14:00-16:00 | GI Oncology Chairs: Betsy Half, Revital Kariv, Zohar Levi

11:00-11:30 Beyond Lynch syndrome: Current and novel genetics syndromes. Elizabeth E. Half, M.D, Head GI Malignancy Unit, Gastroenterology

Department, Rambam Health Care Campus, Haifa,11:30-11:50 Universal screening for Lynch syndrome. How do we do it?. Zohar Levy, M.D, The Gastroenterology Department, Rabin

Medical Center Petah Tikva11:50-12:00 Methylation, analysis in CRC. Irit Solar. PhD, Department of Pathology, Tel-Aviv Medical Center,

Tel-Aviv. University12:00-12:20 Chemoprevention for GI Neoplasia - Where are we in 2014? Nadir Arber, M.D MSc, MHA, Integrated Cancer Prevention

Center and Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv

12:20-12:40 Advanced Oncogenetic Testing Guy Rosner, M.D, Department of Gastroenterology, Tel Aviv

Medical Center, Tel Aviv, Affiliated to Sackler School of Medicine, Tel-Aviv University

12:40-13:00 Panel Discussion13:00-13:30 The future of GI fellowship - To be announced

13:30-15:30 Lunch Break

IGA - Annual meeting Eilat 2014, Personal Gastroenterology

SESSION 1 | 15:30-16:35 | ABSTRACTSChairmen: Haim Shirin, Ori Segol

15:30-15:35 Opening Remarks Zamir Halpern15:35-15:45 The clinical and immunological significance of low level of

infliximab in the absence of anti-infliximab antibodies in patients with IBD

Ungar, B.(1), Anafy, A.(1), Yavzori, M.(1), Picard, O.(1), Fudim, E.(1), Kopylov, U.(1), Ron,Y.(2), Yanai, H.(2), Dotan, I.(2), Chowers,Y.(3), Eliakim, R.(1), Ben-Horin, S.(1)

(1) Department of Gastroenterology, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel-Aviv University (2) IBD Center, Department of Gastroenterology, Tel-Aviv Sourasky Medical Center & Sackler School of Medicine, Tel-Aviv University (3) Rambam Health Care Campus & Bruce Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel

15:45-15:55 The use of the pediatric ulcerative colitis activity index (PUCAI) in adults with acute severe ulcerative colitis (ASC)

Koslowsky,B.(1), Travis, S., Livovsky, D.(1), Adar, T.(1), Gupta, A., Turner, D.(2)

(1)Department of Gastroenterology, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel-Aviv University (2)Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, The Hebrew University of Jerusalem; Israel

15:55-16:05 Tricyclic antidepressants (TCA) for the treatment of tenesmus secondary to rectal prolapse

Livovsky, D., Adar, T., Lysy, J. The Digestive Diseases Institute, Shaare Zedek Medical Center,

Affiliated with the Hebrew University School of Medicine Jerusalem

THURSDAY | 6.2.2014

16:05-16:15 Inhibition of eotaxin-1 (CCL-11) ameliorates DSS-induced colitis – A novel potential therapeutic approach for inflammatory bowel disease

Adar, T., Shteingart, S., Livovsky, D., Bar-Gill Shitrit, A., Mahamid, M., Koslowsky, B., Melamud, B., Goldin, E. Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem, Israel

16:15-16:25 Radiofrequency Ablation Treatment of Radiation Proctitis: Results from an European Collaborative Study

Wengrower, D.(1), Dray, X.(2), Carlino,A.(3), Gonzalez,P.(4), Battaglia,G.(5), Adar, T.,(1), Pérez-Roldán,F.(4), Camus,M.(2), Marteau,P.(2), Repici, A.(6)

(1) Digestive Diseases Institute, Shaare Zedek Medical Center and Hebrew University Medical School, Jerusalem, Israel,

(2)Gastroenterology, Paris 7 University & APHP Lariboisière Hospital, Paris, France, (3) Gastroenterology, Istituto Clinico Humanitas, Milano, Italy, (4) Digestive Unit, Hospital General Mancha Centro, Alcazar de San Juan, Spain, (5) Endoscopy Unit, Istituto Oncologico Veneto I.R.C.C.S., Padova, (6) Digestive Diseases Institute, Istituto Clinico Humanitas, Milano, Italy

16:25-16:35 The Yield of Endoscopic Investigation for unexplained weight loss Abu Freha, N.(1), Fich, A.(1), Avrahm, S.,(1), Gohar, N.(2), Etzion, O.(1) (1) Institute of Gastroenterology and Hepatology, Soroka University

Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel. (2) Soroka Clinical Research Center (SCRC), Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba

THURSDAY | 6.2.2014

SESSION 2 | 16:35-16:55 | The Future of Endoscopy Prof. Peter Siersema, MD, PhD, Department of Gastroenterology

and Hepatology, University Medical Center Utrecht, Netherland. Guest Speaker

16:55-17:25 Coffee Break and Visit the Medical Exhibition

SESSION 3 | 17:25-19:10 | Personal MedicineChairmen: Zamir Halpern, Yaron Niv

17:25-17:30 Introduction to Personal Medicine Prof. Zamir Halpren17:30-18:10 Personal Cancer Introduction: Kariv Revital, Half Elizabeth17:30-17:40 Novel gene chip technologies for personalized colorectal cancer

medicine diagnostic and treatment Prof. Bercovich Dani, PhD, Head of MSc program in

Biotechnology, Human Molecular Genetics & Pharmacogenetics, Tel Hai College, Scientific Director, GGA - Galil Genetic Analysis

17:40-17:50 From Single Genes to Exome Sequencing in Pronto Diagnostics’ Clinical Laboratory

Dr. Shomrat Ruth, PhD, Director of Diagnostic Laboratory Pronto Diagnostics Ltd. 17:50-18:00 Oncotest Prof. Friedman Eitan, M.D, Geneticist and Director of the

Oncogenetics Sheba Nedical Center, Tel Hashomer18:00-18:10 Debate Summary - Karive Revital M.D, Elizabeth Half M.D18:10-18:30 Towards personalized genomics: Rewriting the genome to

understand its function Prof. Eran Segal PhD., Department of Computer Science and

Applied Mathematics, The Weizmann Institute, Rehovot

THURSDAY | 6.2.2014

18:30-18:50 Personal Medicine in IBD Dr. Dan Turner, M.D, Pediatric Gastroenterology Unit, Shaare

Zedek, Medical Center The Hebrew University of Jerusalem, Jerusalem

18:50-19:10 Personal Medicine in Liver Disease Prof. Yaron Ilan, M.D, Department of Internal Medicine Hadassah Medical School, Jerusalem

SESSION 4 | 19:10-20:00 | Who needs Rome IV?Chairmen: Ami Sperber

19:10-19:25 PRO Prof. Douglas Drossman, M.D, University of North Carolina School

of Medicine, USA19:25-19:40 CON Prof. Nick Talley, Dean (Health) University of Newcastle

Callaghan, NSW, Australia19:40-20:00 Debate

THURSDAY | 6.2.2014

SESSION 5 | 08:30-09:50 | ABSTRACTSChairmen: Ian Gralnek & Iris Dotan

08:30-08:40 Duodenal Adenoma Surveillance for Familial Adenomatous Polyposis (FAP) Patients Utilizing Endoscopy and Endoscopic Ultrasound: Results of Ten Years of Follow-up

Gluck, N., Strul, H., Rozner, G., Leshno, M., Santo, E. Department of Gastroenterology, Tel-Aviv Sourasky Medical

Center Tel-Aviv University08:40-08:50 Characrerization of Risk Factors for Colonoscopy Complications

in a Referral Medical Center Santo, E., Meilik, A., Ackerman, H., Melhem, A., Halpern, Z.,

Bruck, R. Institute of Gastroenterology and Liver Diseases, Tel Aviv Sourasky

Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

08:50-09:00 A Novel Balloon Colonoscopy for Increased Polyp Detection Rate- Results of a Randomized Tandem Study

Halpern, Z.(1), Shpak, B.(2), Gralnek,I.(3), Rochberger, S.(2), Moshkowitz,M.(2), Melhem,A. (1), Grinshpon,R.(1), Pfefer,J.(1), Santo,E.(1)

(1)Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, (2) Department og Gastroeterology, Laniado Medical Center, Nethanya, (3) Institiue of Gasdtronetrology RAMBAM healthcare Campus

09:00-09:10 The importance of local eotaxin-1 - Eosinophil axis in inflammatory bowel disease, Results of a prospective observational study

Adar, T.(1), Shteingart, S.(1), Ben-Yaacov, A.(1), BG Shitrit, A.(1), Shmorak, S.(1), Vernea, F.(1), Goldin, E.(1)

(1)The Digestive Diseases Institute, Shaare Zedek Medical Center, Affiliated with the Hebrew University School of Medicine Jerusalem

FRIDAY | 7.2.2014

09:10-09:20 Metabolic Features are Associated with Colonic Polyps and their Neoplastic Potential

Fliss Isakov, N.(1), Zelber-Sagi, S.(1,2), Halpern, Z.(1), Webb, M.(1), Gluzman, I.(1), Kariv, R.(1)

(1)Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Tel Aviv, (2) University of Haifa, School of Public Health, Faculty of Social Welfare and Health Sciences, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv,

09:20-09:30 Deep Enteroscopy with a Conventional Colonoscope: Multicenter Study Using the NaviAid™ AB Device

Santo, E., Halpern, Z . Dept. of Gastroenterology, Tel Aviv Medical Center, Tel Aviv, Israel, Affiliated to Sackler School of Medicine, Tel-Aviv University

09:30-09:40 To PEG or not to PEG this is the question. Mizrahi,M., Khoury,T., Abu Rmaileh,A., Kopelman,Y., Gastroenterology and liver disease Institute, Department

of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

09:40-09:50 MUTYH mutations and variants in Jews of North-African origin with or without minimal colorectal adenomatous polyposis

Rosner, G., (1), Bercovich, D. (1), Etzion,Y., Pel,S.(1), Samuel,Z.(1), Strul, H. (1), Santo, E.(1), Halpern, Z.(1), Kariv, R.(1)

(1)Dept. of Gastroenterology, Tel Aviv Medical Center, Tel Aviv, Israel, Human Molecular Genetics and Pharmacogenetics, Migal - Galilee Bio-Technology Center, Kiryat-Shmona, 11016 and Tel-Hai Academic College, Israel, Affiliated to Sackler School of Medicine, Tel-Aviv University

FRIDAY | 7.2.2014

SESSION 6 | 09:50-11:00 | The usage of computers in modern medicineChairmen: Ian Grelnik and Alex Fisch

09:50-10:20 The Health Technology Revolution: Get Up to Speed, or Get Passed By

Prof. Brennan Spiegel, MD, MSHS, David Geffen School of Medicine, UCLA, USA - Guest Speaker

Innovative Technology in Israel - The start up nation10:20-10:30 Medication Mangement - Gets personal Omri Shor Founder & CEO Medisafe10:30-10:40 Treato- Medivizor- DARIO Oren Fuerst10:40-10:50 Discussion

10:50-11:20 Coffee Break and Visit the Medical Exhibition

SESSION 7 | 11:20-11:50 | Non Pharmacological Therapy of GERD 2014 Prof. Ronnie Fass, MD, Chairman of the Division of

Gastroenterology and Hepatology and Director of the Esophageal and Swallowing Center, Metro Health Medical Center, Cleveland

SESSION 8 | 11:50-13:30 | SHORT COMMUNICATIONSChairperson: Ran Oren, Nadir Arber

11:50-11:53 The association between inflammatory bowel disease (IBD) and parity

Bar-Gil Shitrit, A.(1), Shaubi, M.(2), Adar, T.(1), Koslowsky, B.(1), Goldin, E.(1), Grisaru- Granovsky, S.(2) (1)Digestive Diseases Institute, Shaare Zedek Medical Center

affiliated with the Hebrew University Medical School, Jerusalem, Israel. (2)Department of Obstetrics and gynecology, Shaare zedek Medical center, Jerusalem, Israel

FRIDAY | 7.2.2014

11:53-11:56 Post-Endoscopic Retrograde Cholangiopancreatography Bacteremia among Out-Patients in comparison with In-hospital patient population

Mlynarsky, L., Melhem,A., Santo, E. The institute of Gastroenterology and Liver diseases, Tel-Aviv

Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University

11:56-11:59 Colorectal Cancer among the Bedouin Population in Southern Israel

Abu Freha, N.(1), Fich, A.(1), Barnes K., I.(2), Barris, H.(2), Starker,E.(2), Halpern, M.(2), Niv, Y.(2) Levi, Z(2)

(1)Institute of Gastroenterology and Hepatology, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel. (2)The Gastroenterology Department, Rabin Medical Center, Petah Tikva

11:59-12:02 Inflammatory bowel diseases characteristics among Israeli Arabs Mahamid, M.(1,2), Bar-Gil Shitrit, A.(1), Koslowsky,B.(1), Ghantous,R.(2),

Abu-Khalil, S.(2), Safadi, R.(2,3)

(1)Department of Gastroenterology, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel Aviv University

(2) Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem Israel, (3) Hadassa Ein Karem Medical Center, Jerusalem Israel

12:02-12:05 Using the Aldrete Scoring System to Assess Post Sedation Recovery Time after Endoscopic Procedures - A Tertiary Referral Center Experience

Horev, N.(1), Kayless, H.(2), Niv, Y.(1), Dickman, R.(1)

(1)Division of Gastroenterology, (2)Internal Medicine C, Rabin Medical Center, Beilinson Hospital, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

12:05-12:08 Clostridium difficile infection rate of inflammatory bowel disease patients in a tertiary center in Israel

Maharshak, N., Ofer, A., Davidov, O., Dotan, I. IBD Center, Department of Gastroenterology and Liver Diseases,

FRIDAY | 7.2.2014

Tel Aviv Medical Center, affiliated to the Sackler School of Medicnie, Tel Aviv University, Tel Aviv, Israel

SESSION 9 | 12:10-13:30 | SHORT COMMUNICATIONSChairperson: Alexandra Lavie, Elizabeth Half

12:10-12:20 The correlation between Streptococcus bovis positivity in colonic content and advanced colonic lesion

Paritsky, M.(1), Peretz, A.(2)

(1)Gastroenterologic Unit, (2)Clinical Microbiology Laboratory Baruch Padeh Medical Center, Poria12:20-12:30 The severity of symptoms related to irritable bowel syndrome is a

risk factor for the misclassification of significant organic disease Carter, D.(1, 2), Bardan, E.(2), Derazne, E.(1), Tzur, D.(1), Novis,B.(2), Levy, G.(1), Beer-Gabel, M.(2)

(1) Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel. (2) Israel Defense Force, Medical Corps. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

12:30-12:40 Thrombosis in Inflammatory Bowel Disease Patients is driven by Inflammation Rather than by Thrombophilia

Yanai, H.(1), Waizbard, A.(1), Kopilov, U.(2), Ben-Horin, S.(2), Lubetsky, A.(3), Dotan, I.(1)

(1)IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, (2)Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, (3)Institute of Thrombosis, Hemostasis and the Israel National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv

12:40-12:50 Oral Antibiotic Cocktail (MADoV) for Treatment of Refractory Severe Colitis

Turner, D.(1), Levine, A.(2), Kolho, KL.(3), Shaoul, R.(4), Lev Zion, R.(1),

FR IDAY | 7.2.2014

Rachman, Y.(1), Ledder, O.(1) (1)Pediatric Gastroenterology Unit, Shaare Zedek Medical Center,

The Hebrew University of Jerusalem; Israel; (2) Wolfson Medical Center, Holon, Israek; (3)Pediatric Gastroenterology, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland; (4) Pediatric Gastroenterology Unit, Rambam Medical Center, Haifa, Israel

12:50-13:00 Predictors of formation of antibodies to infliximab (ATI) and secondary loss of response in IBD patients treated with infliximab

Ungar, B.(1,3), Kopylov, U.(1,3), Yavzori, M.(1,3), Fudim, E.(1,3), Picard, O.(1,3), Lahat, A.(1,3), Avidan, B(1,3), Lang, A.(1,3), Weiss, B.(2,3),

Chowers, Y.(4), Eliakim, R.(3), Ben-Horin, S.(1,3)

(1)Department of Gastroenterology, Sheba Medical Center Tel Hashomer, (2)Edmond & Lily Safra Children’s Hospital, Tel-Hashomer, (3)Sackler School of Medicine, Tel-Aviv University

(4) Rambam Health Care Campus & Bruce Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel

13:00-13:10 Increased Levels of Serum Alanine Impair NK Function and Predict Severity of Liver Fibrosis in NAFLD patients

Amer, J.(1), Bsaso, H.(1), Mahamid, M.(2,3), Abu-Tair, L.(1), Doron, S.(1), Ghantous, R.(2), Safadi, R.(1,2)

(1)Liver Unit, Institute of Gastroenterology and Liver Diseases. Hadassah-Hebrew University Hospital, Jerusalem,

(2) The Liver Unit, Holy Family Hospital, Nazareth, (3)Digestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem.

13:10-13:20 Discriminating Between Irritable Bowel Syndrome and Inflammatory Bowel Diseases by Exhaled Breath Analysis

Karban,A.(1), Nakhleh, M.(2)*, Rainis, T.(3), Kaufman, E.(1), Jeries, R.(2) Ivgi, H.(2), Díaz-Rodríguez, P.(4), Cancilla, JC.(4), Torrecilla, JS.(4),

Haick, H.(2)

*Shared first authorship (1) Internal Medicine C and Gastroenterology Depratments,

Rambam Medical Center, Haifa, Israel (2) Department of Chemical Engineering and Russell Berrie

Nanotechnology Institute, Technion, Technion - Israel Institute of Technology, (3) Department of Gastroenterology, Bnai Zion Hospital, Haifa, Israel, (4) Department of Chemical Engineering, Complutense University of Madrid, 28040 Madrid, Spain.

13:20-13:30 Hearing loss in patients with inflammatory bowel disease (IBD) Wengrower,D.(1), Shaul, C.(2), Peleg, U.(2), Cohen, L.(1), Gross,M.(3),

Koslowsky, B.(1)

(1) Department of gastroenterology, Shaare-Zedek Medical Center, Jerusalem

(2) Department of Otolaryngology Head and Neck Surgery, Shaare Zedek Medical Center, Jerusalem

(3) Department of Otolaryngology Head and Neck Surgery, Hadassah Medical Center, Jerusalem

13:30-14:00 Business Meeting