Science is Beautiful

actual size

10 × 10

Contents

Introduction 6

Cellular 10

Blood 36

Brain 64

Organs 84

Disease 122

Medicine 158

Index 190

Picture Credits 192

HUMANBODY_SPDS_253x253cor.indd 5 22/07/2014 12:35HUMANBODY_SPDS_253X253 P001-192_5-5.pgs 22.07.2014 13:15 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN TEXT BLACK

Macrophage and platelets

(coloured scanning electron micrograph)

Platelets are fragments of white blood cells,

and the two are the maintenance team of

the blood supply. This image shows platelets

(in purple) still attached to a macrophage

white blood cell (pink). Macrophages clean the

system by engulfi ng and destroying unwelcome

pathogens, dead cells and other cellular debris.

Platelets repair leaks in the system by clotting

blood. Too few platelets can result in excessive

bleeding; too many can lead to thrombosis,

when a clot obstructs the blood supply.

(Magnifi cation: x7000 at 10cm/4in size)

Blood 47


Contents

Introduction 6

Cellular 10

Blood 36

Brain 64

Organs 84

Disease 122

Medicine 158

Index 190

Picture Credits 192


Macrophage and platelets

(coloured scanning electron micrograph)

Platelets are fragments of white blood cells,

and the two are the maintenance team of

the blood supply. This image shows platelets

(in purple) still attached to a macrophage

white blood cell (pink). Macrophages clean the

system by engulfi ng and destroying unwelcome

pathogens, dead cells and other cellular debris.

Platelets repair leaks in the system by clotting

blood. Too few platelets can result in excessive

bleeding; too many can lead to thrombosis,

when a clot obstructs the blood supply.

(Magnifi cation: x7000 at 10cm/4in size)

Blood 47


Liver cells (coloured scanning electron micrograph)

This image shows several specialized elements (organelles) within two liver

cells (hepatocytes). Immediately above the nucleus (large yellow ovoid,

lower left of centre), the wavy blue lines are folds of tissue producing

proteins, steroids and other material. The blue lines on the right are the

Golgi apparatus which prepares protein involved in secretion. Large pale

yellow spots are fat droplets, smaller ones waste-digesting lysosomes. The

green spots are mitochondria, which generate energy; the brown matter is

energy-storing glycogen. (Magnification: unknown)

HUMANBODY_SPDS_253x253cor.indd 30 22/07/2014 12:36HUMANBODY_SPDS_253X253 P001-192_30-30.pgs 22.07.2014 13:16 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN TEXT BLACK HUMANBODY_SPDS_253x253cor.indd 31 22/07/2014 12:36HUMANBODY_SPDS_253X253 P001-192_31-31.pgs 22.07.2014 13:16 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN

Liver cells (coloured scanning electron micrograph)

This image shows several specialized elements (organelles) within two liver

cells (hepatocytes). Immediately above the nucleus (large yellow ovoid,

lower left of centre), the wavy blue lines are folds of tissue producing

proteins, steroids and other material. The blue lines on the right are the

Golgi apparatus which prepares protein involved in secretion. Large pale

yellow spots are fat droplets, smaller ones waste-digesting lysosomes. The

green spots are mitochondria, which generate energy; the brown matter is

energy-storing glycogen. (Magnification: unknown)


HUMANBODY_SPDS_253x253cor.indd 84 22/07/2014 12:40HUMANBODY_SPDS_253X253 P001-192_84-84.pgs 22.07.2014 13:18 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN

OrgansHUMANBODY_SPDS_253x253cor.indd 85 22/07/2014 12:40HUMANBODY_SPDS_253X253 P001-192_85-85.pgs 22.07.2014 13:18 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN TEXT BLACK


OrgansHUMANBODY_SPDS_253x253cor.indd 85 22/07/2014 12:40HUMANBODY_SPDS_253X253 P001-192_85-85.pgs 22.07.2014 13:18 Rival Colour Ltd BLACK YELLOW MAGENTA CYAN TEXT BLACK

Kidney glomeruli (coloured scanning electron micrograph)

Like a shrub in full bloom, flowers of blue glomeruli grace the orange

stems of blood vessels in the human kidney. Glomeruli consist of a tight

knot of blood capillaries covered in podocyte cells. Podocytes have footlike

extensions which they wrap around the capillaries, leaving slits between

them. The slits act as tiny filtration units to remove toxic waste products

from the blood. The filtered fluid then drains to the bladder as urine.

(Magnification: unknown)


Kidney glomeruli (coloured scanning electron micrograph)

Like a shrub in full bloom, flowers of blue glomeruli grace the orange

stems of blood vessels in the human kidney. Glomeruli consist of a tight

knot of blood capillaries covered in podocyte cells. Podocytes have footlike

extensions which they wrap around the capillaries, leaving slits between

them. The slits act as tiny filtration units to remove toxic waste products

from the blood. The filtered fluid then drains to the bladder as urine.

(Magnification: unknown)



Bacteriophage (coloured transmission

electron micrograph)

Bacteriophages are viruses that infect bacteria;

this one, a T4 bacteriophage (orange), has just

injected its viral DNA into an E. coli bacterium

(blue). It is anchored to the surface of the

cell by spidery tail fibres. The tail contracts

to allow a syringe-like tube below its base to

puncture the cell membrane, emptying the

DNA contents of the head into the bacterium.

New T4 phages then grow, kill and depart from

the host cell within 30 minutes. (Magnification:

x65000 at 6x7cm/2¼x2¾in size)

Disease 155



Bacteriophage (coloured transmission

electron micrograph)

Bacteriophages are viruses that infect bacteria;

this one, a T4 bacteriophage (orange), has just

injected its viral DNA into an E. coli bacterium

(blue). It is anchored to the surface of the

cell by spidery tail fibres. The tail contracts

to allow a syringe-like tube below its base to

puncture the cell membrane, emptying the

DNA contents of the head into the bacterium.

New T4 phages then grow, kill and depart from

the host cell within 30 minutes. (Magnification:

x65000 at 6x7cm/2¼x2¾in size)

Disease 155


February 2015Science & Nature / Science & Technology$35.00 ($39.50 Canada)Hardcover with Jacket10 × 10 • 192 pages (all in color)978-1-84994-192-1

DISCLAIMERReviewers are reminded that changes may be made in this uncorrected proof before books are printed. If any material from the book is to be quoted in a review, the quotation should be checked against the final bound book. Dates, prices, and manufacturing details are subject to change or cancellation without notice.

To order book, scan here

Take a fantastic journey through the human body, thanks to the magic of technology and the most spectacular microscopic images ever created. These pictures, as beautiful as any art, provide a window into the wonder of our brains, cells, hormones, even our diseases. Enjoy the collection purely as a visual voyage or as a means of understanding the science behind the images—which all include the scale of the photography as well as the scientific details in layman’s terms.

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Colin Salter is the coauthor of Everything You Need to Know About Inventions (Thunder Bay Press). He is a history and science writer who has written about everything, including the private lives of marine gastropods. His contributions to Chambers’ Biographical Dictionary include the entries for 500 living scientists.

For more information, contact Josh Redlich at (646) 688-2484 or [email protected]

pub date february 2015

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Science is Beautiful