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Schizophrenia and schizophrenia-like disorders Dr: Weibo Liu E-mail:[email protected] The Second Affiliated Hospital Zhejiang University College of Medicine

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Page 1: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Schizophrenia and schizophrenia-like disorders

Dr: Weibo Liu E-mail:[email protected]

The Second Affiliated Hospital Zhejiang University

College of Medicine

Page 2: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Category of psychotic disorders

• Schizophrenia (SC)

• Schizoaffective disorder

• Schizophreniform disorder

• Brief psychotic disorder

• Delusional disorder

Page 3: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Introduction

• The definition of schizophrenia

• The symptom of schizophrenia

• Diagnostic criteria of schizophrenia (DSM-IV and ICD-10)

• The therapeutic principle of schizophrenia

• The factors influencing prognosis of schizophrenia

• The concept and diagnostic significance of insight

Page 4: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

“Big” Names associated with SC

(1) Kraepelin ---Dementia praecox

(2)Eugen Bleuler-- formal thought

disorder(splitting)

(3)Kurt Schneider-first-rank symptoms

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Definition of SC

•Schizophrenia is a disorder characterized by apathy, absence of initiative (avolition), and affective blunting

•Patients have alterations in thoughts, perceptions, mood, and behavior

•Many schizophrenics display delusions, hallucinations and misinterpretations of reality

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Epidemiology — gender and age

• SC is equally prevalent in men and women.

• On set is earlier in men (in the teens or 20s) than in women (in the 20s or early 30s).

• It's uncommon for children to be diagnosed with SC and rare for those older than 40.

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Moises HW, Zoega T, Gottesman II. The glial growth factors deficiency and synaptic

destabilization hypothesis of schizophrenia. BMC Psychiatry. 2002 Jul 3;2(1):8.

Page 8: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Epigenetic Code

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Etiology of SC

• Genetic factors

• Biochemical factors

• Neuropathology

• Neural circuits

• Psychoneuroimmunology

• Psychoneuroendocrinology

• ……

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Genetic factors

• A genetic contribution to SC, and a high proportion of the variance in the liability to SC is due to additive genetic effects

• But, Most patients have no family history of SC, is a complex genetic disease– Multiple genes (epistasis) and environmental exposures (interaction)

are involved in risk.

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Biochemical factors

• Dopamine hypothesis

• Serotonin

• Glutamate

• Norepinephrine

• GABA

• Neuropeptides

• Acetylcholine and nicotine

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Dopamine hypothesis in CNS

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Brain Structure & Brain Function

Ventricle Enlargement (MRI)

Hypofrontality (fMRI)

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Clinical feature of Schizophrenia

Positive

symptoms

1

Mood

symptoms

3

Cognitive

impairment

42

Negative

symptoms

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Positive symptoms

• Hallucinations are most commonly auditory or visual, but hallucinations can occur in any sensory modality

• Delusions--fixed false beliefs that cannot be corrected by reason

• Thought disorder is characterized by loose associations, tangentiality, incoherent thoughts, neologisms, thought blocking, thought insertion, thought broadcasting, and ideas of reference

• Disorganized behavior

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Negative symptoms

• Poverty of speech (alogia) or poverty of thought content

• Flat affect

• Loss of motivation (avolition)

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Mood symptoms

• Common and severe

• Depression or mood swings

• People with schizophrenia often seem inappropriate and odd, causing others to avoid them, which leads to social isolation

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Cognitive impairment

• Exhibit subtle cognitive dysfunction in the domains of attention, executive function, working memory, and episodic memorysuch as: Problems with making sense of information

Difficulty paying attention

Memory problems

• The cognitive impairment seems already to be present when patients have their first episode and appears largely to remain stable over the course of early illness

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Classification of schizophrenia

• A – paranoid type schizophrenia

• B – disorganized type schizophrenia

• C – catatonic type schizophrenia

• D – undifferentiated type schizophrenia

• E – residual type schizophrenia

Page 20: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Paranoid type schizophrenia

• Characterized by preoccupation with one or more

delusions or frequent auditory hallucinations

• No prominent disorganized speech, disorganized or

catatonic behavior, or flat or inappropriate affect

• Best prognosis

Page 21: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Disorganized type schizophrenia

• Characterized by prominent disorganized speech,

disorganized behavior, and flat or inappropriate affect

• worse prognosis

Page 22: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Catatonic type schizophrenia

Characterized by at least 2 of the following:

• Motoric immobility

• Excessive motor activity

• Extreme negativism or mutism

• Peculiar voluntary movements such as bizarre posturing

• Echolalia or echopraxia

Page 23: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Undifferentiated type schizophrenia

• Meets criteria for SC, but can not be Characterized by paranoid, disorganized, or catatonic type

Page 24: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Residual type schizophrenia

Characterized by the absence of prominent delusions, disorganized speech and grossly disorganized or catatonic behavior and continued negative symptoms or two or more attenuated positive symptoms

Once a Schizophrenic,

Always a Schizophrenic?

Page 25: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

DSM-Ⅳ diagnostic criteria for schizophrenia

A. Two or more of the following symptoms present for one month:

1.Delusions

2.hallucinations

3.disorganized speech

4.grossly disorganized or catatonic behavior

5.negative symptoms (ie,affective flattening,alogia,avolition)

B. Decline in social and/or occupational functioning since the onset of illness

C. Continuous signs of illness for at least six months with at least one month of active symptoms

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D. Schizoaffective disorder and mood disorder with psychotic features have been excluded

E. The disturbance is not due to substance abuse or a medical condition

F. If history of autistic disorder or pervasive developmental disorder is present, schizophrenia may be diagnosed only if prominent delusions or hallucinations have been present for one month

DSM-Ⅳ diagnostic criteria for schizophrenia

Page 27: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

ICD-10 diagnositic criteria for schizophrenia

1. At least one of the following:• Thought echo, insertion, withdrawal, or broadcasting.

• Delusions of control, influence, or passivity; clearly referred to body or limb movements or specific thoughts, actions, or sensations; and delusional perception.

• Hallucinatory voices giving a running commentary on the patient's behavior or discussing him/her between themselves, or other types of hallucinatory voices coming from some part of the body.

• Persistent delusions of other kinds that are culturally inappropriate or implausible, (e.g. religious/political identity, superhuman powers and ability).

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2. Or, at least two of the following:• Persistent hallucinations in any modality, when accompanied by fleeting

or half-formed delusions without clear affective content, persistent over-valued ideas, or occurring every day for weeks or months on end.

• Breaks of interpolations in the train of thought, resulting in incoherence or irrelevant speech or neologisms.

• Catatonic behavior such as excitement, posturing, or waxy flexibility, negativism, mutism, and stupor.

• Negative symptoms such as marked apathy, paucity of speech, and blunting or incongruity of emotional responses.

• A significant and consistent change in the overall quality of some aspects of personal behavior, manifest as loss of interest, aimlessness, idleness, a self-absorbed attitude, and social withdrawal.

ICD-10 diagnositic criteria for schizophrenia

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A case of SC

What’s the symptoms?

How to make a diagnose?

Page 30: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Differential diagnosis with SC

• Psychotic disorder due to a general medical condition

CNS infections, lupus, multiple strokes, HIV …

• Substance-induced psychotic disorder

Amphetamines, cocaine, phencyclidine(PCP) …

• Mood disorder with psychotic features

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Therapeutic approach of SC

• “ UCLA Recovery Criteria ”

Recovery criteria must be met in each of 4 domains

Improvement in each domain must be sustained concurrently for ≥2 y

Level of recovery in these 4 domains is measured by:

- Symptom remission

- Appropriate role function

- Ability to perform day-to-day living tasks without supervision

- Social interaction

Liberman RP et al. Int Rev Psychiatry. 2002;14;256-272.

Page 32: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Therapeutic goals

• Reduce or eliminate symptoms

• Maximize quality of life and adaptive functioning

• Promote and maintain recovery from the debilitating effects of illness to the maximum extent possible

Page 33: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Treatment of SC

Pharmacotherapy

antipsychotic medication

*Electroconvulsive (ECT)

Treatment

Psychosocial interventions

Family interventions

Supported employment

Assertive community treatment

Social skills training

Cognitive behaviorally oriented psychotherapy

Page 34: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Phases of treatment in SC

Acute

Phase

4-8weeks

1

Maintenance

Phase

≥1-2 years

32

Stabilization

phase

≥6 weeks

Three steps in whole treatment phases

Page 35: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Acute Phase Treatment

• Reducing the severity of psychosis and associated symptoms (e.g., agitation, aggression, negative symptoms, affective symptoms)

• Ensuring the safety of the patient and others because of socially damaging behaviour

Page 36: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Stabilization Phase

• If the patient has improved with a particular medication regimen, continuation of that regimen and monitoring are recommended for at least 6 months

• Reducing stress on the patient and provide support to minimize the likelihood of relapse, enhance the patient’s adaptation to life in the community

• Consolidation of remission, and promote the process of recovery

Page 37: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Maintenance phase

• Ensuring that symptom remission is sustained, continuation rehabilitation that the patient is maintaining or improving his life quality

• Most patients are at very high risk of relapse in the absence of antipsychotic treatment. It is generally recommended that multiepisode patients receive maintenance treatment for at least 5 years

Page 38: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Indication for hospitalization

• Psychotic symptoms prevent the patient from caring for his basic needs

• Suicidal ideation secondary to psychosis

• Dangerous to self or others

• With command hallucinations to harm self or others, especially with a history of acting on hallucinations

Page 39: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Medication Treatment

• Antipsychotics can help control the hallucinations, delusions, and thinking problems associated with the illness.

• Patients may need to try several different antipsychotic medications before they find the medicine or combination of medicines that works best for them.

Page 40: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Binding profile of antipsychotics

BINDING PROFILE OF ANTIPSYCHOTICS

CLOZAPINEOLANZAPINE HALOPERIDOL RISPERIDONE

H1αααα2αααα1Musc5HT2C5HT2AD4D2

SERTINDOLE SEROQUEL ZIPRASIDONE ZOTEPINE

DATA FROM BYMASTER ET AL., 1996 & SCHOTTE ET AL., 1996

D1

Fig. 1.

Page 41: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Conventional/typical Antipsychotics

• The antipsychotics in longest use are called conventional antipsychotics. Examples are: Haldol (haloperidol)Stelazine (trifluoperazine)Mellaril (thioridazine) Thorazine (chlorpromazine)Navane (thiothixene) Trilafon (perphenazine)Prolixin (fluphenazine)

• Conventional antipsychotics are becoming obsolete. Because of side effects, experts usually recommend using a newer atypical antipsychotic rather than a conventional.

Page 42: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Extrapyramidal side effects (EPS)

• More often be seen in the patients with the medication of conventional antipsychotics

• Due to blockade of dopamine receptors in the nigrostriatal pathway of the basal ganglia in the brain

• Manifestation as: acute dystonia, drug-induced parkinsonian syndrome, akathesia

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Atypical Antipsychotics

• Atypical antipsychotics work in a different way than the conventional antipsychotics. Examples are: Aripiprazole (Abilify)Clozapine (Clozaril)Olanzapine (Zyprexa)Paliperidone (Invega)Quetiapine (Seroquel)Risperidone (Risperdal)Ziprasidone (Geodon)

• much less likely to cause the distressing movement side effects.Common side effects include weight gain, diabetes and high blood cholesterol.

• The experts recommend the newer atypical medications as the treatment of choice for most patients with schizophrenia.

Page 44: Schizophrenia and schizophrenia-like disordersm-learning.zju.edu.cn/G2S/eWebEditor/uploadfile/20111102045628_391183939256.pdfSchizophrenia and schizophrenia-like disorders Dr: WeiboLiu

Stages of Illness

Healthy

Worsening

Severity of

Signs and

Symptoms

Gestation/Birth 10 Puberty 20 30 40 50

Years

Natrual History of Schizophrenia

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Separate Components of Schizophrenia?

Constitutional

Vulnerability

Prodromal

State

Psychosis

Deterioration

Neurodevelopmental

Neurodegeneration

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Risk factors of SC

• Having a family history of schizophrenia

• Exposure to viruses, toxins or malnutrition while in the womb

• Stressful life circumstances

• Older paternal age

• Taking psychoactive drugs during adolescence and young adulthood

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The factors influencing prognosis of SC

Concise textbook of clinical psychiatry, third edition,p163

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Judgment and Insight

Insight—conscious recognition of one’s condition, in psychiatry, it

refers to the conscious awareness and understanding of one’s

psychodynamics and symptoms of maladaptive behavior

• Patients with Sc are described as having poor insight into the nature

and the severity of their disorder

• Lack of insight is associated with poor compliance with treatment

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