SCALABLE PRODUCTION OF POLYMERIC NANOPARTICLES

YING LIU

ASSISTANT PROFESSOR

DEPARTMENT OF CHEMICAL ENGINEERING

DEPARTMENT OF BIOPHARMACEUTICAL SCIENCES

UNIVERSITY OF ILLINOIS AT CHICAGO

NANOPARTICLES FOR DRUG DELIVERYIncrease hydrophobic compound solubility and bioavailability

Rate Ai (C

sat - C

bulk )

Targeting drug delivery

Passive targeting tumors (EPR)

Functional surfaces

PEG: bio-inert, long circulating

PAA: mucoadhesive

PEG-ligand: active targeting

Protection from degradation

Sustained drug release

Nanoparticle stabilized with block

copolymers

Reproducible, large scale production of particles with controlled properties

Formation Stability Application

Research in laboratories

>20,000

Clinical application

0

HOW TO GET THERE?

FLASH PRECIPITATION AND DRY PROCESS

Scalable and continuous process Long-term stability Enhanced oral bio-availability (>1000 compared to

the pure drug and >10 compared to the Labrasol®)

>50% drug loading controlled size distribution and surface properties

INCREASED BIOAVAILABILITY AND FUNCTIONALITY

SR13668 Bioavailability in dogs

Curcumin for attenuating morphine tolerance and dependence using mouse model

ADVANTAGES OF THE MICROSCALE

DAVID EDDINGTON

ASSISTANT PROFESSOR

DEPARTMENT OF BIOENGINEERING

MICROFLUIDICS AND DIAGNOSTICS

UNIVERSITY OF ILLINOIS AT CHICAGO

Rapid Diffusion

Large surface to volume ratio

Laminar flow

Process integration

ADVANTAGES OF THE MICROSCALE

Mohammed et al, 2009, Lab on a Chip

Brett et al, 2012, Lab on a Chip

Sinkala et al, 2012, Lab on a Chip

Launiere et al, 2012, Analytical Chemistry

Current Tools: Hypoxic Chambers

•Crude, inefficient, and problematic

Cannot replicate gradients of oxygen

• found across all tissues in every animal

Microfluidic devices can control oxygen over many levels

•Cells (multiwell plate and open-well)•Tissues (islets and brain slices)•Animals (wound healing)

OXYGEN IS A KEY METABOLIC VARIABLE

FUNCTIONAL ASSAY FOR ISLETS

HIGH VS LOW POTENCY ISLETS

1000 human islets transplanted into nude mice

Our device can evaluateislet tissue better thanstandard methods

Standard evaluation shows no difference in function

Gold standard = 30 day mouse transplantation model

Quick, but poor predictor Predicts outcome, but only in retrospect

POWER CONVERTERS

MAHSHID AMIRABADI

ASSISTANT PROFESSOR

DEPARTMENT OF ELECTRICAL & COMPUTER ENGINEERING

POWER ELECTRONICS, RENEWABLE ENERGY SYSTEMS, ELECTRIC AND HYBRID ELECTRIC VEHICLES, AC DRIVES

UNIVERSITY OF ILLINOIS AT CHICAGO

POWER CONVERTERS

Power converters control and process the flow of electrical energy.

These circuits are integral part of many systems including, but not limited to, renewable energy systems and electric and hybrid electric vehicles.

Power Electronics is an Enabling Technology.