Cellular Respiration

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“Luft Syndrome” (pg 166) 1. Read 2. Write down something you found interesting. 3. Write a question that you have.

“Pick Up Info” one person at a time. What is a one sentence summary of Luft syndrome?

“Pick Up Info”

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• Hypothesize why there are more mitochondria in people with Luft syndrome.

Aerobic Cellular Respiration• extracts energy from food in the presence of oxygen • energy is used to synthesize ATP from ADP and Pi

• eukaryotes & prokaryotes that are obligate aerobes undergo Cellular respiration

“The Powerhouse”

Aerobic Cellular Respiration

4 stages: 1.Glycolysis 2.Pyruvate oxidation (Transition

stage) 3.Citric acid cycle 4.Electron transport Chain &

oxidative phosphorylation

Note the graphic on the next slide and consider:• Make note of where each stage of CR takes place. You may want to add that information to your diagram of the mitochondria.• At what stage of Cellular Respiration is most of the ATP made?

Cellular Respiration

Pyruvate Oxidation

1. Glycolysis• takes place in cytoplasm • enzymes break down one molecule of glucose into

two molecules of pyruvate • some ATP and NADH are produced

2. Pyruvate Oxidation (transition stage)

• occurs in the mitochondria • pyruvate is transported (via carrier protein) into

mitochondria and is oxidized, forming acetyl-CoA • CO2 and NADH are produced

3. Citric Acid (Krebs) Cycle• takes place in the mitochondria • acetyl-CoA enters a cycle and is completely oxidized

to CO2

• ATP, NADH and FADH2 are produced

4. Electron Transport…• takes place in mitochondria • the NADH and FADH2 from the first 3 stages are

oxidized • H2O and a large amount of ATP is produced (32-34)

http://www.sumanasinc.com/webcontent/animations/content/cellularrespiration.swf

1. Substrate-level phosphorylation - catalyzed by a kinase - phosphate is transferred directly from a substrate

ATP can be produced in two ways:

2. Oxidative phosphorylation - catalyzed by ATP synthase - process uses energy transferred indirectly from a series of redox reactions

What if there is no O2?• many organisms can extract energy from food

without using oxygen using anaerobic respiration and fermentation

• much lower amount of energy release in anaerobic pathways

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Classwork/Homework

1. Read 4.1 2. 1-7 pg 171 3. Make a summary statement for each of

stage of the CR.