8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

1/99

Kbffsmaotbc[gdpjc8

UfwcrKgjkujgtmfasga`[gdpjmaonfrMdpgkt

Cvgjugtmfa

[tgamsjgf Dgj`fag`f

SamvcrsmtyfnKgjmnframg,Lcricjcy

Gppjmc`MdpgktCvgjugtmfa[prmao

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

2/99

Sajcss`gtgkfjjcktmfamskbcgp,gsgdpjcmsrcqumrc`tf

m`catmnytbckgusgjcnncktfnmatcrcst

Pwficyqucstmfas8

Bfwjgroc`fcstbcsgdpjcacc`tflctfkrc`mljy `ctcktgomvcacnncktsmzc6

Bfwwmjjtbcsgdpjclckbfsca6

;=.=50=; 7 ?>;=.=50=; Urfl 1 N 4 5.5555

\csm`ugj | .5? >7

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

5/99

@uctflu`octkfastrgmats,wckgafajykfjjcktgsgdpjcfn;,555flscrvgtmfas.Pbccstmdgtc`mdpgktmstbcnfjjfwmao8

. rcorcss jayVrga`fd c`uVrga`fd

[furkc | [[ `n D[ Audlcr fn fls 4 ;555

-------------+------------------------------ N( 7,

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

6/99

Mdgomacafwtbgtwckgafajykfjjcktgsgdpjcfn;55flscrvgtmfas.Pbccstmdgtc`mdpgktmstbcnfjjfwmao8

. rcorcss jayVrga`fd c`uVrga`fd

[furkc | [[ `n D[ Audlcr fn fls 4 ;55

-------------+------------------------------ N( 7,

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

7/99

4Macjmomljc

4Cjmomljc

7.Ufpujgtmfa

Cxtcragj^gjm`mty

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

8/99

@ctcrdmamaobfwjgroctbcsgdpjcdustlctflcgljctf

`ctcktgacnnckt(makgsctbmscnncktcxmsts)msiafwagsUfwcrKgjkujgtmfa

Ufwcrkgjkujgtmfama`mkgtcstbcdmamdud sgdpjcsmzc

acc`c`tfkfa`uktgamdpgktcvgjugtmfaga`tfgaswcrtbcpfjmkyqucstmfafnmatcrcst

Prg`cfnnlctwccasgdpjcsmzcga`kfst

2

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

9/99

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

10/99

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

11/99

-7

-0

-;

5

.

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7

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5 355 7555 7355

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

64/99

KgscMM8Kjustcrc`\ga`fdmzgtmfa

>0

. sgdpsm 5 5.

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

65/99

>3

. sgdpkjus, flskjus(75) rbf(5.7?)

[gdpjc [mzc G`hustc` nfr Kjustcr @csmoa

a7 (uakfrrcktc`) 4 ;=;

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Cstmdgtc` sgdpjc smzc pcr orfup8

a7 (kfrrcktc`) 4 ==3

a< (kfrrcktc`) 4 ==3

MKK

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

66/99

MKK

>>

5

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.

.?

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

67/99

g`cqugtcsgdpjcsmzcstf`ctcktkgusgjcnnckts

Jfwpfwcrmskfddfamadgayskmcakcs8

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

68/99

>2

(DkIcazmcctgj

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

69/99

>=

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

70/99

Sa`crsmzc`stu`mcsgrcgwgstcfnrcsfurkcsnfraft

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?5

0 [gdpjmao [trgtcoy (Fptmfagj)

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

71/99

0.[gdpjmao[trgtcoy(Fptmfagj)

[mzcmsafttbcfajyrcjcvgatngktfr,tbcwgytbcsgdpjcms

`rgwanrfdtbcpfpujgtmfafnmatcrcst

[gdpjmaorcqumrcstbrccstcps(Ocrtjcr ctgj

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

72/99

[gdpjmaoNrgdc

Bfwwmjjyfunma`tbcpfpujgtmfafnmatcrcst6

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?

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

77/99

??

\csujtsnrfdfaccxpcrmdcat

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

78/99

Cstmdgtc`pfvcrtyrgtc

[gdpjmaocrrfr

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?2

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

79/99

?=

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\D[C4squgrcrfft(;Q

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

80/99

25

Gvcrgoccrrfrtca`stfzcrf(JgwfnJgrocAudlcrs)

ualmgsc`cstmdgtfrfntrucprfpfrtmfa

Afrdgj@mstrmlutmfa(KcatrgjJmdmtPbcfrcd)

Cnncktfnpfpujgtmfasmzcfaprckmsmfa(A4

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

81/99

27

\D[Cmakrcgsc`lyvcryjmttjc!

Jcssfa78Ufpujgtmfasmzc`fcsaftdgttcrnfrprckmsmfa

Cnncktfnsgdpjcsmzcfaprckmsmfa(a4055)

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

82/99

2Jcssfa;8Ojflgjgvcrgocmsgwcmobtc`dcgafnma`mvm`ugjcstmdgtcsnfrcgkbstrgtg

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

87/99

[trgtmnmkgtmfapursucstwfofgjs8

Mdprfvcprckmsmfafntbcfvcrgjjcstmdgtc

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2?

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

88/99

22

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

89/99

2=Jcssfa08Urfpfrtmfagjgjjfkgtmfaomvcsdfrcprckmscnfrkfuatrygsgwbfjc

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

90/99

=5Jcssfa38Acydga gjjfkgtmfa`fcsaftomvcusglcttcrgpprfxmdgtmfa

Kjustcrga`Dujtmstgoc[gdpjmao

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

91/99

\ga`fdsgdpjmaomsaftkfddfagppjmc`maprgktmkc

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Kjustcr(kgjjc`Urmdgry[gdpjmaoSamtmasfdckgscs)

Bfuscbfj`s/ma`mvm`ugjs

=7

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

92/99

Orfupuamtsmatfagturgjkjustcrs

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=

Gppca`mx8Ssmaokfatrfjvgrmgljcs

8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

97/99

Kfasm`crtbcnfjjfwmaoFJ[rcorcssmfa8

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

98/99

\ckgjjtbcnfjjfwmaorcsujt8

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8/12/2019 Sampling and Power Calculations IAE (Extended 2014)

99/99

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==

8k

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