S7E

PERSONNEL PLACEMENT

LANE C A wnsEs~

-Deadlines: Ads are due by Thursday,10 a.m., 2 weeks prior to the issue date.Science is published each Friday,except the last Friday of the year. Callfor holiday deadlines. Advertisementsmust be submitted in writing.

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POSITIONS OPEN

The Division ofEndocrinology and Metabolism at theUNIVERSITY OF CALIFORNIA, IRVINE (UCI),invites applications and nominations for a tenure-trackFACULTY POSITION at the ASSISTANT PRO-FESSOR level. Candidates should have expertise inmolecular and cellular approaches to study aspects relatedto the endocrine system. Applicants must have an M.D.or M.D./Ph.D. degree and have a strong record ofresearch accomplishments, with the potential to developan independent research program. The division is com-mitted to excellence in endocrinology while providing afertile environment for interactive research at UCI andaffiliated institutions.

Interested applicants should send their curriculumvitae, a statement of research interest, and names andaddresses of at least three references to: Dr. MurrayKorc, Chief, Division of Endocrinology and Metabo-lism, Department of Medicine, UCI Medical Center,P.O. Box 14091, Orange, CA 92613-1491. UCI is anAjlrmative Action/Equal Opportunity Employer.

GENETICSASSISTANT PROFESSOR

The University of Tampa invites applications for atenure-track position beginning in January 1993 to teachgenetics, evolutionary biology, introductory biology formajors, and biological science for nonmajors. A EU-KARYOTIC GENETICIST with broad training inevolutionary biology is preferred. Ph.D. requed. riorteaching and research experience with undergraduatesdesirable. Send curriculum vitae, a statement of teachingphilosophy, a statement of research interests, officialtranscripts, and three letters of recommendation, by 28August 1992, addressed to: Dr. Stanley Rice, Chair-man, Department of Biology, co Human Resources,University ofTampa, 401 West Kennedy Boulevard,Tampa, FL 33606-1490. The University ofTampa is anEqual Opportunity/Affirmative Action Employer.

MOLECULAR-CELLULAR NEUROBIOLO-GIST. The Neurosciences Group of the Loeb ResearchInstitute at the Ottawa Civic Hospital, a teaching insti-tution affiliated with the University of Ottawa, invitesapplications for two appointments at the ASSISTANTPROFESSOR level. We are seeking candidates with aPh.D. or M.D. and three or more years of postdoctoratetraining and demonstrated excellence, originality andproductivity in molecular biology applied to neurobiol-ogy. Our research program is multidisciplinary and fo-cuses on CNS development, ion channel and receptorfunction, neural circuitry regulating body fluid and car-diovascular homeostasis, and mechanisms governingneuronal/glial responses to ischemia. At least one ap-pointment will be in the area of signal transduction, butoutstanding applicants using molecular approaches inother areas of neuroscience will be considered. In accor-dance with Canadian immigration requirements, this adver-tisement is directedfirst, but not solely, to Canadian citizensand permanent residents. Please forward curriculum vitaewith names of three references and statement of goals/interests by 1 September 1992 to: Dr. Leo R1enaud,Associate Director, Loeb Research Insitute, OttawaCivic Hospital, 1053 Carling Avenue, Ottawa, On-tario, Canada KlY 4E9.We support an Equal Opportunity Employment and a

smoke-free environment.

VISITING FACULTY POSITIONThe Faculty of Biological Science at The University of

Tulsa has openings for up to three VISITING ASSIS-TANT PROFESSORS to teach introductory courses inthe areas of general biology, cellular biology, anatomyand physiology, and genetics for both majors and non-majors. The salary is competitive and the 1-year appoint-ments begin 31 August 1992. The department has afaculty of 16 andoffers B.S., M.S., and Ph.D. degrees.The University of Tulsa is a private, comprehensive

university with a strong commitment to teaching andresearch. Applicants should have a Ph.D. degree andteaching experience. Send curriculum vitae and threeletters of reference to: Dr. Richard I. Reeder, Facultyof Biological Science, The University of Tulsa, 600South College Avenue, Tulsa, OK 74104.The University ofTulsa, an Equal Opportunity/Affirma-

tive Action Employer, is committed to diversifyng itsfacultyand staff. Members of underrepresented groups (people ofcolor, people with disabilities, women, veterans, etc.) are

strongly encouraged to apply.

POSITIONS OPEN

ASSISTANT PROFESSOR OF NUTRITION. A10-month, tenure-track position is available in the Grad-uate Program in Nutrition at the University at Buffalo(UB). Ph.D. in nutrition required, preferably followedby postdoctoral research in nutrition science. R.D. desir-able. Successful candidates are expected to develop aresearch progra in nutrition that can attract extramuralfunding, advise students, teach graduate and undersrad-uate courses and participate on committees. Deadline is31 July 1992 or until position is filled. Send curriculumvitae, transcripts, three references, and a letter statingresearch interests and plans to: Atif B. Awad, Ph.D.,Director, 301 Parker Hail, UB, Buffalo, NY 14214.UB is an Affirmative Action/Equal Opportunity Employer.

Virginia Polytechnic Institute and State University,Department of Fisheries and Wildlife Sciences, is accept-ing applications for a VISITING ASSISTANT PRO-FESSOR in forest-wildlife stewardship. The successfulcandidate is expected to develop and implement a land-owner assistance program to enhance wildlife values onprivate nonindustrial forest lands in Virginia and toconduct other related extension specialist activities. Womenand minorities are encouraged to apply. Closing date is 1 July1992. Apointment is for 1 year beginning 1 September1992, probably renewable for a second year, and possiblyconvertible to a tenure-track position later. Send letter ofinterest, resume transcripts, examples of publications, andnames of three references to: Dr. Larry A. Nielsen,Professor and Head, Department of Fisheries andWidldlie Sciences, Virgima Tech, Blasburg VA24061-0321. Virginia Polytechnic Institute and State Uni-versity is an Equal Opportunity/Affirmative Action Employerand hires only U.S. citizens or others authorizedfor employ-ment in the United States.

PLANT MOLECULAR BIOLOGIST (PMB)-ASSISTANT PROFESSOR. The Department of PlantBiology, University of New Hampshire (UNH), invitesapplications for a tenure-track position. The selectedcandidate will be expected to develop independent aswell as collaborative research in molecular biology withpotential relevance to the improvement of economicallyimportant plants. The research program will be expectedto attract external funding. Applicants must have a Ph.D.and postdoctoral research training in plant molecularbiology. A strong commitment to undergraduate andgraduate teaching and research is expected. Teachingduties will include one undergraduate course and twograduate courses in the areas of expertise. Applicationreview will begin 15 July 1992 and continue until theposition is filled. Submit curriculum vitae, graduateschool transcripts, list of publications, description offuture research and teaching interests, and three letters ofreference to: Professor Subhash C. Minocha, Chair,PMB Search Committee, Department of Plant Biol-ogy, University of New Hampshire, Durham, NH03824-3597. Telephone: 603-862-3840; FAX: 603-862-4757. Hiring is contingent upon eligibility to work inthe United States. Women and minorities are encouraged toapply. UNH is an Affirmative Action/Equal EmploymentOpportunity Employer.

FACULTY POSITIONSAT THE UNIVERSITY OF TEXAS

HEALTH SCIENCE CENTER AT TYLERWe are presently seching for faculty members to

establish independent research programs in the Depart-ments of Biochemistry, Molecular Biology, Physiologyand Cell Biology. Generous start-up funds for investiga-tors are available and ample research space is ready oroccupancy in newly constructed laboratories. Appoint-ments may be made at any level, but ASSISTANT orASSOCIATE PROFESSOR level individuals are pre-ferred. Applicants should have a Ph.D. and at least 2years of postdoctoral experience. The research institute'semphasis is on research associated with heart and lungdiseases and all basic research related to these areas.Salaries are state-supported, and there are no formalteaching requirements. Tyler is an attractive small citywith a good and safe school system amid the forests andlakes ofeast Texas, about 80 miles from Dallas. Potentialcandidates with strong scientific credentials should sendcurriculum vitae, a brief statement of research interestsand goals and the addresses and telephone numbers ofthree references to: Dr. Michael K Pangburn, Ph.D.,Chairman, Search Committee, Department of Bio-chemistry, University ofTexas Health Science Center,Tyler, TX 75710-2003. The University of Texas is anAffirmative Action/Equal Opportunity Employer MIFID.

SCIENCE * VOL. 256 * 12 JUNE 1992

CONDmONS: Personnel advertising isaccepted only with the understanding that theadvertisers do not discriminate amongapplicants on the basis of race, sex, religion,age, color, national origin, handicap or sexualpreference. The AAAS encouragesemployers to actively recruit and employunderrepresented minority groups. Sciencereserves the right, at its discretion, to declineto publish advertisements submitted to it.

1580

Postdoct Oppotu

Listed below are a few of the excellent opportunities forconducting research that are now available with leading scientistsat the National Institutes of Health.

Cell DifferentiationT.R. Breitnan, PhD

The modification ofproteins by retinoids and other ligandsis being studied with a special focus on the regulation of celldifferentiation and growth by these modifications. Experience inmolecular biology, protein purification, and protein chemistrypreferred. This position may be filled at the Senior StaffFellow(assistant professor equivalent) level. Laboratory of BiologicalChemistry (OE-14), NCI, Building 37, Room 5D02.

Developmental and Molecular PharmacologyDouglas E. Brenneman, PhD

The role ofneuropeptides and growth factors mediatingneuron-glial interactions during development is studied in cellcultures derived from the central nervous system. The focus ofthe research is on the mechanism of action and developmentalexpression ofvasoactive intestinal peptide, cytoldnes and a neuro-nal survival factor recently discovered by our group. Experiencein basic biochemical techniques and molecular biology is desir-able. Laboratory of Developmental Neurobiology (OE-14),NICHD, Building 36, Room 2A21.

Molecular NeurobiologyDavid C. Klein, PhD

The developmental and neural regulation ofgene expres-sion in the pineal gland are being studied. Studies focus on sero-tonin N-acetyltransferase, hydroxyindole-O-methyltransferase,and other pineal-specific gene products involved in regulatingmelatonin synthesis. This position has excellent long-term poten-tial for creative and productive investigators. Laboratory ofDe-velopmental Neurobiology (OE-14), NICHD, Building 36,Room 4A07.

Molecular NeuropharmacologyDavid R. Sibley, PhD

The cellular and molecular biological characteristics ofdopamine, serotonin and other neurotransmitter receptors arebeing investigated. Cell biology projects include studyingbiochemical mechanisms of receptor-effector coupling, Gprotein interactions, and receptor regulation in clonal celllines. Molecular biology projects involve cloning novel recep-tor subtype cDNAs/genes, analysis and characterization of

receptor/gene structure, and regulation of gene expression innormal and pathophysiological states. Experimental Therapeu-tics Branch (OE-14), NINDS, Building 10, Room 5C108.

Sexual DevelopmentDean Hamer, PhD

The molecular biology and genetics of sexual differentiationofthe brain are being studied in organisms as diverse as Dros-ophila, rats and humans. Projects include isolation of sexualbehavior mutants and sexually dimorphic mRNAs and linkageanalysis ofhuman sexual orientation. Applicants with a back-ground in molecular biology, behavioral science or human genet-ics are invited to apply. Laboratory of Biochemistry (OE-14),NCI, Building 37, Room 4A13.

Signal TransductionlGene Expression During AgingGeorge S. Roth, PhDJames A. Joseph, PhD

The possible mechanisms for age changes inG proteincoupled inositol-1,4,5-triphosphate (IP13) formation in parotidand brain; age changes in D2 receptor gene expression in stri-atum; cell death and resistance to oxygen radical damage; andsignal transduction deficits in Alzheimer's disease are being ex-amined. Laboratory of Cellular and Molecular Biology (OE-14),NIA, Francis Scott Key Medical Center, Baltimore, MD 21224.

Additional Postdoctoral Feliowship OpportunitiesFor an on-line listing of additional postdoctoral openings

you may access the NIH EDNET Bulletin Board's POSTDOCconference via modem (1,3014922221 or 1,8003582221). Thesettings for modem access are "7,Even,1". When connected toNIH, type in ",vtlO" at the connect message, "F5E" at initial,and "AJL1" at account.

Those interested in receiving information on other post-doctoral opportunities in NIH research laboratories, as well asinformation on clinical training opportunities, may contact theOffice of Education, Building 10, Room 1C129. Phone: 301-496-2427.

To ApplyIfyou hold a PhD, MD, or equivalent degree and would like

to be considered for one ofthese positions, please send a coverletter, curnicudum vitae, bibliography, and statement of researchinterests to the address listed with each position.In addition, please arrange to have letters of ,_. IP\5>recommendation sent from three scientists ^who can provide an evaluation ofyour qualifi- 11 -idecations. at AHECK\

Office OfEducationBuilding 10, Room 1C129, 9000 Rockville Pike, Bethesda, MD 20892 * 301-496-2427 * FAX 301-402-0483

Equal Opportunity Employer

RESEARCH INVESTIGATORJoin Sterling Winthrop and be a part of a team dedicalenhancement of scientific discovery. Sterling 1Pharmaceuticals Research Division is the worldwide phariresearch and development organization of Sterling Winthr(currently seek a Protein Chemist to join our inter-disciplinary team at our Great Valley, PA facility.The successful candidate will develop, implement and validatenovel and established methods for the characterization of pro-tein conjugates for FDA filings. This position will also interactwithin a research group to develop novel methodologies in sup-port of discovery and development projects.

The ideal candidate will have a Ph.D. degree and 2 years experience in biomoleculecharacterization. Demonstrated proficiency and innovation in protein characteriza-tion methods (edman degradation, amino acid analysis, mass spectrometry, peptidemapping) is expected. Experience in GMP/GLP procedures, carbohydrate structuralanalysis or the biophysical characterization of macromolecules is a plus.

At Sterling Winthrop, you'll enjoy a highly competitive salary and benefits package.For confidential consideration, forward your resume and salary requirements to:

STERLINGAct WINThROP

PharmaceuticalsResearch DivisionA Division of Sterling Winthrop Inc.A Subsidiary of Eastman Kodak Co.

1IBiPostdoctoral

osition

CardiovascularPosition available in the laboratory of Dr.Janet Robishaw at the Weis Center forResearch. This position offers a uniqueopportunity to combine pharmacologicaland molecular biological approaches toinvestigate the function of differenta,-adrenergic receptor and C proteinsubtypes in neonatal, rat cardiacmyocytes. The successful applicant forthis position will have a Ph.D. degreewith experience in one or more of thefollowing areas: cell culture, transfec-tion/microinjection of cDNAs into cells,analysis of receptor-C protein couplingand phospholipase C.

The Weis Center for Research is a well-equipped facility located in a semi-ruralarea. Competitive salary and fringebenefits are available. Send curriculumvitae and names of three references to:Human Resources (JDR), GeisingerClinic, 100 N. Academy Avenue,Danville, PA 17822-3024.

Gelsinser.E.G. E.M/F/H/V

Human ResourcesGV-77-92Sterling Withrop PRD9 Great Vailey ParkwayMalvern, PA 19355

Equal Opportunity Employer, M/FIDIV

A 2-year postdoctoral position inelectrophysiology is currently avail-able in the Pharmacology Depart-ment at 1C1 Pharmaceuticals Group,for independent and collaborativeresearch on the action of drugs andneuromodulators on neuronal cal-cium channels. Candidate will beinvolved in ongoing research usingthe patch-clamp technique in com-bination with molecular biology toexamine calcium channel regula-tion in acutely isolated and culturedneurons.

Experience in brain slicetechniquesand knowledge of whole-cell patch-clamp helpful. Familiarity withcomputer-based data acquisitionand analytical techniquesdesirable.Interested candidates should sub-mit a curriculum vitae and names/letters of reference to: Dr. J. M. H.ffrench-Mullen, Dept. of Pharma-cology, ICI Pharmaceuticals Group,Concord Pike and New MurphyRoad, Wilmington, DE 19897.

,fi Pharmaceuticals

Equal Opportunity Employer M/F.

POSITIONS OPEN

FACULTY POSITIONMARINE ECOLOGIST. The University of Oregon

(UO) invites applicants for a tenure-track faculty posi-tion in the Department of Biology at the level ofASSISTANT PROFESSOR. The successful candidatewill be based at the university's Oregon Institute ofMarine Biology (OIMB) in Charleston and will interactwith faculty and students at the main campus in Eugene.We encourage applicants whose research centers on

marine processes at any or several ofthe following levels:(1) interactions between or among marine organisms,e.g., symbioses, community ecology, or ecosystem dy-namics; (2) processes controlling life histories of marineorganisms. We are most interested in candidates whocombine empirical and experimental approaches withquantitative, theoretical andor molecular techniques.

Applicants should be able to interact closely with otherfaculty members at O1MB who have strong researchprograms in aspects ofmicrobial physiology and ecology,invertebrate biochemistry, physiology and evolution, andlarval biology. Applicants will be expected to establish anactive research program, advise graduate students, andteach undergraduate and graduate courses. Postdoctoralexperience is expected. Preference will be given to can-didates with an established record of outstanding re-search and a commitment to excellence in undergraduateand graduate education.

Please submit curriculum vitae and a statement ofresearch interest and have four letters ofrecommendationsent to: Chair, Marine Biology Search Committee,0IMB, University of Oregon, Charleston, OR97420. Closing date is 1 August 1992. The UO is anAffirmative Action/Equal Opportunity Institution committedto cultural diversity.

UNIVERSITY OF TORONTOCENTRE FOR RESEARCH

IN NEURODEGENERATIVE DISEASESApplications are invited for two positions in a recently

established neurodegenerative disease research centrewith emphasis on Aixheimer's disease. Ph.D.'s or M.D.'sat the ASSISTANT, ASSOCIATE or FULL PRO-FESSOR level are sought to join this team of sevenP.1's. Candidates must have expertise in one of thefollowing areas of neurobiology: transgenic models, bio-chemically oriented molecular biology, protein structure,or gene regulation. Start-up funds provided; successfulcandidates must initiate independent and original re-search programs.The University of Toronto encourages applicationsfrom

qualified men and women, members of visible minorities,aboriginal peoples and persons with disabilities. In accordancewith Canadian Immigration requirements, this advertisementis directed to Canadian citizens and permanent residents.Send curriculum vitae, a research statement and three

letters of reference prior to 1 August 1992 to: Dr. D. R.McLachlan, Centre for Research in Neurodegenera-tive Diseases, Tanz Neuroscience Building,6Queen'sPark Crescent West, Toronto, Ontario, Canada M5S1A8.

FACULTY POSITIONS IN CELL,MOLECULAR AND STRUCTURAL BIOLOGY

Applications are invited for tenure-track positions inthe Department of Cell, Molecular and Structural Biol-ogyatNorthwestemUniversityMedicalSchool. ASSIST-ANT to FULL PROFESSOR applicants must have aPh.D., M.D., or equivalent degree, with research expe-rience in cell, molecular, or structural biology. Applicantswill be screened with respect to their ability to carry onvigorous independent research and to participate in thevarious teaching programs administered by the depart-ment. Candidates whose research interests include devel-opmental biology, biochemistry, and structural biologyare encouraged to apply, although outstanding appli-cants with research interests in other areas of molecularbiology will be considered. Send complete curriculumvitae and a brief description of research interests by 15September 1992 to: Dr. Rex Chisholm, Chairman,Search Committee, Department of Cell, Molecularand Structural Biology, Northwestern UniversityMedical School, 303 East Chicago Avenue, Chicago,IL 60611.

Northwestern University is an Equal Opportunity/Affir-mativeAction Educator and Employer and invites applicationsfrom all qualified individuals. Applicationsfrom women andminorities are especially sought.

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POSITIONS OPEN

PHYSIOLOGY, ASSISTANT PROFESSOR (re-search track) position available for investigations on themolecular and biochemical properties of calmodulin-regulated enzymes induding-myosin light chain kinasesand nitric oxide synthases. An integrative research pro-gram on the biological adaptations of vascular smoothmuscle and endothelial cells offers collaborative opportu-nities dealing with growth responses, dynamic regulationof contractile elements and signal transduction pathways.Experience in molecular biology required. Please sendcurriculum vitae with three references listed to: James T.Stull, Ph.D., Department ofPhysiology, University ofTexas Southwestern Medical Center at Dallas, 5323Harry Hines Boulevard, Dallas, TX 75235-9040,telephone: 214-688-6849, FAX: 214-688-2974. AnAffirmative Action/Equal Opportunity Employer.

ASSISTANT/ASSOCIATE PROFESSORNEUROBIOLOGY

COLUMBIA UNIVERSITYApplications are invited for three tenure-track posi-

tions in the Center for Neurobiology and Behavior, atColumbia University, College of Physicians and Sur-geons. Applicants must possess a Ph.D. or M.D. degreeand have at least 2 years of postdoctoral training. Suc-cessful candidates will be expected to develop a vigorous,independent research program in one of three areas: (1)computational neuroscience (theoretical or combinedexperimental/theoretical approaches); (2) analysis of themolecular mechanisms of transmitter release; (3) analysisof the function and control of transcription factors in thenervous system. Submit curriculum vitae, names andaddresses of three references,- and summary of researchobjectives to: Search Committee, Center for Neurobi-ology and Behavior, New York State Psychiatric Insti-tute, 722 West 168 Street, New York, NY 10032. AnEqual Opportunity/Affirmative Action Employer.

CELL PHYSIOLOGISTS/MOLECULAR BIOLOGISTS

The Department of Physiology and Biophysics at theUniversity of Texas Medical Branch (UTMB) at Gal-veston invites applications for tenure-track positions atthe ASSISTANT, ASSOCIATE AND FULL PRO-FESSOR LEVELS. Candidates using state-of-the-artmethods to study cellular and subcellular physiology areespecially encouraged to apply. Candidates must havePh.D. and/or M.D. degrees. Salaries and start-up findsare highly competitive. The department offers a stimu-lating scientific environment with major researchstrengths in the study of membrane transport systemsand is deeply committed to high-quality research andteaching. Send complete curriculum vitae, includingpublications list, briefstatement of future research plans,and names and addresses of three references, to: Dr.Simon A. Lewis, Head of Search Committee, Depart-ment of Physiology and Biophysics, University ofTexas Medical Branch, Galveston, TX 77555-0641.UTMB is an Equal Opportunity/Affirmative Action Em-ployer M/F/H/V. UTMB hires only individuals authorizedto work in the United States.

PHARMACOLOGY-UNIVERSITY OF PENN-SYLVANIA. The Department of Pharmacology is re-cruiting four to six additional faculty to the tenure track atthe rank of ASSISTANT, ASSOCIATE or FULLPROFESSOR. Investigators with interests in the broadareas of ANALYTICIMOLECULAR PHARMA-COLOGY and CELLULAR/MOLECULAR PHAR-MACOLOGY will be appointed. Examples of potentialareas of interest indude: (1) structure and function ofbiomolecules using one or more of the following ap-proaches: NMR, EPR, MS, molecular modeling, affinitylabeling, and site-directed mutagenesis; (2) enzyme-inhib-itor/receptor-ligand design; (3) drug or second-messengermetabolism; (4) growth factor signaling; (5) gene manip-ulation (e.g., gene transfer, embryonic stem cells andrransgenics); and (6) ion channel/brain slice electrophysi-ology. Applicants should have postdoctoral research expe-rience and the ability to develop a strong extramurallyfunded research program. Renovated laboratory space andstart-up funds are available. Applications fom women andminorities are especially encouraged. Applicants should sub-mit curriculum vitae, selected reprints or preprints, astatement of research interests, and three letters of recom-mendation to: Search Committee, De t ofPhar-macology, University of Pennsylvania School of Med-icine, Philadelphia, PA 19104-6084. The University ofPennsylvania is an Equal Opportnity/Afirmative ActionEmployer.

|~~~Hm Produc tsCoprain aedn aufcuen

sales and an impressive record ofgrowth and profitability.As a GLOBAL research-based pharmaceutical company, we are committed tohelping people lead healthier lives through innovative pharmaceutical andnutritional products. It is from this commitment and position of strength that wemove forward with a major expansion of our research and development activities.Current expansion in our Cell Biology and Neurochemistry Laboratories hasresulted in the following opportunities.

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SIGNAL TRANSDUCTIONThis group is responsible for bringing second messenger expertise(1-proteins,DAG/phosphoinositide turnover) to bear on the study of neurotransmitter receptorfunction and effector coupling in neuronal cell lines. These studies will be anintegral part of our increasing research effort in stroke and neurodegeneration. Weare seeking a Ph.D. Scientist with 5+ years of experience in cell signaltransduction (receptor/effector coupling). This individual will conduct functionalpharmacological studies in our mechanism-based CNS programs and will provideCore Group support for programs in other divisions.

STROKE/NEURODEGENERATION LABORATORYWe are seeking a Ph.D. Scientist with 3+ years of postdoctoral experience inassessing potential neuroprotective agents in in vitro and in vivo models ofneurodegeneration. Research experience with noninvasive imaging assessmenttechniques of cerebral ischemia is preferred to facilitate our stroke/neuro-degeneration research program.

INTRACELLULAR PROTEIN PROCESSINGThis group studies labile and permanent changes in Central Nervous Systemproteins in response to pharmaceuticals and in stroke/ischemia/neurodegeneration.The research focus will be phosphorylation/dephosphorylation by kinases/phosphatases and both receptor and non-receptor forms of protein tyrosinekinases. We are seeking a Ph.D. Scientist with 5+ years of experience inintracellular protein processing. Research experience in post-translationalprocessing/membrane insertion of proteins is preferred to facilitate our research inthe field of Alzheimer's disease and other neurodegenerative diseases.

B.S.M.S. PHARMACOLOGISTSWe seek Pharmacologists with 0-5 years experience to provide technical supportfor our Principal Scientists in various groups. Our Signal Transduction grouprequires experience in cell culture, second messenger biochemical assays, cyclicnucleotide measurements and phosphoinositol hydrolysis. Our NeurochemistryLaboratory requires experience in ligand/receptor pharmacology and generalneurochemical techniques (HPLC, radioenzymatic biochemical techniques). OurIntracellular Protein Processing group requires experience in general proteinbiochemistry, cell culture, enzymatic assays and protein kinase measurement.

The Wyeth-Ayerst Princeton, New Jersey research laboratory is in a locationrenowned for its excellent quality of life and easy access to the cultural,educational and recreational resources of both New York City and Philadelphia.Please respond by sending your resume to: Employment Supervisor, Wyeth-Ayerst Research, Dept. CNS, CN 8000, Princeton, NJ 08543-8000. An EqualOpportunity Employer, M/F/D/V.

As an established leader in carbohydrate engineering,Alpha-Beta Technology is utilizing its patentedtechnologies to develop an exciting array of proprietarypharmaceutical products. We are seeking an articulate,experienced professional to play a critical role in the prod-uct approval process.

Director ofRegulatory AffairsBe a key contributor to our expanding success, report-ing directly to Alpha-Beta's President/CEO. Your creden-tials must include 3-5 years' Regulatory Affairs experiencein a biotech or pharmaceutical operation, with demon-strated leadership in regulatory relationship building andattendant documentation procedures. You must have in-depth experience with FDA interaction-CBER relation-ships highly desirable. A working knowledge of IND, PLAand NDA preparation is essential, as is a strong graspof GMP and GCP for effective interaction with Research,Quality, Clinical Affairs and Manufacturing groups. A BSin Pharmacy, Molecular Biology or Analytical Chemistryis required; an MS would be helpful.At Alpha-Beta we reward our talented staff with a com-petitive salary and benefits package as well as the sup-port, respect and recognition necessary for personalgrowth. Please send your resume in confidence to:Robert Sawdon, Alpha-Bela Technology, One Innova-tion Drive, Worcester, MA 01605 Principals. No phonecalls, please. An Equal Opportunity Employer.

Alcohol MetabolismFellowshiip.

The Unit of Pharmacokinetic Studies, Laboratory ofClinical Studies, invites qualified individuals to apply for apostdoctoral fellowship to study the effects of ethanol with-drawal on drug-metabolizing enzymes. Basic studies of en-zyme activity and clinical studies involving altered pharmaco-kinetics of therapeutic agents are ongoing. A background inbiochemistry or pharmacology and experience with in vitroenzyme assays and/or HPLC is preferred.

Individuals with less than three years postdoctoral experi-ence may apply by submitting a amdium viaae, three letters ofreference and a statement ofresearch interests to Ms. KathleenHanratty, Personnel Management Branch.

Alcohol, DrugAbuse, and MentalHea dii oanBuilding 31, Room 1B58, 9000 Rocville Pike Bethesda, MD 20892

Equal Oppoity Employr

SENIORSCIENTlSTTChiron Corporation is a leading East Bay-based biotechnol-ogy company developing products to diagnose, prevent andtreat serious human disease. We currently have an openingfor a Senior Scientist.

You will optimize the expression of recombinant therapeuticand diagnostic proteins in bacteria. You will also develophostlvector expression systems and genetic screens whilecollaborating on medium and culture condition optimizationwith fermentation development.

Requires a PhD and 5+ years' pharmaceutical/biotechnologyexperience. Strong background in microbial physiology andgenetics, and experience with heterologous protein expres-sion, are necessary. Interest in secretory protein processingand a creative, critical scientific approach to microbial ex-pression is desired. Individual must be highly self-motivatedand possess management and team leadership skills.

Chiron offers a competitive salary and benefits package.For immediate consideration, please send your resume toChiron Corporation, Human Resources Department, Box 92-181,4560 Horton Street, Emeryville, CA94608. We are an Equal Opportu-nity Employer.

C 0 R P 0 R A T I 0 N

THE DEPARTMENT OF OBSTETRICS,GYNECOLOGY, AND

REPRODUCTIVE SCIENCESUNIVERSITY OF PITTSBURGH

SCHOOL OF MEDICINEThe Department of Obstetrics, Gynecology and ReproductiveSciences at the University of Pittsburgh has the following full-timefaculty positions available:Assistant Professor of Obstetrics and Gynecology: A position is

available for an individual with a basic science backgroundstudying the biochemistry and molecular biology of endothelialcell responses. This individual should have extensive labora-tory experience, be able to work independently and be com-petent to train fellows and graduate students. Salary will becommensurate with experience, training, and achievements.

Assistant Professor of Obstetrics and Gynecology: A position isavailable for a basic scientist with a primary interest in molec-ular biology. The individual should be experienced in themolecular biology of connective tissue and be interested inarticipating in studies related to reproductive physiology.Experience and the ability to work independently is required,

as is the willingness and ability to teach and train postdoctoralfellows and graduate students. Salary will be commensuratewith experience, training, and achievements.

Professor of Obstetrics and Gynecology: Two positions areavailable for basic scientists experienced in the physiology ofpregnancy and parturition. Individuals should have a clearrecord of experience in working with groups of researchers,have a national reputation, and should be willing and able totrain graduate students and postdoctoral fellows.

Send inquiry and curriculum vitae for any of the above positions to:James M. Roberts, M.D.

Professor and Vice-Chairman, ResearchDepartment of Obstetrics, Gynecology

and Reproductive SciencesMagee-Womens Hospital

300 Halket StreetPittsburgh, PA 15213-3180

The University of Pittsburgh is an equal opportunity,affirmative action employer.

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TA

TECHNOLOGY

YRC-cMCNRC - Canada's top R&D organization - helps itsindustry partners become stronger global competitors.Currently, NRC's Institutefor Biological Sciences islooking for those rare people who can help further ourrecord of excellence.

The mission of the Institute for Biological Sciencesis to perform frontier research focused primarily onareas of mammalian biosciences that require a multi-disciplinary approach, hold good potential for appli-cation, and are oriented towards Canadian social,industrial and economic development.

Director General(Ottwas, OntIPo)

Reporting to the Vice-President, Biotechnology, theDirector General will provide leadership and direc-tion and will be responsible for management of theInstitute with respect to its mandated activities andeffective operation. The incumbent will manage threeresearch sections and an administrative group con-sisting of approximately 140 scientists, technical offi-cers and administrative personnel. The Director

General will also be responsible for a budget of $12million, including salaries. He/she will be expectedto form linkages and encourage collaboration withexternal organizations, both nationally and interna-tionally. As a senior NRC manager, the DirectorGeneral will also participate in the strategic planningof NRC.

Candidates must have a Ph.D. in a discipline relatedto the activities of the Institute, as well as extensiveexperience as a research scientist in University,Industry or Government and extensive experience inworking through individuals and groups, as a man-ager, to accomplish organizational objectives involvingthe planning, execution and review functions withinan R&D environment. Knowledge of both the Englishand French languages is required. A security screeningwill also be required.SALARY RANGE: From $81,800 to $101,400 per

annum.Apply in writing, before July 29, 1992, giving com-

plete details of education and experience to: TheRecruitment and Staffing Section, National ResearchCouncil of Canada, Ottawa, Ontario, K1A OR6. Inreply, please quote BS-92-01.SCI.

Na~ona Research Conseil naonaCouncl C ada d recherchesCanada

cawcNRC - Canada's top R&D organization - helps itsindustry partners become stronger global competitors.Currently, NRC's Institute for Biological Sciences islooking for those rare people who can help further ourrecord ofexcellence.

Research Officers(Ottawav, Ontano)The Institute for Biological Sciences performs fron-

tier research focused on areas of mammalian bio-sciences that require a multidisciplinary approach,hold good potential for application, and are orientedtowards Canadian social, industrial, and economicdevelopment. The Institute has advanced equipmentand facilities and provides for an integrated multidis-ciplinary approach in the areas indicated below.The Structural Immunobiology Section invites can-

didates with a strong interest in the chemistry or biol-ogy of cell surface carbohydrates who are interestedin applying the techniques of molecular biology tonovel problems in glycobiology.

The Protein Structure and Design Section invitescandidates in two specific areas. Trained crystallog-raphers are required with demonstrated abilities forsolving protein structures. Also required are candi-dates with a background in the use of structural databases, bioinformatics and computer modelling inprotein and peptide research.The Institute invites applications for up to three

staff scientific positions, with a term of up to fiveyears. Interested individuals must possess a Ph.D.in a relevant field. Successful applicants will beencouraged to compliment existing projects.

Applicants should submit a resume and a brief(five page) research proposal outlining realisticobjectives and resources requirements for researchin any of the above mentioned areas prior to July 30,1992 to: The Recruitment and Staffing Section,National Research Council of Canada, Ottawa,Ontario, K1A OR6. In reply, please quote referencenumber BS-92-00.SCI

No Natonal Research Conseil natonal*I~E Council Canada do recherches Canada Canada

I,' Canadl

POSITIONS OPEN

The Fogarty International Center (FIC), NationalInstitutes of Health (NIH), Public Health Service, Be-thesda, Maryland, is recruiting for the position ofPRO-GRAM OFFICER FOR BIODIVERSITY, GS-13/14 ($46,210 to $80,087 per year depending uponqualifications). Incumbent serves as staff specialist for allinstitutional and other award programs related to biodi-versity administered or supported by the Fogarty Inter-national Center. Applicants should have training andexperience in a scientific discipline related to biodiversity.For further information including qualifications require-ments, contact: Ms. Sharon Nie , PersonnelOfficer, FIC, at: 3014964625; FAX: 301-402-1135. Applications must be received by 22 June 1992.U.S. citizenship required. NIH is an Equal OpportunityEmployer.

CHAIRPERSONDEPARTMENT OF PREVENTIVE MEDICINE

AND COMMUNITY HEALTHTHE UNIVERSITY OF TEXAS

MEDICAL BRANCHGALVESTON, TEXAS

Applications are invited for the position of Professorand Chair ofthe Department ofPreventive Medicine andCommunity Health (PM/CH) in the School of Medi-cne. The University of Texas Medical Branch (UTMB)is a modemn health sciences center consisting of SchoolsofMedicine, Nursing, Allied Health Sciences, and Grad-uate Biomedical Sciences. Also on campus are TheInstitute for Medical Humanities, The Marine Biomedi-cal Institute, and the Shriners Burns Institute. UTMBhas a significant clinical component consisting of sevenhospitals, employs 8400 people, and has 2200 studentsenrolled. A faculty of 700 is involved in the teachingresearch, and service roles of the institution. UTMB iscommitted to the development of a Department ofPM/CH with strength in teaching, scientific inquiry, andservices which promote health and well-being. The suc-cessful candidate should be supportive of the mission ofpreventive medicine, should have an interest in develop-ing programs which focus on analysis of problems mhealth and medical care, and will be expected to interfacethis department with the other clinical departments andschools on campus and in the surrounding area.

Candidates must have a distinguished record of schol-arship and professional achievement and should demon-strate experience, strong leadership qualities, and admin-istrative ability. Curriculum vitae and names of three ormore references should be included with a letter ofapplication. Review of applications will begin 30 May1992. Send applications to: Dr. C .Cooper,Chair, PM/CH Search Committee, D rnt ofPharmacology and Toxicology J31, UTME, Gal-veston, TX 77550.UTMB is an Equal Opportunity/AflirmativeAction Em-

ployerM/F/V/H. UTMB hires only individuals authorizedto work in the United States.

FACULTY POSITIONPROGRAM IN PROTEIN STRUCTURE

AND DESIGNUNIVERSITY OF MICHIGAN

A search is being reopened for a tenured or tenure-track position (rank open) associated with the Progamin Protein Structure and Design. The academic appoint-ment will be in the Department of Chemistry, with a

joint research appointment in the Biophysics ResearchDivision. We seek an individual who will interact withand complement the existing structure groups in theprogram (x-ray crystallography; EPR, NMR, and vibra-tional spectroscopies; electron microscopy; theoreticaland computational techniques). Senior candidates musthave an internationally recognized proam, and juniorcandidates must provide evidence of ability to develop a

strong research program oriented around modern theo-retica approaches to analyzing and predicting proteinstructure and function. Teaching duties will be associatedprimarily with the Departnent of Chemistry. Interestedcandidates should send curriculum vitae documentingqualifications, professional accomplishments, and futureresearch plans and arrange for three letters of reference tobe submitted before 1 September 1992 to: ProfessorRobert L. Kuczkowski, Chairman, Department ofChemisty, The University of Michigan, Ann Arbor,MI 48109-1055. The University of Michigan is an

Affirnative Action/Equal Opportunity Employer.

POSITIONS OPEN

DIRECTOR FORGLOBAL CHANGE COORDINATIONJoint Oceanographic Institutions Incorporated (JOI)

is seeking a senior-lev scientist to head a community-based national office that will facilitate collaborativeplanning among U.S. and international ocean globalchange programs.The office will provide the ocean science community

with a central focus for information on research oppor-tunities; analyze long-term science requirements andfacilities availability; facilitate interagency planning forglobal change; produce newsletters and brochures forpolicy-makers and the public; provide material in re-sponse to requetsforinfbrmation from policy-makers, themedia and the public; and undertake other coordinationtasks at the request of NSF, other agencies, and scienceplanning committees, both national and international.The office is, at present, funded by the National

Science Foundation (NSF) under terms of a cooperativeagreement between JOI and the NSF. JOI is a consor-tium of ten U.S. academic oceanographic institutionsestablished to bring their collective capabilities to bear onlarge oceanographic research projects. The consortium, anonprofit corporation, acts as a coordinating body andmanager for its member institutions and the academiccommunity.

Qualifications necessary for the director's positioninclude a Ph.D. or equivalent experience in oceanogra-phy or related biological or earth science and a workingknowledge of the academic community and federal gov-ernmental agencies. Familiarity with the internationalscientific community is also desirable. Good organiza-tional, management, and writing skills are essential.

Please respond in writing to: Joint OceanographicInstitutions Incorporated, Attention: Personnel Of-fice-GC, 1755 M asscusetts Avenue, N.W., Suite800, Washington, DC 20036-2102.JOI is an Equal Opportunity Employer, M/F/V/H.

DIVISION HEAD, DIVISION OF NEPHROL-OGY AND HYPERTENSION. We are seeking adistinguished PHYSICIAN SCIENTIST who isBoard-certified in internal medicine and nephrology toprovide dynamic scientific and clinical leadership to theDivision of Nephrology and Hyrtension at the StateUniversity of New York (SUNY) at Stony Brook. Thedivision comprises 11 physician scientists, two Ph.D.'s,and four fellows who are stationed at Stony Brook andthe Northport Veterans Administration (VA) Hospital.The division's faculty is engaged in NIH- and VA-fundedresearch activities as well as active clinical programs.Please send correspondence about this position to: Dr.Barry Coller, Division of Hematology, SUNY atStony Brook, Stony Brook, NY 11794-8151. SUNYat Stony Brook is an Afllrmative Action/Equal OpportunityEducator and Employer.

A& UNIVERSMTOF%WFLORIDA

VICE PRESIDENT FOR RESEARCHAND DEAN OF GRADUATE SCHOOL

Applications and nominations are invited for the dualposition of vice president for research and dean of thegraduate school at the University of Florida. Successfulcandidates will have significant experience and demon-strated success in university-based research environments.The doctoral or equivalent degree in an appropriate areaof specialization and relevant experience are necessary.

Applications should include a current resume andnames, addresses and telephone numbers of at least threereferences. Nominations and applications should be sub-mitted not later than 15 September 1992 to: Dr. YngveOhm, Chair, Vice President Search Committee, Of-fice of the President, 226 Tigert Hall, University ofFlorida, Gainesville, FL 32611. The University ofFlor-ida is an Equal Opportunity/Affirmative Action Employer.Minorities and women are encouraged to apply.POSTDOCTORAL POSITION to study molecu-

lar, immunochemical and biochemical properties of neu-

roendocrine regulation in the inner ear. Candidatesshould possess a Ph.D. or M.D. degree. Experience inmolecular and cell biological techniques desired. Replyto: Dr. Kyle E. Rarey, University of Florida HealthScience Center, Department of Anatomy and CellBiology, P.O. Box 100235, Gainesville, FL 32610.Telephone: 904-392-3420, FAX: 904-392-3305.

SCIENCE * VOL. 256 * 12 JUNE 1992

University of LondonWye College

Department of Biochemistryand Biological Sciences

SERC and AFRC PostdoctoralResearch Assoclateships In

PLANT MEMBRANE TRANSPORTBIOPHYSICS AND BIOCHEMISTRYAppican are invited for PostdAssoahips in te area of plant and fugalmembrane transport. The posts are fundbythe British Science and Enginerin and tAgriculture and Food Research Councils onh RA1A scale (£12,129 to £19,328 per an-num; a further 6% increase pending). Bothposts are available starting 1 September 1992,in the first instance for up to 2 years. Thesucessul ca idates will pin an interdiscipli-na7y group at Wye College and te University

nnearby Canterury, engaged instructural and functional stues of ion chan-nels and H+-coupled taspore. One prolect,funded the SERC, focuses on charactesing K+ chan us sin record-ing techniques and incorporatng chn inplanar bilayers. The second project, funded byte AFRC, is directed tothe mechanism(s) andcontrol of NO - transpott and will invole ap-plying irsceular recording techniques-in-ciuding voltage campng and ion-selectiveeectrodes-s well as radioOcer flux metods. Some prior experience in these and/orreed techniqueswould be an advantage. Forfurther details, contact Dr. Michael R. Blatt[phone (0233) 812401 extension 371: fax(0233) 813140; ovseas prefi 44-233 and thenumber]. There is no closing date; applica-tions-to inciude a covering ler, curmculumvitae, list of publications and the names of threeindividuals from whom letters of reference maybe sought-h id be sent at the earliest pos-sible convenince to Dr. Blatt Deparbet ofBiochemistry and Bbigical Sciences, Univer-sity of London, Wye College, Wye, Kent TN255AH, England.Wye Collbge Is equa opportunis

HERMANN-VON-HELMHOLTZ-PROGRAMME

The government minister for re-search and technology is granting,within the framework of the promo-tional programme of

NEURO-BIOLOGYResearch grants for a limited timefor, in particular, qualified Germanyoung scientists in the sector ofneurobiology and who, after at leasta one year stay abroad, wish toreturn to Germany. The researchgrant will be awarded, as a rule, for2 years. It comprises a position onthe basis of BAT 11 a/b and aninclusive lump sum for appropriatematerials. The awarding of the re-search grant will be carried out onthe basis of a selection board pro-cedure according to scientific fac-tors. A return to the same institutewhere the candidate has beenworking in Germany before movingabroad is not possible for this grant.A leaflet concerning the researchgrant and application form can beobtained from the department re-sponsible at:Naturwlsensalches und Medi-zinlches Inst~ an der UnhvrstTObingen In Reudilngen, Gustav-Wemer-Sha 3, D-7410 ReutlngnTelq*po: 07121/3198 O, Teleax: -16

MC-cMCNRC - Canada's top R&D organization - helps itsindustry partners become stronger global competi-tors. Currently, NRC's Institute for BiologicalSciences is looking for those rare people who canhelp further our record ofexcellence.

Group Leader(Ottawa, Ontario)

The Institute for Biological Sciences requires an

experienced scientist to lead a group in proteincrystallography and molecular modelling. Theappointment is seen as a pivotal position at theinterface of structure-function determination andthe Institute's other groups involved in proteinengineering. The successful candidate will beexpected to formulate a research strategy in molec-ular modelling and structure determination thatbuilds on existing programs in the group and theInstitute's other sections. Currently this work

includes protein engineering, cathepsins, 1PTH B.Thuringiensis toxins, xylanase enzymes, molecularmodelling of carbohydrate antigens and antibodyengineering of their corresponding binding sites.

Applicants must possess a Ph.D. in Chemistry,Physics, Biochemistry or any other related field aswell as extensive post-doctoral experience in thefield of protein crystallography and/or molecularmodelling of proteins. A strong background instructure and function of proteins, knowledge ofthe use of modelling methods, and a generalknowledge of modem computer systems are alsorequired.SALARY RANGE: Commensurate with qualifi-

cations.Resumes should be forwarded prior to June 30,

1992, to: The Recruitment and Staffing Section,National Research Council of Canada, Ottawa,Ontario, K1A OR6. In reply, please quote referencenumber BS-92-05.GM

I_* National Research Conseil national* Council Canada de recherches Canada Canada

A TIMEFORACEEThe recent opening of the new Glaxo Inc. Girolami Research Institute, located in Research Triangle Park, NC, represents Glaxo's continued commitment in the pharmaceuticalindustry to the discovery ofdrugsfor unmet patient needs. Scientists engaged in Glaxo's expanding research and development programn at the Center have a premierfacility inwhich to work.The expansion of our Nuckar Magnefic Resonance Group, within the Department ofSloucuaand Diophyuic Chemiiy, has created inmediate openings for the followingprofessionals.

SR SCIENThST7be sected indWidual will work closely with biologists and medicinal chemists in the discovery ofnovl therapeutic entitiesfor the treatment ofcancer, inflammationor metabolic diseases. Tbis PhD. lee xposition requires previotxstpdcioral eFerience and proven skl~s in stnrctural determinations ofproteins or nucekic acidsusing multi-dimensional/multi-nuclear NMR methods. A strong pbyicl sciences acround with a working knowlede of nuclear spin physics is desired.Please refer toJob #9141-SS-SC on all resumes.

POSTI1XJ7RAL FELOWTbe selected individual wdi be responsiblefor methods developed and/or structure detomination of macrmolculs conidered to be innovative taygetsforpbarmaceutical intenention. We seek candidates with graduate training and intersts in multi-dtimnsinal/multi-resonance AMl methods and other NMRafplications for structural studies.Please refer to Job #9141-PD-SC on all resumes.Our state-of-the-art Structural and Biopbyical Cbemistry Department offers a stimulating, col/aborative environment among the established NM/ crstaography,computational, protein chemistry and mass spectroscopy groups. Our wor*ing environment includes BnruerAMX-6 and AMX-500 NMR spectrometers upgradedfortriple-resonance experiments, an extensive computing netwuotr wit an SGI-38(G7X computersewer, SG1, and access to the Comvex-220 and Cray Y-MPat the nearbyNorth Carolina Supercomputer Cener~Join Glaxo and enjoy an excellent salary, flexible benefits, an on-site recreation andfitness center, a spirit ofenthusiasm and teamwork and outstandingopportunities for career satisfaction. Equally appealing is our world famous scientific, industrial and academic community in Research Trangle Park NC. Sendyour resume, INDICAflNG THE CORRESPONDING JOB # and salary biory to: Huma Resouces Depaufmen Glaxo Inc, P.Q Box 13394 ReseacbThanle Park NC 27709. (No Pbone Calls or Agency Referrals, Please) An Equal Opportunity Employer MUIV.

Glaxo Inc.

RESEARCH SCIENTIST

Pharmacokinetics and Drug MetabolismSphinx Pharmaceuticals Corporation is a rapidly growing company dedicatedto the discovery and development of novel therapeutics for human diseasebased on interactions with key intracellular enzymes involved in signal trans-duction pathways.

We currently have an opening for a Research Scientist in our Pharmacokinet-ics and Drug Metabolism group. The successful candidate should have a Ph.D.in pharmacokinetics, biochemistry, or a related field with at least 1-3 yearsexperience conducting preclinical/clinical pharmacokinetic studies. Experi-ence with bioanalytical assay development using HPLC and GC desirable.

Sphinx Pharmaceuticals offers competitive compensation and comprehen-sive benefits as well as an attractive relocation policy. We are located in theResearch Triangle area of North Carolina which offers excellent living condi-tions and outstanding schools. For confidential consideration, please forwardyour curriculum vitae, list of publications and names of three references, to:SPHINX PHARMACEUTICALS CORPORATION, Position # 179, P.O.Box 52330, Durham, NC 27717. An Equal Opportunity Employer.

SPHINXPHARMACEUTICALSCORPORATION I

POSITIONS OPEN

A POSTDOCTORAL POSITION is available from1 September 1992 (negotiable) to work with Drs. BarryHalliwell and Carroll Cross, studying the mechanisms bywhich toxic gases (03, NO2, cigarette smoke) oxidativelydamage the human lung. Work will be based at Univer-sity ofCalifornia, Davis (UCD), but some visits to KingsCollege, London, to learn methods may be arranged.Applicants should have a Ph.D. in biological sciences orchemistry. Experience in HPLC, GC or MS is preferred.Apply to: Dr. Cross, Pulmonary Medicine, 4301 XStreet, UCDMC, Sacramento, CA 95817; FAX: 916-734-7924; telephone: 916-734-3564. Equal Opportu-nity Employer/Affirmative Action.

POSTDOCTORAL POSITIONS for recentPh.D.'s to participate in an action research program onthe structure, regulation and expression of human DNArepair genes and enzymes. Current research efforts focuson the molecule defects which underlie cancer-pronehuman genetic disorders and structural analysis of mul-tifunctional repair enzymes by site-specific mutagenesis.Submit curriculum vitae and the names of three refer-ences to: Dr. Michael A. Sirover, FELS INSTITUTEFOR CANCER RESEARCH AND MOLECULARBIOLOGY, Temple University School of Medicine,3420 North Broad Street, Philadelphia, PA 19140.Equal Opportunity Employer.

POSTDOCTORAL POSITION IN NEURO-ETHOLOGY to study the biophysical mechanisms ofendogenous burst generation and its modulation inneurons in Aplysia calfornica and the role of thesebursting neurons in the control of autonomic function.Experience in intracellular recording techniques is pre-ferred. Send curriculum vitae, names and addresses ofthree references, and brief statement of research intereststo: Dr. John Koester, Center for Neurobiology andBehavior, Columbia University Medical Center, 722West 168 Street, New York, NY 10032. AffirmativeAction/Equal Opportunity Employer.

POSTDOCTORAL POSITION. Available imme-diately to study the neuronal cytoskeleton using a widevariety of morphological and biochemical techniques.Principal interests in the laboratory indude the mecha-nisms by which axonal and dendritic microtubules areorganized and how they contribute to the fundamentalpolarity of the neuron. Send curriculum vitae and threeletters of reference to: Dr. Peter W. Baas, DepartmentofAnatomy, University ofWisconsin Medical School,1300 University Avenue, Madison, WI 53706.

POSTDOCTORAL POSITION IN MOLECU-LAR IMMUNOLOGY to study somatic mutation ofimmunoglobulin genes in B lymphocytes. Research willfocus on identifying DNA sequences that target hyper-mutation to antibody variable genes. Candidate shouldhave a strong background in molecular biology andimmunology. Please send curriculum vitae and threeletters of recommendation to: Dr. P. J. Gearhart, De-partment of Biochemistry, Johns Hopkins UniversitySchool of Hygiene, 615 North Woffe Street, Balti-more, MD 21205. Equal Opportunity Employer.

POSTDOCTORAL position available to study andro-gen-dependent gene expression and factors that interactwith receptor to confer transcriptional specificity. Regula-tion ofthe mouse sex-limited protein (Slp) gene is studiedby transfection, protein-DNA binding, and in transgenics.Knowledge ofmolecular biological techniques is required;experience in protein biochemistry is preferred. Send cur-riculum vitae and names of three references to: Diane M.Robins, Department ofHuman Genetics, University ofMichian Medical School, Medical Science II 4708,AimArbor, MI 48109-0618. Affirmative Action/EqualOpportunity Employer.

POSTDOCTORAL POSITION available immedi-ately at the University ofCalifornia, San Francisco, in thelaboratories of Dr. Susan Fisher and Dr. Caroline Dam-sky to study human placental (trophoblast) development.Previous experience in imunolocalization techniquesand in situ hybridization required. Some experience inother molecular techniques desirable. Send curriculumvitae and three letters ofrecommendation to: Dr. SusanFisher or Dr. Caroline Damsky, HSW 604, Univer-sity of California, San Francisco, CA 94143-0512.An Affirmative Artio~/Equal Opportunity Employer.

UNIVERSITY OF CALIFORNIA,IRVINE

COLLEGE OF MEDICINEDEPARTMENTS OF PSYCHIATRYAND BIOLOGICAL CHEMISTRYHUMAN MOLECULAR GENETICS:

ASSISTANT/ASSOCIATE/FULL PROFESSOR

The Department of Psychiatry has an imme-diate opening for a tenured or tenure trackfaculty position. Research should empha-size the application of molecular genetics/molecular biological approaches to under-standing inherited neurodegenerative orneuropsychiatric disorders. However, out-standing applicants in any area of humangenetics will be considered. The successfulapplicant will have a joint appointment in theDepartments of Psychiatry and BiologicalChemistry which, in conjunction with twoother departments, participates in a multidis-ciplinary Graduate Program in Molecular Bi-ology, Genetics and Biochemistry. This indi-vidual will also play an important role inhelping to develop a major Human Genomeeffort at U.C. Irvine. The appointment will bemade at the Assistant, Associate or fullProfessor level, depending upon back-ground and qualifications.Candidates should have a Ph.D. or M.D., atleast two years postdoctoral experience andshould have demonstrated excellence andproductivity in research. Applications shouldinclude a cover letter, curriculum vitae, astatement of research interests and thenames and addresses of three people whocan be contacted for letters of reference.Applications should be sent to: John J. Was-muth, Chair, Psychiatry/Biological Chemis-try Search Committee, Department of Bio-logical Chemistry, College of Medicine,D240 Med Sci I, University of California,Irvine, CA 92717.UCI is an Affirmative Action, Equal Opportu-nity Employer. Women and minorities areencouraged to apply.

THE AUCKLAND UNIVERSITYNEW ZEALAND

SENIOR LECTURESHIP(NON-MEDICAL) IN ANATOMY

Department of AnatomySchool of MedicineVacancy UAC 153

The vacancy is at the Senior Lecur (Non-Medi-cal) level for a person experiend in cell andtissue biology. The Departm of Anatomy iscurrenty acquiring funds for the purchase of aconfocal laser scanrig micrscope and the ap-pointee would have as a prime responsibility thelanagemntand direction ofthe confocal unit and

the a i computer graphics facility.Carites are expected to have an ap riae

qualifcquatio and teaching exper-ence in cell and tissue biology. They should have aproven record of research in an area of cel andtissue biology, and wel developed skis and expe-rience in confocal laser scanning microscopy andcomputer imaging technology. The successful ap-plicant must be qualified to assume responsiblityfor the academ direction, supervs and devel-opment ofconfocal mioscopyand the associatedcomputer graphics facility in te School of Medi-cine.Commencing salary will be bished within therange of $NZ52,000-$NZBO,944 per annum.Condito of Appointm and Method of Applica-tion are available from the Assistan Registrar,Academic Appointments, University of Audada,Private Bag, Aucdnd, New Zealand, to whomapplictions should be forwarded by 10 July 1992.Pease quote Vacancy Number UAC 153 in allcERrespondence.

The Unhewsrty of AucklandAn Equal Empo Opportnity Employer

WB NICOLL,REGISTRARUniverity of AudandPrivate BagAund, New Zeland

-a1

POSITIONS OPEN

POSTDOCTORAL POSITIONA position is available in gastrointestinal cell biology

to study the effects ofgastrointestinal peptides on variousgastrointestinal target cells in vitro. Candidate withexperience in cell biology, receptor binding assays, signaltransduction and cellular biochemistry is desirable. Sendletter stating interest, curriculum vitae, bibliography andnames of three references to: Dr. Jerry D. Gardner,Associate Chairman, Department of Internal Medi-cine, St. Louis University School of Medicine, St.Louis, MO 63104.

St. Louis University is an Equal Opportunity/AffirmativeAction Employer.

MYiu TUFTS UNIVERSITYSCHOOL OF MEDICINE

POSTDOCTORAL POSITIONS are available towork on two projects: one to analyze the mechanismsgenerating somatic mutation of autoantibodies and theother to define the interactions ofy/b T cells with B cells.Both projects will involve cellular and molecular tech-niques.

Applications, together with curriculum vitae and thenames of three referees, should be addressed to: Dr.Henry H. Wordis, Department of Pathology, TuftsUniversity School of Medicine, 136 Harrison Ave-nue, Boston, MA 02111. FAX: 617-350-8590.

POSTDOCTORAL POSITIONPhysiologically based modeling of metal (Zn, Cd, Hg)

accumulation in fish. Initial focus will be on modelingfish size-specific, accumulation kinetics. Training in theuse of radiotracers is essential. Must be a U.S. citizen.Send curriculum vitae and names of three references to:Dr. Michael C. Newman, University of Georgia'sSavannah River Ecology Laboratory (SREL), F.O.Drawer E, Aiken, SC 29801. Search will remain openuntil 10 July 1992. SREL is an Equal OpportunityEmployer. Women and minorities are especially encouraged toapply.

POSTDOCTORAL POSITION IN MOLECU-LAR PATHOLOGY. Available to study the pathogen-esis and develop new strategies for human genetic diseasemutation analysis in a well-established molecular pathol-ogy laboratory for 2 years. Candidates must have a Ph.D.or M.D. with experience in molecular genetics. Availablesummer or fall of 1992. Send curriculum vitae and thenames of three references to: Thomas W. Prior, Ph.D.,The Ohio State University, Department ofPathology,North 322 Doan Hall, 410 West 10th Avenue, (Co-lumbus, OH 43210. The Ohio State University is anEqual Opportunity/Affirmative Action Employer. Qualifiedwomen, minorities, Vietnam-era veterans, disabled veteransand the disabled are encouraged to apply.

SEVERAL POSTDOCIORAL POSITIONS avail-able for recent Ph.D.'s with experience in molecular biol-ogy to do work on identification of regulatory proteinsinvolved in gene expression and on projects ptaining tomolecular reproduction. Positions are availab for up to 3years at a starting salary ranging from $25,000 to $27,000Cdn. depending on experience and qualifications. Pleaseforward curriculum vitae and the names and addresses ofthree refrrences by 30 June 1992 to: Dr. John S. D.Chan, Uniersity of Montreal, Maisonneuve-Rose-mont Hospital, Research Center, 5415 Boulevard dePAssomption, Montreal, Quebec, Canada HiT 2M4.

POSTDOCTORAL POSITIONSCELL CYCLE REGULATION II

Persons interested in eukaryotic cell cycle research areinvited to apply for postdoctoral positions in the labora-tory of Steve Osmani [see EMBO]. 10, 2669 (1991);Cell 67, 283 (1991); EMBOJ. 11, no. 6 (in press) forrecent publications and Nature 353, 701 (1991) forreview].The Weis Center is a well-equipped modem research

facility located in an attractive region of central Pennsyl-vania. Competitive salary and fringe benefits are avail-able. For consideration, please send curriculum vitae andnames of three references to: Human Resources De-partient (SO), Geisinger Clinic, 100 North Acade-my Avenue, Danvile, PA 17822-3024.

| ~~~Research ScientistsIMMUNOLOGISTS/VIROLOGISIS

Wyeth-Ayerst Research is a major division of Fortune 100 American Home ProductsCorporation, a leading manufacturer and marketer of health care products withmulti-billion dollar annual sales and an impressive record of growth and profitability.

As a GLOBAL research-based pharmaceutical company, we are committed tohelping people lead healthier lives through innovative pharmaceutical andnutritional products. It is from this commitment and position of strength that wemove forward with a major expansion of our research and development activities.

We currently have opportunities for Research Scientists within the Biotechnologyand Microbiology Division of our Radnor, PA headquarters. You will be part of a

team working on anti-viral and vaccine approaches to Human Papillomaviruses. Theideal candidates will have a Ph.D., at least 3 years post-doctoral experience and a

record of high productivity in the field of virology. Preference will be given tocandidates with a solid background in viral immunology and/or expertise in in vitroand in vivo papillomavirus models (HPV, CRPV, BPV).Wyeth-Ayerst offers excellent compensation and benefits programs. For immediateconsideration, forward your resume in confidence to: WYETH-AYERSTRESEARCH PERSONNEL, Position #57, P.O. Box 8299, Philadelphia, PA19101-0082. Equal Opportunity Employer, M/F/D/V responses encouraged.Principals Only.

____________________________ Valuing diversityrecognizing service

Co-ordinatorForest Ecology/Impact

$46,000 - $70,800 (Cdn Funds)The Ministry of Natural Resources, Ontario Forest Research Institute,seeks a knowledgeable research scientist to provide scientific andadministrative leadership to the forest-ecology/impact researchprogram. Working at the Centre for Northern Forest EcosystemResearch, you will advance knowledge of forest-ecosystem structure,function and processes necessary to evaluate impacts on the forestenvironment and improve forest-management practices. Location:Thunder Bay, Canada.Qualifications: Master's degree in forestry or biological science, withspecialization to the PhD level, or equivalent experience, in forestecology and environmental impacts; extensive practical application inforest-ecology research; proven leadership skills; comprehensiveknowledge of ecosystem dynamics, silvicultural methods, soilprocesses, plant growth and development, statistical methods, and useof laboratory and field equipment; superior communication skills.Please send application or resume, quotin!g file NR-2028/92, by July 20,1992 to: Human Resources Section, Ministry of Natural Resources,70 Foster Drive, Suite 400, Sault Ste. Marie, Ontario, Canada, P6A 6V5.

Ontario(| Public Service

DEDICATED TO EMPLOYMENT EQUITY

mI1Am

yof California l OPPORTUNITIES INiton of Chan- mintment will be

ne of the nine Gelman Sciences is forming a BIOTECHNOLOGY PRODUCT

voted solely to DEVELOPMENT TEAM to work together within tissue culture and

remost health biotechnology filtration markets to assess customer needs and identify

ledicine, Nurs- new product direction. The team will have responsibility for translating

vard advanced highly technical abstract ideas into specific product prototypes.

e basic natural This high technology manufacturer of microfiltration products for re-e campus is a search laboratories, health care and process industries seeks creative,

esearch in the highly motivated individuals with a minimum of 3 years experience in

t enrolment is developing products to meet the needs of the scientific consumableabout 15,000.

billion dollars. A combination of the following qualifications along with excellentan Ambulatory communication skills is required.Institute whichind research. In LABORATORY TECHNOLOGY DEVELOPMENT/MARKETINGin some 10~BS,MSor Ph.D. incell ormolecularbiologyor immunology,experience

ie campus and in separation sciences with marketing/sales ofconsumablesa big plus.

Me of Universityagated powers ENGINEERING TECHNICAL DEVELOPMENT SPECIALISTadministration. BS or MS in Engineering field with experience designing plastic

rably research prototypes and familiarity in working directly with customers.

e record. Appli- For immediate consideration forthesechallenging opportunities, please

Id nominations send your resume and salary history to:

><lbGeimanSciencesHuman Resources Department

Blotechnology Product Development

92, to be given 600 S. Wagner Road, Ann Arbor, Ml 48106

N EMPLOYERGelman Sciences i an Equal Opportunity Ermployer

Chemical

FAulty Position

University of Rhode IlandPh.D. SCENTIST Graduate School of m

TAc~~~~~~~~~~~~~~e invie persons specializing in open-ocean pro-|CAfT1 URERllt cesses to apply for a tenure-track faculty posi-

tion in Chemical Oceanography. A Ph.D. is re-Pall Corporation has achieved global quired by the time of hire, and the position willleadership in filtration due to our pur- be filled at the Assistant or Associate Professor

suit of technological excellence. level. The successful applicant must demonstrate

We seek anindividual to provide the ability to establish an active research pro-We seek an individual to provide gram, advise graduate students, and develop and

technical support for our Biomedical teach one or more courses in marine chemistry

Products delivering presentations and and related areas. For the rank of Associate Pro-seminars to leading hospitals, medical lessor, the applicant must have demonstrated a

education institutions and professional strong record of independent research and

societies. You will work in conjunc- publication.

tion with our Regional Managers Preference will be given to persons with ex-

throughout the country. perience in studying the use of chemical tracers

To qualify you will have 3-5 years or biogeochemical cycles, in either case with a

experience & a Ph.D. in Physiology, focus on the open ocean. In addition, preference

Cell Biology, or Life Sciences. An will be given to candidates who show promise

interest or background in health care of complementing other programs at the Graduate

or medical research along with previ- School of Oceanography, including physical

ous teaching experience is helpful. oceanography, marine and atmospheric

Extensive travel required.chemistry, biological oceanography, and paleo-oceanography. The preferred date of hire is on

You will receive a competitive salary or before Jan. 1, 1993.

& participate in our comprehensive Send curriculum vitae, the names of fourbenefits program. Only resumes with references and a summary of research interestssalary history will be considered to Professor Michael E.Q. Pilson, Search Com-

mittee Chair, Marine Chemist (Position No.Human Resources DepL (SL.521) 091117), University of Rhode Island, P.O. Box G,

Kingston, RI 02881. Applications will be reviewed

2200PALL COBRP. beginning July 1, or unIianAtion/eqlion is filled.

>b2200 NORTHERN BLVD. URI is an Affirmative Action/Equal Opportunity

EAST HIIlS, NY 11548 Employer.inFIr~ iAn Equal Oppouniy Em~loy

CHANCELLORUNIVERSITY OF CALIFORN

SAN FRANCISCOThe President and The Regents of the Universilinvite nominations and applications for the poscellor of the San Francisco campus. The appoieffective July 1, 1993.The University of California, San Francisco, is ccampuses of the University, and the only one delthe health sciences. It is one of the world's fosciences universities. Its schools of Dentistry, Ming, and Pharmacy and the Graduate Division avprofessional degrees and doctoral degrees in theand behavioral sciences relevant to health. Thimajor clinical and research center for cancer treplantation, AIDS, pediatric specialties and for rbasic biomedical sciences. The 1991-92 studenapproximately 3,750; faculty and staff numberThe campus annual budget is approximately oneThere are three general acute-care hospitals, ECare Center, and the Langley Porter Psychiatricis devoted to psychiatric patient care, teaching ataddition, the campus has affiliated programsinstitutions throughout California.The Chancellor is the chief executive officer of this responsible to the President. Within the scopepolicy the Chancellor exercises very broad delland is responsible for all aspects of campus;Candidates should have demonstrated experieministration of substantial organizations, prefeiuniversities, and should have a strong scholarlycations, accompanied by current resumes, anmay be addressed to:

The PresidentAttn: Search B300 Lakeside DriveUniversity of CaliforniaOakland, California 94612-355

And should be received no later than July 8, 191full consideration.AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTIOI

Quality ControlManager

A leading biotechnology companyon Long Island, NY has a groundfloor opportunity for a hands-onQuality Control Manager respon-sible for performing and managingall QC activities and establishingSOP's to achieve GMP levels.Must have B.S./B.A. in Biology orChemistry plus 3-5 years' experi-ence with GMP level qualitycontrol systems within the biotechindustry. Knowledge of antibody,immunoassay and DNA probeproducts desirable. Strong commu-nication and interpersonal skillsessential.Qualified candidates may submitresumes, including salary historyto:

Oncogene Science, Inc.106 Charles Undbergh Blvd.

Uniondale, NY 1 1553ATTN: FR

Equal Opportunity Employer

1

U.S. Department of Energy DistinguishedPostdoctoralRelserch ProgramRes~earch Opportunities .nPb.ysica.Sciences," Com'puter' Sciences,. andEngineering ., ...

Research in DOE-ponsore programs... ..:TeG.nambl at various natonllaboratorIes :.- .

..Stipen of $52,800 .....

Doctoral degree rec.l.ed.ae..r 1989U..... ..... '.eligib

Application de .1..2.

.......

For Information and ajpplkclons: ...

DOE Distinguish Potd ...raRe.rh Program.. ...

Science/Engineering Educition..Division .. :

~~~~~~~~~~~~~~~~~~~~... ............. .. .......

Oak RidgeInstitue Scinc. and Edui .........cP.O. BoxI.17US.......akS idge, Tennese 38 ..1..1........

(615)576-9934

... ... ... ~ ~~~~~~~~. ..

DSooral by l. US.Dof E ot;n~vmsoly redS en -dW.c 1989

h [.2:~~~.

Postdoctoral FellowDEVELOPMENTAL HEMATOLOGY

AmgtP, ri industry leader in applied biotechnology, has anopportunpity for a Postdoctoral Scientist in the Cell BiologyLaborato of the Developmental Hematology DepartmentThe m rea of interest in this group is the study and identi-.. finovel growth factors controlling early developmentof hmatopoietic stem cells and primitive progenitors of the:yeloid and lymphoid lineages.Candidates for this position must have a Ph.D. in Cell Biology,

pr.eferaby with an emphasis on hematopoietic cell growthand diffrentiation. Experience with both in vitro and in vivoassays and models is highly desirable.

.... :. ..i... ..

.s..1~~~~~~gmWi nt iw.hich individual contributions and achievements are highlyvalued. There are excellent opportunities for personal andcareergriowth and a strong compensation and benefits pack-age, including equity offerings. Qualified candidates shouldsend a resume, in confidence, to: Amgen Inc., Dept IM,Mail Stop T-1-A-207, Amgen Center, Thousand Oaks, CA91320-1789. Amgen is an equal opportunity employer.

AMOEN.oPrincipals only, please.

RESEARCH SCIENTISTSThe Miles Research Center (MRC) in West Haven is the U.S.pharmaceutical research arm of Miles Inc., Pittsburgh, locat-ed on a campus-like setting near the Long Island Sound. TheMRC is being developed into a world-class research complex,including a new research institute for metabolic diseases.

This institute will be developed to uncover the basic mecha-nisms in the pathophysiology of type II diabetes, its complica-tions, and obesity with a long term goal of developing noveltherapeutics for the treatment of these diseasesApplicationsare now being accepted from Ph.D. or M.D. scientists whowant to conduct research on insulin action and signal trans-duction mechanisms, glucose transport, insulin secretion, obe-sity and appetite regulation and complications of diabetes.

The applicants should have 2 or more years of postdoctoralexperience that demonstrate creativity and productivity in re-search in these or related areas. Backgrounds in molecularbiology, biochemistry, cell biology or physiology are desirable.

Miles Research Center offers highly attractive compensationcommensurate with qualifications and a benefits packageincluding 401(k) and relocation assistance. These positionsand the research environment inour new West Haven facilityallow for a professional working environment conducive tocareer development. For immediate and confidential consid-eration, please send your resume including salary history to:Dept. CC-MD, Miles Inc., 400 Morgan Lane, West Haven,CT 06516. An Equal Opportunity Employer M/F/H/V.

The University of Ziurich, Switzerland, Instituteof Physiology, invites applications for the tenuredposition (at the Extraordinariat level) of a

Professor of PhysiologyApplicants should have an outstanding researchrecord in neurophysiology, e.g. on sensory sys-tems, nerve-muscle interactions or developmen-tal neurophysiology. Preference will be given tocandidates working at the cellular level with astrong background in advanced electrophysio-logical and molecular techniques. The candidateshould be able to teach in German within twoyears.Applications are to be sent before June 30th1992 to Prof. B. Gahwiler, Physiology SearchCommittee, Brain Research Institute, AugustForel-Strasse 1, CH-8029 Zurich/Switzerland.Applicants are asked to first request instructionsfor the format of the application from: Medizinis-ches Dekanat, UniversitAt Zurich, Gloriastr. 23,CH-8091 Zurich, Fax (01) 255 45 65.

=- ---- -- --- 1 1

E

againin Pharmaceutals Inc.

Scientist/Senior ScientistSepsis/ShockCandidates should have interest andexperience in:* in vivo animal models; monitoring

physiological parameters* testing and evaluatingpharmacological agents

* statistical analysisWe are seeking a motivated Pharma-cologist/Physiologist for researchand programs investigating sepsisand shock and anti-in fectivesdevelopment. Candidates must havea Ph.D. with 5+ years experience.Supervisory experience a plus.

Assistant/AssociateScientist VirologyCandidates should have interest andexperience in:

* molecular biology techniques* manipulation, growth, propagationand culturing human and animalviruses (e.g. vaccinia, polio)

We are seeking an energetic, highlymotivated individual with a BS or MSand 3+ years experience to workwith a renowned Senior Scientist as

part of an antiviral drug discoveryteam.

For consideration, please submit cu-

rriculum vitae (indicate positiondesired), description of researchinterests and salary requirements to:Director of Human Resources,MAGAININ PHARMACEUTICALS INC.,5110 Campus Drive, PlymouthMeeting, PA 19462.

Magainin Pharmaceuticals Inc., islocated in new, state-of-the-art facilitiesin suburban Philadelphia. We offerexcellent salaries, benefits, outstandingscientific interactions and theopportunity to change the future oftherapeutics. An Equal OpportunityEmployer. No phone calls, please.

POSITIONS OPEN

POSTDOCTORAL POSITION available immedi-ately to join an active research group studying thephysiology and molecular biology of the human prolac-tins. Caididates must have either a Ph.D. or M.I. andexperience in molecular biology, cell culture, or proteinbiochemistry. Send curriculum vitae and names of threereferences to: Dr. Edith Markoff, Division ofEndocri-nology, Children's Hospital Medical Center(CHMC), Eliand and Bethesda Avenues, Cincinnati,OH 45229. CHMC is an Affirmative Action/Equal Op-portunity Employer.POSTDOCTORAL POSITIONS. Positions are im-

mediately available for fellows to work on immunobiol-ogy of HIV or T cell/NK cell recognition of bacterialantigens. Send curriculum vitae and references to: Dr.Gary R. Klimpel, Department of Microbiology J-19,University of Texas Medical Branch (UTMB),Galveston, TX 77555-1019. UTMB is an Equal Op-portunity M/F/H/VAflirmative Action Employer. UTMBhires only individuals authorized to work in the UnitedStates.

POSTDOCTORAL POSITIONS: (1) Examine thebasis for ethanols effects on calcium channels in peptid-ergic nerve terminals (2) examine the basis of action ofgeneral anesthetics on ligand-gated receptors and voltage-gated channels expressed in oocytes from mRNA. Train-ing in voltage clamp techniques and/or molecular biologyis required. Please send curriculum vitae and the names ofthree references to: Dr. Steven N. Treistman, Depart-ment of Pharmacokogy, University of MassachusettsMedical School, 55 Like Avenue North, Wormer,MA 01655. The University of Massachusetts is an EqualOpportunity Employer.

POSTDOCTORAL POSITION available 1 July1992 to study erythroid transcription regulation (partic-ularly nuclear matrix/cis-acting factors interrelation).Experience in basic molecular biology techniques and/orcell culture preferred. Send curriculum vitae to: Dr.Ronald Nagel or Dr. Eric Bouhassira, Department ofMedicine/Hematology, Albert Einstein College ofMedicine, 1300 Morris Park Avenue, U-921, Bronx,NY 10461. U.S. citizen orgreen card required.

POSTDOCTORAL POSITIONThe Institute of Wildlife and Environmental Toxicol-

ogy has an immediate opening for a POSTDOCTOR-AL FELLOW to use a geographic information system ina generalized ecological risk classification for farm ponds.Must have a strong background in the use ofARC/INFOsoftware. Experience with SUN workstations and/orremotely sensed data is desirable. One-year position withpossibility of extension. Salary will be $25,000 to$30,000. Applicants should send curriculum vitae andthree letters of recommendation to: Dr. KennethDixon, The Institute of Wildlife and EnvironmentalToxicology, P.O. Box 709, Pendleton, SC 29670.MOLECULAR BIOLOGY POSTDOCTORAL/

RESEARCH ASSOCIATE: Several positions areavailable to become part of an interdisciplinary researchteam using molecular biology to study growth, develop-ment and differentiation. The successful candidate(s) willutilize either the lysyl oxidase or protamine gene system.Interested individuals should forward their curriculumvitae, copies of representative publications and threeletters of recommendation to: Dr. Stephen A. Krawetz,Department of Molecular Biology and Genetics,Wayne State University (WSU) School of Medicine,2228 Scott Hall, 540 East Canfield, Detroit, MI48201. WSU is an Equal Opportunity Employer.POSTDOCTORAL FELLOWSHIP-HIV RE-

SEARCH. Section on Clinical and Molecular Retrovi-rology, Laboratory of Immunoregulation, National In-stitute of Allergy and Infectious Diseases, National In-stitutes of Health (NIH), Public Health Service, hasavailable a 2- or 3-year intramural research fellowship tostudy gene transfer and adoptive immunotherapy inAIDS treatment. Candidates wishing to begin researchbetween 1 July and 1 September 1992 are encouraged toapply. An M.D. or Ph.D. degree is required, and a strongbackground in molecular genetics is preferred. Salaryrange: $32,000 to $38,500 per year. Send curriculumvitae and the names of three references to: Dr. David I.Cohen, Laboratory of Immunoregulation, NIAID,NIH, Building 10, Room 11B13, 9000 RockviilePike, Bethesda, MD 20892. Meets requirements forNIH HIV Loan Repayment Program. NIH is an EqualOpportunity Employer.

POSITIONS OPEN

POSTDOCTORAL FELLOWSHIPSBRAIN DRUG DELIVERY

UCLA BRAIN RESEARCH INSTITUTE. Na-tional Research Service Award Institutional TraiingProgram supports 2- or 3-year postdoctoral researcfellowships to study brain drug delivery and blood-brainbarrier transport biology. Experience in oligonucleotideor peptide chemistry, receptor biology, and animal phys-iology and pharmacology desired. Competitive salaryplus medical insurance. Positions available now and in1993. Send curriculum vitae and three letters ofreferenceto:

Dr. William M. PardridgeBrain Research Institute

University of California Los AngelesSchool of Medicine

Los Angeles, CA 90024-1761or FAX to: 310-206-5163.An Equal Opportunity Employer.

U.S. Department of Agriculture (USDA), Agricultur-al Research Service (ARS). SOIL MICROBIOLO-GIST, Horticultural Crops Research, Corvallis, Oregon.POSTDOCTORAL RESEARCH ASSOCIATE willwork on aspects of symbiotic biology involving VA-mycorrhizal fungi and N2-fixing bacteria under green-house and in vitro conditions. Experience with VAMfungi, familiarity with plant physiology and biochemistryrequired. Two-year, renewable appointment. Startingsalary: $32,000 per year with benefits. Call: GaborBethlenfalvay at 503-750-8785 (research), or PatRoberts at 301-344-3138 (application procedures).Inquiries should be received by 2 July 1992. ARS is anEqual Opportunity Employer.

ASSISTANT RESEARCH SCIENTISTA POSTDOCTORAL position is available in the

laboratory of Dr. Ross Basch to study the growth anddifferentiation of human hematopoietic cells in immu-nodeficient mice. The research involves the isolation andcharacterization of the human bone marrow cells whichserve as hematopoietic progenitors. Experience in tissueculture and molecular biology is desirable.

Salary is competitive and excellent fringe benefits areprovided.

Please send your curriculum vitae to: Dr. R. S. Basch,Department of Pathology, New York UniversityMedical Center, 550 First Avenue, New York, NY10016. Equal Opportunity Employer MIF.

CHEMISTRY, RESEARCH ASSOCIATE. Dryline synthesis of metal oxoalkoxides, complexes of poly-oxometalates with 0, N donor ligands; characterizationusing multinuclear NMR, IR, EPR, GC-MS techniques;electrochemistry and x-ray crystallography. Candidateshould have Ph.D. degree in inorganic chemistry anddemonstrate strong background in synthesis of metal-oxide materials, organic ligand synthesis and spectro-scopic characterization tecg:ques, single-crystal x-raydiffraction. $23,300 per year full time. Send resume, listof publications, and three professional references by 13July 1992 to: Inorganic Research Associate SearchCommittee, Department of Chemistry, Room 1-014CST, SYRACUSE UNIVERSITY, Syracuse, NY13244-4100. Affirmative Action/Equal Opportunity Em-ployer.

RESEARCH ASSOCIATE for university in centralOhio. Develops and implements computer-user interfacesystems and equipment for protein sequence searching ofbiological databases; constructs computer instrumentinterfacing equipment to study transport of drugs acrossmembranes and interfaces; assists in preparation of grantproposals and publishes articles in peer-reviewed jour-nals; develops and installs software; oversees graduateresearch assistants. No experience required in aboveduties but applicants will qualify with Ph.D. in pharma-ceutical analysis or analytical chemistry and 2 years ofresearch experience in constructing computer-instrumentinterfacing equipment to study transport of drugs acrossmembranes, programming in C and Assembly languagesand using IBM AIX operating system (experience may begained concurrent with degree). Forty hours per week,8:00 a.m. to 5:00 p.m., Monday to Friday; salary:$25,320 per year. Must haveproofoflegal authority to workpermanently in the United States. Send resumes in dupli-cate (no calls) to: G. Maugans, JO #1260385, OhioBureau of Employment Services, P.O. Box 1618,Columbus, OH 43216.

SCIENCE * VOL. 256 * 12 JUNE 1992

- ----- -------

Section Qes.

Membrane Biophysics.

The Laboratory ofMembraneBiochemistry and Biophysics, directedby Dr. Norman Salem, Jr., conductsbasic and clinical studies on the func-tions of polyunsaturated lipids. Thisnewly formed laboratory is seekingapplications for two tenure-track posi-tions at the Section Chief level provid-ing an opportunity to form and adminis-ter their own research group. These willbe in the areas ofNMR and Fluores-cence Spectroscopy and are availableimmediately.

It is expected that each section will

focus upon a series of interrelated prob-lems dealing with the molecular associa-tions, biophysical properties, protein-lipid interactions and membrane func-tions of polyunsaturated phospholipids.Of particular interest are those speciescontaining docosahexaenoic acid(C22:6n3), an essential fatty acid in thenervous and visual systems. Studies willbe conducted in collaboration withbiochemists and the Section ofMassSpectrometry. The laboratory is wellequipped with its own NMR spectros-copy and fluorescence lifetime instru-

mentation and future expansion isplanned. The NMR group will also haveaccess to imaging instrumentationwithin the NIH In VivoNMR Center.

Salary is negotiable and dependsupon skills and experience. U.S. citizen-ship or permanent resident status isrequired. Minority applicants are en-couraged to apply. Interested applicantsshould apply by submitting a cumeulumvitae, three letters of reference and astatement of research interests to Ms.Kathleen Hanratty, Personnel Manage-ment Branch.

_=~~~~~~~9_AlcholDrugAbuse, and Mental Health Administii

Building 31, Room 1B58, 9000 Rockville Pike Bethesda, MD 20892Eq Oppo Employer

SAVE 25%Running your recruitment advertisement oncemay not be enough. Place the same ad againwithin the next four issues and we will give you25% off your second insertion.

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Science Classified Advertising1333 H Street, N.W.

Washington, D.C. 20005Phone: 202-326-6541/6555

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The Institute of Molecular Biology, Inc. (IMB) is a rapidlygrowing biotechnology company committed to bringing qualitypharmaceuticals to the health care field. IMB offers theopportunity to work among a group of dedicated, highlyrespected scientists in a newly constructed facility in theMassachusetts Biotechnology Research Park locatedapproximately 40 miles outside Boston, MA. IMB is seekingto fill new positions in the following areas:

Senior Molecular BiologistDevelop and optimize unique expression systems for recom-binant proteins, particularly yeast and E. coli; work closelywith manufacturing in scale-up of processes. Identify andcharacterize unique genes using Northem and Southernhybridization; cloning, sub-cloning and sequencing tech-niques. Expression of novel proteins. Requires Ph.D. inmolecular biology. Two to three years' work experience inmolecular biology and/or completion of post-doctoral trainingpreferable.

Applied Research ScientistThis position involves designing and conducting in vivo effi-cacy studies in several areas of tissue repair and coordinat-ing the conduct of the supporting analytical and in vitro evalu-ations. The ideal candidate would have expertise in: 1. Thephysiology of bone/nerve/skin growth or repair; 2. Polypeptidegrowth or differentiation factors; and 3. The statistical analy-sis of data and writing of scientific reports. A working knowl-edge of common protein chemistry and molecular biologytechniques helpful. Requires an M.D., Ph.D., D. V.M. orequivalent.IMB is an equal opportunity employer and offers competitivesalary and benefits. For consideration please send yourresume to: Human Resources, Institute of MolecularBiology, Inc., One Innovation Drive, Worcester, MA01605-4308.

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IBI, the leading developer ofMacintosh applications for

molecular biology research, isseeking two people to join ourin-house development team.

Ui~ii1!Experienced software

professional to manage in-houseMacintosh development team.Knowledge of "C", the Mac

Toolbox, and experience in a teamenvironment a must. Cross

platform experience (Windows,OS/2, OPEN LOOK and otherGUl's) would be desirable.

Experienced Macintoshprogrammer to develop and

maintain cutting edge Macintoshapplications. Must haveexperience with "C" on the

Macintosh. C++, experience withobject-oriented programming

techniques, and the LifeSciences desirable.

Competitive compensationpackage includes paid medical,

dental insurance andcompany bonus.

If you are interested in joiningthe IBI and Kodak team in

developing innovative softwaretools for the Life Science Research

community, send a currentresume, including salary historyand position desired, to IBI,

Software Development Group.

INTERNATIONAL BIOTECHNOLOGIES, INC.Subsidiary of Eastman Kodak Company

A_ P.O. Box 9558, New Haven, CT 06535

An Equal Opportunity Employer

Cardiovascular DiseaseCOR Therapeutics, Inc. is a young, growing biotechnology company located in theSan Francisco Bay Area. We specialize in the development of novel therapeutics forthe treatment of various aspects of atherosclerosis-induced cardiovascular disease.COR is actively recruiting highly qualified Scientists to join our multidisciplinaryresearch teams in the following areas:

IN VIVO PHARMACOLOGY We are seeking a Scientist with a pharmacol-ogy background to develop thrombosis and vascular cell proliferation animalmodels and to evaluate anti-restenosis compounds.

CELLULAR ADHESION INHIBITORS- We are accepting applications fromindividuals to participate in a program to develop inhibitors for cellular adhesionsrelating to thrombosis, inflammation and reperfusion injury. The successful candi-date will have a PhD and postdoctoral experience in cell biology or biochemistry.

ORGANIC/MEDICINAL CHEMISTRY Medicinal Chemists are sought forour drug discovery efforts in receptor antagonists and protease inhibitors based onsynthetic peptide leads.

PROTEIN CHEMISTRY -One position exists for a Scientist with a backgroundin protein chemistry to work on purification and structure/function relationships ofcoagulation proteins.

COR Therapeutics, Inc. offers competitive salaries, benefits and attractive equitypositions to its employees combined with the challenge and opportunity to makesignificant research contributions. To apply, please send curriculum vitae to: CORTherapeutics, Inc., Human Resources (Ref. #J92), 256 East Grand Avenue,South San Francisco, CA 94080. COR is an equal opportunity employer.

R< COR THERAPEUTICS, INC.

Reprinted from the April 3 issue of SCIENCE this specialsection explores exciting new techniques and innovations

taking place with computer technology in science.

Highlights of this special section include:* Computer Experimentation - from physics to biology* Massive Parallelism - promises and problems* Mathematicians and the Computer Revolution*Overview of New Products

To order your copy send $3.00 plus postage to: SCiENCEPostage (per copy): US: $1.50 Attn: Corrine Harris

Int'l Surface: $2.00 1333 H Street, N.W.Int'l Air: $5.00 Washington, D.C. 20005

Visa and MasterCard orders accepted by fax (202) 682-0816For information on bulk orders call (202) 326-6527

POSITIONS OPEN

RESEARCH ASSOCIATE for northwestern Ohiobiomedical research facility. Research project studyingthe protein P59. The duties of research associate in thisprogram include: (1) grow and maintain the IM9 cellline of human lymphocytes, (2) isolate and purify P59and other steroid receptor binding proteins and heatshock proteins with conventional chromatography, im-munoaffinity chromatography, HPLC, gel filtration, etc.,(3) perform various assays to characterize the purifiedproteins, such as Western blot, gel electrophoresis, ligandbinding study, reconstitution, etc., (4) clone the genemapping chromosome crawing, etc., (5) express theisolated gene in mammalian cels, and (6) perform site-directed mutagenesis to investigate the structure-func-tion relationship. M.S. in pharmacology or molecularbiology with the master's project being a laboratorystudy in protein purification and characterization as wellas molecular cloning required. No experience required.Forty hours per week, hours 8:30 a.m. to 5:00 p.m.,Monday to Friday; salary: $24,000 per year. Must haveproof of legal authority to work permanently in the UnitedStates. Send resume in duplicate (no calls) to: G.Maugans, JO #1333689, Ohio Bureau of Employ-ment Services, P.O. Box 1618, Columbus, OH43216.

RESEARCH ASSOCIATEDEPARTMENT OF CHEMISTRYMASSACHUSETTS INSTITUTE

OF TECHNOLOGY (Mfl)The Massachusetts Institute of Technology Depart-

ment ofChemistry has an immediate opening for a Ph.D.in chemistry or physics to participate in high-resolutionstudies of liquid-crystal phase transitions.

Candidate must have a strong background in ac-calorimetric techniques, electronic design, computer con-trol, and data processing. Experience with liquid crystaltheory and glass transitions also required. The work willinvolve both calorimetric research on thermotropic liq-uid crystals and significant design, construction, andtesting ofnew high- and low-frequency dynamic specific-heat spectroscopy. Salary range: 25,000 to $30,000 peryear. Send r6sume and names of three references to:

Professor Carl GarlandRoom 6-237

Massachusetts Institute of TechnologyCambridge, MA 02139

MIT is an Equal Opportunity/AffirmativeAction Employer.

RESEARCH SCIENTISTS (Two positions). Du-ties: Carry out laboratory functions related to isolationand characterization of natural products with experiencein chromatographic separations and HPLC analysis.Requirement: Ph.D. in a science. Preference: Experiencein natural products research. Salary range: $23,000 to$27,000 per year.BOTANIST or PLANT SCIENTIST. Duties: Plant

collection of cultivated and wild plants and evaluation ofmedicinal plants in cultivation. Ability to work with amultidisciplinary team of plant scientists and chemists todevelop medicinal plants. Requirements: Master's degreein a plant science. Preferences: Training or experience inplant taxonomy, wild plant collection, or sampling forplant growth or phytochemistry. Salary range: $20,000to $24,000 per year.RESEARCH ASSOCIATES (Two positions). Du-

ties: Carry out laboratory functions related to isolationand characterization of natural products. Requirements:B.S. and laboratory experience or equivalent. Preference:Master's degree in chemistry or natural products. Salaryrange: $20,000 to $24,000 per year, based upon expe-rience and education.RESEARCH ASSOCIATE. Duties: Design and

conduct greenhouse and field studies on the cultivationof medicinal plants, interest in multidisciplinary researchwith other plant scientists and phytochemists to enhancethe production of active compounds in medicinal plants.Requirements: Master's degree in a plant science. Pref-erence: Master's degree in horticulture, agronomy, for-estry or botany. Experience in greenhouse and field trials.Salary range: $20,000 to $24,000 per year.

Deadline: All positions open until filled. Send resume,transcripts, and reprints to: Business Offices, School ofPharmacy/Research Institute of Pharmaceutical Sci-ences, 206W Faser Hall, University of Mississippi,University, MS 38677. The University ofMississippi isan Affirmative Action/Equal Opportunity Employer.

POSITIONS OPEN

California Institute of Technology (Caltech) is seekingan ASSOCIATE BIOLOGIST to participate in anongoing research program on the evolution and molec-ular biology of RNA plant and animal viruses. Dutiesinclude cDNA cloning and sequencing of viral RNAgenomes, development of cloning procedures suitable forhigh-throughput automated DNA sequencing, and syn-thesis of oligonucleotide probes.

Candidate must have a Ph.D. in biology and three ormore years of postdoctoral experience in the molecularbiology of both lant and animal viruses. The candidatemust have knowredge of and demonstrated ability in thefollowing techniques, as evidenced by refereed publica-tions: isolation of nondegraded preparations of viraland cellular RNAs, cDNA cloning and sequencing ofviral RNA, in vitro mutagenesis, in vitro transcriptionand translation, RNA transfection in both plant andanimal systems, electron microscopy, and immunologicalprocedures such as ELISA and Western blot analysis. Inaddition, preference will be given to candidate withextensive experience with synthetic oligonucleotide syn-thesis and automated DNA sequencing.

Salary is $36,750 per annum. Caltech is an EqualOpportunity Employer. Women and minorities are encour-aged to apply. Please send curriculum vitae to: MikeMiranda, Administrator, Division of Biology, 156-29, California Institute ofTechnology, Pasadena, CA91125.

CELL SORTER OPERATORThe Uniformed Services University of the Health

Sciences (USUHS) invites applications for a position inthe Biomedical Instrumentation Center (BIC) in the F.Edward Hebert School of Medicine. The BIC providescentralized equipment and service support for biomedicalresearch at the university. The center seeks an individualto set up and operate a cell sorting facility. The individualshould ave a familiarity with microbiology, cell biology,and cellular immunology. In addition, the candidateshould have several years of cell sorting experience. Thecenter currently has a Coulter Epics Elite FACS and aBecton Dickinson FACscan. Full performance level of theposition is equivalent to GS-12 (salary range: $38,861 to$50,516 per year). Please submit an SF 171 no later than31 July 1992 to: Civilian Human Resources Manage-ment Directorate (#92-09RA), Uniformed ServicesUniversity of the Health Scinces, 4301 Jones BridgeRoad, Bethesda, MD 20814-4799. USUHS is an EqualOpportunity/Affinnative Action Employer.

SENIOR GENETICISTTYSON FOODS

Tyson Foods, Inc. is seeking a Senior Geneticist for itsSwine Division. Responsibilities include maintainingnucleus herd, sow and boar inventories, evaluating per-formance, and analysing genetic and other research dta,etc. A Ph.D. in genetics is required, as well as 2 to 4 yearsof experience. Please send or FAX resume to:

Russeli TooleyP.O. Box 2020

Springdale, AR 72765-2020FAX: 501-7564217

Affirmative Action/Equal Opportunity Employment Em-ployer.

MOLECULAR BIOLOGISTThe Mianmi Vascular Institute (MVI), Miami, Florida,

seeks a molecular biologist (Ph.D. or M.D.) to head aresearch program in postangioplasty restenosis and relat-ed areas of vascular biology. Excellent communicationskills and experience with allaspects ofmolecular biologyand tissue culture are required. Current funding is desir-able. Salary is highly competitive and commensurate withexperience. An attractive benefits package is included. Afunded position for a research assistant is available. Thereare opportunities to develop graduate student programsin cooperation with the University of Miami and/orFlorida International University. MVI, an internationallyrecognized center for cardiac aid circulatory disorders, islocated at Baptist Hospital ofMiami on a 70-acre campusboasting Italian Renaissance architecture and lush, sub-tropical landscaping. Interested individuals should sendcurriculum vitae and names of three references to: GaryJ. Becker, M.D., F.A.C.C., Miami Vascular Institute,Baptist Hospital of Miami, 8900 North KendallDrive, Miami, FL 33176.

POSITIONS OPEN

MOLECULAR AND CELLULARNEUROBIOLOGISTS

MONTREAL NEUROLOGICAL INSTITUTEMcGILL UNIVERSITY

The Montreal Neurological Institute (MNI) is estab-lishing a research group of five molecular and/or cellularneurobiologists to study mechanisms of neuronal surviv-al. Neurotrophins and other survival-promotin mole-cules will be one, although not the only, research focus.A mid-career or senior scientist with a strong publicationrecord and funding history is being sought as groupleader. Other appointments will be made at appropriateranks with McGill University's Faculty of Medicine. Thegroup will be housed in newly developed laboratoryspace and provided with ample set-up funds. The aca-demic environment and collaborative potential for neu-roscience at the MNI, at McGill and in Montreal areexcellent. Montreal is a cosmopolitan, bilingual cityknown for its high quality of life.

Applications should be sent to: Dr. Richard A. Mur-phy, Director, Montreal Neurological Institute, 3801University Street, Montreal, Quebec, Canada H3A2B4. The deadline for receipt of applications is 31August 1992.

McGill University is committed to Equity in Employment.

RESEARCH SCIENTISTS. Biomedical leader incryopreservation of transplantable tissue is currently of-feting excellent career opportunities for two Ph.D.-levelresearch scientists. As part of an innovative researchteam, each scientist will be expected to manage his/herown primary research project and to collaborate onassociated projects. Project management experience isdesirable. HEMOSTASIS RESEARCH. Requires aPh.D. in biochemistry/physiology with specific trainingand research experience in the area of blood coagulationfactors, clot formation and wound healing. DISINFEC-TION/STERILIZATION RESEARCH. Requires aPh.D. in biological sciences with specific training andresearch experience in the area of inactivation of infec-tious agents and/or cell and tissue physiology. We offeran excellent salary and comprehensive health package,401K, cafeteria plan and relocation expense assistance.Please respond in confidence to: Dr. B. Morse, Cryo-Life, Inc., 2211 New Market Parkway #142, Mari-etta, GA 30067. Equal Opportunity Employer.

PHYSIOLOGIST/MOLECULAR BIOLOGIST.ASSISTANT RESEARCH BIOLOGIST. Depart-ment of Obstetrics, Gynecology and Reproductive Sci-ences. University of California, San Francisco (UCSF).To pursue studies in regulation of growth and differen-tiation in fetal steroidogenic organs. Must have knowl-edge and experience in molecular biology, growth factorsand steroid biochemistry. Extramural funding. Apply to:Thomas J. Musci, M.D., Department of Obstetrics,Gynecology and Reproductive Sciences, UCSF, SanFrancisco, CA 941430556, by 26 June 1992. Univer-sity of California is an Equal Opportunity/Afirmative Ac-tion Employer. Women and minorities are encouraged toapply.

SOFTWARE ENGINEERING GROUP LEADERThe Jackson Laboratory and the Mouse Genome

Informatics Project seek a software engineering groupleader to oversee design and implementation of a data-base of genetic and physical mapping information, ana-lytical routines, graphical interfaces, and display toolsthat support the use of the laboratory mouse as a modelfor human genetic diseases. This project, which is a fullyfunded component of the NIH Human Genome Pro-gram, will establish a comprehensive, centralized infor-mation resource for the genetics research community.The scientist will be the senior computing scientist in agroup including software engineers, geneticists, and mo-lecular biologists. Applicants with a Ph.D. degree incomputer science are strongly preferred. Broad technicalexperience in data management, relational and object-oriented databases, graphical user interfaces, and datavisualization is required. Preference will be given to thosewho have managed software teams in a scientific envi-ronment. Application deadline: open until filled. Applyto: Dr. Joseph H. Nadeau, Project Leader, MouseGenome Informatics Project, Jackson Laboratory,600 Main Street, Bar Harl, ME 04609.

TheJackson Laboratory is an Equal Opportunity/Affir-mative Action Employer.

SCIENCE * VOL. 256 * 12 JUNE 19921596

PROGRAM OF EXCELLENCE INMOLECULAR BIOLOGY OF THE HEART AND LUNG

Special Postdoctoral PositionsThe University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung, funded by the National Heart, Lung and

Blood Institute of NIH, has as a goal the application of molecular genetic approaches to study heart and lung function. Postdoctorals workclosely with the sponsor in initial years but are encouraged to develop a research program separate from that of the sponsor and applyfor independent funding during the final year.The Program is open to Ph.D.s or M.D.s with training in molecular genetics who wish to apply their skills to significant problems of heart

or lung or to individuals with strong backgrounds in heart and lung who wish to develop molecular genetic tools for continued study of theseproblems. We are particularly interested in recruiting minorities to the Program. Stipends begin at $26,000 per year with benefits. Openingsare available in several of the laboratories listed below.

Na,K-ATPase gene regulation and structure-function studies including identification of the cardiac glycoside binding site using site specificmutagenesis. Jerry B. Lingrel, Ph.D.Characterization of lung surfactant proteins and genes. Jeffrey Whitsett, M.D.Collagen gene expression in the lung. Winston Kao, Ph.D.Structure-function relationships and genetic regulation of Ca-transporting ATPases of intracellular and plasma membranes.Gary Shull, Ph.D.Study of cardiac contractile proteins and growth and developmental control of muscle and pulmonary proteins. Jeffrey Robbins, Ph.D.Transcriptional analysis of lung surfactant protein gene promoters. Donal Luse, Ph.D.Manipulating genes important in heart and lung development by insertional mutagenesis and targeted modification in ES cells.Steven Potter, Ph.D.Structure and function of Ca+ + channel proteins (heart, brain, vascular smooth muscle) and gene regulation; isolation of receptors forcalcium antagonists. Arnold Schwartz, Ph.D.Role of apolipoproteins in heart and lung development and in resistance to disease. Judith Harmony, Ph.D.Gene targeting in ES cells using homologous recombination. Focus is an vasculogenesis, angiogenesis and cardiogenesis.Thomas Doetschman, Ph.D.The genetics of human cardiovascular disease. Anil Menon, Ph.D.

Applicants should submit a C.V. and the names of three references to Jerry B. Lingrel, Ph.D., Director, Program of Excellence inMolecular Biology, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine,Cincinnati, Ohio 45267-0524.

Affirmative Action/Equal Opportunity Employer

DirectorEarth Sciences Division

Lawrence Berkeley Laboratory, a multi-disciplinary research and developmentcenter, funded by the U.S. Department of Energy is currently inviting applicationsfor the position of Director, Earth Sciences Division.The Director will coordinate a broad program of integrated research in geology,geophysics, geochemistry and hydrogeology, and will be responsible for develop-ing interdisciplinary projects in such areas as the earth science aspects ofenvironmental studies, petroleum reservoir engineering, nuclear waste disposal,and geothermal energy. The Earth Sciences Division has a staff of approximately200, including 40 principal investigators and faculty scientists with an annualbudget of over $1 3M. The Division Director also participates in formulating theresearch policy and long-term direction of the Laboratory as a whole. The Directoris expected to maintain a strong personal involvement in research.

This position requires a Ph.D. or equivalent in Earth Sciences or a related field,combined with a distinguished record of scientific achievement and programmanagement. The candidate must have demonstrated capabilities in scientificleadership and must have strong management and administrative skills, creativityin decision making and problem solving and experience in human resourcemanagement.

The closing date for the submission of applications is July 30, 1992. Applicants mustsubmit two copies of resume, salary history, and the names and addresses of threereferences to: ESD Search Committee, Job H/7347, c/o Employment Office,Bldg. 90/1042, Lawrence Berkeley Laboratory, One Cyclotron Road, Berkeley,CA 94720. An equal opportunity employer.

| ||2 LAWRENCE BERKELEY LABORATORYUNIVERSITY OF CALIFORNIA

_ U.S. Department of Energy

UNIVERSITY OF VIRGINIADirector

Molecular Biology Instituteand Markey Center

Nominations and applications are invited forthe Directorship, which can start during the1992-93 academic year, later if necessary. TheInstitute and the Center, managed conjointly atpresent, command significant resources. TheInstitute is supported primarily with universityfunds. The Markey Center for Research on theMolecular Biology of Cellular Signaling Pro-cesses is funded by a five-year grant from theMarkey Charitable Trust. Core space of some12,000 square feet and core facilities for theCenter are located in the School of Medicine.The more than fifty molecular biologists com-prising the parent Institute are members, how-ever, of departments of the College of Arts andSciences as well as of the School of Medicine.All members hold regular faculty appointments,as will the new Director.

Candidates should have a strong researchprogram in one of the molecular subdisciplines ofsignaling, e.g., membranes and receptors, signaltransduction, genome-level processes, molecu-lar structure. Candidates should be eligible forthe rank of Professor. Scientific managementexperlence would be helpful but is not a prereq-uisite for appointment. Administrative arrange-ments, salary, and departmental affiliation areflexible and will depend upon experience.

Applicants should provide a curriculum vitae, afull bibliography, and the names of three refer-ees. Nominations may be offered by letter.Please address:

Markey Search CommitteeBox 56, MR-4 BuildingUnhesty of VrginIa

Chart ev , VA 22908Applications should be complete by July 31,

1992; but the search will continue, and additionalapplications will be accepted as necessary, untilthe position is filled.The University of Virginia is an Equal Opporitun^Affirmative Acton Empdoyer.Women and minorities are encourd to appy.m

m

Synergen is a young andrapidly growing researchbased biopharmaceuticalcompany using the latestadvances in recombinant DNAtechnology, molecular biologyand manufacturing technol-ogy. Our focus is on thediscovery, development, andproduction of protein-basedhuman pharmaceuticals forthe treatment of serioushuman diseases. We cur-rently have need for thefollowing professional:PHARMACOLOGY

SCIENTISTWe are seeking a generalistwith a broad-based researchbackground to test molecularlyderived proteins in a variety ofanimal models of humandisease. The qualified candi-date must have extensiveknowledge of and experiencein animal model testing, andinflammation, neuroscience,growth factors or cytokines; aPh.D. in Physiology or Phar-macology is required.Synergen offers a competitivecompensation package,generous benefits, an open,non-traditional work-place andcorporate financial stability.Located at the base of theRocky Mountains, Boulder,Colorado is renowned for itsbeauty, culture and naturalattractions. Please send yourresume to: EmploymentManager, Box PS, Synergen,Inc., 1885 33rd Street, Boul-der, CO 80301. We are anEqual Opportunity Employer.

SYNERGEN

POSITIONS OPEN

NATURAL PRODUCTS CHEMIST. CampbellResearch and Development, a division of the CampbellSoup Company, in Davis, California, is seeking a naturalproducts chemist. The successful candidate must be ableto independently develop methods for the isolation,identification and further analysis of plant metabolitesusing GC, HPLC and other appropriate methods.Knowledge of plant metabolites ("phytochemicals") asrelated to human nutrition is desirable. Must have excel-lent communication skills. Requires Ph.D. or M.S. innutrition, biochemistry, chemistry or other areas relatingto human health and plant metabolites. Starting date: 1August 1992. Facility located 6 miles from the Universityof California, Davis, campus. Submit resume, transcriptsand names ofreferences to: Ms. Dawn Adams, CampbellResearch and Development, 28605 County Roadl04,Davis, CA 95616. Telephone: 916-753-2116.

QUANTITATIVE ECOLOGIST-FISHERIES(Re-advertised). A position is available immediately fora quantitative fisheries ecologist with expertise in apply-ing statistical and population models to conduct assess-ments and population analyses of regional fisheries. Theposition (Assistant Marine Scientist-Contract) at theMarine Resources Research Institute [South CarolinaWildlife and Marine Resources Department (SCW-MRD)] is on a federally funded contract. Applicantshould hold the Ph.D. degree and be experienced instatistics and population modeling of fisheries data. Thesuccessful candidate is expected to participate in fieldwork and to develop and apply innovative analyses tolong-term fishery-independent sampling data on south-eastern reef fishes. Prior to 15 July 1992, please sendcurriculum vitae, statement of research interests andgoals (fewer than three pages), and three letters ofreference to: Dr. George R Sedberry, Fisheries Ecol-ogist Search, Marine Resources Research Institute,P.O. Box 12559, Charleston, SC 29422-2559. TheSCWMRD prohibits discrimination on the basis ofrace, sex,color, national origin, handicap or age.

STAFF SCIENTIST/SCIENTISTCENTER FOR BIOMEDICAL RESEARCH

THE POPULATION COUNCILThe Population Council is seeking a scientist for its

Contraceptive Development Program. Advanced degree(Ph.D., M.D., D.V.M., or equivalent) in immunology,endocrinology, or reproductive physiology-preferablyrelating to reproductive physiology or contraception.Minimum of 2 years of relevant postdoctoral training,including experience in antibody production, character-ization, and small animal surgery. Salary will dependupon qualifications and experience. Excellent benefits.Send resume to: Dr. Rosemarie Thau, The PopulationCouncil, Center for Biomedical Research, TowerBuilding, 1230 York Avenue, New York, NY 10021.An Equal Opportunity Employment Employer MIF.

SCIENTIST/MOLECULAR BIOLOGISTResearch scientist sought for research center at public

university in southern Ohio to carry out independentresearch project focused on the definition of the molec-ular basis ofgrowth hormone's physiological effects (andpotential pharmacological impacts) using in vivo (trans-genic mice) and in vitro (tissue culture) models. He/shewill: (1) conduct experiments using gene cloning, DNAsite-specific mutagenesis, gene sequencing, immunopre-cipitation, protein structure/function analysis, radioim-mune and radioreceptor assays, and tissue culture, usingstate-of-the-art techniques; (2) perform transgenic ani-mal screening and animal surgery; and (3) operate stan-dard molecular biological equipment and instrumenta-tion. This (nonfaculty) scientist will also (co-) write grantapplications and contract proposals; train graduate stu-dents and postdoctoral fellows; make proprietary andconfidential presentations to corporate sponsors; super-vise and manage the operation of his/her laboratory;perform at the level ofan already well-trained, technicallycompetent molecular biologist. Education: Ph.D. or M.D.in molecular biology or physiology. Experience: 2 years(in the job described). Experience could be gainedduring or after the attainment of the Ph.D. (or M.D.).Hours: Forty hours per week, 8:00 a.m. to 5:00 p.m.,Monday to Friday. Salary: $33,000 to $46,758 per year.Must have proofoflegal authority to work permanently in theUnited States. Send resum6 in duplicate (no calls) to: J.Davies, JO #1227533, Ohio Bureau of EmploymentServices, P.O. Box 1618, Columbus, OH 43216.

POSITIONS OPEN

STAFF ANALYTICAL CHEMIST, for manufac-turer in the Cincinnati area. Development of analyticalresearch methods for the characterization of taste/flavorin beverage products. Contribute to projects which willresearch the effects of chemical taste/flavors in existingbeverage products and the development ofnew products.Identify and characterize products' raw materials, pack-aging, and finished products by a variety of chromato-graphic and spectroscopic methods and innovative tech-nologies. Manage routine, day-to-day analysis of submit-ted samples, use multivariate analysis techniques to re-duce data and model product performance and chemical/flavor correlations. Interact closely with chemicalengineers as a team member on developing projects.Ph.D. or completion of all requirements for Ph.D. inchemistry (with research emphasis in analytical chemis-try) required plus 1 year of experience in job offered or 1year ofexpenence as pre- or postdoctoral researcher inanalytical chemistry and development and application ofspectroscopic methods for chromatography. One year ofexperience must involve research in developing chro-matographic detectors and techniques; applied work incapillary LC, HPLC and capillary electrophoresis; andspectroscopic analysis using FTIR, MS, UV-Vis. Oneyear of experience also must involve optics, lasers andmathematical methods for optimization of instrumentperformance; and interfacing chromatographs and spec-trometers to computers.

Forty hours per week, 8:00 a.m. to 4:30 p.m. Salary:$48,300 per year. Must have proofoflegal authority to workpermanently in the United States. Send resume in duplicate(no calls) to: C. Bussard, JO #1230842, Ohio Bureauof Employment Services, P.O. Box 1618, Columbus,OH 43216.

ANNOUNCEMENTS

AQUATIC BIOLOGY and PLANT ECOLOGYapplications for nomination for NSERC Women's FacultyAwards are invited. Must be female Canadian citizens orlanded immigrants with a Ph.D. Preferred areas ofresearchare aquatic biology, molecular biology, mycology, plantecology, and plant morphology. Send curriculum vitae,statement of research interests, and reprints to: R J. F.Smith, Biology Department, University of Saskatch-ewan, Saskatoon, Sask., S7N 0WO Canada, by 20 July1992. Telephone: 306-966-4400, FAX: 306-966-4461, BITNET: SMITHR@ SASLUSASKCA.

MEETINGS

MAJOR INTERNATIONAL CONFERENCEON WATER DISINFECTION

The First International Conference on the Safety ofWater Disinfection: Balancing Chemical and MicrobialRisks will be held in Washington, D.C., 31 August to 3September 1992. A distinguished group of internationalexperts will review the current science on the potentialhealth risks of exposure to chemical byproducts of waterdisinfection processes compared with those from micro-bial contamination of drinking water. The conference issponsored by the International Life Sciences Institute(ILSI), U.S. Environmental Protection Agency, U.S.Food and Drug Administration, Pan Amerncan HealthOrganization, World Health Organization, and Ameri-can Water Works Association. For further informationcontact: Diane Dalisera, ILSI, 1126 Sixteenth Street,N.W., Washington, DC 20036, telephone: 202-659-0074.

MARKETPLACE

Circle No. 3 on Readers' Service Card

SCIENCE * VOL. 256 * 12 JUNE 1992

.P-lAftat Systemi 1000 providesreagents for isolation of mRNA from upto 2g of tissue. The amount of tissue ineach isolation can vary from as muchas 1g to as little as 15mg. mRNArecovery is proportional to tissue mass.Up to 20 50mg isolations may beperformed with one PolyATtractSystem 1000.

For moreinformation aboutPromega's newPolyATtract System1000, pleaserequest informationpacket LF063.

Circle No. 18 on Readers' Service Card

0o

Promega Corporation2800 Woods Hollow RoadMadison, WI 53711-5399 USATelephone 608-274-4330FAX 608-273-6967Telex 62057092

800-356-9526Fax 800-356-1970©1992, Copyright Promega CorporationAll rights reserved.

.I.-

W~

ForCKINE Research

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The Broadest Spectrum ofPremium Quality CytokinesThe cytokine laboratories of R&D Systems provide the most extensive line of both naturaland recombinant cytokines. Each protein carries the following assurances:

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Full Biological ActivityThe biological activity of each cytokine isdetermined by bioassay. A description of theappropriate bioassay and the typical ED50 rangeis included in each package insert.

Highest PurityAll are greater than 97% pure, as determinedby N-terminus analysis as well as SDS-PAGEvisualized by silver stain.

Additional ReagentsR&D Systems produces over 250 cytokinerelated reagents (e.g. neutralizing and detectionantibodies, genes, probes, and cytokine ELISAassay kits) to provide investigators with a solidfoundation on which to do cytokine research.

To obtain a catalog, detailed product information or to place an order call 1-800-343-7475.

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R&D Systens614 McKinley Place N.E.Minneapolis, MN 55413Telephone: 800-343-7475Fax: (612) 379-6580

1-800-343-7475Circle No. 4 on Readers' Service Card

SYSTEMS