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Product Information
Cilomilast(SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). Cilomilast(SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast(SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast(SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects. [1]
Biological Activity
[1] MARY S. BARNETTE et al. JPET.1998,284(1):420-426
[2] Neil F. Badham et al. Org. Proc. Res. Dev. 2003,7(1):101-108
References
Novel Kinase Inhibitors for cell signaling & oncology research
S1455 Cilomilast
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
343.42C20H25NO4
DMSO99%at -20℃ 2 years153259-65-5
Notes
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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MSDS & CoA
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Selleck Overnight Delivery Service
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under
the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended
storage temperature,most are recommended stored at -20 .Many products are stable in the short-term at temperatures that differ from that
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save
you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage
recommendations on the product data sheet.
℃
Synonyms: Ariflo, SB-207499
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