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M.Wt: 394.72Formula: C16H21Cl2N3O2.HClSolubility: DMSOPurity: >99%Storage: at -20℃ 2 yearsCAS No.: 3543-75-7Biological Activity of Bendamustine Hydrochloride:Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma. [1] Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. [2]This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 μm. [3]References on Bendamustine Hydrochloride:[1] http://en.wikipedia.org/wiki/Bendamustine[2] http://www.cancer.gov/drugdictionary/?CdrID=350251[3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317 [4] http://www.rxlist.com/treanda-drug.htm
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Product Information
Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma.[1] Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.[2] This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 μm. [3]
Biological Activity
[1] http://en.wikipedia.org/wiki/Bendamustine
[2] http://www.cancer.gov/drugdictionary/?CdrID=350251
[3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317
[4] http://www.rxlist.com/treanda-drug.htm
References
Novel Kinase Inhibitors for cell signaling & oncology research
S1212 Bendamustine Hydrochloride
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
394.72C16H21Cl2N3O2.HClUnknown99%at -20℃ 2 years3543-75-7
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℃
N
N
NCl
Cl
OHO
HCl
Synonyms: Ribomustin, Treanda, SDX-105
