Embed Size (px)
Citation preview
![Page 1: Ru-MACHO® Ru-MACHO®-BH [R0136] - TCI Chemicals Ru-MACHO® 200mg / 1g R0137 Ru-MACHO®-BH 200mg / 1g These products were merchandized under the technical tie-up with TAKASAGO INTERNATIONAL](https://reader036.pdfslide.us/reader036/viewer/2022071715/5b0612b07f8b9ad1768c4a53/html5/thumbnails/1.jpg)
RR033E 20140620www.TCIchemicals.com
800-423-8616 / 503-283-1681888-520-1075 / 503-283-1987
Tel : Fax :
Tel : +32 (0)3 735 07 00Fax : +32 (0)3 735 07 01E-mail : [email protected]
Tel : +49 (0)6196 64053-00Fax : +49 (0)6196 64053-01E-mail : [email protected]
Tel : +44 (0)1865 784560Fax : +44 (0)1865 784561E-mail : [email protected]
Tel : 1800 425 7889 / 044-2262 0909Fax : 044-2262 8902E-mail : [email protected]
Tel : +81 (0)3-5640-8878 Fax : +81 (0)3-5640-8902E-mail : [email protected]
Tel : 800-988-0390 / 021-67121386Fax : 021-6712-1385E-mail : [email protected]
Ordering and Customer Service
Tel : 800-423-8616Fax : 888-520-1075
Availability, price or speci�cation of the listed products are subject to change without prior notice. Reproduction forbidden without the prior written consent of Tokyo Chemical Industry Co., Ltd.
Ruthenium Complex Catalysts for Hydrogenation of Esters to Alcohols
New
R0136 Ru-MACHO® 200mg / 1gR0137 Ru-MACHO®-BH 200mg / 1g
These products were merchandized under the technical tie-up with TAKASAGO INTERNATIONAL CORPORATION. Ru-MACHO® is a registered trademark of TAKASAGO INTERNATIONAL CORPORATION.
N P
PRu
H
Cl COPh
Ph
HPhPh
W. Kuriyama et al., Org. Process Res. Dev. 2012, 16, 166.
AlcoholEster
R0136 (0.1 mol%)H2 (5 MPa)
NaOMe (0.1 eq.)
MeOH, 16 h
From the technical document of TAKASAGO INTERNATIONAL CORPORATION
AlcoholEster
R0137 (0.1 mol%)H2 (5 MPa)
THF, 80 °C, 16 h
Ru-MACHO®[R0136]
Ru-MACHO®-BH[R0137]
N P
PRu
H
H COPh
Ph
H
BH3
PhPh
Substrate
Product
Yield (%)
CO2Me
CH2OH
90 92 98*
BnO CO2Me
BnO CH2OH
CO2Me
CH2OH
N
N CH2OH
CO2Me
86
*neat, 150 °C, 2 h
Substrate
Product
Yield (%) 77 78 9388
O
NHCbz
O
OHHO
NHCbz
O
O
CO2Me
CO2MeO
O
CH2OH
CH2OH
PhCO2Me
PhCH2OH
CO2Me
NHBoc
CH2OH
NHBoc
ee (%)
ee (%) = (% ee of Substrate) - (% ee of Product)
<1 <1 <12
∆
∆
Advantages
Reaction Examples
・ Catalyze the Hydrogenation of Esters to Alcohols・ The Reaction Proceeds in Various Solvents (neat, methanol, THF, etc.)・ It Can Reduce Sterically-bulky Substrates because of its Heat Stability・ The Addition of Base is Unnecessary by Using R0137
![[hs] O poder do macho](https://img.pdfslide.us/doc/110x75/54e29ea24a7959b1198b4937/hs-o-poder-do-macho.jpg)
