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RNA interference (RNAi) [aka post-transcriptional gene silencing (PTGS)]. - PowerPoint PPT Presentation
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“RNA interference not only promises to explain biological mysteries, but is also turning out to be a powerful research tool and a potential new source of medical breakthroughs. Like so much of biology these days, this is a story of migraine-inducing complexity.”
U.S. News and World Report, March 3, 2003
RNA interference (RNAi) [aka post-transcriptional gene silencing (PTGS)]
From Nature 418:244
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Quality control: nonsense-mediated decay
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Organism Number of genes
Virus 8-200
E. coli ~4000
Yeast 6241
C. elegans (nematodes) 18, 424
Drosophila (fruit fly) 13,601
Arabidopsis (plant) ~25, 000
Human ~33,000
Human ~ 24, 000 genes
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