Rich LaDuca

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Richard J. LaDuca

Genencor/Danisco

March 15, 2010

World BiofuelsMarkets

Amsterdam

BioIsoprene Monomer:Development of a Bio-basedProcess for Production of Isoprenefrom Renewable Resources


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Apply name/department/presentation title in 'header and footer'

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Purpose for Today:

Bio-product Target: Isoprene /BioIsoprene Monomer

What makes BioIsoprene Monomer a good target?

Collaborative approach to development

Building a BUSINESS PLATFORM

Biochemicals

Biofuels

CH2

CC

H2C

CH3H

Isoprene


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Genencor at a Glance.

History traced to 1982

May 2005: Division of Danisco

Industrial Biotechnology Focus

> $800 MM USD annual turnover

Core Competency: Design &Operation of the Cell Factory

Industrial Enzymes

Metabolic Pathway Engineering

We develop and produce enzymes forindustrial applications.

1,3 Propanediol

Ascorbic Acid


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Building Block Biochemicals:


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Add Isoprene to the list of buildingblock biochemicals.


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Why go after Isoprene?

TREESBIOBASEDPROCESS

CHEMICALSYNTHESIS

PETROLEUMCRACKING

Slow

Notcommerciallyrelevant

Extractive

distillation fromEthylene &Propyleneproduction

Price linked tooil prices

Moving tolight streams

High cost

Petroleumfeedstocks

Mfg.infrastructure inRussia & Japan

Renewable

feedstocks GHG reduction

Low Cost

BiochemicalAND Biofuel

Products


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Isoprene Market Segmentation

Tires

62%

Mechanical

Goods

4%

Other

9%

Medical /

Personal Care

6%

Adhesives

19%

Big Market: (~800 kt; 2008 volume basis) Tires (450-500 kt)

Adhesives (150 kt)

Medical / Personal Care (40-50 kt)

Strategic Raw Material:

Synthetic Rubber Natural Rubber Replacement

Current Commercial Processes:

Petroleum-based feedstocks

Cost linked to oil

Availability of supply has been an issueBioIsoprene Process:

Renewable raw materials

Polymer-Grade

Sustainable

Low Cost

Why go after Isoprene?


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Genencor and Goodyear will jointlydevelop BioIsoprene Process

A collaborative research initiative

Joint multimillion-dollar investment

BioIsoprene product is a biobased,

renewable alternative to thepetroleum-based isoprene

BioIsoprene product is a business

platform chemical

Genencor will lead commercialdevelopment

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Genencor and Goodyear leveragingeach others expertise

CH2

CC

H2C

CH3H

Integrated biobased process for production of BioIsoprene

RenewableFeedstock(s) Microbial StrainDevelopment Large ScaleFermentation

BioIsoprene

recovery &purificationknowhow

Polymer-Grade

BioIsopreneProduct


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Material Challenges: Tire Industry

Synthetic &

Natural Rubber

43%

Carbon Black

& Silica

27%

Steel

10%

Fabric

5% Chemicals

10%

Oil

5%

Over 70% of raw materials

are petroleum derived

Renewable/Sustainable Feedstocks

Develop alternative to NaturalRubber

Eliminate dependence onpetrochemical waste streams forisoprene feedstocks

Reduce need for Carbon Black

Reduce material & energy waste fromspent tires

Recyclability

Improve performance while reducingweight: traction, wear, fuel economy,noise, etc.


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Value of BioIsoprene Product:

To Goodyear:

Strategic Raw Material forSynthetic Polyisoprene Rubber

Cost

Sustainability Decrease dependence on

natural rubber sourcing

To Genencor:

Builds off of corecompetencies

Consistent with Strategic

Intent to grow newbusinesses

Builds off of know-how andpast successes

Aligns complementary skills,investment, strategic intent and market

connectivity


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BioIsoprene Product will Enable:

Alternative supply of a key strategic raw materialfor synthetic rubber

Decreased dependence on natural rubber sourcing

Reduced petroleum price impact on isoprene costs

Supply of isoprene de-linked from petroleumprocessing

Isoprene cost savings

Movement to a more sustainable isoprene

production method

Enhanced availability of supply

A Bio-based process forISOPRENE

from renewable raw materials

Specialty

Polymers

Adhesives

Synthetic Rubber


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BioIsoprene Process:

rDNA Process

Renewable raw materialfeedstocks

Metabolic Pathway engineeringof isoprenoid pathways

Isoprene product produced ingas phase

Polymer grade product

Integrated bio/chemical process

Details: Tuesday March 16th; Dr.Karl Sanford; Next GenerationBiofuels Session

Renewable

Feedstocks

Polymer GradeBioIsoprene

Product

Gas-phase

BioIsoprene

product recovered& purified to liquid-

phase


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BioIsoFuels

+

C15Isomers +

+ C10Isomers

Transportation /Jet FuelsBusiness

Chemical

Catalysis

BioIsoprene

Product

CH2

CC

H2C

CH3H

Biochemicals Business:

Tires

Adhesives Specialty Polymers

BioIsoprene C5 Biorefinery:Business Platform

+ Fuel Partner

RenewableFeedstock(s)

Microbial StrainDevelopment

Large ScaleFermentation

BioIsoprene

recovery &purificationknowhow


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BioIsoprene Product EnablesBiorefinery Approach:

BioIsoprene process, developed jointly byGenencor and The Goodyear Tire & RubberCompany

BioIsoprene Production:

rDNA

Biomass-based

Gas Phase Product

Establishes C5 Platform (5-carbon molecule) toproduce valuable products:

A Business Platform Chemical Biochemicals: Tires; Adhesives; Specialty

Elastomers

Biofuels: Liquid transportation Fuels; JetFuels

Concept BioIsopreneTM Tirefor the UN Climate Summit,

Dec 2009, CPH

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Rich LaDuca