Revised 8/1/2018 Zhenmin Lei, M.D., Ph.D. ZHENMIN LEI, M.D ... CV.pdf · Revised 8/1/2018 Zhenmin Lei, M.D., Ph.D. 2 HONORS AND AWARDS HONORS 1. Who’s Who in America, since 2000

Revised 8/1/2018 Zhenmin Lei, M.D., Ph.D.

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ZHENMIN LEI, M.D., Ph.D.

Dept. of OB/GYN and Women’s Health

412 A-55 Building University of Louisville School of Medicine

500 South Preston Street Louisville, KY 40202

(502) 852-5509 (502) 852-0881

[email protected]

EDUCATION 1995 - Ph.D. Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, Kentucky 40292 1984 - M.S. Histology and Embryology, Tianjin Medical College, Tianjin, P.R. China 1980 - M.D. Medicine, Fujian Medical College, Fuzhou, Fujian, P.R. China ACADEMIC APPOINTMENTS 2009 – Present Professor with tenure, Vice-Chair for Research and Co-Director of the

Research Working Group, Dept. of Obstetrics/Gynecology and Women’s Health, School of Medicine, University of Louisville, Louisville, KY 40292

2001 – 2008 Associate Professor with tenure, Dept. of Obstetrics/Gynecology and

Women’s Health, School of Medicine, University of Louisville, Louisville, KY 40292

1995 – 2000 Assistant Professor, Division of Reproductive Endocrinology & Infertility,

Dept. of Obstetrics/Gynecology and Women’s Health, University of Louisville, Louisville, KY 40292

1987 - 1990 Postdoctoral Research Fellow, Division of Reproductive Endocrinology &

Infertility, Department of Obstetrics & Gynecology, School of Medicine, University of Louisville, Louisville, KY 40292

1984 - 1987 Instructor, Department of Histology & Embryology, Fujian Medical College, Fujian, P.R. China 1980 - 1982 Assistant, Department of Histology & Embryology, Fujian Medical College, Fujian, P.R. China PROFESSIONAL MEMBERSHIPS 1. The American Association for the Advancement of Science 2. The American Endocrine Society 3. The Society for the Study of Reproduction 4. Public Responsibility in Medicine and Research (PRIM&R)


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HONORS AND AWARDS HONORS

1. Who’s Who in America, since 2000 2. Guest Professor, Fujian Medical College, Fujian, P.R. China, since 2000 3. Faculty of 1000 Medicine – Reproductive Endocrinology, since 2006 4. Guest Professor, Affiliated Tumor Hospital, Tianjin Medical University, Tianjin, P.R. China,

Since 2013 AWARDS

1. Society for Gynecologic Investigation President’s award, with Dr. Han SW, 1996 2. Society for Gynecologic Investigation President’s award, with Dr. Hu YL, 1997 3. Society for Gynecologic Investigation President’s award, with Dr. Zhou XL, 1998 4. Society for Gynecologic Investigation President’s award, with Dr. Yang M, 1999 5. Research! Louisville, Medical Student Research award, with Dr. Jones E., 1999 6. The 6th Royan International Reproductive Biomedicine & Stem Cell Research Award, 2005 7. Research! Louisville, the Most Promising Research Project award, with Dr. Clark BJ, 2005 8. Society for the Study of Reproduction Lalor Fellows award, with Dr. Yuan FP, 2006 9. Pacific Coast Reproductive Society, Outstanding Paper Award, with Dr. Travis McCoy, 2010 10. Society for Gynecologic Investigation President’s award, with Dr. Chen DB, 2013 PEER REVIEWER OF MANUSCRIPTS and AD-HOC REVIEWER OF GRANTING AGENCIES

Andrologia Biology of Reproduction Journal of Endocrinology Molecular and Cellular Endocrinology Reproductive Biology & Endocrinology Asian Journal of Andrology Experimental Biology and Medicine Reproductive Toxicology

Journal of Reproductive Sciences (Former J of SGI) Journal of Andrology Maternal-Fetal & Neonatal Medicine

Human Reproduction Molecular Human Reproduction PCNA Placenta ISRN Obstetrics & Gynecology (Editorial Board) Research Grant Proposals submitted to: Physiology & Pharmacology Panel, the Wellcome Trust (2001-2017) Action Medical Research, United Kingdom (2004) Dept. of Innovation, Italian Ministry of Health, Italy (2009-2013) Alzheimer's Association (2012) AREA Study Section, NIH (2013) CMIR Study Section, NIH (2013-2017)

TEACHING (MENTORED & THESIS SUPERVISION IN A RESEARCH SETTING)

1. Total nineteen postdoctoral Research Associates, six graduate students and three undergraduates (partial listing below).

S. Mishra, Ph.D. 1998-2001 (Postdocl) W. Zou, Ph.D. 1999-2002 (Postdoc)


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B. Xu, M.D. 2000-2002 (Postdoc) P. Ponnuru, Ph.D. 2002-2003 (Postdoc) H. Fluhr, B.S. 2003-2004 (Med student) G. Sauter, B.S. 2003-2004 (Med student) D. Lin, M.D., M.S. 2002-2004 (Postdoc) Y. H. Yu, M.D. 2002-2004 (Postdoc) G. Bodek, Ph.D. 2003-2005 (Postdoc) X. Huang, Pharm. D. 2004-2006 (Postdoc)

F. Yuan, M.D. 2003-2007 (Postdoc) J. Lin, M.D., Ph.D. 2005-2011 (Postdoc) S.Q. Li, M.S. 2008-2010 (Graduate student) Y. L. Gao, M.D. 2006-2010 (Postdoc) Hougland M.T., Ph.D. 2006-2013 (Undergraduate honors & PhD theses) Bajramovic M., B.S. 2008 (Undergraduate honors thesis) Jia Zhu, B.S. 2010-2011 (Graduate student) J. S. Moore, B.S. 2011 (Med Student) Yan He, M.D., Ph.D. 2011-2013 (Postdoc) Paul Davis, B.S. 2013-2014 (Med Student,DIR Program) F.Y. Xing, Ph.D. 2013-2014 (Postdoc) Chi Zhang, M.S. 2010-Present (Graduate student) G.Z. Wu, M.D., Ph.D. 2014-2015 (Postdoc) J.K. Marner, M.S. 2014 (Med Student) Y.B. Pan, M.D. 2014-2015 (Postdoc) L.Y. Liu, M.D. . 2014-2017 (PhD Student) Billiken Lin, M.D. 2016-2017 (Postdoc) Zhouwen Liang, Ph.D. 2016-2017 (Postdoc) Kaimin Guo, M.D. 2016- (PhD Student)

2. Total twenty-four clinical fellows of Reproductive Endocrinology & Infertility and Gynecological

Oncology Fellowship Programs, Dept. of Ob/Gyn & Women’s Health (partial listing below).

P. Lin, M.D. 1998-2001 Board certified reproductive endocrinologist M. Abdallah, M.D. 1999-2002 Board certified reproductive endocrinologist D. Chudgar, M.D. 2000-2003 Board certified reproductive endocrinologist M. Abdullah, M.D. 2001-2004 Board certified reproductive endocrinologist D. Woodford, M.D. 2003-2006 Board certified reproductive endocrinologist P. S. Uzelac, M.D. 2006-2009 Board certified reproductive endocrinologist T. W. McCoy, M.D. 2007-2010 Board certified reproductive endocrinologist A. K. Moore, M.D. 2009-2012 Board certified reproductive endocrinologist T Justice, M.D. 2010-2013 Board eligible reproductive endocrinologist S. Redding, M.D. 2011-2014 Board eligible reproductive endocrinologist M. S. Krause, M.D. 2012-2014 Board certified reproductive endocrinologist N. E. Deveneau, M.D. 2012-2014 Board certified urogynecologist K. A. Ehlers, M.D. 2014-2017 Board eligible reproductive endocrinologist Yelena Dondik, M.D. 2015-2018 Board eligible reproductive endocrinologist M. L. Mann, M.D., 2016- REI fellow

RESEARCH FUNDING

1. CO-INVESTIGATOR, 50% EFFORT, DIRECT GONADOTROPIN REGULATION OF HUMAN FALLOPIAN TUBES, NICHD, NIH R01 HD-31971, 09/01/94 THROUGH 09/30/01, $914,536 (TOTAL)


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2. PI, 10% EFFORT, CLONING A 95 KDA TRANSCRIPTION FACTOR INVOLVED IN THE TRANSCRIPTIONAL REGULATION OF THE GNRH GENE BY LH/HCG, GRANT-IN-AID, UNIVERSITY OF LOUISVILLE, 11/1/96 THROUGH 10/31/97, $9,925 (DIRECT)

3. PI, 10% EFFORT, TARGETED DISRUPTION OF THE MOUSE LUTEINIZING HORMONE RECEPTOR GENE, KY-EPSCOR, 09/01/1998 THROUGH 02/29/00, $15,012 (DIRECT)

4. PI, 25% EFFORT, ROLE OF LH IN GNRH NEURONS DURING REPRODUCTIVE SENESCENCE, NIA, NIH R03 AG16959, 04/01/99 THROUGH 09/30/01, $69,701 (TOTAL)

5. CO-PI, 25% EFFORT, THE PROTECTIVE ROLE OF HCG IN BREAST CANCER, SERONO INTERNATIONAL, 11/30/01 THROUGH 12/31/04, $200,000 (DIRECT)

6. PI, 25% EFFORT, CONSEQUENCES OF THE MALE LH RECEPTOR GENE KNOCKOUT, NICHD, NIH R03 HD40223, 04/1/01 THROUGH 03/31/04, $144,000 (TOTAL)

7. CO-PI, 50% EFFORT, OVARIAN FAILURE IN LH/HCG RECEPTOR KNOCKOUT ANIMALS, NICHD, NIH R01HDO44655-01, 09/1/02 THROUGH 02/29/08, $1,158,300 (TOTAL)

8. CO-INVESTIGATOR, 5% EFFORT, NEUROENDOCRINE AND TESTICULAR MECHANISMS IN MALE INFERTILITY, KY-EPSCOR, 6/1/05 THROUGH 5/31/06, $20,000 (DIRECT)

9. PI, 5%, LUTEINIZING HORMONE AND ALZHEIMER’S DISEASE, KSEF-148-502-05-149, 11/1/05 THROUGH10/30/08, $59,994 (DIRECT)

10. PI, 25% EFFORT, THE MECHANISM OF CRYPTORCHIDISM IN LH RECEPTOR KNOCKOUT ANIMALS, NICHD, NIH, 1R01HD057501-01, 04/01/08 THROUGH 05/31/13, $1,628,040 (TOTAL)

11. CO-INVESTIGATOR, 5% EFFORT, EFFECT OF A PCOS-LIKE HYPERANDROGENIC ENVIRONMENT ON HUMAN OVARIAN FOLLICULAR DEVELOPMENT, RESEARCH INITIATION GRANT, UNIVERSITY OF LOUISVILLE, 6/1/09 THROUGH 5/31/10, $5,000 (DIRECT)

12. PI, 20% EFFORT, THE ROLE ZNF403 IN REGULATION OF PLACENTAL DEVELOPMENT. NICHD, NIH, 12/01/13 THROUGH 11/30/18 (PENDING)

13. CO-INVESTIGATOR, 5% EFFORT, ROLE OF PACAP IN PITUITARY-GONAD AXIS DEVELOPMENT. NICHD, NIH, 12/01/11 THROUGH 11/30/16 (PENDING)

14. PI, 5% EFFORT, DYSREGULATION OF THE THECAL PI3K SIGNALING IN POLYCYSTIC OVARY SYNDROME. KSEF, 07/01/13 THROUGH 6/30/14.

15. FACULTY, NIDDK, NIH T35 DK072923 SUMMER ENDOCRINE RESEARCH TRAINING PROGRAM GRANT FOR MEDICAL STUDENTS, 2011-2015.

ABSTRACTS AND PRESENTATIONS

A. Oral Presentations (National/International Meetings)

1. Kara A Ehlers, Billiken Lin, Xian Li, Kelly Pagidas, Zhenmin Lei (2016) Dysregulation of the Hippo Pathway in Selective Theca Cell Phosphatase and Tensin Homolog (tPten) Mutant Mice Exhibiting A Polycystic Ovarian Syndrome (PCOS)-Like Phenotype. American Society for Reproductive Medicine (ASRM). Salt Lake City, UT

2. Zhenmin Lei (2015) ZFP403, A novel tumor suppressor candidate in breast cancer. 2015 Nobel Prize Laureate Summit on Biomedical Sciences: Frontiers in Cancer Research, Tianjin China

3. Guizhu Wu, Shawn Redding, Xian Li, Henry Bohler, CheMyong Ko, Austin J. Cooney, Zi-Jian Lan, and Zhenmin Lei (2015) Disruption of Hippo signaling in the ovaries of selective theca cell Pten deleted mice with PCOS-like phenotype. The 48th Annual Meeting of Society for the Study of Reproduction, San Juan, Puerto Rico

4. ZM Lei, X Li, CM Ko, A J. Cooney, ZJ Lan, (2014) Anovulation in Mice Carrying A Constitutively Active Kras in Theca and Interstitial Cells. The 47th Annual Meeting of Society for the Study of Reproduction, Grand Rapids, MI, Abst. #27

5. Shawn D Redding, Xian Li, Guizhu Wu, CheMyong Ko, Austin J Cooney, Henry Bohler, Zi-


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Jian Lan, Zhenmin Lei, (2014), Transforming growth factor-β1 (TGF-β1) and fibroblast growth factor-7 (FGF-7) elevated in ovaries of selective theca cell phosphatase and tensin homolog mutant (tPtenMT) mice with PCOS-like phenotype. American Society for Reproductive Medicine (ASRM), Honolulu, Hawaii

6. Miriam S. Krause, Zi-Jian Lan, Xian Li, Steven T. Nakajima and ZM Lei (2013) Selective theca cell Pten mutant (tPtenMT) in mice causes PCOS-like morphology and reveals an important role of the PI3 kinase signal pathway in regulation of folliculogenesis. IFFS/American Society for Reproductive Medicine (ASRM), Boston, MA

7. Li SQ, Moore AK, Lan ZJ, Zhu J, Li X, Lin J, He Y, Franklin TE, Nakajima ST, ZM Lei (2013) Targeted Disruption of Znf403 Reveals Its Vital Role in Regulation of Placental Development. The 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, Abst. #O-171

8. Lei ZM, Li X, Zhu, J, Rao, CV, Lin J (2012) Neural actions of luteinizing hormone and Alzheimer’s disease. International Conference and Exhibition on Neurology & Therapeutics, Las Vegas, NV

9. ZM Lei, JS Moore, X Li, J Zhu, Ch V. Rao, J Lin (2012) Improvement of brain amyloid deposition in LH receptor knockout (LHRKO)/APP bigenic mice via upregulation of IL6 expression. The 15th World Congress of Gynecological Endocrinology, Firenze, Italy

10. ZJ Lan, H Zhou, X Li, J Lin, CJ Ko, AJ Cooney, ZM Lei (2011) Deletion of Phosphatase and Tensin Homolog in Theca and Interstitial Cells Leads to Development of Polycystic Ovary Syndrome in Young Adult Mice. The 44th Annual Meeting of Society for the Study of Reproduction, Portland, OR, Abst. #206

11. Barski OA, Salabei JK, Ivanova M, Li XP, McCoy T, ZM Lei, Petrash MJ, Bhatnagar A (2010) Novel AKR1Bs in human and mouse. The 15th International Symposium of Enzymology and Molecular Biology Carbonyl Metabolism, Lexington, KY

12. Z.M. Lei, X. Li, C. Schwabe, C.V. Rao, F.P. Yuan (2008) The role of LGR8 in mediating androgen-induced inguinoscrotal testis descent in luteinizing hormone receptor knockout animals. The 41st Annual Meeting of Society for the Study of Reproduction, Kailua-Kona, HI, Abst. #299

13. F.P. Yuan, Ch.V. Rao, Z.M. Lei (2007) Increased LGR8 expression by androgens is necessary for gubernaculum development and inguinoscrotal testis descent in LH receptor knockout animals. The 40th Annual Meeting of Society for the Study of Reproduction, San Antonio, TX, Abst. #284

14. F.P. Yuan, X. Li, Ch.V. Rao, Z.M. Lei (2006) Testicular phenotype in double LH receptor and FSH-β subunit knockout mice. The 39th Annual Meeting of Society for the Study of Reproduction, Omaha, NE, Abst. #8 (Lalor Fellows award)

15. FP Yuan, Ch V Rao, ZM Lei (2005) Involvement of decreased LGR8 expression in inguinoscrotal maldescent of the testes in LH receptor knockout animals. The 38th Annual Meeting of Society for the Study of Reproduction, Quebec City, Quebec, Canada, Abst. #103

16. Woodford D, Li X, Lei ZM, Rao ChV (2005) The lack of LH and FSH signaling in the ovary differentially alters the expression of cyclooxygenase-2, amphiregulin and Müllerian inhibiting substance. The 52nd Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #666

17. Yuan FP, Rao ChV, Lei ZM (2004) Evidence for unbalanced androgen-estrogen signaling in the failure of testicular descent in LH receptor knockout mice. The 37th Annual Meeting of Society for the Study of Reproduction, Vancouer, BC, Canada, Abst. #12

18. Lo CK, Lei ZM, ChV Rao, Lamb DJ (2003) De novo testosterone production in a luteinizing hormone receptor knock out mouse after transplatation of Leydig stem cells. The 59th Annual Meeting of the American Society for Reproduction Medicine, San Antonio, TX, Abst. #640

19. Ponnuru P, Lei ZM, Rao ChV (2003) Ovarian structure changes in LH receptor knockout animals and the effect of estradiol and progesterone replacement therapy. The 36th Annual


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Meeting of Society for the Study of Reproduction, Cincinnati, OH, Abst. #7 20. Yu YH, Lei ZM, Rao ChV (2003) Adrenals phenotype in LH receptor knockout animals. The

36th Annual Meeting of Society for the Study of Reproduction, Cincinnati, OH, Abst. #270

21. Lin DX, Lei ZM, Li X, Rao ChV (2004) Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling. XIII International Workshop on the Development & Function of the Reproduction Organs, Copenhagen, Denmark

22. Lei ZM, Zou W, Xu B, Li X, Foltz M, Rao ChV (2002) Analysis of spermatogenic failure in LH receptor knockout animals. The first Asia-Pacific Forum on Andrology, Shanghai, China, Abst. #O4-3

23. Rao ChV, Mishra S, Zou W, Foltz M, Xu B, Li X, Lei ZM (2001) Targeted disruption of LH receptor gene reveals the importance of uterine LH signaling. The 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, Canada, Abst. #7.

24. Lei ZM, Zou W, Mishra S, Foltz M, Xu B, Li X, Rao ChV (2001) Unique uterine and ovarian ERa and ERb changes in LH receptor knockout animals. The 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, Canada, Abst. #33.

25. Rao ChV, Lei ZM (2001) Consequences of targeted inactivation of LH receptors. In the Program of the XII International Workshop on the Development and Function of the Reproductive Organs. Advances in Reproductive Research: From Follicle Culture to Nuclear Transfer and Embryonic Stem Cells, Abst. #22.

26. Lei ZM, Mishra S, Zou W, Xu B, Li X, Rao ChV (2001) Altered steroid hormone signaling in testes of LH receptor knockout mice. The 83ndAnnual Meeting of the Endocrine Society, Denver, CO, Abst. #OR17-1.

27. Rao ChV, Neale JR, Mishra S, Pierce WM, Lei ZM (2001) Bone changes in LH receptor knockout animals. The 83ndAnnual Meeting of the Endocrine Society, Denver, CO, Abst. #OR24-2.

28. Rao ChV, Li X, Manna SK, Lei ZM, Aggarwal BB (2001) Regulation of gene ex-pression and transcription factors in MCF-7 cells by human chorionic gonadotropin. The 83ndAnnual Meeting of the Endocrine Society, Denver, CO, Abst. #OR50-5.

29. Mishra S, Lei ZM, Rao ChV (2000) Gonadal failure in LH/hCG receptor knockout mice: increased apoptosis and decreased telomerase levels. The 33rd Annual Meeting of Society for the Study of Reproduction, Madison, WI, Abst. #236

30. Zhang YM, Lei ZM, Rao ChV (1998) Human macrophages contain luteinizing hormone and chorionic gonadotropin receptors. The 45th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #F212

31. Yang M, Lei ZM, Rao ChV (1999) Novel regulation of indoleamine 2,3-dioxygenase gene by chorionic gonadotropins (hCG) in human syncytiotrophoblasts: implications support the premise that hCG prevents fetal rejection by the maternal immune system. The 32nd Annual Meeting of Society for the Study of Reproduction, Pullman, WA, Abst. #450

32. Zhang W, Lei ZM, Rao ChV (1998) Signaling and the requirement of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors in the action of LH/hCG to increase the expression of 5-lipoxygenase gene in HN33p neurons. The 31st Annual Meeting of Society for the Study of Reproduction, College Station, TX, Abst. # 89

33. Wang P, Lei ZM, Rao ChV (1998) Cyclic AMP/protein kinase A signaling in luteinizing hormone and human chorionic gonadotropin action to increase the oviductal glycoprotein synthesis in bovine tubal epithelial cells. The 31st Annual Meeting of Society for the Study of Reproduction, College Station, TX, Abst. #137

34. Huang ZH, Lei ZM, Rao ChV (1996) Rat anterior pituitary contains luteinizing hormone/human chorionic gonadotropin receptors. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #OR22-8

35. Tao YX, Lei ZM, Rao ChV (1996) Human epididymis contains luteinizing hormone/chorionic gonadotropin receptors. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #OR21-2


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36. Lei ZM, Taylor DD, Gercel-Taylor C, Rao ChV (1996) Tumorigenic potential of human chorionic gonadotropin in choriocarcinoma JAR cells. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #99

37. Tao YX, Lei ZM, Rao ChV (1995) Novel expression of luteinizing hormone/human chorionic gonadotropin receptor gene in rat mammary glands. The Endocrine Society 77th Annual Meeting, Washington DC. Abst. #OR21-3

38. Lei ZM, Rao ChV, Hiatt ES (1994) Novel expression of LH/hCG receptors and their functional coupling to the negative regulation of GnRH gene in immortalized hypothalamic neuronal GT1-7 cells. Society for Gynecologic Investigation 41st Annual Meeting, Chicago, IL, Abst. #O214

39. How H, Zuo J, Lei ZM, Spinnato JA II, Rao ChV (1994) Human myometrial estradiol and progesterone receptor changes in preterm and term deliveries. Society for Gynecologic Investigation 41st Annual Meeting, Chicago, IL, Abst. #P203

40. Cao H, Lei ZM, Rao ChV (1993) Pre- and Post-transcriptional mechanism involved in epidermal growth factor regulation of human chorionic gonadotropin biosynthesis and secretion in human choriocarcinoma cells. The 5th Meeting of the European Placenta Group, Manchester, UK. Abst. #A8.

41. Toth P, Li X, Lei ZM, Rao ChV (1993) Human amnion is a novel target of direct regulation by human chorionic gonadotropin. Society for Gynecologic Investigation 40th Annual Meeting, Toronto, Canada. Abst. #S64.

B. Poster Presentations (National/International Meetings)

1. Kaimin Guo, Yan He, Lingyun Liu, Zuowen Liang, Xian Li, Hongliang Wang, Zhenmin Lei (2018) ablation of Ggnbp2 impairs meiotic DNA double strand break repair during spermatogenesis in mice. The 51th Annual Meeting of Society for the Study of Reproduction, New Orleans, LA

2. Yelena Dondik, Zhenmin Lei, Jeremy Gaskins, Kelly Pagidas (2018) Minichrosome maintenance complex 8 and 9 gene expression in the menstrual cycle and unexplained primary ovarian insufficiency. American Society for Reproductive Medicine (ASRM). Denver, CO

3. Lingyun Liu, Yan He, Linying Zhou, Xian L2, Kaimin Guo, Hongliang Wang and Zhenmin Lei (2017) Ggnbp2 Null Mutation Leads to Male Infertility in Mice Due to a Defect at the Spermatid Stage of Spermatogenesis. The 50th Annual Meeting of Society for the Study of Reproduction, Washington, D.C, Abst. #P441

4. YH Hu, ZJ Lan, S Zhang, X Li, HX Zhou, JX Ding, CM Klinge, AJ Cooney, ZM Lei, J Zhang (2016) GGNBP2 to suppress tumor growth through modulating ERa action in breast cancer. The 2016 ASCO Annual Meeting, Chicago, IL, Abst. #el2009

5. Shengqiang Li, Andrew K. Moore, Jia Zhu, Xian Li, Yangbin Pan, Huaxin Zhou, Jing Lin, Yan He, Fengying Xing, Tanya E. Franklin, Steven T. Nakajima, Jixiang Ding, Austin J. Cooney, Zi-Jian Lan, Zhenmin Lei (2015) ZNF403 is essential for pregnancy success through the regulation of mouse trophoblast stem cell proliferation and differentiation in the placenta. The 16th World Congress on Human Reproduction, Berlin, Germany, Abst. #P175

6. Lei ZM, SQ Li, X Li, J Zhu, ZJ Lan, J Lin (2013) Germ cell selective deletion of Numb/Numbl causes cystic dilation of the rete testis in mice. The 46th Annual Meeting of Society for the Study of Reproduction, Montréal, Québec, Canada. Abst. #780

7. Gao Y, Lei ZM, Lu C, Roisen F, El-Mallakh RS (2013) Differentiation of olfactory neuroepithelial progenitors derived from bipolar and non-bipolar subjects. The 10th International Conference on Bipolar Disorders, Miami, FL

8. Zheng Y, Song J, Lei ZM, Chen DB (2013) Targeted Disruption of Caveolin-1 Gene Leads to IUGR in Association with Markedly Decreased Angiogenesis and Increased Nitrosative Stress in the Placenta. The 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, Abst. #S-073


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9. Lei ZM, Lin J, Zhu J, Li X, Ko CM, Lan ZJ (2012) Expression of Genomic Functional Estrogen Receptor 1 (Esr1) in Mouse Sertoli Cells. The 45th Annual Meeting of Society for the Study of Reproduction, State College, PA, Abst #611

10. Y Siow, SQ Li, J Lin, X Li, ZJ Lan, Rao, CV, ME Fallat, ZM Lei (2011) Identification of gubernacular androgen responsive genes in luteinizing hormone receptor knockout mice. The 44th Annual Meeting of Society for the Study of Reproduction, Portland, OR, Abst #564

11. Li SQ, Lin J, Li X, Araki Y, Lan ZJ, Lei ZM (2010) Germ cell-selective ablation of Fgfr-1 or Fgfr-2 in mice does not affect male fertility. The 43nd Annual Meeting of Society for the Study of Reproduction, Milwaukee, WI, Abst. #510

12. TW McCoy, X Li, ST Nakajima, ME Fallat, ZM Lei, Y Siow (2010) FSH receptor, Mullerian-inhibiting substance and MIS-II receptor expression in human ovarian preantral follicle stages. The 57th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, Abst. #254

13. Gao YL, El-Mallakh RS, Brill S, Lei ZM, Lingrel JB (2010) Sodium pump alpha2 hemideficient mouse as an animal model for manis. The 65th Annual Meeting of the Society of Biological Psychiatry, New Orleans, LA, Abst. #443

14. Peterson S, Masri B, Gao Y, Hougland T, Lei ZM, El-Mallah RS, Adham N, Gyertyan I, Kiss B, Caron MG (2010) Interference with D2 dopamine receptor b-arrestin 2 signaling may relate to the antimanic effects of cariprazine. The 65th Annual Meeting of the Society of Biological Psychiatry, New Orleans, LA, Abst. #813

15. Gao Y, Killingbeck SR, Lei ZM, Lu C, Roisen F, El-Mallakh RS (2010) Intracellular pH in olfactory neuroepithelial cells derived from bipolar subjects and psychiatrically normal controls. The 65th Annual Meeting of the Society of Biological Psychiatry, New Orleans, LA, Abst. #830

16. ZM Lei, X Li, FP Yuan, L Lin, CL Cook, CV Rao, J Lin (2010) Luteinizing hormone receptor knockout ameliorates amyloid burden in a mouse model of Alzheimer’s disease. The 14th International Congress of Endocrinology, Kyoto, Japan, Abst. #P7-2-5

17. PS Uzelac, X Li, J Lin, LN Youngblood, ST Nakajima, ZM Lei (2009) Effects of gestational diabetes mellitus on the endocrine networks in the human placenta. The 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland,UK Abst. #338

18. N Adham, G Samoriski, YL Gao, T Hougland, ZM Lei, R S El-Mallakh, B Kiss, I Gyertyán, Z Szombathelyi (2009) Cariprazine (RGH-188), a potential antipsychotic with dopamine D3/D2 functional antagonist properties, attenuates manic-like behaviors in anima models. The 39th

Annual Meeting of the Society for Neuroscience, Chicago, IL 19. SQ Li, ZJ Lan, X Li, J Lin, ZM Lei (2009) Expression of fibroblast growth factor (FGF)-4, -8

and FGF receptor-1, -2 in the mouse testis during postnatal development. The 42nd Annual Meeting of Society for the Study of Reproduction, Pittsburgh, PA, Abst. #672

20. H Zhou, LH Liu, AJ. Cooney, ZM Lei, ZJ Lan (2009) Expression of a putative transcriptional factor, zinc finger protein 105, in mouse testis. The 42nd Annual Meeting of Society for the Study of Reproduction, Pittsburgh, PA, Abst. #684

21. Gao YL, Galante M, El-Mallakh J, Lei ZM, Nurnberger J, El-Mallakh RS (2009) BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorder. The 8th International Conference on Bipolar Disorder, Pittsburgh, PA, Abst. #P77

22. Gao YL, Lei, ZM, Lu C, Roisen FJ, El-Mallakh RS (2009) Olfactory neuroepithelial progenitors derived from bipolar disorder are more susceptible to ionic stress induced apoptosis. The 8th International Conference on Bipolar Disorder, Pittsburgh, PA, Abst. #P78

23. Lin J, Lei ZM, Rao CV (2008) LH/hCG dependent expression of uterine matrix metalloproteinases. The 55th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA. Abst. # 871

24. Willett L, Gao YL, Lei ZM, C Lu, F Roisen, WI Winstead, Rif S. El-Mallakh (2008) Effects of


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brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. The 63rd Annual Scientific Convention & Meeting of the Society of Biological Psychiatry, Washington D.C. Abst. # 949

25. Gao YL, Lei ZM, C Lu, F Roisen, Rif S. El-Mallakh (2008) Effect of elevated intracellular sodium concentration on the expression of the bipolar candidate gene transient receptor protein Melastatin subtype 2 (TRMP2). The 63rd Annual Scientific Convention & Meeting of the Society of Biological Psychiatry, Washington D.C. Abst. # 257

26. Gao YL, Hougland MT, Herman L, Lei ZM, El-Mallakh J R, Banerjee PK, Rif S. El-Mallakh (2008) Effect of memantine in an animal model of mania. The 63rd Annual Scientific Convention & Meeting of the Society of Biological Psychiatry, Washington D.C. Abst. #164

27. Hougland MT, Gao YL, Herman L, Ng CK, Lei ZM, Rif S. El-Mallakh (2008) [18F]-Fluorodeoxyglucose position emission tomography in an animal model of mania. The 63rd Annual Scientific Convention & Meeting of the Society of Biological Psychiatry, Washington D.C. Abst. #190

28. J. Lin, ZM Lei, X Li, Ch V Rao (2007) Uterine phenotype in double versus single LH receptor and FSH-b subunit knockouts. The 54th Annual Meeting of the Society for Gynecologic Investigation, Reno, NV, Abst. #158

29. Bodek G, Lei ZM, Rao ChV (2006) Decreased ovarian response to exogenous gonadotropins due to luteinizing hormone/chorionic gonadotropin receptor haploinsufficiency. The 53rd Annual Meeting of the Society for Gynecologic Investigation, Toronto, Ontario, Canada, Abst. #296

30. Clark BJ, Corbitt C, Klinge C, Lei ZM, States JC (2006) Decreased serum testosterone levels in adult male mice prenatally exposed to arsenite. The 88th Annual Meeting of the Endocrine Society, Boston, MA, Abst. # P1-170

31. Woodford D, Li X, Lei ZM, Rao ChV (2006) Altered ovarian expression of betacellulin and amphiregulin in LH receptor and FSH-β subunit knockout animals. The 53rd Annual Meeting of the Society for Gynecologic Investigation, Toronto, Ontario, Canada, Abst. #593

32. Lin J, Lei ZM, Li X, Yuan FP, Rao ChV (2006) Consequences of double knockout of LH receptor and FSH-β subunit genes in female mice. The 53rd Annual Meeting of the Society for Gynecologic Investigation, Toronto, Ontario, Canada, Abst. #590

33. Rao ChV, Bodek E, Yu YH, Lei ZM (2005) Molecular characterization of the adiposity in LH receptor knockout mice. The 52nd Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #367

34. Lei ZM, Yuan FP, Yu YH, Li X, Rao ChV (2005) LH receptor deficiency increases susceptibility to alkylating agent induced lymphomagenesis. The 52nd Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #908

35. Lin DX, Lei ZM, Rao ChV (2004) LH receptor inactivation and LH receptor gene therapy revealed that uterine COX-2, but not COX-1, is LH responsive. The 37th Annual Meeting of Society for the Study of Reproduction, Vancouer, BC, Canada, Abst. #433

36. Fluhr H, Sauter G, Licht P, Lei ZM, Rao CV (2004) Uterine expression of leukemia inhibitory factor (LIF) and interleukin (IL)-11 mRNA is altered in LH/hCG receptor knockout mice. The 48thSymposion of German Society of Endocrinology, Dresden, Germany, Abst. #V37

37. Ponnuru P, Lei ZM, Rao ChV (2004) Ovarian aging as a function of LH receptor gene dose. The 51th Annual Meeting of the Society for Gynecologic Investigation, Houston, TX, Abst. #180

38. Lin DX, Lei ZM, Rao ChV (2004) Differential gene expression in LH receptor knockout uterus. The 51th Annual Meeting of the Society for Gynecologic Investigation, Houston, TX, Abst. #948

39. Yu YH, Lei ZM, Rao ChV (2004) The development of obesity in LH receptor knockout females. The 51th Annual Meeting of the Society for Gynecologic Investigation, Houston, TX, Abst. #182

40. Lei ZM, Rao ChV (2003) Cytokine storm in LH receptor knockout female mice. The 50th


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Annual Meeting of the Society for Gynecologic Investigation, Washington, DC, Abst. #346

41. Chudgar D, Lei, ZM, Rao ChV (2003) Orthotopic transplantation of LH receptor knockout and normal ovaries. The 50th Annual Meeting of the Society for Gynecologic Investigation, Washington, DC, Abst. #256

42. Rao ChV, Zou W, Xu B, Foltz M, Li X, Lei ZM (2002) Uterine androgen receptor changes in LH receptor knockout animals. The 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #549

43. Lei ZM, Zou W, Xu B, Foltz M, Li X, Rao ChV (2002) Uterine progesterone receptor A and B changes in LH receptor knockout animals. The 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #535

44. Lei ZM, Zou W, Xu B, Foltz M, Li X, Rao ChV (2002) Aromatase gene expression in gonads of LH receptor knockout animals. The 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #536

45. Russo IH, Lei ZM, Russo J, Ma B, Rao ChV (2002) Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene alters mammary gland development. The 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, Abst. #554

46. Carlson HE, Kane P, Lei ZM, Li X, Rao ChV (2002) LH/hCG receptors are present in gynecomastia tissues. The 84thnnual Meeting of the Endocrine Society, San Francisco, CA, Abst. #P2-683

47. Lei ZM, Xu B, Foltz M, Li X, Mishra S, Rao ChV (2002) Male phenotype and its reversal by testosterone replacement therapy of LH receptor knockout animals. The 84th Annual Meeting of the Endocrine Society, San Francisco, CA, Abst. #P3-56

48. Goodarzi MO, Dawson D, Li X, Lei ZM, Shintaku P, Rao ChV, Herle AJV (2002) Postmenopausal testosterone production and virilization in bilateral macronodular adrenal hyperplasia: evidence of control by ectopic LH receptors. The 84thnnual Meeting of the Endocrine Society, San Francisco, CA, Abst. #P2-629

49. Lei ZM, Xu B, Foltz M, Li X, Rao ChV (2002) Testicular macrophage changes in LH receptor knockout animals. The 35th Annual Meeting of Society for the Study of Reproduction, Baltimore, MA, Abst. #115

50. Abdallah M, Lei ZM, Li X, Ackermann D, Greenwold N, Jauniaux E, Rao ChV (2001) Human fetal organs contain hCG/LH receptors. The 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, Canada, Abst. #200.

51. Zou W, Lei ZM, Mishra S, Foltz M, Xu B, Li X, Rao ChV (2001) Gonadal gene expression changes in LH receptor knockout animals. The 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, Canada, Abst. #759.

52. Mishra S, Lei ZM, Rao ChV (2001) LH receptor knockout animals reveal fetal and adult type leydig cell dependence on LH signaling. The 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, Canada, Abst. #824.

53. Lin PC, Li X, Lei ZM, Rao ChV (2001) Human cervix LH/hCG receptors are functional. The 83ndAnnual Meeting of the Endocrine Society, Denver, CO, Abst. #P2-431.

54. Lei ZM, Mishra S, Zou W, Xu B, Foltz M, Rao ChV (2001) Epididymal phenotype in LH receptor knockout animals and the effect of testosterone replacement therapy. The 34rd Annual Meeting of Society for the Study of Reproduction, Ottawa, Canada, Abst. #298.

55. Mishra S, Lei ZM, Foltz M, Rao ChV (2001) Knockout of LH receptors revealed reproductive abnormalities in older heterozygous female siblings. The 34rd Annual Meeting of Society for the Study of Reproduction, Ottawa, Canada, Abst. #448.

56. Lei ZM, Mishra S and Rao ChV (2000) Targeted disruption of the luteinizing hormone/human chorionic gonadotropin receptor gene: characterization of male phenotype. The 33rd Annual Meeting of Society for the Study of Reproduction, Madison, WI, Abst. #467

57. Lei ZM, Mishra S and Rao ChV (2000) Targeted disruption of the luteinizing hormone/human chorionic gonadotropin receptor gene: characterization of female phenotype. The 82nd


11

Annual Meeting of the Endocrine Society, Toronto, Canada, Abst. #1285 58. Lin PC, Li X, Lei ZM, Rao ChV (2000) Human cervix contains luteinizing hormone and

chorionic gonadotropin receptors. The 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, Abst. #2296

59. Mishra S, Lei ZM, Rao ChV (2000) Bovine oocytes and early embryos contain luteinizing hormone/human chorionic gonadotropin receptors. The 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, Abst. #1335

60. Li X, Lei ZM, Rao ChV (2000) Human bone contains functional luteinizing hormone/human chorionic gonadotropin receptors. The 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, Abst. #259

61. Wy L, Carlson HE, Kane P, Li X, Lei ZM, Rao ChV (2000) Cushing’s syndrome secondary to an hCG/LH receptor positive adrenal carcinoma presenting in the postpartum period. The 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, Abst. #2040

62. Mishra S, Lin PC, Lei ZM, Rao ChV (2000) Evidence for the presence of human chorionic gonadotropin/luteinizing hormone receptors in human oocytes and early embryos. The 47th

Annual Meeting of the Society for Gynecologic Investigation, Chicago, IL, Abst. #576 63. Lei ZM, Rao ChV (2000) The immuno-protective role of human chorionic gonadotropin at

fetal-maternal interface. The 47th Annual Meeting of the Society for Gynecologic Investigation, Chicago, IL, Abst. #504

64. Kurtzman J, Jones E, Goldsmith LJ, Spinnato J, McFarling L, Lei ZM, Rao ChV (2000) Inhibition of preterm delivery by human chorionic gonadotropin is associated with down-regulation of myometrial gap junctions. The 2000 Annual Meeting of Society for Maternal-Fetal Medicine, Miami, FL, Abst. #668

65. Zhang YM, Lei ZM, Rao ChV (1999) Nuclear epidermal growth factor receptors inhibit the transcription of human chorionic gonadotropin/luteinizing hormone receptor gene in isolated human trophoblasts nuclei. The 81st Annual Meeting of the Endocrine Society, San Diego, CA, Abst. # P3-530

66. Li X, Lei ZM, Rao ChV (1999) The actions of human chorionic gonadotropin in MCF-7 cells support the premise that it may protect woman against breast cancer. The 81st Annual Meeting of the Endocrine Society, San Diego, CA, Abst. # P3-195

67. Han S.W, Zhou XL, Lei ZM, Rao ChV (1999) Role of luteinizing hormone in human endometrial carcinoma. The 81st Annual Meeting of the Endocrine Society, San Diego, CA, Abst. # P1-593

68. Yang M, Lei ZM, Rao ChV (1999) Mechanism of leukemia inhibitory factor induced differentiation of human cytotrophoblasts into syncytiotrophoblasts. The 81st Annual Meeting of the Endocrine Society, San Diego, CA, Abst. # P1-6

69. Mishra S, Lei ZM, Rao ChV (1999) A novel role for luteinizing hormone in promoting the development of early bovine embryos into blastocytes through its actions on oviductal epithelial cells. The 32nd Annual Meeting of Society for the Study of Reproduction, Pullman, WA, Abst. #185

70. Zhou XL, Lei ZM, Rao ChV (1999) Functional importance of urinary bladder luteinizing hormone/human chorionic gonadotropin receptors. The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #731.

71. Akerman F, Li X, Lei ZM, Rao ChV (1999) Human fetal membranes and umbilical cord express leptin and its receptor genes. The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #206

72. Amesse LS, Yang M, Lei ZM, Rao ChV (1999) The expression of leptin and its receptor genes during the differentiation of human cytotrophoblasts into syncytiotrophoblasts. The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #396

73. Zhang YM, Lei ZM, Rao ChV (1999) Functional importance of human monocyte luteinizing hormone and chorionic gonadotropin receptors. The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #46


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74. Yang M, Lei ZM, Rao ChV (1999) How does epidermal growth factor promote the differentiation of human cytotrophoblasts into syncytiotrophoblasts? The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #31

75. Mishra S, Lei ZM, Rao ChV (1999) Novel effect of luteinizing hormone and human chorionic gonadotropin on the release of sperm bound to oviductal epithelial cells. The 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #45

76. Zhou XL, Lei ZM, Rao ChV Rao (1998) Human adrenal cortical H295R cells contain functional luteinizing hormone/ chorionic gonadotropin receptors: A potential explanation for increased androgen levels in chronic anovulatory women. The 45th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #45

77. Eblen A, Bao S, Lei ZM, Sanfilippo JS, Rao ChV (1998) Human sperm contains luteinizing hormone and chorionic gonadotropin receptors. The 45th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, Abst. #F278

78. Lei ZM, Rao ChV (1998) Inhibition of transcription of rat gonadotropin releasing hormone (GnRH) gene by luteinizing hormone and human chorionic gonadotropin (LH/hCG) in GT1-7 neurons involves a homeodomain transcription factor. The 80th Annual Meeting of the Endocrine Society, New Orleans, LA, Abst. #P3-638

79. Han SW, Lei ZM, Rao ChV (1998) Hormonal regulation of ectopic human chorionic gonadotropin (hCG) synthesis by human fallopian tube epithelial cells. The 80th Annual Meeting of the Endocrine Society, New Orleans, LA, Abst. #P1-350

80. Shapira A, Lei ZM, Rao ChV (1998) Treatment of homozygous HIV-1 transgenic mouse pups with human chorionic gonadotropin (hCG) up-regulates the skin hCG/luteinizing hormone receptor levels. The 80th Annual Meeting of the Endocrine Society, New Orleans, LA, Abst. #P2-149

81. Yang M, Lei ZM, Rao ChV (1998) Central role of human chorionic gonadotropin in the differentiation of human cytotrophoblasts as determined by the antisense oligonucleotide approach. The 31st Annual Meeting of Society for the Study of Reproduction, College Station, TX, Abst. # 421

82. Zhou XL, Lei ZM, Rao ChV (1998) Signaling and the requirement of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors in LH/hCG action to increase the cyclooxygenase-2 gene expression in human endometrial gland epithelial cells. The 31st Annual Meeting of Society for the Study of Reproduction, College Station, TX, Abst. # 405

83. AL-Hader AA, Tao YX, Lei ZM, Rao ChV (1997) Regional distribution of luteinizing hormone/human chorionic gonadotropin receptors in fetal rat brains. The 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, Abst.# P2-382

84. Bian L, Lei ZM, Rao ChV (1997) Epidermal growth factor stimulates the mitogen activated protein kinase in nuclear membranes of JEG-3 human choriocarcinoma cells. The 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, Abst. # P3-555

85. Lei ZM, Rao ChV (1997) human chorionic gonadotropin transcriptionally inhibits tyrosine hydroxylase via Oct-2 transcription factor in GT1-7 neurons. The 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, Abst. # P3-554

86. Han SW, Lei ZM, Rao ChV (1997) Regulation of luteinizing hormone/human chorionic gonadotropin receptor levels in human fallopian tube epithelial cells by estradiol and human chorionic gonadotropin. The 44th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, Abst. # 605

87. Zhou XL, Lei ZM, Rao ChV (1997) Regulation of cyclooxygenase-2 in human endometrial glandular epithelial cells by human chorionic gonadotropin and luteinizing hormone. The 44th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, Abst. # 633

88. Bao S, Lei ZM, Rao ChV (1997) The presence of functional luteinizing hormone/chorionic gonadotropin receptors in human prostate cell lines. The 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, Abst. # P3-403


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89. Corley DR, Li x, Lei zm, Sanfilippo JS, Rao ChV (1997) Regulation of rat gonadotropin releasing hormone gene by steroidogenic factor-1 in GT1-7 neurons. The 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, Abst. # P3-544

90. Zhang W, Lei ZM, Rao ChV (1997) The presence of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors and the effect of exogenous hCG on the mRNA levels of 5-lipoxygenase (5-Lo) in immortalized hippocampal, HN33p neurons. The 30th Annual Meeting of Society for the Study of Reproduction, Portland, OR, Abst. # 563

91. Al-Hader AA, Lei ZM, Rao ChV (1996) Neurons from fetal rat brains contain functional luteinizing hormone/human chorionic gonadotropin receptors. The 29th Annual Meeting of the Society for the Study of Reproduction, London, Ontario, Canada, Abst. #150

92. Han SW, Z.M. Lei and Ch.V. Rao (1996) Transcriptional regulation of prolactin gene by chorionic gonadotropin during the differentiation of human endometrial. The 29th Annual Meeting of the Society for the Study of Reproduction, London, Ontario, Canada, Abst. #343

93. Huang ZH, Lei ZM, Rao ChV (1996) Transcriptional and posttranscriptional mechanisms in human chorionic gonadotropin and gonadotropin releasing hormone regulation of luteinizing hormone alpha-subunit gene expression. The 29th Annual Meeting of the Society for the Study of Reproduction, London, Ontario, Canada, Abst. #336

94. Lei ZM, Rao ChV (1996) Effect of human chorionic gonadotropin on Oct-2 transcription factor in GT1-7 neurons. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #P3-204

95. Al-Hader AA, Lei ZM, Rao ChV (1996) Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #P3-335

96. Rodway MR, Lei ZM, Rao ChV (1996) The presence of functional human chorionic gonadotropin (hCG)/luteinizing hormone (LH) receptors in immortalized human term placental WT49 and HP-A1 cytotrophoblasts. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #P3-446

97. Han SW, Lei ZM, Rao ChV (1996) Homologous downregulation of luteinizing hormone (LH)/chorionic gonadotropin (CG) receptors by a post-transcriptional mechanism during the differentiation of human endometrial stromal cells into decidua. The 10th International Congress of Endocrinology, San Francisco, CA, Abst. #P3-349

98. Rodway MR, Lei ZM, Rao ChV (1996) Treatment of cultured human syncytiotrophoblasts with chorionic gonadotropin down-regulates gonadotropin-releasing hormone transcripts. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #42

99. Han SW, Lei ZM, Rao ChV (1996) Regulation of cyclooxygenase-2 by chorionic gonadotropin in differentiation of human endometrial stromal cells into decidua. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst.#66

100. Bird JS, Li X, Lei ZM, Sanfilippo J, Yussman MA, Rao ChV (1996) Regulation of androgen receptors and type I 5-alpha reductase in human skin by chorionic gonadotropin. The 43rd Annual Meeting of the Society for Gynecologic Investigation, Philadelphia, PA, Abst. #195

101. Sun T, Lei ZM, Rao ChV (1996) Novel regulation of oviductal glycoprotein by human chorionic gonadotropin in mucosal cell cultures. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #198

102. Hu YL, Lei ZM, Rao ChV (1996) Cis-acting elements and trans-acting proteins in the increased transcription of human chorionic gonadotropin/luteinizing hormone receptor gene in choriocarcinoma cells as compared with normal term pregnancy placenta. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #600

103. Tao YX, Heit M, Lei ZM, Rao ChV (1996) Trigone of human urinary bladder is a novel site of luteinizing hormone/chorionic gonadotropin receptor expression. The 43rd Annual Meeting


14

of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #616 104. Lojun S, Bao S, Lin J, Lei ZM, Rao ChV (1996) The expression and functional relevance of

chorionic gonadotropin/luteinizing hormone receptors in human breast cell lines. The 43rd Annual Meeting of the Society for gynecologic Investigation, Philadelphia, PA, Abst. #621

105. Lei ZM, Rao ChV (1995) Cis-elements and trans-acting factors in the transcriptional inhibition of gonadotropin releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. The Endocrine Society 77th Annual Meeting, Washington DC., Abst. #P1-545

106. Hu Y, Lei ZM, Rao ChV (1995) Identification and characterization of negative control region and transacting proteins in the 5'-flanking region of luteinizing hormone/human chorionic gonadotropin receptor gene. The Endocrine Society 77th Annual Meeting, Washington DC, Abst. #P1-542

107. Huang ZH, Lei ZM, Rao ChV (1995) Functional relevance of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors in alpha T3 gonadotrope cells. The 28th Annual Meeting of the Society for the Study of Reproduction, Davis, CA Abst. #342

108. Han SW, Lei ZM, Rao ChV (1995) Regulation of cyclooxygenase-2 (cox-2) by human chorionic gonadotropin (hCG) in mucosal cells from human fallopian tubes. The 28th Annual Meeting of the Society for the Study of Reproduction, Davis, CA Abst. #385

109. Pabon JE, Bird JS, Li X, Lei ZM, Sanfilippo J, Yussman MA, Rao ChV (1995) Novel presence of human luteinizing hormone(LH)/chorionic gonadotropin (hCG) receptors in human skin. The 42nd Annual Meeting of the Society for Gynecologic Investigation, Chicago, IL Abst. #P382

110. Lei ZM, Rao ChV (1994) Molecular mechanism in down-regulating action of human chorionic gonadotropin on the expression of gonadotropin-releasing hormone gene in immortalized hypothalamic GT1-7 neurons. The 27th Annual Meeting of Society for Study of Reproduction, Alma, MI, Abst. #315

111. Cao H, Lei ZM, Rao ChV (1994) Functional nuclear epidermal growth factor receptors in normal human placenta and JEG-3 choriocarcinoma cells. The 76th Annual Meeting of the Endocrine Society, Anaheim, CA, Abst. #275

112. Lei ZM, Rao ChV (1994) Signaling and trans-acting factors in down-regulating action luteinizing hormone (LH) and human chorionic gonadotropin (hCG) on the expression of gonadotropin releasing hormone (GnRH) gene in immortalized hypothalamic GT1-7 neurons. The 76th Annual Meeting of the Endocrine Society, Anaheim, CA, Abst. #44

113. Woodworth SH, Lei ZM, Rao ChV, Yussman MA, Spinnato J II, Tanabe T, Yokoyama C (1993) Expression of thromboxane (TX) A2 synthase gene in fetoplacental unit from normal and preeclamptic pregnancies. Society for Gynecologic Investigation 40th Annual Meeting, Toronto, Canada. Abst. #P238.

114. Lin J, Lei ZM, Gall TA, Hong L, Wu WX, Gall SA, Peiper SC, Rao ChV (1993) Novel expression of hCG/LH receptor protein and receptor mRNA transcripts in leukocytes from pregnancy. Society for Gynecologic Investigation 40th Annual Meeting, Toronto, Canada. Abst. #P124.

115. Rao ChV, Li X, Toth P, Lei ZM (1993) Expression of epidermal growth factor, transforming growth factor-alpha and their common receptor and its functional relevance to eicosanoid biosynthetic pathway in human umbilical cords. The Endocrine Society 75th Annual Meeting, Las Vegas, NV. Abst. #266.

116. Licht P, Lei ZM, Rao ChV, Merz WE (1992) A Novel effect of bredfeldin A (BFA): inhibition of hCG alpha and beta-subunit mRNA levels in choriocarcinoma cells and evidence for a possible intracrine regulation of hCG biosynthesis. The Endocrine Society 74th Annual Meeting, San Antonio, TX, Abst. #1555.

117. Lincoln SL, Lei ZM, Rao ChV, Ackermann DM (1992) The increased expression of hCG/LH receptors in adenomyosis. Society for Gynecologic Investigation 39th Annual Meeting, San Antonio, TX, Abst. #425.


15

118. Lei ZM, Rao ChV, Satyaswaroop PG, Day TG (1992) The expression of hCG/LH receptors in human endometrial carcinomas. Society for Gynecologic Investigation 39th Annual Meeting, San Antonio, TX, Abst. #209.

119. Kornyei JL, Lei ZM, Rao ChV (1991) Human myometrial smooth muscle cells are novel targets of direct action of hCG. Society for Gynecologic Investigation 38th Annual Meeting, San Antonio, TX, Abst. #445.

120. Lei ZM, Rao ChV (1991) The presence of thromboxane A2 synthase and specific thromboxane A2 binding sits in bovine corpora lutea. Society for the Study of Reproduction 24th Annual Meeting, Vancouver, British Columbia, Canada. Abst. #188.

121. LeiZM, Chakraborty C, Rao ChV (1990) Nuclear epidermal growth factor receptors in human placenta. The American Society for Cell Biology 30th Annual Meeting, San Diego, CA, Abst. #522.

122. LeiZM, Chakraborty C, Rao ChV, Mitchell DE (1990) Light and electron microscope immunocytochemical studies on hCG/LH receptors in human and bovine corpora lutea: cellular localization, cycle dependence and subcellular distribution. The Endocrine Society 72nd Annual Meeting, Atlanta, GA, Abst. #466.

123. Reshef E, Lei ZM, Rao ChV (1990) Identification of human chorionic gonadotropin/ luteinizing hormone (hCG/LH) receptors in blood vessels of the nonpregnant human uteri. Society for Gynecologic Investigation 37th Annual Meeting, St. Louis, MO, Abst. #49.

124. Lei ZM, Spaulding T, Rao ChV, Bailey-Pridham D, Yussman MA (1990) Eicosanoid synthesizing enzymes in pregnant human myometrium: dependence on labor at term and preterm pregnancy. Society for Gynecologic Investigation 37th Annual Meeting, St. Louis, MO, Abst. #147.

125. Swanson MS, Lei ZM, Rao ChV (1990) The presence of specific and discrete thromboxane (TX)A2 binding sites in non pregnant human myometrium. Society for Gynecologic Investigation 37th Annual Meeting, St. Louis, MO, Abst. #398.

126. Bailey-Pridham D, Lei ZM, Rao ChV, Reshef E, Luborsky J (1989) The presence gonadotropin receptors in human fallopian tubes. The American Fertility Society 45th Annual Meeting, San Francisco, CA, Abst. #0-026.

127. Lei ZM, Rao ChV, Luborsky J (1989) The presence of human chorionic gonadotropin/luteinizing hormone (hCG/LH) receptors in human placenta and fetal membranes. Society for the Study of Reproduction 22nd Annual Meeting, Columbia, MO, Abst. #256.

128. Reshef E, Lei ZM, Chegini N, Rao ChV, Luborsky JL (1989) The presence of human chorionic gonadotropin/luteinizing hormone (hCG/LH) receptors in non-pregnancy human uteri. Society for Gynecologic Investigation 36th Annual Meeting, San Diego, CA, Abst. #585.

129. Bailey-Pridham D, Lei ZM, Chegini N, Rao ChV, Yussman MA (1989) Immunocytochemical localization of 5- and 12-lipoxygenases and cyclooxygenase in human

granulosa cells from preovulatory follicles. Society for Gynecologic Investigation 36th Annual Meeting, San Diego, CA, Abst. #380.

130. Chegini N, Lei ZM, Rao ChV, Alila HW, Hansel W (1989) Cellular distribution of cyclooxygenase (CO), prostacyclin (PGI2-S) and thromboxane A2 (TXA2-S) synthases in bovine corpora lutea (BCL) during the cycle. The American Society for Cell Biology and the American Society for Biochemistry and Molecular Biology Joint Meeting, San Francisco, CA, Abst. #1058.

131. Rao ChV, Chegini N, Lei ZM (1989) Nuclei and cytoplasmic organelles of human placental, fetal membrane and decidual cells from mid and term pregnancy contains epidermal growth factor receptors (EGF-R). The American Society for Cell Biology and the American Society for Biochemistry and Molecular Biology Joint Meeting, San Francisco, CA, Abst. #1056.

132. Lei ZM, Chegini N, Rao ChV, Alila MW, Hansel W (1989) Epidermal growth factor receptors (EGF-R) in bovine corpora lutea during the cycle. The American Society for Cell Biology


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and the American Society for Biochemistry and Molecular Biology Joint Meeting, San Francisco, CA, Abst. #1057.

133. Bailey-Pridham D, Lei ZM, Chegini N, Rao ChV, Yussman MA (1988) The presence of 5- and 12-lipoxygenase and cyclooxygenase enzymes in human granulosa cells from preovulatory follicles. The 2nd International Conference on Leukotrienes and Prostanoids in Health and Disease, Jerusalem, Israel. Abst. #18.

134. Rao ChV, Lei ZM, Chegini N (1988) Cellular distribution of 5-lipoxygenase, 12-lipoxygenase and cyclooxygenase in non-pregnant human uteri. The 2nd International Conference on Leukotrienes and Prostanoids in Health and Disease, Jerusalem, Israel. Abst. #49.

135. Chegini N, Lei ZM, Rao ChV (1988) Light and electron microscope immunocytochemical localization of epidermal growth factor (EGF) receptors in bovine corpora lutea of pregnancy. The 7th Ovarian Workshop, Tacoma, WA, Abst. #24.

136. Lei ZM, Chegini N, Rao ChV (1988) Light microscope immunocytochemical localization of eicosanoid synthesizing enzymes in bovine corpora lutea. The 8th International Congress of Histochemistry & Cytochemistry, Washington, D.C., Abst. #382.

137. Lei ZM, Chegini N, Rao ChV, Bischof P, Stoelk E (1988) Immunocytochemical localization of pregnancy associated plasma protein A (PAPPA) in human corpora lutea of various reproductive states. The 8th International Congress of Histochemistry & Cytochemistry, Washington, D.C., Abst. #381.

138. Chegini N, Lei ZM, Rao ChV, Stoelk E (1988) Cellular composition of human corpora lutea in various reproductive states. Society for Study of Reproduction 21st Annual Meeting, Seattle, WA, Abst. #400.

139. Stoelk E, Chegini N, Lei ZM, Rao ChV, Bryant-Greenwood G, Sanfilippo J (1988) Light and electron microscope immunocytochemical localization of relaxin in human corpora lutea in various reproductive states. Society for the Study of Reproduction 21st Annual Meeting, Seattle, WA, Abst. #432.

140. Lei ZM, Zhang YC (1987) Effects of glucocorticoid on hypothalamus-pituitary-thyroid axis of rat. The 1st National Conference of Neuroendocrinology, Shanghai, P.R. China.

141. Zhang YC, Lei ZM (1984) Iodine content in thyroid of thiourea goitrogenic mouse, the histochemical study. The 2nd National Conference of Prevention & Cure of Endemic Diseases. Guiyang, P.R. China.

142. Lei ZM, Liu LQ, Gao ZQ, Zhang YC (1984) Improving pre-embedding method for immuno-electron microscope. The 1st National Conference of Techniques of Histology and Embryolog, Changsha, P.R. China.

C. Poster Presentations (Local/Regional Meetings)

1. Yonglin Gao, Kristofer K Rau, Zhenmin Lei, Rif S. El-Mallakh (2017) Membrane potential of differentiated olfactory neuroepithelial progenitors derived from bipolar and no-bipolar subjects. The 27th Annual Neuroscience Day, Society for Neuroscience, The Louisville Chapter, Louisville, KY, Abst. #33

2. Rajashekar Reddy Yeruva, Rif S. El-Mallakh, Yonglin Gao, Gulay Tegin, Kavita Lohano, Zhenmin Lei (2016) Ethanol and Lithium Normalize Glutamate-Induced Elevation of Intracellular Sodium in Olfactory Neuroepithelial Progenitors from Subjects with Bipolar Illness but not Non-Bipolar Controls: Biologic Evidence for the Self-Medication Hypothesis. Res Louisville 2016, University of Louisville, Louisville, KY

3. Yonglin Gao, Welby Winstead, Zhenmin Lei, Chengliang Lu, Fred J. Roisen, Rif S El-Mallakh (2014) Glutamate Induced Apoptosis in Human Olfactory Neuroepithelial Progenitors Derived from Bipolar and Non Bipolar Subjects. Res Louisville 2014, University of Louisville, Louisville, KY

4. Jonathan Marner, Zhenmin Lei , Xian Li, Guizhu Wu, (2014) Elevation of DENND1A in the Ovaries of Selective Theca Cell Phosphatase and Tensin Homolog (tPten) Mutant Mice with PCOS-Like Phenotype. Res Louisville 2014, University of Louisville, Louisville, KY


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5. Shawn Redding, Xian Li, Guizhu Wu, CheMyong Ko, Austin J. Cooney, Henry Bohler, Zi-Jian Lan, and Zhenmin Lei (2014) Dysregulation of Transforming Growth Factor-ß1 (TGF-ß1) and Fibroblast Growth Factor-7 (FGF-7) Expression in the Ovaries of Selective Theca Cell Phosphatase and Tensin Homolog (tPten) Mutant Mice with PCOS-like Phenotype. 10th Kentucky Innovation & Entrepreneurship Conference, Louisville, KY, Abst. #22

6. Davis P, Justice T, He Y, Li X, Lan ZJ, ZM Lei (2013) ZNF403 expression and function in gonads. Res Louisville 2013, University of Louisville, Louisville, KY, Abst. Med-29

7. YL Gao, C Lu, ZM Lei, FJ Roisen, RS El-Mallakh (2012) Characterization of olfactory neuroepithelial progenitors derived from bipolar and non-bipolar subjects. Res Louisville 2012, University of Louisville, Louisville, KY, Abst. #RA-74

8. J Moore, J Lin, X Li, J Zhu,C Rao, ZM Lei (2011) Amelioration of Amyloidopathy in LH Receptor Knockout (LHRKO)/APP transgenic Mice through Enhanced IL6 Expression. Res Louisville 2011, University of Louisville, Louisville, KY, Abst. #MED-56

9. E Schroeder, YL Gao, ZM Lei, CL Lu, FJ Roisen, Rif El-Mallakh (2011) Microarray of Apoptosis-related Genes in a Novel Cellular Model: Olfactory Neuroepithelial Neural Progenitors from Bipolar Subjects. Res Louisville 2011, University of Louisville, Louisville, KY, Abst. #GRM-25

10. YL Gao, CL Lu, ZM Lei, FJ Roisen, Rif S. El-Mallakh (2011) Effect of hydrocortisone on differentiation of olfactory neuroepithelial progenitor cells derived from bipolar and non-bipolar subjects. Res Louisville 2011, University of Louisville, Louisville, KY, Abst. #RA-74

11. A Gilani, YL Gao, CL Lu, ZM Lei, FJ Roisen, Rif S. El-Mallakh (2011) Effect of hydrocortisone on apoptosis of olfactory neuroepithelial progenitors derived from bipolar and non-bipolar subjects. Res Louisville 2011, University of Louisville, Louisville, KY, Abst. #PRF-42

12. YL Gao, SJ Khundmiri, NA Delamere, ZM Lei, CL Lu, F Roisen, ED Lederer, RS. El-Mallakh (2010) Effect of Ouabain on Intracellular pH of Olfactory Neuroepithelial Progenitor Cells Derived from Bipolar and Non-bipolar Subjects. Res Louisville 2010, University of Louisville, Louisville, KY, Abst. #RA-78

13. K Bodarya, M Jhaveri, YL Gao, ZM Lei, J Lingrel, RS El-Mallakh (2010) Knock Out of the Alpha2 Isoform of the Sodium Pump as an Animal Model for Mania. Res Louisville 2010, University of Louisville, Louisville, KY, Abst. #RS-96

14. RS El-Mallakh, YL Gao, ZM Lei, CL Lu, W Winstead, F Roisen (2010) Neuronal Progenitor Cells Obtained from Bipolar Subjects have an Increased Sensitivity to Proapoptotic Stimuli than Cells Obtained from Non-Bipolar Control Subjects. Res Louisville 2010, University of Louisville, Louisville, KY, Abst. #F-8

15. RS. El-Mallakh, SR Killingbeck, ZM Lei, C Lu, FJ Roisen, YL Gao (2009) Intracellular pH in olfactory neuroepithelial cells derived from bipolar subjects and psychiatrically normal controls. Res Louisville 2009, University of Louisville, Louisville, KY, Abst.#F10

16. Bajramovic M, Lei ZM, Ch. V. Rao, Li X, Lin J, Corbitt C (2007) Anxiety in female wild type and LHRKO mice. Kentucky Art and Science Fair

17. Gao YL, Lei ZM, Roisen F, Lu C, El-Mallakh R (2006) Monensin increases intracellular sodium and reduces mRNA of TRPM in olfactory neuroepithelial-derived progenitors. Res Louisville 2006, University of Louisville, Louisville, KY, Abst.#PRF28

18. Gao YL, X. Huang, ZM Lei, Rif S. El-Mallakh, C. Lu, Roisen F (2006) Effect of monensin on intracellular sodium concentrations in human olfactory neuroepithelial cells. Neuroscience Day, Louisville Chapter, Louisville KY

19. Clark BJ, Corbitt C, Klinge CM, Lei ZM, States JC (2005) Decreased serum testosterone levels in adult male mice exposed prenatally to arsenite. Res Louisville 2005, University of Louisville, Louisville, KY (The First Place in the Most Promising Research Project Category)


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20. Huang X, Lei ZM, Li XP, R. S. El-Mallakh (2004) Response of sodium pump to ouabain challenge in human glial cells in culture. Neuroscience Day, Louisville Chapter, Louisville, KY

21. Jones E, Kurtzman LJ, Goldsmith J, Spinnato L, Mcfarling, Lei ZM, Rao ChV (1999) Inhibition of preterm delivery by human chorionic gonadotropin is associated with down-regulation of myometrial gap junctions. Res Louisville 1999, University of Louisville, Louisville, KY (The 2nd Place in Medical Student Research Category)

PUBLICATIONS

A. Peer-reviewed

1. Jiu-Zhen Jin, Zhenmin Lei, Zi-Jian Lan and Jixiang Ding (2018) Inactivation of Fgfr2 gene in mouse secondary palate mesenchymal cells leads to cleft palate. Reprod Toxicol 77: 137-142

2. Yelena Dondik, Zhenmin Lei, Jeremy Gaskins, Kelly Pagidas (2018), Minichromosome maintenance complex component 8 and 9 gene expression in the menstrual cycle and unexplained Primary Ovarian Insufficiency. J Assist Reprod Genetics (In Press)

3. Zi-Jian Lan, Zhenmin Lei, Alexandros Yiannikouris, Thirupathi Reddy Yerramreddy, Xian Li, Hayley Kincaid, Katie Eastridge, Hannah Gadberry, Chloe Power, Rijin Xiao, Olivia Seale, Karl Dawson, Ronan Power (2018) Discovery of a small molecule to activate insulin receptor signaling in insulin-resistant type 2 diabetes. Science Signaling (In review)

4. Kaimin Guo, Yan He, Lingyun Liu, Zuowen Liang, Xian Li, Lu Cai, Zi-Jian Lan, Junmei Zhou, Hongliang Wang, Zhenmin Lei (2018) ablation of ggnbp2 impairs meiotic dna double strand break repair during spermatogenesis in mice. J Cell & Mol Med 22:4863-4874, doi: 10.1111/jcmm.13751

5. Kate V. Meriwether, Venkatakrishna Jala, Jeremy Gaskins, Deslyn TG. Hobson, Zhenmin Lei (2018)The vaginal and urinary microbiome in premenopausal women with interstitial cystitis/bladder pain syndrome as compared to normal controls: a cohort study. Int Urogynecol J (In review)

6. Tammy Movsas, Kwoon Wong, Michael Ober, Robert Sigler, Zhenmin Lei, and Arivalagan Muthusamy (2018) Confirmation of luteinizing hormone (LH) in living human vitreous and the effect of LH receptor reduction on murine electroretinogram. Neuroscience 385: 1-10

7. Enrico Velardi, Jennifer J. Tsai, Stefan Radtke, Kirsten Cooper, Kimon Argyropoulos, Shieh Jae-Hung, Lauren F. Young, Amina Lazrak, Odette M. Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R. Jenq, Alan M. Hanash, Prema Narayan, Zhenmin Lei, Malcolm A. Moore, Hans-Peter Kiem, Marcel R.M. van den Brink and Jarrod A. Dudakov (2018) Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injuries. Nature Med DOI:10.1038/nm.4470

8. Gao, Yonglin; Lohano, Kavita; Delamere, Nicholas; Lei, Zhenmin; El-Mallakh, Rif (2018) Ethanol Normalizes Glutamate-Induced Elevation of Intracellular Sodium in Olfactory Neuroepithelial Progenitors from Subjects with Bipolar Illness but not Non-Bipolar Controls: Biologic Evidence for the Self-Medication Hypothesis. Bipolar Disorders (In review)

9. Lingyun Liu,Yan He, Kaimin Guo, Linying Zhou, Xian Li, Michael Tseng, Cai Lu, Zi-Jian Lan, Junmei Zhou, Hongliang Wang and Zhenmin Lei (2017) Ggnbp2 Null Mutation Leads to Male Infertility inn Mice Due to a Defect at the Spermiogenesis Stage. Am J Pathol 187: 2508-2519

10. ZJ Lan, MS Krause, SD Redding, X Li, GZ Wu, HX Zhou, HC Bohler, C Ko, AJ Cooney, JM Zhou and ZM Lei (2017) Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice. Mol Cell Endocrinol 44: 26-37

11. Yonglin Gao, Welby Winstead, Zhenmin Lei, Chengliang Lu, Fred J Roisen, Rif S. El-Mallakha (2017) Olfactory neuroepithelial neural progenitor cells from subjects with bipolar I disorder. J Central Nervous Disease DOI:10.1177/1179573517694529


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12. Takashi Tanaka, Mito Kanatsu-Shinohara, Zhenmin Lei, Ch. Venkateswara Rao and Takashi Shinohara (2016) LH-testosterone pathway regulates mouse spermatogonial stem cell self-renewal by suppressing Wnt5a expression in Sertoli cells. Stem Cell Reports, 7(2): 279-91

13. Zi-Jian Lan, YunHui Hu, Sheng Zhang, Xian Li, Huaxin Zhou, Jixiang Ding, Carolyn M. Klinge, Austin J. Cooney, Jin Zhang and Zhenmin Lei (2016)GGNBP2 Acts as a Tumor Suppressor by Inhibiting ERα Activity in Breast Cancer Cells. Breast Cancer Res Tr 158: 263–276

14. SQ Li, AK Moore, J Zhu, X Li, HX Zhou, J Lin, Y He, FY Xing, HC Bohler, JX Ding, AJ Cooney, ZJ Lan and ZM Lei (2016) Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod 94(2):41

15. Emily Schroedera, Yonglin Gao, Zhenmin Lei, Fred Roisenc, Rif S. El-Mallakha (2016) The gene BRAF is under-expressed in bipolar subject olfactory neuroepithelial progenitor cells undergoing apoptosis. Psychiatry Research DOI: 10.1016/j.psychres.2015.12.018

16. Rif S. El-Mallakh, Ralphiel S. Payne, Avital Schurr, Yonglin Gao, Zhenmin Lei, Béla Kiss, István Gyertyán, Nika Adhame (2015) Cariprazine Delays Ouabain-Evoked Epileptiform Spikes and Loss of Activity in Rat Hippocampal Slices. Psychiatry Res 229:370-373

17. Azadi A, Patnaik SS, Jasinski JB, Francis S, ZM Lei, Liao J, Deveneau NE and Ostergard DR (2015) Morphologic Evaluation of Post-implanted Monofilament Polypropylene Mesh Utilizing a Novel Technique with Scanning Electron Microscopy Quantification. Surg Technol Int 26:169-73

18. Li Jiao, Su Wei, Zhang Sheng, Hu Yunhui, Liu Jingjing, Zhang Xiaobei, Bai Jingchao, Yuan Weiping, Hu Linping, Cheng Tao, Zetterberg Anders, ZM Lei, Zhang Jin (2015) EGFR and AKT1 Gene Copy Numbers by Multi-Gene Fluorescence in Situ Hybridization Impact on Prognosis in Breast Cancer. Cancer Sci 106: 642-649

19. Jai Parkash, Zhennin Lei and C.V. Rao (2015) The presence of human chorionic gonadotropin/luteinizing hormone receptors in pancreatic β cells. Reprod Sci 22(8): 1000-1007, DOI: 10.1177/1933719115570910

20. SQ Li, ZJ Lan, X Li, J Lin1 and ZM Lei (2014) Role of postnatal expression of fgfr1 and fgfr2 in testicular germ cells on spermatogenesis and fertility in mice. J Reprod lnferti 15(3): 122-133

21. Jing Lin, Jia Zhu, Xian Li, Shengqiang Li, Zijian Lan, Jay Ko and ZM Lei (2014) Expression of Genomic Functional Estrogen Receptor 1 (Esr1) in mouse Sertoli Cells. Reprod Sci 21 (11):1411-1422

22. Yuehai Wang, Huixia Lu, Huili Lin, ZM Lei, Xiaoqing Chen, Mengxiong Tang, Fei Gao, Mei Dong, Rongda Li, Ling Lin (2014) Apolipoprotein E-knockout mice on high-fat diet show autoimmune injury on kidney and aorta. Biochem Bioph Res Commun 450(1):788-93

23. Gao YL, Malhar Jhaveri, ZM Lei, Brandy L Chaneb, Jerry Lingrel, Rif S El-Mallakh (2013) Glial-specific gene alterations associated with manic behaviors. Int J Bipolar Disorders 1:20 (doi:10.1186/2194-7511-1-20)

24. Gao YL, M. Galante, J. El-Mallakh, JI Jr Nurnberger, NA Delamere, Lei ZM, El-Mallakh RS (2012) BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorder. Psychiatr Genet 22:253-255

25. Gao YL, Payne RS, Lord J, Schurr A, Houglan T, Loard J, Herman L, Lei ZM, Banerjee P, El-Mallakh RS (2011) Memantine reduces mania-like symptoms in animal models. Psychiatric Res 188:366-371

26. LF Morris, S Park BA, T Daskivich, BM Churchill, CV Rao, ZM Lei, D Martinez, MW Yeh (2011) Virilization of a female infant by a maternal adrenocortical carcinoma. Endocrine Practice 17(2):e26-31

27. Gao YL, Lei ZM, Lu C, Roisen F, El-Mallakh RS (2010) Effect of ionic stress on apoptosis and expression of TRPM2 in human olfactory neuroepithelial-derived progenitors. World J Biol Psychia 11(8):972-84


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28. Yu Y, Yuan F, Li X, Lin D, Lan ZJ, Rao CV, Lei ZM (2010) Luteinizing hormone receptor deficiency increases the susceptibility to alkylating agent-induced lymphomagenesis in mice. Hormones and Cancer 1:256-264

29. Willett L, Gao Y, Lei ZM, Lu C, Roisen FJ, Winstead WI, El-Mallakh RS (2010) Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry Res, 178(2):391-4

30. Dongming Xu, Ling Lin, Xiahong Lin, Ziyang Huang, ZM Lei (2010) Immunoregulation of Autocrine prolactin: Suppressing the Expression of Costimulatory Molecules and Cytokines in T Lymphocytes by Prolactin Receptor Knockdown. Cell Immunol 263:71-78

31. Peter S. Uzelac, Xian Li, Jing Lin, Lyndsey D. Neese, Ling Lin, Steven T. Nakajima, Henry Bohler, ZM Lei (2010), Dysregulation of leptin and testosterone production and their receptor expression in the human placenta with gestational diabetes mellitus. Placenta 31:581-588

32. FP Yuan, X Li, J Lin, C Schwabe, EE Büllesbach, CV Rao, Z M Lei (2010) The Role Of RXFP2 In Mediating Androgen-Induced Inguinoscrotal Testis Descent In Luteinizing Hormone Receptor Knockout mice. Reproduction 139:1-11

33. ZM Lei, J Lin, X Li, S Li, HX Zhou, Y Araki, ZJ Lan (2010) Postnatal Male Germ Cell Expression of the Cre Recombinase in Tex101-iCre Transgenic Mice. Genesis (Sep 17-Epub). DOI: 10.1002/dvg.20675

34. HX Zhou, LH Liu, H Zhang, AJ Cooney, ZM Lei, ZJ Lan (2010) Expression of zinc finger protein 105 in the testis and its role in male fertility. Mol Reprod Dev 77:511-520

35. J Lin, X Li, FP Yuan, L Lin, CL Cook, CV Rao, ZM Lei (2010) Genetic Ablation of Luteinizing Hormone Receptor Improves the Amyloid Pathology in a Mouse Model of Alzheimer’s Disease. J Neuropath Exp Neuro 69:253-256

36. Hamid, Gao YL, Lei ZM, Hougland MT, El-Mallakh RS (2009) Effect of ouabain on sodium pump alpha-isoform expression in an animal model of mania. Prog Neuropsychopharmacol Biol Psychia 33:1103-1106

37. Huang X, Lei ZM, Li XP, El-Mallakh RS (2009) Response of sodium pump to ouabain challenge in human glioblastoma cells in culture. World J Biol Psychia 10:884-92

38. Soukhova-O’ Hare GK, Shah ZA, Lei ZM, Nozdrachev AD, Rao CV, Gozal D (2008) Erectile dysfunction in a murine model of sleep apnea. Am J Resp Critical Care Medicine 178:644-650

39. Hougland MT, Gao YL, Herman L, Chin Ng, Lei ZM, El-Mallakh RS (2008) [18F]-Fluorodeoxyglucose positron emission tomography in an animal model of mania. Psychiatr Res: Neuroimaging 164:166-171

40. Lei ZM, M. Yang, X. Li, O. Takikawa, Ch. V. Rao (2007) upregulation of placental indoleamine 2,3-dioxygenase by human chorionic gonadotropin. Biol Reprod 76:639-644

41. Casadesus G, Milliken EL, Webber KM, Bowen RL, Lei ZM, Rao ChV, Atwood CS, Nilson JH, Perry G, Keri RA, Smith MA (2007) Declines in cognitive performance are associated with increased luteinizing hormone levels in mice. Mol Cell Endocrinol 269:107-111

42. ChV Rao, ZM Lei, (2007) The past, present and future of nongonadal LH/hCG actions in reproductive biology and medicine. Mol Cell Endocrinol 269:2-8

43. X Huang, ZM Lei, RS El-Mallakh (2007) Lithium normalizes elevated intracellular sodium. Bipolar Disord, 9:298-300

44. FP Yuan, DX Lin, ChV Rao, ZM Lei (2006) Cryptorchidism in LHRKO Animals and the Effect of Testosterone Replacement Therapy. Human Reprod 21:936-942

45. Soukhova-O’Hare G, Lei ZM, Falcone JC, Barati MT, Feitelson JBA, Rao ChV, Fleming JT (2005) Bone arterioles from ovariectomized rats have smaller baseline diameters but normal eNOS expression and NO-mediated dilation. Life Sciences 77: 1799-1812

46. Lin DX, Lei ZM, Rao ChV (2005) The expression of uterine cyclooxygenase-2 is dependent on luteinizing hormone signaling. Biol Reprod 73: 256-260

47. Chudgar D, Lei ZM, Rao ChV (2005) Orthotopic transplantation of LH receptor knockout and wild-type ovaries. Life Sciences 77: 2656-2662


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48. Lin DX, Lei ZM, Li X, Rao ChV (2005) Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling. Mol Cell Endocrinol 234:105-116

49. Lei ZM, Mishra S, P. Ponnuru, Li X, Yang ZW, Rao ChV (2004) Testicular phenotype in luteinizing hormone receptor knockout animals and the effect of testosterone replacement therapy. Biol Reprod 71:1605-1613

50. Carlson HE, Kane P, Lei ZM, Li X, Rao ChV (2004) Presence of LH/hCG receptors in male breast tissues. J Clin Endocrinol Metab 89:4119-4123

51. Lo K, Lei ZM, Rao ChV, Lamb DJ (2004) De novo testosterone production in luteinizing hormone receptor knockout mice after transplantation of Leydig stem cells. Endocrinology 145: 4011-4015

52. Rao ChV, Zhou XL, Lei ZM (2004) Functional luteinizing hormone/ chorionic gonadotropin receptors in human adrenal cortical H295R cells. Biol Reprod 71:579-587

53. Rao ChV, Li X, Manna SK, Lei ZM, Aggarwal BB (2004) Functional chorionic gonadotropin/luteinizing hormone receptors in human breast cancer MCF-7 cells. J Biol Chem 279:25503-25510

54. Abdallah MA, Lei ZM, Li X, Greenwold N, Nakajima ST, Jauniaux E, Rao ChV (2004) Human fetal nongonadal tissues contain human chorionic gonadotropin/luteinizing hormone receptor. J Clin Endocrinol Metab, 89:952-956

55. Lin P, Li X, Lei ZM, Rao ChV (2003) Human cervix contains functional luteinizing hormone/human chorionic gonadotropin receptors. J Clin Endocrinol Metab, 88: 4309-3414

56. Yang M, Lei ZM, Rao ChV (2003) The central role of human chorionic gonadotropin in the formation of human placental syncytium. Endocrinology 144:1108-1120

57. Zhang YM, Rao ChV, Lei ZM (2003) Macrophages in human reproductive tissues contain luteinizing hormone/chorionic gonadotropin receptors. Amer J Reprod Immunol 49:93-100

58. Mishra S, Lei ZM, Rao ChV (2003) A novel role of luteinizing hormone in the embryo development in cocultures. Biol Reprod 68:1455-1462

59. Lei ZM, Zou W, Mishra S, Li X, Rao ChV (2003) Epididymal phenotype in LH receptor knockout mice and the responses to testosterone replacement therapy. Biol Reprod 68: 888-895

60. Goodarzi MO, Dawson D, Li X, Lei ZM, Shintaku P, Rao ChV, Herle JV (2003) Virilization in bilateral macronodular adrenal hyperplasia controlled by the luteinizing hormone receptor. J Clin Endocrinol Metab 88:73-77

61. Wy LA, Carlson HE, Kane P, Li X, Lei ZM, Rao ChV (2002) Pregnancy-associated Cusing’s syndrome secondary to an LH/hCG receptor-positive adrenal carcinoma. Gynecol Endocrinol 16:413-417

62. Bhatnagar KP, Li X, Lei ZM, Rao ChV (2002) Human Pineal LH receptor. Biotech Histochem, 77:223-228

63. Akerman F, Lei ZM, Rao Ch V. (2002) Human umbilical cord and fetal membranes co-express leptin and its receptor genes. Gynecol Endocrinol, 16:299-30

64. Rao CV, Lei ZM (2002) Consequences of targeted inactivation of LH receptors. Mol Cell Endocrinol 187:57-67

65. Lei ZM and Rao ChV (2001) Neural actions of luteinizing hormone and human chorionic gonadotropin. Sem Reprod Med, 19:103-109

66. Eblen A, Bao S, Lei ZM, Nakajima ST, Rao ChV (2001) The presence of functional luteinizing hormone/human chorionic gonadotropin receptors in human sperm. J Clin Endocrinol Metab 86:2643-2648

67. Lei ZM, Mishra S, Zou W, Xu B, Foltz M, Li X, Rao ChV (2001) Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol 15:184-200

68. Corley DR, Li X, Lei ZM, Rao ChV (2000) Potential regulation of gonadotropin-releasing hormone gene by steroidogenic factor-1-like protein. Mol Hum Reprod 6:671-676


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69. Akerman FM, Lei ZM, Rao ChV, Nakajima ST (2000) hCG receptor defect leading to a case of spontaneous ovarian hyperstimulation syndrome. Fert Steril 74:403-404

70. Jauniaux E, Bao S, Eblen A, Li X, Lei ZM, Meuris S, Rao ChV (2000) hCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21. Mol Hum Reprod 6:5-10

71. Zhang W, Lei ZM, Rao ChV (1999) Immortalized hippocampal neurons contain functional luteinizing hormone/human chorionic gonadotropin receptors. Life Sci 65:2083-2098

72. Kurtzman JT, Spinnato JA, Goldsmith LJ, Zimmerman MJ, Klem M, Lei ZM, Rao ChV (1999) Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model. Am J Obstet Gynecol 181:853-857

73. Han S.W., Z.M. Lei and Rao ChV (1999) Treatment of human endometrial stromal cells with chorionic gonadotropin promotes their morphological and functional differentiation into decidua. Mol Cell Endrinol 147:7-16.

74. Hu YL, Lei ZM, Rao ChV (1999) Determinants of transcription of the chorionic gonadotropin/luteinizing hormone receptors gene in human breast cells. Breast J 5:186-193. 75. Lei ZM, Taylor DD, Gercel-Taylor C, Rao ChV (1999) Tumorigenic potential of human

chorionic gonadotropin in choriocarcinoma JAR cells. Trophoblast Res 13:147-160. 76. Zhou XL, Lei ZM, Rao ChV (1999) Treatment of human endometrial gland epithelial cells

with chorionic gonadotropin/luteinizing hormone increases the expression of cyclooxygenase-2 gene. J Clin Endocrinol Metab 84:3364-3377.

77. Hu YL, Lei ZM, Rao, ChV (1998) Analysis of the promoter of the luteinizing hormone/human chorionic gonadotropin receptor gene in neuroendocrine cells. Life Sci 63:2157-2165.

78. Tao YX, Heit M, Lei ZM, Rao ChV (1998) The urinary bladder of a woman is a novel site of luteinizing hormone-human chorionic gonadotropin receptor gene expression. Am J Obstet Gynecol 179:1026-1031.

79. Thompson DA, Othman MI, Lei ZM, Li X, Huang ZH, Eadie DM, Rao ChV (1998) Localization of the receptor for luteinizing hormone/chorionic gonadotropin in neural retina. Life Sci 63:1057-1064.

80. Bian L, Lei ZM, Rao ChV (1998) Mitogen activated protein kinase is involved in epidermal growth factor regulated protein phosphorylation in nuclear membranes isolated from JEG-3 human choriocarcinoma cells. Eur J Biochem 253:545-551.

81. Bird JS, Li X, Lei ZM, Sanfilippo J, Yussman MA, Rao ChV (1998) Luteinizing hormone and chorionic gonadotropin decrease type 2 5-alpha reductase and androgen receptor protein levels in women’s skin. J Clin Endocrinol Metab 83:1776-1782.

82. Tao YX, Lei ZM, Rao ChV (1998) Novel expression of luteinizing hormone/human chorionic gonadotropin receptor gene in rat seminal vesicles. J Andrology 19:343-347.

83. Al-Hader AA, Lei ZM, Rao ChV (1997) Fetal rat brains contain functional luteinizing hormone/human chorionic gonadotropin receptors. Early Pregnancy: Biol Med 3:323-329.

84. Al-Hader AA, Lei ZM, Rao ChV (1997) Novel expression of functional luteinizing hormone/human chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. Biol Reprod 56:501-507.

85. Lojun S, Bao S, Lei ZM, Rao ChV (1997) The presence of functional luteinizing hormone/chorionic gonadotropin receptors in human breast cell lines. Biol Reprod 57:1202-1210.

86. Sun T, Lei ZM, Rao ChV (1997) Novel regulation of the oviductal glycoprotein gene expression by luteinizing hormone in bovine oviductal epithelial cells. Mol Cell Endocrinol 131:97-108.

87. Huang ZH, Lei ZM, Rao ChV (1997) Novel independent and synergistic effects of human chorionic gonadotropin and gonadotropin releasing hormone on the expression of luteinizing hormone alpha-subunit gene in alpha T3 gonadotrope cells. Mol Cell Endocrinol 130:23-31.

88. Han SW, Lei ZM, Rao ChV (1997) Homologous downregulation of luteinizing


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hormone/chorionic gonadotropin receptors by increasing the degradation of receptor transcripts in human uterine endometrial stromal cells. Biol Reprod 57:158-164.

89. Lei ZM, Rao ChV (1997) Cis-acting elements and trans-acting proteins in the transcriptional inhibition of gonadotropin releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. J Biol Chem 272:14365-14371.

90. Tao YX, Lei ZM, Rao ChV (1997) Luteinizing hormone/human chorionic gonadotropin receptors in lactating rat mammary glands. Life Sci 60:1297-1303.

91. Al-Hader AA, Lei ZM, Rao ChV (1997) Neurons from fetal rat brains contain functional luteinizing hormone/human chorionic gonadotropin receptors. Biol Reprod 56:1071-1076.

92. Tao YX, Bao S, Ackermann DM, Lei ZM, Rao ChV (1997) Expression of luteinizing hormone/human chorionic gonadotropin receptor gene in benign prostatic hyperplasia and prostate carcinoma. Biol Reprod 56:67-72.

93. Hu YL, Lei ZM, Rao ChV (1996) Cis-acting elements and trans-acting proteins in the increased transcription of human chorionic gonadotropin/luteinizing hormone receptor gene in choriocarcinoma cells as compared with normal term pregnancy placenta. Endocrinology 137:3897-3905.

94. Pabon JE, Bird JS, Li X, Huang Z-H, Lei ZM, Sanfilippo J, Yussman MA, Rao ChV (1996) Human skin contains luteinizing hormone/chorionic gonadotropin receptors. J Clin Endocrinol Metab 81:2738-2741.

95. Han SW, Lei ZM, Rao ChV (1996) Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin in mucosal cells from human fallopian tubes. Endocrinology 137:2929-2937.

96. Pabon JE, Li X, Lei ZM, Sanfilippo J, Yussman MA, Rao ChV (1996) Novel presence of luteinizing hormone/chorionic gonadotropin receptors in human adrenal glands. J Clin Endocrinol Metab 81:2397-2400.

97. Han SW, Lei ZM, Rao ChV (1996) Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into decidua. Endocrinology 137:1791-1797.

98. Li X, Lei ZM, Rao ChV (1996) Human chorionic gonadotropin down-regulates the expression of gonadotropin releasing hormone receptor gene in GT1-7 neurons. Endocrinology 137:899-904.

99. Toth P, Li X, Lei ZM, Rao ChV (1996) Expression of human chorionic gonadotropin (hCG)/Luteinizing hormone receptors and regulation cyclooxygenase-1 gene by exogenous hCG in human fetal membranes. J Clin Endocrinol Metab 81:1283-1287.

100. Környei JL, Li X, Lei ZM, Rao ChV (1996) Restoration of human chorionic gonadotropin response in human myometrial smooth muscle cells by treatment with follicle stimulating hormone (FSH): evidence for novel expression of FSH receptor gene in human myometrium. Eur J Endocrinol 134:225-231.

101. Huang ZH, Lei ZM, Rao ChV (1995) Immortalized anterior pituitary alpha T3 gonadotropes contain functional luteinizing hormone/human chorionic gonadotropin receptors. Mol Cell Endocrinol 114:217-222.

102. Tao YX, Lei ZM, Hofmann GE. Rao ChV (1995) Human intermediate trophoblasts express chorionic gonadotropin/Luteinizing hormone receptor gene. Biol Reprod 53:899-904.

103. How H, Huang ZH, Zuo J, Lei ZM, Spinnato JA II, Rao ChV (1995) Myometrial estradiol and progesterone receptor changes in preterm and term pregnancies. Obstet Gynecol 86:936-940.

104. Lei ZM, Rao ChV (1995) Signaling and transacting factors in the transcriptional inhibition of gonadotropin releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. Mol Cell Endocrinol 109:151-157.

105. Cao H, Lei ZM, Rao ChV (1995) Consequences of antisense human chorionic gonadotropin alpha-subunit cDNA expression in human choriocarcinoma JAR cells. J Mol Endocrinol 14:337-347.

106. Singh M, Zuo J, Li X, Ambrus G, Lei ZM, Yussman MA, Sanfilippo JS, Rao ChV (1995)


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Decreased expression of functional human chorionic gonadotropin/ luteinizing hormone receptor gene in human uterine leiomyomas. Biol Reprod 53:591-597.

107. Tao YX, Lei ZM, Woodworth SH, Rao ChV (1995) Novel expression of luteinizing hormone/chorionic gonadotropin receptor gene in rat prostates. Mol Cell Endocrinol 11:R9-R12.

108. Lin J, Lojun S, Lei ZM, Wu WX, Peiper SC, Rao ChV (1995) Lymphocytes from pregnant women express human chorionic gonadotropin/ luteinizing hormone receptor gene. Mol Cell Endocrinol 111:R13-R17.

109. Cao H, Lei ZM, Bian L, Rao ChV (1995) Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta. Endocrinology 136:3163-3172.

110. Rao ChV, Li X, Toth P, Lei ZM (1995) Expression of epidermal growth factor, transforming growth factor-alpha and their common receptor genes in human umbilical cords. J Clin Endocrinol Metab 80:1012-1020.

111. Környei JL, Li X, Lei ZM, Rao ChV (1995) Analysis of epidermal growth factor action in human myometrial smooth muscle cells. J Endocrinol 146:261-270.

112. Lukacs H, Hiatt ES, Lei ZM, Rao ChV (1995) Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats. Hormones and Behavior 29:42-58.

113. Lin J, Lei ZM, Lojun S, Rao ChV, Stayaswarsop PG, Day TG (1994) Increased expression of luteinizing hormone/human chorionic gonadotropin receptor gene in human endometrial carcinomas. J Clin Endocrinol Metab 79:1483-1491.

114. Zuo J, Lei ZM, Rao ChV (1994) Differential cyclooxygenase-1 and -2 gene expression in human myometria from preterm and term deliveries. J Clin Endocrinol Metab 79:894-899.

115. Cao H, Lei ZM, Rao ChV (1994) Transcriptional and post-transcriptional mechanisms in epidermal growth factor regulation of human chorionic gonadotropin (hCG) subunits and hCG receptor gene expression in human choriocarcinoma cells. Endocrinology 135:962-970.

116. Lei ZM, Rao ChV (1994) Novel expression of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and their role in the down-regulating action of hCG on gonadotropin releasing hormone gene expression in immortalized hypothalamic neurons. Mol Endocrinol 8:1111-1121.

117. Zuo J, Lei ZM, Rao ChV (1994) Human myometrial chorionic gonadotropin/ luteinizing hormone receptors in preterm and term deliveries. J Clin Endocrinol Metab 79:907-911.

118. Woodworth SH, Li X, Lei ZM, Rao ChV, Yussman MA, Spinnato JA II, Yokoyama C, Tanabe T, Ulrich V (1994) Eicosanoid biosynthetic enzymes in placental and decidual tissues from preeclamptic pregnancies: increased expression of thromboxane A2 synthase gene. J Clin Endocrinol Metab 78:1225-1231.

119. Licht P, Cao H, Zuo J, Lei ZM, Rao ChV, Merz WE, Day TG Jr (1994) Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. J Clin Endocrinol Metab 78: 1188-1194,

120. Rao ChV, Li X, Toth P, Lei ZM, Cook VD (1993) Novel expression of functional human chorionic gonadotropin/luteinizing hormone receptor gene in human umbilical cords. J Clin Endocrinol Metab 77:1706-1714.

121. Kornyei JL, Lei ZM, Rao ChV (1993) Human myometrial smooth muscle cells are novel targets of direct regulation by human chorionic gonadotropin. Biol Reprod 49:1149-1157.

122. Licht P, Cao H, Lei ZM, Rao ChV, Merz WE (1993) Novel self-regulation of human chorionic gonadotropin biosynthesis in term pregnancy human placenta. Endocrinology 133:3014-3025.

123. Lei ZM, Rao ChV, Kornyei JL, Licht P, Hiatt ES (1993) Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 132:2262-2270.

124. Lei ZM, Toth P, Rao ChV, Pridham D (1993) Novel co-expression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors and their ligand hCG in human


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fallopian tubers. J Clin Endocrinol Metab 77:863-872. 125. Lei ZM, Rao ChV (1993) Expression of epidermal growth factor (EGF) receptor and its

ligands, EGF and transforming growth factor-alpha, in human fallopian tubes. Endocrinology 131:947-957.

126. Lincoln SR, Lei ZM, Rao ChV, Yussman MA (1993) The expression of human chorionic gonadotropin/human luteinizing hormone receptors in ectopic human endometrial implants. J Clin Endocrinol Metab 75:1140-1144.

127. Lei ZM, Rao ChV, Lincoln SR, Ackermann DM (1993) Increased expression of human chorionic gonadotropin/luteinizing hormone receptors in adenomyosis. J Clin Endocrinol Metab 76:763-768.

128. Shi QJ, Lei ZM, Rao ChV, Lin J (1993) Novel role human chorionic gonadotropin in differentiation of human cytotrophoblasts. Endocrinology 132:1387-1395.

129. Swanson MS, Lei ZM, Swanson PH, Rao ChV (1992) The expression of thromboxane A2 synthase and thromboxane A2 receptor gene in human uterus. Biol Reprod 47:105-117.

130. Lei ZM, Reshef E, Rao ChV (1992) The expression of human chorionic gonadotropin/luteinizing hormone receptors in human endometrial and myometrial blood vessels. J Clin Endocrinol Metab 5:651-659.

131. Lei ZM, Rao ChV (1992) The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria. Endocrinology 130:861-869.

132. Lei ZM, Rao ChV, Ackermann DM, Day TG (1992) The expression of human chorionic gonadotropin/human luteinizing hormone receptors in human gestational trophoblastic neoplasms. J Clin Endocrinol Metab 74:1236-1241.

133. Lei ZM, Rao ChV (1992) Gonadotropin receptors in human fetoplacental unit: implications for hCG as an intracrine, paracrine and endocrine regulator of human fetoplacental function. Trophoblast Res 6:213-224.

134. Bibbins PE Jr, Rao ChV, Carman FR, Chegini N, Lei ZM (1991) Role of luteal cell nucleus in the expression of gonadotropin action. J Endocrinol Invest 14:391-400.

135. Chegini N, Lei ZM, Rao ChV (1991) Nuclear volume and chromatin conformation of small and large bovine luteal cells: effect of gonadotropins and prostaglandins and dependence on luteal phase. Cell Tissue Res 264:453-460.

136. Chegini N, Lei ZM, Rao ChV, Hansel W (1991) Cellular distribution and cycle phase dependency of gonadotropin and eicosanoid binding sites in bovine corpora lutea. Biol Reprod, 45:506-513.

137. Stoelk E, Chegini N, Lei ZM, Rao ChV, Bryant-Greenwood G, Sanfilippo J (1991) Immunocytochemical localization of relaxin in human corpora lutea: cellular and subcellular distribution and dependence on reproductive state. Biol Reprod 44:1140-1147.

138. Chegini N, Lei ZM, Rao ChV, Bischof P (1991) The presence of pregnancy-associated plasma protein-A in human corpora lutea: Cellular and subcellular distribution and dependence on reproduction state. Biol Reprod 44:210-206.

139. Lei ZM, Chegini N, Rao ChV (1991) Quantitative cell composition of human and bovine corpora lutea from various reproductive states. Biol Reprod 44:1148-1156.

140. Mitchell D, Lei ZM, Rao ChV (1991) The enzymes in cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism in human corpora lutea: Dependence on luteal phase, cellular and subcellular distribution. Prostaglandins Leukotrienes and Essential Fatty Acids 43:1-12.

141. Chegini N, Rao ChV, Lei ZM (1990) Autoradiographic localization of specific prostacyclin binding sites in bovine corpora lutea of pregnancy. Mol Cell Endocrinol 71:133-140.

142. Reshef E, Lei ZM, Rao ChV, Bailey-Pridham D, Chegini N, Luborsky JL (1990) The presence of gonadotropin receptors in non-pregnant human uterus, human placenta, fetal membranes and decidua. J Clin Endocrinol Metab 70:421-430.

143. Bailey-Pridham D, Lei ZM, Chegini N, Rao ChV, Yussman MA, Cook CL (1990) Light and electron microscope immunocytochemical localization of 5- and 12-lipoxygenases and


26

cyclooxygenase enzymes in human granulosa cells from preovulatory follicles. Prostaglandins Leukotrienes and Essential Fatty Acids 39:231-238.

144. Chen YQ, Lei ZM (1989) Beta-glycuronidase activity of leukocytes in patients with gastrointestinal tumors. J Fujian Medical College 30:125-132.

145. Chen AM, Lei ZM (1989) Effects of glucocorticoid on the heart and liver of rat. J Tianjin Medical College 2:3-5.

146. Zhang YC, Lei ZM (1984) Palladiophilic granules of neurons and their relationship to receptors of thyroid hormone in the CNS of mouse. Chinese J Anat 7:386-388.

147. Lei ZM, Gao ZQ, Chen AM, Liu LQ, Zhang YC (1984) Glucagon-like immunoreactive cells in the thymus of chicken. Chinese J Anat 7:288-289.

148. Lei ZM, Chen AM, Gao ZQ, Liu LQ, Xu SM, Zhang YC (1984) Immunocytochemical studies of A. B. D. cells of Langerhans islets in rats affected by glucocorticoid. Sichnan J Anat 4:1-4.

149. Lei ZM, Chen AM, Gao ZQ, Liu LQ, Xu SM, Zhang YC (1983) Immunocytochemical localization of thyrotropin releasing hormone-like cells in rat pancreas. Chinese J Anat 6:349-351.

B. Non peer-reviewed

1. Jing Lin, Zhenmin Lei, (2016) Chromatin immunoprecipitation with estrogen receptor 1 and the promoter of Greb1 in TM4 Sertoli cells. In Estrogen Receptors Methods and Protocols, Methods in Molecular Biology 1366, Kathleen M. Eyster Editor, Humana Press, Springer, New York, pp. 67-77, DOI: 10.1007/978-1-4939-3127-9_7.

2. Rao ChV, ZM Lei (2003) Knockout of gonadotropins and their receptor genes. In Encyclopedia of Hormones, Helen L. Henry and Anthony W. Norman, Eds, Female Reproduction Section Editor, Evan R. Simpson, Academic Press, San Diego, CA, Vol. 2, pp. 554-562

3. Lei ZM, Rao ChV (2002) Early pregnancy promoting actions of LH and hCG. In Advances in Gynecological Endocrinology, Genazzani AR, Petraglia F & Artini PG, Eds, The Parthenon Publishing Group, London, pp.185-192

4. Lei ZM, Rao ChV (2001) Protective role of human chorionic gonadotropin and luteinizing hormone against breast cancer. In Cancer & Pregnancy, Barnea ER, Jauniaux E, Schwartz PE, Schofield PN, Eds, Springer-Verlag, London, pp209-215

5. Lei ZM, Rao ChV (2000) Endocrinology of trophoblast tissue. In Principles and Practice of Endocrinology and Metabolism, 3rd edition, Becker, K.A. Ed, Lippincott Williams & Wilkins, Philadelphia, PA, Chap 112, pp180-186

6. Lei ZM, Rao ChV (1999) Direct luteinizing hormone regulation of male reproductive tract. In Current Knowledge in Reproductive Medicine, Coutinho AM & Spinola P Eds., Elsevier Science B.V. Amsterdam, The Netherlands, pp3-9.

7. Licht P, Lei ZM, Rao ChV and Merz ME (1994) The presence and functional relevance of hCG/LH receptors in normal human placenta and choriocarcinomas. In Implantation and Early Pregnancy in Humans, Barnea ER, Grudzinskas JG and Maruo T, Eds, Parthenon Publishing Group Ltd., UK. pp. 235-246.

8. Rao ChV, Reshef E, Lei ZM (1991) Gonadotropin receptors in nongonadal reproductive tissues. ARTA 1:241-253.

9. Lei ZM, Rao ChV (1990) Immunocytochemical localization of gonadotropin receptors in human placenta and fetal membranes. In Proceeding of XIIIth World Congress on Fertility and Sterility: New Concepts in Reproduction, Boutaleb Y, Ed, Parthenon Publishing Group Ltd., UK, 6:129-137.

10. Rao ChV, Chegini N, Lei ZM (1989) Immunocytochemical localization of 5-lipoxygenase, 12-lipoxygenase and cyclooxygenase in non-pregnant human uteri. In Leukotrienes and prostanoids in health and disease New Trends Lipid Mediators Res, Zor U, Ed, Basel, Karger, Switzerland, Vol. 3, pp283-286.

11. Chegini N, Lei ZM, Rao ChV (1989) Light and electron microscope immunocytochemical


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localization of epidermal growth factor receptors in bovine corpora lutea of pregnancy. In Growth Factor and the Ovary (A. Hershfield ed.) Plenum Publishing Co. pp213-219.

12. Rao ChV, Chegini N, Lei ZM (1988) Epidermal growth factor in human placenta. In Placental Protein Hormone, Mochizuki M, Ed, Elsevier Science Publishers B.V. (Biomedical Division), Netherlands, pp171-182.

13. Lei ZM (1984) Effects of glucocorticoid on hypothalamus-pituitary-thyroid axis of rat. (Thesis for Master of Science).

14. Lei ZM, Zhang YC (1983) Brain specific acidic proteins: S-100 and 14-3-2 protein. Acta Academiae Medicinae Tianjin 4:101-105.

15. Lei ZM, Zhang YC (1983) Recent advances of thyrotropin releasing hormone. J Foreign Medicine: Endocrinology 4:180-183.

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Revised 8/1/2018 Zhenmin Lei, M.D., Ph.D. ZHENMIN LEI, M.D ... CV.pdf · Revised 8/1/2018 Zhenmin Lei, M.D., Ph.D. 2 HONORS AND AWARDS HONORS 1. Who’s Who in America, since 2000