Review Questions for Exam 2 2011

8/3/2019 Review Questions for Exam 2 2011

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What is the most common cause of cancer

death in women in the United States?

1. Breast cancer

2. Lung cancer3. Colorectal cancer

4. Basal cell carcinoma

5. Melanoma



A chromosome entering meiosis is composed of two chromatids,each of which is a single DNA molecule. At the end of meiosis I,

how many chromosomes and chromatids are there per cell?

1. 23; 23

2. 23; 46

3. 46; 23

4. 46; 46



A chromosome entering meiosis is composed of two chromatids,each of which is a single DNA molecule. At the end of meiosis II,

how many chromosomes and chromatids are there per cell?

1. 23; 232. 23; 46

3. 46; 23

4. 23; 23



What is the most common cause of cancer

death in women in the United States?

1. Breast cancer

2. Lung cancer

3. Colorectal cancer


5. Melanoma



1. Mitotic activity2. Atypical cells

3. Autonomous growth

4. Metastasis

A study is performed to analyze characteristics of malignantneoplasms in biopsy specimens. The biopsies were performed onpatients who had palpable mass lesions on digital rectalexamination. Of the following microscopic findings, which is mostlikely to indicate that the neoplasm is malignant?



What is the most common cancer in men in the US?

1. Prostate cancer

2. Lung cancer

3. Colorectal cancer


5. Melanoma



Review of a series of surgical pathology reports indicates that a

certain type of neoplasm is graded as grade I on a scale of I to III.Clinically, some of the patients with this neoplasm are found to bestage I. Which of the following is the best interpretation of a

neoplasm with this stage I designation?

1. It is unlikely to be malignant.

2. It has metastasized via lymphatics.

3. It is anaplastic.

4. It is well-differentiated andlocalized.



What syndrome is characterized by inherited mutations

of the p53 tumor suppressor gene?

1. Bloom syndrome

2. Li-Fraumeni syndrome

3. Nevoid basal cell carcinoma syndrome

4. Fetal alcohol syndrome

5. Wernicke syndrome



Which of the following malignancies is not associated

with Epstein-Barr virus infection?

1. Nasopharyngeal carcinoma

2. Burkitt lymphoma3. B-cell lymphomas in the immunosuppressed

4. Kaposi sarcoma

5. Hodgkins lymphoma



A 41-year-old woman has a squamous cell carcinoma of the cervix. She

is found to have a positive serologic test for syphilis. Which of thefollowing is most likely to have initiated the development of hercervical cancer?

1. Human papillomavirus infection

2. Diabetes mellitus, type II

3. Heavy cigarette smoking

4. Pelvic inflammatory disease5. Previous cancer chemotherapy



Which are characteristics of hermaphroditism?

1. Presence of both testicular and ovarian tissue

2. 46,XX karyotype with normal ovarian tissue

but ambiguous or male external genitalia3. 46, XY karyotype with testes AND incomplete

masculization of genital ducts and genitalia

4. 46, XY karyotype with apparently normalfemale external genitalia



A 16-year-old diabetic patient is administered glucosesolution intravenously by mistake at the ER. Her next

plasma glucose measurement is 350mg/dL (normalrange is 70-110mg/dL). What is the bodys physiological

response to this homeostatic deviation?

1.Initiates corrective mechanisms to restore plasma

glucose

2.Decreases endogenous insulin secretion3.Decreases glucose uptake by the brain

4.Mobilizes extra glucose from the liver



What is the contribution of the Respiratory System to the

maintenance of homeostasis?

1.Obtains O2 from and eliminates carbon dioxide (CO2) to the

external environment

2.Removes excess water, salt, acid and electrolytes from the

plasma3.Transports nutrients, gases, wastes, electrolytes and

hormones between organs

4.Transports water and electrolytes from the external

environment to the internal environment



Which fluid compartments make up the internal

environment?

1.Extracellular fluid + intracellular fluid

2.Intracellular fluid + interstitial fluid

3.Intracellular fluid + total body fluid

4.Plasma + interstitial fluid



Why do multi-cell organisms need an internal

environment?

1.homeostasis is the underlying theme of physiology

2.most cells are in contact with the external

environment3.most cells are only in contact with the internal

environment

4.the primary function of most body systems is the

maintenance of homeostasis



The incidence of sickle cell anemia among blacks is 1

in 400. Calculate the frequency of heterozygotes for

sickle cell gene, encoding -globin, in this population.

1. 1 in 6

2. 1 in 11

3. 1 in 20

4. 1 in 22

5. 1 in 44



What is the karyotype? (Just include the

affected arms, not the regions or the bands.)



Which pedigree shows an X-linked recessive

mode of inheritance?

A B



Mutations leading neurofibromatosis type I are scattered across

the neurofibromin gene, with inherited mutations being uniqueto a family.

The statement above regarding theneurofibromin gene indicates what type of

genetic heterogeneity?

A. Allelic

B. Clinical or phenotypic

C. Locus

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Review Questions for Exam 2 2011